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Structural attributes of model protein formulations prepared by rapid freeze-drying cycles in a microscale heating stage.

Björn-Hendrik Peters et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 347-356 (2014-03-13)

Downscaled freeze-drying was demonstrated to be a valuable alternative for formulation development and optimization. Although the pore structure is known to exert a major influence on the freeze-drying cycle, little is known about the ones of microscale preparations. This study

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Evaluation of some water-miscible organic solvents for spray-drying enzymes and carbohydrates.

Anke Sass et al.

Drug development and industrial pharmacy, 40(6), 749-757 (2013-04-20)

The spray-drying behaviour of 16 water-miscible organic solvents on a bench-scale machine (Büchi B290 with inert loop) was determined under mild-to-moderate process conditions, namely inlet gas temperature of 130 °C and liquid feed flow rate of ≤3 mL/min. The solvents with boiling

The surface charge of liposomal adjuvants is decisive for their interactions with the Calu-3 and A549 airway epithelial cell culture models.

Pall Thor Ingvarsson et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(3), 480-488 (2014-04-15)

One of the main reasons for the unmet medical need for mucosal vaccines is the lack of safe and efficacious mucosal adjuvants. The cationic liposome-based adjuvant system composed of dimethyldioctadecylammonium (DDA) bromide and trehalose 6,6'-dibehenate (TDB) is a versatile adjuvant

A Guide for Ex Vivo Handling and Storage of Stool Samples Intended for Fecal Microbiota Transplantation.

Sebastian D Burz et al.

Scientific reports, 9(1), 8897-8897 (2019-06-22)

Owing to the growing recognition of the gut microbiota as a main partner of human health, we are expecting that the number of indications for fecal microbiota transplantation (FMT) will increase. Thus, there is an urgent need for standardization of

Effect of lyophilization on liposomal encapsulation of salmon calcitonin.

Janani Swaminathan et al.

Journal of liposome research, 24(4), 297-303 (2014-04-09)

The intent of this work was to assess the impact of lyophilization on the encapsulation of salmon calcitonin (sCT) into liposomes. Four different liposomal formulations were investigated, i.e. DPPC:Chol:DSPE-PEG(2000) (75:20:5 and 65:30:5) and DPPC:Chol (80:20 and 66.7:33.3). Lipid films were

Measurement of shrinkage and cracking in lyophilized amorphous cakes. Part I: final-product assessment.

Sabine Ullrich et al.

Journal of pharmaceutical sciences, 104(1), 155-164 (2014-11-26)

An experimental technique is presented to determine independently shrinkage and cracking in lyophilized amorphous cakes based on photographic imaging of their top surface. An inverse correlation between cake shrinkage and cracking during freeze-drying is seen. Shrinkage relaxes the drying tension

Drying and denaturation characteristics of whey protein isolate in the presence of lactose and trehalose.

M Amdadul Haque et al.

Food chemistry, 177, 8-16 (2015-02-11)

The denaturation kinetics of whey protein isolate (WPI), in the presence and absence of lactose and trehalose, was quantified in a convective air-drying environment. Single droplets of WPI, WPI-lactose and WPI-trehalose were dried in conditioned air (2.5% RH, 0.5m/s air

The importance of formulation in the successful lyophilization of influenza reference materials.

Chinwe Duru et al.

Biologicals : journal of the International Association of Biological Standardization, 43(2), 110-116 (2015-01-24)

Lyophilized Influenza antigen reference reagents are a critical resource in the quality control of influenza vaccines. A standard formulation has been used successfully at NIBSC for many years however, following the unexpected occurrence of a collapsed appearance in a particular

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