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Jean-Saville Cummings et al.
Vaccine, 32(43), 5577-5584 (2014-08-19)
Innate mechanisms are critical for the development of the host immune responses to antigen. Particularly, early interaction between natural killer (NK) cells and dendritic cells (DC) greatly impacts the establishment of both innate and adaptive immune responses. In this study
Shu-Ching Chen et al.
PloS one, 9(11), e109961-e109961 (2014-11-13)
Emerging evidences have shown that diabetes mellitus not only raises risk but also heightens mortality rate of cancer. It is not clear, however, whether antitumor CD8+ cytotoxic T lymphocyte (CTL) response is down-modulated in diabetic hosts. We investigated the impact
Kristen N Pollizzi et al.
PloS one, 10(4), e0121710-e0121710 (2015-04-08)
mTOR is a central integrator of metabolic and immunological stimuli, dictating immune cell activation, proliferation and differentiation. In this study, we demonstrate that within a clonal population of activated T cells, there exist both mTORhi and mTORlo cells exhibiting highly
Monique R Anderson et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 9(4), 522-532 (2014-05-23)
HTLV-1 is a human retrovirus that is associated with the neuroinflammatory disorder HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). In these patients, HTLV-1 is primarily found in the CD4(+)CD25(+) T cell subset (Regulatory T cells:Tregs), which is responsible for peripheral immune
Javier Sánchez-Rodríguez et al.
Journal of biomedical nanotechnology, 11(10), 1783-1798 (2015-10-28)
The concept of a "microbicide" was born out of the lack of a vaccine against HIV and the difficulty of women in ensuring the use of preventive prophylaxis by their partners, especially in developing countries. Approaches using polyanionic carbosilane dendrimers
Katherine C Upchurch et al.
Immunology letters, 168(1), 89-97 (2015-09-19)
Toll-like receptor 7 (TLR7) agonists are of interest as vaccine adjuvants and cancer therapeutics. Therefore, development of new TLR7 agonists that can efficiently promote host immune responses without evoking side effects is of great importance. Here, we describe two new
Maha Moussa et al.
Vaccine, 33(19), 2273-2282 (2015-04-01)
Novel HIV vaccine vectors and strategies are needed to control HIV/AIDS epidemic in humans and eradicate the infection. DNA vaccines alone failed to induce immune responses robust enough to control HIV-1. Development of lentivirus-based DNA vaccines deficient for integration and
Emeka B Okeke et al.
Journal of immunology (Baltimore, Md. : 1950), 193(2), 655-662 (2014-06-20)
Regulatory T cells (Tregs) are essential for maintenance of peripheral tolerance, and defects in Treg function have been linked to several autoimmune diseases. We previously reported that depletion of Tregs resulted in mortality to an otherwise nonlethal dose of LPS
Yang Liu et al.
PloS one, 9(8), e103938-e103938 (2014-08-02)
The chemokine CXCL12 regulates multiple cell functions through its receptor, CXCR4. However, recent studies have shown that CXCL12 also binds a second receptor, CXCR7, to potentiate signal transduction and cell activity. In contrast to CXCL12/CXCR4, few studies have focused on
Rui Liu et al.
Rheumatology (Oxford, England), 54(2), 332-342 (2014-08-30)
The aim of this study was to investigate the effect of umbilical cord mesenchymal stem cells (UC-MSCs) on circulating T follicular helper (cTfh) cells in primary SS (pSS) patients. The percentage of CXCR5(+)PD-1(+)CD4(+) T cells in peripheral blood mononuclear cells
Stefano Pianta et al.
Stem cell reviews, 11(3), 394-407 (2014-10-29)
We previously demonstrated that cells derived from the mesenchymal layer of the human amniotic membrane (hAMSC) and their conditioned medium (CM-hAMSC) modulate lymphocyte proliferation in a dose-dependent manner. In order to understand the mechanisms involved in immune regulation exerted by
Yong Woo Ji et al.
Investigative ophthalmology & visual science, 55(10), 6829-6838 (2014-09-27)
We aimed to determine the role of CCR7+CD11b+ cell lymph node (LN) homing and T-cell differentiation in dry eye (DE)-induced immunopathogenesis and investigate the therapeutic effects of cyclooxygenase-2 (COX-2) and prostaglandin E2/eicosanoid-prostanoid (PGE2/EP) inhibitors against DE. Six-week-old female C57BL/6 mice
Themis Alissafi et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5812-5824 (2015-05-08)
Foxp3(+) regulatory T cell (Treg)-based immunotherapy holds promise for autoimmune diseases. However, this effort has been hampered by major caveats, including the low frequency of autoantigen-specific Foxp3(+) Tregs and lack of understanding of their molecular and cellular targets, in an
Raquel Cabezón et al.
Journal of leukocyte biology, 97(4), 751-760 (2015-01-28)
The aim of this study was to test the hypothesis whether MERTK, which is up-regulated in human DCs treated with immunosuppressive agents, is directly involved in modulating T cell activation. MERTK is a member of the TAM family and contributes
Woong Heo et al.
Molecular medicine reports, 11(3), 1800-1806 (2014-11-12)
Radiotherapy has been used to treat cancer for >100 years and is required by numerous patients with cancer. Ionizing radiation effectively inhibits the growth of cancer cells by inducing cell death and increasing anticancer immunity, through the induction of natural
Zhitao Wang et al.
Cancer immunology, immunotherapy : CII, 64(3), 389-399 (2014-12-31)
Myeloid-derived suppressor cells (MDSCs) are heterogeneous, immature, myeloid progenitor cells, which suppress immune responses against tumors. CD14(+)HLA-DR(-/low) monocytic MDSCs (M-MDSC) are increased in patients suffering from multiple myeloma (MM). However, the frequency and function of M-MDSCs with the relationship between
Giuseppina Barutello et al.
Oncoimmunology, 4(5), e1005500-e1005500 (2015-07-15)
Maternal immunization is successfully applied against some life-threatening infectious diseases as it can protect the mother and her offspring through the passive transfer of maternal antibodies. Here, we sought to evaluate whether the concept of maternal immunization could also be
Supawadee Umthong et al.
Journal of microbiology and biotechnology, 25(4), 526-536 (2014-10-29)
Leptospirosis is a worldwide zoonotic disease caused by pathogenic Leptospira, a genus of which more than 250 serovars have been identified. Commercial bacterin vaccines are limited in that they lack both cross-protection against heterologous serovars and long-term protection. This study
Masahiro Kitabatake et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1480-1488 (2015-01-21)
Peritoneal B1a cells expressing CD5 and CD11b generate autoantibody-producing precursors in autoimmune-prone mice. Previous studies show reduced JNK signaling in peritoneal B1a cells of female New Zealand Black mice and an abnormal increase of protein phosphatase 2A subunit G5PR that
Vipul K Pandey et al.
International immunopharmacology, 23(2), 480-488 (2014-10-04)
Dendritic cells (DC) play a central role in the development of an adaptive immune response against tumor. In addition to its role in antigen presentation, DC also possesses cytotoxic activity against tumor cells. We have earlier shown phenotypic and functional
Ang Huang et al.
Journal of immunology (Baltimore, Md. : 1950), 193(11), 5461-5469 (2014-10-26)
Although myeloid-derived suppressor cells (MDSCs) are well known for their immunosuppressive function in several pathological conditions, the role of MDSCs in hepatitis B virus infection remains obscure. In this study, we investigated the frequency and function of MDSCs in the
Ying Chen et al.
BMC immunology, 16, 29-29 (2015-05-20)
Scavenger receptor A (SRA) is expressed predominantly in phagocytic cells playing an essential role in the host immune defense against invading microorganisms. Our previous study reported the presence of SRA in a soluble form in patients with infection of hepatitis
Wei-Ling Chang et al.
Oncotarget, 6(37), 39806-39820 (2015-10-09)
Nitroxoline is an antibiotic by chelating Zn2+ and Fe2+ from biofilm matrix. In this study, nitroxoline induced G1 arrest of cell cycle and subsequent apoptosis in prostate cancer cells through ion chelating-independent pathway. It decreased protein levels of cyclin D1
Zhenyu Xiao et al.
Cancer letters, 360(2), 302-309 (2015-02-28)
Human hepatocellular carcinoma (HCC) has a high rate of tumor recurrence and metastasis, resulting in shortened survival times. The efficacy of current systemic therapies for HCC is limited. In this study, we used xenograft tumor models to investigate the use
Jessica Mayeux et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 1955-1963 (2015-07-26)
Tight control of B cell differentiation into plasma cells (PCs) is critical for proper immune responses and the prevention of autoimmunity. The Ets1 transcription factor acts in B cells to prevent PC differentiation. Ets1(-/-) mice accumulate PCs and produce autoantibodies.
Zhe Gao et al.
Biochemical pharmacology, 92(2), 358-368 (2014-09-15)
Strategy on activated T cells is an effective treatment for T cell mediated diseases. By using a synthesized chromone derivative, we examined its effects on the activated T cells. This compound, (Z)-1,3-dihydroxy-9-methyl-13H-benzo[b]chromeno[3,2-f][1,4]oxazepin-13-one (neochromine S5), exhibited immunosuppressive activity in vitro and
Yong-Qin Wang et al.
Immunology, 142(4), 603-613 (2014-03-29)
The c-Jun N-terminal kinase (JNK) signalling pathway appears to act as a critical intermediate in the regulation of lymphocyte activation and proliferation. The majority of studies on the importance of JNK are focused on its role in T helper responses
Michela Terlizzi et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 37(4), 214-224 (2014-04-10)
The biology of plasmacytoid dendritic cells (pDCs) in tumors is an emerging area of investigation. pDCs populate many human solid tumors, including lung cancer. The aim of our study was to understand the role of pDCs in pulmonary metastases during
Sanda Stankovic et al.
Journal of immunology (Baltimore, Md. : 1950), 195(10), 4892-4899 (2015-10-11)
The ability of CD4 T cells to give rise to specialized T follicular helper cells (TFH) critical to initiating appropriate Ab responses is regulated by environmental cues in lymphoid tissues draining the site of infection. In this study, we used
Riyanto Heru Nugroho et al.
Journal of bioscience and bioengineering, 120(4), 396-404 (2015-03-22)
Acid stress has been reported to inhibit cell growth and decrease productivity during bio-production processes. In this study, a metabolomics approach was conducted to understand the effect of lactic acid induced stress on metabolite pools in Saccharomyces cerevisiae. Cells were
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