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Ji Eun Lee et al.
Scientific reports, 5, 8420-8420 (2015-02-13)
Polypyrrole (PPy)/cellulose (PPCL) composite papers were fabricated by vapor phase polymerization. Importantly, the vapor-phase deposition of PPy onto cellulose was assisted by employing different co-vapors namely methanol, ethanol, benzene, water, toluene and hexane, in addition to pyrrole. The resulting PPCL
J Rossaint et al.
Journal of thrombosis and haemostasis : JTH, 11(2), 335-344 (2012-12-13)
Integrin-mediated platelet function plays an important role in primary hemostasis. Growth-differentiation factor 15 (GDF-15) has been shown to inhibit β(2) -integrin activation in leukocytes. We investigated the effect of GDF-15 on platelet integrin activation in vitro and in different in
Jihong Li et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(10), 2321-2329 (2014-08-26)
Treatment of myocardial infarction within the first 1 to 2 hours with a thrombolytic agent, percutaneous coronary intervention, or an αIIbβ3 antagonist decreases mortality and the later development of heart failure. We previously reported on a novel small molecule αIIbβ3
Manish Charan et al.
Antimicrobial agents and chemotherapy, 58(6), 3389-3398 (2014-04-09)
The plastid of the malaria parasite, the apicoplast, is essential for parasite survival. It houses several pathways of bacterial origin that are considered attractive sites for drug intervention. Among these is the sulfur mobilization (SUF) pathway of Fe-S cluster biogenesis.
Alexandre Rodrigues Lobo et al.
Journal of nutritional science and vitaminology, 60(6), 397-402 (2014-01-01)
In animal models, Fe overload is associated with organ oxidative stress and tissue injury. In this context, luminal Fe may affect the mucosal barrier and function or generate a pathological milieu in the intestine that triggers epithelial cell stress. Here
Dongying Ma et al.
Blood, 122(25), 4094-4106 (2013-10-26)
The identity of vampire bat saliva anticoagulant remained elusive for almost a century. Sequencing the salivary gland genes from the vampire bat Desmodus rotundus identified Desmolaris as a novel 21.5-kDa naturally deleted (Kunitz 1-domainless) form of tissue factor pathway inhibitor.
Olga Shevchuk et al.
Methods in molecular biology (Clifton, N.J.), 983, 419-429 (2013-03-16)
Dictyostelium discoideum cells are "professional phagocytes," as they ingest a large variety of bacteria, yeast, and inert particles. Several bacterial pathogens are able to survive intracellularly within specialized vacuoles of D. discoideum by interfering with host signaling pathways. To better
Patrick Münzer et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(1), 61-71 (2013-11-16)
Platelet activation is essential for primary hemostasis and acute thrombotic vascular occlusions. On activation, platelets release their prothrombotic granules and expose phosphatidylserine, thus fostering thrombin generation and thrombus formation. In other cell types, both degranulation and phosphatidylserine exposure are modified
Ko-Lin Kuo et al.
PloS one, 7(12), e50295-e50295 (2012-12-12)
The association between intravenous (IV) iron administration and outcomes in hemodialysis (HD) patients is still debated. Therefore, this study was aimed to assess the relationship between the IV administration of ferric chloride hexahydrate (Atofen®) and cardiovascular (CV) outcome and the
Małgorzata Goralska et al.
Investigative ophthalmology & visual science, 54(12), 7666-7673 (2013-11-07)
Intracellular iron trafficking and the characteristics of iron distribution from different sources are poorly understood. We previously determined that the lens removes excess iron from fluids of inflamed eyes. In the current study, we examined uptake and intracellular distribution of
J P Dzoyem et al.
Journal of ethnopharmacology, 160, 194-201 (2014-12-06)
Oxidative stress and inflammatory conditions are among the pathological features associated with the central nervous system in Alzheimer׳s disease. Traditionally, medicinal plants have been used to alleviate inflammation, pains and also other symptoms possibly associated with Alzheimer׳s disease. Therefore, the
Nilaksh Gupta et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(1), 160-168 (2013-11-02)
Proteasome inhibitors used in the treatment of hematologic cancers also reduce thrombosis. Whether the proteasome participates in platelet activation or function is unclear because little is known of the proteasome in these terminally differentiated cells. Platelets displayed all 3 primary
Munasib Khan et al.
Phytotherapy research : PTR, 28(9), 1349-1358 (2014-03-13)
Crude extract of Lens culinaris (Lc.Cr), which tested positive for presence of anthraquinones, flavonoids, saponins, sterol, tannins, and terpenes exhibited protective effect against castor oil-induced diarrhea in mice at 100-1000 mg/kg. In rabbit jejunum preparations, Lc.Cr caused relaxation of spontaneous contractions
O M Vasyliv et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 75(2), 37-44 (2013-06-01)
Superoxide dismutase, as one of the enzymes of cells' antioxidant defensive system, catalyzes superoxide anion-radical (O2-) dismutation with O2 and H2O2 forming. The influence of such transition metal compounds, as FeSO4, FeCl3, MnCl2, NiCl2, and CoCl2 on superoxide dismutase activity
Gabriel A Agbor et al.
Pharmaceutical biology, 52(9), 1128-1133 (2014-03-19)
Justicia hypocrateriformis Vahl (Acanthaceae) is used as an herbal remedy for diarrhea in Cameroon folk medicine. This study evaluates the antidiarrheal and antioxidant properties of the aqueous extract of J. hypocrateriformis (JH). Preliminary phytochemical screening and an acute toxicity testing
Wei Li et al.
Journal of hazardous materials, 244-245, 698-708 (2012-11-28)
Changes of fluorescence excitation emission matrixes (EEM) of wastewater caused by Fenton process (FP) and Fenton-like process (FLP) were quantified in this study. Their association with the generation of hydroxyl radicals, formation of oxidation products of effluent organic matter (EfOM)
Xiehong Cao et al.
Angewandte Chemie (International ed. in English), 53(5), 1404-1409 (2014-01-25)
A simple method for the preparation of metal-oxide-coated three-dimensional (3D) graphene composites was developed. The metal-organic frameworks (MOFs) that served as the precursors of the metal oxides were first synthesized on the 3D graphene networks (3DGNs). The desired metal oxide/3DGN
Christopher Pelham et al.
Biochimica et biophysica acta, 1829(12), 1257-1265 (2013-11-05)
Hereditary hemochromatosis (HH) is a common autosomal recessive disorder of iron overload among Caucasians of northern European descent. Over 85% of all cases with HH are due to mutations in the hemochromatosis protein (HFE) involved in iron metabolism. Although the
Jean Paul Dzoyem et al.
Journal of ethnopharmacology, 156, 1-8 (2014-08-26)
Culinary herbs and spices are widely used ethnomedically across Africa. They are traditionally employed in the treatment of several ailments including inflammation disorders, pain alleviation and infectious diseases. Pharmacological studies are necessary to provide a scientific basis to substantiate their
Jin Wang et al.
Journal of environmental sciences (China), 25(2), 308-315 (2013-04-20)
A cake layer is formed by coagulation aggregates under certain transmembrane pressure in the coagulation-microfiltration (MF) process. The characteristics of humic acid aggregates coagulated by different iron-based coagulants, such as charge, size, fractal dimension and compressibility, have an effect on
Efficient generation of ortho-naphthoquinone methides from 1,4-epoxy-1,4-dihydronaphthalenes and their annulation with allyl silanes.
Yoshinari Sawama et al.
Angewandte Chemie (International ed. in English), 52(5), 1515-1519 (2012-12-21)
K Krishnanunni et al.
Journal of food science and technology, 52(5), 2572-2584 (2015-04-22)
The objective of this study is to analyze the chemical composition and volatiles present in two medicinal rice varieties of "karungkuravai" and "mappilai samba" and to investigate their total phenolic content and bio activity. Chemical composition of the rice varieties
Khushwant S Bhullar et al.
Food chemistry, 168, 595-605 (2014-08-31)
Partridgeberry (Vaccinium vitis-idaea) is a polyphenol-rich berry of the Ericaceous family, grown in Newfoundland and Labrador province of Canada. The aims of this study were to identify extraction solvents for the maximum recovery of polyphenols, to establish fractionation technique for
Ali Akbar Asgharinezhad et al.
Analytica chimica acta, 844, 80-89 (2014-08-31)
In this study, diverse types of Fe3O4 nanocomposites modified by polyaniline, polypyrrole, and aniline-pyrrole copolymer were synthesized through chemical oxidative polymerization process for dispersive-μ-solid phase extraction (D-μ-SPE) in the presence of various dopants. The results showed that the nanocomposite modified
M Golder et al.
Thrombosis and haemostasis, 109(1), 53-60 (2012-11-28)
Factor VIII (FVIII), a procoagulant cofactor, plays a crucial role in the intrinsic coagulation cascade. A causal association between elevated FVIII levels and venous thrombosis incidence has been established; no such association has been confirmed with arterial thrombosis. The independent
Ying Duan et al.
Journal of water and health, 12(4), 715-721 (2014-12-05)
The study describes the removal of fluoride from drinking water using activated alumina (AA). AA was modified with H2SO4, FeCl3 and a combination of the two to enhance fluoride adsorption. The AA adsorbents were characterized using Brunauer-Emmett-Teller surface area analysis
Hongzhi Qiao et al.
Biomaterials, 35(25), 7157-7171 (2014-05-28)
Renal fibrosis is a common progressive kidney disease, and there is a lack of efficient treatment for the condition. In this study, we designed a kidney-specific nanocomplex by forming coordination-driven assembly from catechol-derived low molecular weight chitosan (HCA-Chi), metal ions
Cuilian Tao et al.
Dalton transactions (Cambridge, England : 2003), 43(41), 15482-15490 (2014-09-06)
Magnetic mesoporous silica (MMS) nanoparticles with controllable magnetization have been synthesized by encapsulating Fe3O4 nanoparticles in a mesoporous silica matrix. The structure, magnetic heating capacity and drug delivery ability of MMS nanoparticles were evaluated. The results showed that MMS nanoparticles
Jinmyung Cha et al.
Chemical communications (Cambridge, England), 49(5), 457-459 (2012-10-27)
50 nm Magnetic nanocluster (MNC) was deliberately selected as an efficient probe for the magnetic relaxation switching (MRSw) assay. After surface modification of MNCs with poly(acrylic acid) to give PAA-MNCs, and employing streptavidin-biotin interactions for the MRSw assay model, a
Hai-Bo He et al.
Journal of chromatography. A, 1361, 23-33 (2014-08-31)
This paper reports a nanomagnetic polyhedral oligomeric silsesquioxanes (POSS)-directing strategy toward construction of molecularly imprinted hybrid materials for antibiotic residues determination in milk samples. The imprinted polymeric layer was facilely obtained through the copolymerization of active vinyl groups present on
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