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Mingxiang Ye et al.
Cancer letters, 357(1), 196-205 (2014-12-03)
Curcumin has attracted increasing interest as an anti-cancer drug for decades. The mechanisms of action involve multiple cancer-related signaling pathways. Recent studies highlighted curcumin has epigenetic regulatory effects on miRNA in cancers. In the present study, we demonstrated the proapoptotic
Shusuke Toden et al.
Carcinogenesis, 36(3), 355-367 (2015-02-06)
Resistance to cytotoxic chemotherapy is a major cause of mortality in colorectal cancer (CRC) patients. Chemoresistance has been linked primarily to a subset of cancer cells undergoing epithelial-mesenchymal transition (EMT). Curcumin, a botanical with antitumorigenic properties, has been shown to
Rana Tarzemany et al.
PloS one, 10(1), e0115524-e0115524 (2015-01-15)
Connexins (C×s) are a family of transmembrane proteins that form hemichannels and gap junctions (GJs) on the cell membranes, and transfer small signaling molecules between the cytoplasm and extracellular space and between connecting cells, respectively. Among C×s, suppressing C×43 expression
Bopaiah Cheppudira et al.
Expert opinion on investigational drugs, 22(10), 1295-1303 (2013-08-02)
Managing burn injury-associated pain and wounds is a major unresolved clinical problem. Opioids, nonsteroidal antiinflammatory drugs (NSAIDs), antidepressants and anticonvulsants remain the most common forms of analgesic therapy to treat burn patients. However, prolonged treatment with these drugs leads to
Investigations of curcumin and resveratrol on neurite outgrowth: perspectives on spinal muscular atrophy.
Bora-Tatar G, Erdem-Yurter H, et al.
BioMed Research International, 2014, 709108-709108 (2014)
Thitita Unahabhokha et al.
Pharmaceutical biology, 53(3), 457-463 (2014-10-22)
Keloid is an excessive dermal scar occurring in response to skin injuries. Several therapeutic strategies have been proposed to ease the aggressiveness of keloid scarring. Even though the principle mechanism underlying the disease propagation still remains unidentified, several signaling pathways
Kunal Jain et al.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 17(5), 579-591 (2013-08-03)
Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually. The current therapy is inadequate in terms of reducing mortality or post-treatment symptoms such as neurological
Hongbin Ni et al.
The Journal of surgical research, 187(2), 646-652 (2014-02-04)
The present study aimed to investigate the effects of curcumin on the levels of spinal cord labile zinc (Zn) and inflammatory cytokines in rats after traumatic spinal cord injury (SCI). Adult male Sprague-Dawley rats were subjected to laminectomy at T8-T9
Huijin Fan et al.
Targeted oncology, 9(3), 279-286 (2013-07-04)
Fatty acid synthase (FAS) is highly expressed in many kinds of human cancers, including liver cancer. Curcumin is the major active ingredient of Curcuma longa and has long been used to treat a variety of maladies. In the present study
Daijiro Yanagisawa et al.
Neurobiology of aging, 36(1), 201-210 (2014-09-03)
Recent evidence supports the amyloid cascade hypothesis that a pathological change of amyloid β (Aβ) in the brain is an initiating event in Alzheimer's disease (AD). Accordingly, modulating the abnormal Aβ aggregation is considered a potential therapeutic target in AD.
Mona Fouad Mahmoud et al.
Pharmaceutical biology, 52(8), 972-977 (2014-03-13)
Consumption of high fructose is associated with metabolic abnormalities, insulin resistance, and hypertension. It is not known whether this hypertensive effect of fructose is related to metabolic abnormalities or due to the direct effect of fructose on blood vessels. Here
Phyllis Langone et al.
International journal of cancer, 135(3), 710-719 (2013-10-22)
Current therapies for glioblastoma are largely palliative, involving surgical resection followed by chemotherapy and radiation therapy, which yield serious side effects and very rarely produce complete recovery. Curcumin, a food component, blocked brain tumor formation but failed to eliminate established
Deepak Yadav et al.
International journal of pharmaceutics, 477(1-2), 564-577 (2014-12-03)
The present work aims to investigate applicability of antisolvent precipitation method for preparation of nanosized curcumin and to control their characteristics by determining the influence of process and solvents on solid-state properties of curcumin nanoparticles. Effects of different experimental parameters
Fangyuan Chen et al.
Journal of cardiovascular pharmacology, 63(6), 544-552 (2014-04-09)
This study aimed to investigate the effects of curcumin on macrophages polarization and possible mechanism involved, and to analyze the molecular basis of its antiatherosclerosis activity. RAW264.7 macrophages (M0) and M1 macrophages were treated with curcumin at 0, 6.25, 12.5
Tao Zhou et al.
PloS one, 9(9), e107876-e107876 (2014-10-01)
Curcumin, a spice component as well as a traditional Asian medicine, has been reported to inhibit proliferation of a variety of cancer cells but is limited in application due to its low potency and bioavailability. Here, we have assessed the
Fan Meng et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 12-24 (2015-02-18)
Curcumin (CUR) was used as a poorly soluble drug whereas polyvinyl pyrrolidone K90 (PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene glycol 8000 (PEG) were used as hydrophilic polymers. CUR polymer miscibility was evaluated by solubility parameter, melting
Ian M Williams et al.
Neurobiology of disease, 67, 9-17 (2014-03-19)
Niemann-Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder characterised by the storage of multiple lipids, reduced lysosomal calcium levels, impaired late endosome:lysosome fusion and neuroinflammation. NPC is caused by mutations in either of the two genes, NPC1
Khajeelak Chiablaem et al.
Anticancer research, 34(4), 1857-1864 (2014-04-03)
Vasculogenic mimicry (VM) refers to the process in which highly invasive cancer cells mimic endothelial cells by forming blood channels. In the present study, we investigated the effect of curcumin, a natural product from turmeric, on VM of SK-Hep-1 human
Seyung S Chung et al.
Anticancer research, 35(1), 39-46 (2015-01-01)
The cancer stem cell (CSC) model postulates the existence of a small proportion of cancer cells capable of sustaining tumor formation, self-renewal and differentiation. Signal Transducer and Activator of Transcription 3 (STAT3) signaling is known to be selectively activated in
Maurizio Vitadello et al.
The Journal of physiology, 592(12), 2637-2652 (2014-04-09)
Antioxidant administration aimed to antagonize the development and progression of disuse muscle atrophy provided controversial results. Here we investigated the effects of curcumin, a vegetal polyphenol with pleiotropic biological activity, because of its ability to upregulate glucose-regulated protein 94 kDa
Jeffrey M Witkin et al.
CNS & neurological disorders drug targets, 12(4), 487-497 (2013-04-12)
The root extract, curcumin (diferuloylmethane), is a constituent of the ancient herbal medicine Jiawei-Xiaoyaosan that has been used for dyspepsia, stress, and mood disorders. Curcumin engenders a diverse profile of biological actions that result in changes in oxidative stress, inflammation
Dai-Ying Zhou et al.
Biological & pharmaceutical bulletin, 37(6), 1029-1034 (2014-03-22)
Four curcumin analogues ((2E,6E)-2,6-bis(thiophen-3-methylene) cyclohexanone (AS), (2E,5E)-2,5-bis(thiophen-3-methylene) cyclopentanone (BS), (3E,5E)-3,5-bis(thiophen-3-methylene)-tetrahydropyran-4-one (ES) and (3E,5E)-3,5-bis(thiophen-3-methylene)-tetrahydrothiopyran-4-one (FS) as shown in Fig. 1) with different linker groups were investigated for their effects in human prostate cancer CWR-22Rv1 and PC-3 cells. Compounds FS and ES
Min Ruan et al.
International journal of oncology, 44(6), 2103-2110 (2014-03-29)
Increasing evidence suggests that communication between tumor and immune cells can alter the tumor microenvironment in ways that promote tumor development. The purpose of this study was to characterize the immune response elicited by TLR-9-activated OSCC cells, to identify the
Ai-Jun Jiang et al.
Molecular biology reports, 42(1), 267-275 (2014-09-30)
Melanoma is the most malignant skin cancer and is highly resistant to chemotherapy and radiotherapy. Curcumin is a component of turmeric, the yellow spice derived from the rhizome of Curcuma longa. It has been demonstrated to modulate multiple cell signaling
Touqeer Ahmed et al.
Phytotherapy research : PTR, 28(4), 517-525 (2013-07-23)
Alzheimer's disease (AD) is the most common form of dementia. There is limited choice in modern therapeutics, and drugs available have limited success with multiple side effects in addition to high cost. Hence, newer and alternate treatment options are being
Youcai Tang et al.
Laboratory investigation; a journal of technical methods and pathology, 94(5), 503-516 (2014-03-13)
Non-alcoholic steatohepatitis (NASH) is a major risk factor for hepatic fibrogenesis. NASH is often found in diabetic patients with hyperglycemia. Hyperglycemia induces non-enzymatic glycation of proteins, yielding advanced glycation end-products (AGEs). Effects of AGEs are mainly mediated by two categories
R Afrin et al.
Free radical research, 49(3), 279-289 (2014-12-24)
We investigated the effect of curcumin on liver injury in diabetic rats induced by streptozotocin (STZ) through modulation of endoplasmic reticulum stress (ERS) and unfolded protein response (UPR). Experimental diabetes was induced by a single intraperitoneal injection of STZ (55
Feng Xu et al.
The clinical respiratory journal, 9(1), 87-97 (2014-01-28)
Curcumin has remarkable anti-inflammatory and antioxidant properties. However, its effects on bacterium-induced acute lung injury (ALI) are not fully understood. To investigate the protective effects of curcumin on a mouse model of S. aureus-induced ALI. Mice were pretreated with intraperitoneal injection
Niels A J Cremers et al.
International journal of molecular sciences, 15(10), 17974-17999 (2014-10-10)
Mesenchymal stem cell (MSC) administration is a promising adjuvant therapy to treat tissue injury. However, MSC survival after administration is often hampered by oxidative stress at the site of injury. Heme oxygenase (HO) generates the cytoprotective effector molecules biliverdin/bilirubin, carbon
Lindsay A Wegiel et al.
Pharmaceutical development and technology, 19(8), 976-986 (2013-11-07)
We have investigated the physical stability of amorphous curcumin dispersions and the role of curcumin-polymer intermolecular interactions in delaying crystallization. Curcumin is an interesting model compound as it forms both intra and intermolecular hydrogen bonds in the crystal. A structurally
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