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Jianhui Zhu et al.
Journal of proteome research, 13(6), 2986-2997 (2014-05-09)
We have developed herein a quantitative mass spectrometry-based approach to analyze the etiology-related alterations in fucosylation degree of serum haptoglobin in patients with liver cirrhosis and hepatocellular carcinoma (HCC). The three most common etiologies, including infection with hepatitis B virus
Jean Dubayle et al.
Vaccine, 33(11), 1360-1368 (2015-02-11)
Recently, several virus studies have shown that protein glycosylation play a fundamental role in the virus-host cell interaction. Glycosylation characterization of the envelope proteins in both insect and mammalian cell-derived dengue virus (DENV) has established that two potential glycosylation residues
Balaji Bharatwaj et al.
Molecular pharmaceutics, 12(3), 826-838 (2014-12-03)
The purpose of this study was to determine the effect of PEGylation on the interaction of poly(amidoamine) (PAMAM) dendrimer nanocarriers (DNCs) with in vitro and in vivo models of the pulmonary epithelium. Generation-3 PAMAM dendrimers with varying surface densities of
Dafni K Paspaliari et al.
The FEBS journal, 282(5), 921-936 (2015-01-08)
Chitinases and chitin-active lytic polysaccharide monooxygenases (LPMOs) are most commonly associated with chitin metabolism, but are also reported as virulence factors in pathogenic bacteria. Listeria monocytogenes, a well-known virulent bacterium, possesses two chitinases (ChiA and ChiB) and a multi-modular lytic
Yann Bernhard et al.
Dalton transactions (Cambridge, England : 2003), 44(7), 3200-3208 (2015-01-13)
Subphthalocyanine (SubPc), a putative fluorophore for optical imaging (OI), was conjugated to chelating ligands (DOTA, DTPA) affording water-soluble conjugates complexed with (non-radioactive) metals relevant to the following medical imaging techniques/therapies: MRI (Gd), PET (Cu, Ga), SPECT (In, Ga, Lu), RIT
Yu-Shu Huang et al.
Food chemistry, 174, 571-576 (2014-12-23)
Curcumin is the major active ingredient of turmeric and is widely used as a preservative, flavouring and colouring agent. Curcumin is a potent substance with several functions, including antioxidant, antitumor, anti-inflammatory, antimicrobial, antiparasitic, antimutagenic, chemopreventive and chemotherapeutic activities. Matrix-assisted laser
Radka Míková et al.
PloS one, 9(6), e99173-e99173 (2014-06-10)
Vernix caseosa protects the skin of a human fetus during the last trimester of pregnancy and of a newborn after the delivery. Besides its cellular and proteinaceous components, an important constituent and functional agent is a complex lipid fraction, implicated
Lei Zhou et al.
Carbohydrate research, 402, 180-188 (2014-12-17)
C-type lectin-like receptor 2 (CLEC-2) is a newly identified receptor expressed on the platelet surface. It has been reported that CLEC-2 exists as a higher molecular weight (HMW) and a lower molecular weight (LMW) form, which share the same protein
Mariana Camargo et al.
Lipids, 49(9), 943-956 (2014-06-18)
This study proposed lipid fingerprinting of human seminal plasma by mass spectrometry as an analytical method to differentiate biological conditions. For this purpose, we chose infertile men as a model to study specific conditions, namely: high and low seminal plasma
Najla AlMasoud et al.
Analytica chimica acta, 840, 49-57 (2014-08-05)
Over the past few decades there has been an increased interest in using various analytical techniques for detecting and identifying microorganisms. More recently there has been an explosion in the application of matrix assisted laser desorption ionization time of flight
Laura Gallego-Yerga et al.
Organic & biomolecular chemistry, 13(6), 1708-1723 (2014-12-05)
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples of monodisperse gene delivery systems. The possibility to precisely control the architectural features at the molecular level offers unprecedented opportunities for conducting structure-activity relationship studies. A
Xiaojuan Gong et al.
Talanta, 129, 529-538 (2014-08-17)
Amino/hydroxyl-functionalized fluorescent carbon nanodots (C-NanoD) are conveniently synthesized based on hydrothermal carbonization of chitosan at 180°C. Dialysis membranes with small cut-off masses (500-1000 Da) were found useful for removing the side-products and low molecular mass species to purify the C-NanoD
Guodong Fang et al.
Bioresource technology, 176, 210-217 (2014-12-03)
This paper investigated hydroxyl radical (OH) generation from biochar suspensions for diethyl phthalate (DEP) degradation in the presence of oxygen. Electron paramagnetic resonance (EPR) coupled with a salicylic acid trapping method were used to detect free radicals in biochar and
Leila Lo Leggio et al.
Nature communications, 6, 5961-5961 (2015-01-23)
Lytic polysaccharide monooxygenases (LPMOs) are recently discovered enzymes that oxidatively deconstruct polysaccharides. LPMOs are fundamental in the effective utilization of these substrates by bacteria and fungi; moreover, the enzymes have significant industrial importance. We report here the activity, spectroscopy and
Emilie Bana et al.
Molecular carcinogenesis, 54(3), 229-241 (2013-10-25)
Cell division cycle (CDC) 25 proteins are key phosphatases regulating cell cycle transition and proliferation by regulating CDK/cyclin complexes. Overexpression of these enzymes is frequently observed in cancer and is related to aggressiveness, high-grade tumors and poor prognosis. Thus, targeting
Pinakin Sukthankar et al.
Biochimica et biophysica acta, 1838(9), 2296-2305 (2014-02-26)
Branched amphiphilic peptide capsules (BAPCs) are peptide nano-spheres comprised of equimolar proportions of two branched peptide sequences bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK that self-assemble to form bilayer delimited capsules. In two recent publications we described the lipid analogous characteristics of our BAPCs
Hans C van Leeuwen et al.
FEBS letters, 588(23), 4325-4333 (2014-10-12)
Covalent attachment of surface proteins to the cell wall of Gram-positive bacteria requires a sortase-mediated transpeptidation reaction. In almost all Gram-positive bacteria, the housekeeping sortase, sortase A, recognizes the canonical recognition sequence LPXTG (X=any amino acid). The human pathogen Clostridium
Vladimir V Egorov et al.
Prion, 8(5), 369-373 (2015-01-01)
The fibrillogenesis of a peptide corresponding to residues 35-51 of human α-lactalbumin (¹GYDTQAIVENNESTEYG¹⁷) can be dramatically enhanced by the addition of a tetrapeptide TDYG homologous to its C-terminus (TEYG). Generation of spontaneous hydrolytic products similar to this peptide was demonstrated
Tammar Hussein Ali et al.
Colloids and surfaces. B, Biointerfaces, 123, 981-985 (2014-12-04)
A series of sugar-based surfactants, involving a single hydrophobic chain (C12) and two side-by-side arranged head groups, was prepared form simple glucose precursors. All surfactants were highly water soluble and exhibited exclusively micellar assemblies. This behavior makes them interesting candidates
Tino Jaschinski et al.
Rapid communications in mass spectrometry : RCM, 28(13), 1521-1529 (2014-05-28)
Laser desorption ionization for mass spectrometric measurements (LDI MS) is supported by nanostructured materials. This technique helps to overcome known limitations of matrix-assisted laser desorption/ionization (MALDI) and especially avoids interfering signals caused by matrix components. LDI can be supported by
Kinya Iwatsuka et al.
Current eye research, 39(7), 686-694 (2014-01-10)
We compared cultured Statens Seruminstitut rabbit cornea (SIRC) cells and corneal epithelial cells from rabbit eyes by analyzing their N-glycans and glycosaminoglycans (GAGs). This work is a fundamental study on the efficacy of using cultured cells instead of animals for
Erickson M Paragas et al.
Carbohydrate research, 402, 77-80 (2014-12-17)
Neu5Ac2en1Me per-OAc, the fully protected glycal of sialic acid, is a key intermediate in the discovery of therapeutics and diagnostics, including anti-influenza drugs and proteolysis resistant peptidomimetic foldamers. The synthesis of this sialic acid derivative, however, still relies on standard
Ruibing Chen et al.
Journal of proteome research, 13(12), 5767-5776 (2014-09-13)
Temperature changes influence the reaction rates of all biological processes, which can pose dramatic challenges to cold-blooded organisms, and the capability to adapt to temperature fluctuations is crucial for the survival of these animals. In order to understand the roles
Rosica S Petrova et al.
Experimental eye research, 132, 124-135 (2015-01-18)
The expression of the water channel protein aquaporin (AQP)-5 in adult rodent and human lenses was recently reported using immunohistochemistry, molecular biology, and mass spectrometry techniques, confirming a second transmembrane water channel that is present in lens fibre cells in
G Palumbo et al.
Journal of pharmaceutical and biomedical analysis, 14(1-2), 175-180 (1995-12-01)
A high-performance liquid chromatographic method for the simultaneous determination of 5-aminosalicylic acid (5-ASA), acetyl-5-aminosalicylic acid (Ac-5-ASA) and 2,5-dihydroxybenzoic acid (5-HSA) in human endoscopic intestinal biopsy with electrochemical detection has been developed and validated. A liquid-liquid extraction procedure was used to
M L Castillo-García et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 85-90 (2015-02-11)
A new method based on ultra high performance liquid chromatography (UPLC) with photometric and fluorometric detection for the determination of acetylsalicylic acid and its main metabolites, namely gentisic, salicylic and salicyluric acids, in bovine urine samples is reported. Photometric detection
AeRyon Kim et al.
Nature communications, 5, 5369-5369 (2014-11-22)
Immunodominant epitopes are few selected epitopes from complex antigens that initiate T-cell responses. Here to provide further insights into this process, we use a reductionist cell-free antigen-processing system composed of defined components. We use the system to characterize steps in
Yanbo Wei et al.
The Analyst, 140(4), 1298-1305 (2015-01-09)
A very uniform 2,5-dihydroxybenzoic acid (DHB) layer was for the first time constructed and used as a matrix for matrix-assisted laser desorption ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS) for quickly exploring the changes in lipids within
Shadi Toghi Eshghi et al.
ACS chemical biology, 9(9), 2149-2156 (2014-07-17)
Aberrant glycosylation is associated with most of the diseases. Direct imaging and profiling of N-glycans on tissue sections can reveal tissue-specific and/or disease-associated N-glycans, which not only could serve as molecular signatures for diagnosis but also shed light on the
Vasudevan Aparna et al.
PloS one, 9(7), e101840-e101840 (2014-07-16)
Pseudomonas aeruginosa and Escherichia coli are resistant to wide range of antibiotics rendering the treatment of infections very difficult. A main mechanism attributed to the resistance is the function of efflux pumps. MexAB-OprM and AcrAB-TolC are the tripartite efflux pump
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