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Katharina Mahal et al.
Experimental cell research, 336(2), 263-275 (2015-06-24)
Histone deacetylases (HDAC) which play a crucial role in cancer cell proliferation are promising drug targets. However, HDAC inhibitors (HDACi) modelled on natural hydroxamic acids such as trichostatin A frequently lead to resistance or even an increased agressiveness of tumours.
Hayato Kaida et al.
Atherosclerosis, 237(2), 404-409 (2014-12-03)
The purpose of this study was to investigate the relationship between serum levels of malondialdehyde-modified low-density lipoprotein cholesterol (MDA-LDL) and vascular inflammation evaluated by fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT). The study involved 106 consecutive patients (75 males
Camila Nascimento et al.
Thyroid : official journal of the American Thyroid Association, 25(4), 437-444 (2015-01-31)
Aggressive histopathologic subtypes of differentiated thyroid cancer (DTC) are fluorodeoxyglucose (FDG)-avid tumors and are at high risk for persistent/recurrent disease. In these patients, fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is performed in cases of suspicion of recurrence based on thyroglobulin
Daria Zamolodchikov et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(13), 4068-4073 (2015-03-17)
Alzheimer's disease (AD) is characterized by accumulation of the β-amyloid peptide (Aβ), which likely contributes to disease via multiple mechanisms. Increasing evidence implicates inflammation in AD, the origins of which are not completely understood. We investigated whether circulating Aβ could
Ludmila Guralnik et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(4), 518-522 (2015-02-24)
CT-guided fine-needle aspiration (FNA) of lung lesions is subject to sampling errors. The current study assessed whether information provided by (18)F-FDG PET/CT will decrease the false-negative (FN) rate and thus improve the accuracy of CT-guided FNA. Data from 311 consecutive
Zhangjie Su et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(4), 512-517 (2015-02-28)
The 18-kDa mitochondrial translocator protein (TSPO) is upregulated in high-grade astrocytomas and can be imaged by PET using the selective radiotracer (11)C-(R)PK11195. We investigated (11)C-(R)PK11195 binding in human gliomas and its relationship with TSPO expression in tumor tissue and glioma-associated
Aisheng Dong et al.
Clinical nuclear medicine, 40(1), 14-20 (2014-07-08)
The aim of this study was to evaluate F-FDG PET/CT findings of malignant nonepithelial prostate tumors and their correlation with MRI and CT images. FDG PET/CT findings were reviewed in 12 patients with malignant nonepithelial prostate tumor confirmed by pathology.
Jianyong Sheng et al.
ACS applied materials & interfaces, 7(28), 15430-15441 (2015-06-26)
Although several strategies have been applied for oral insulin delivery to improve insulin bioavailability, little success has been achieved. To overcome multiple barriers to oral insulin absorption simultaneously, insulin-loaded N-trimethyl chitosan chloride (TMC)-coated polylactide-co-glycoside (PLGA) nanoparticles (Ins TMC-PLGA NPs) were
Sabrina Jarazo Dietrich et al.
PloS one, 10(6), e0128709-e0128709 (2015-06-06)
Although the testis is considered an immunoprivileged organ it can orchestrate immune responses against pathological insults such as infection and trauma. Experimental autoimmune orchitis (EAO) is a model of chronic inflammation whose main histopathological features it shares with human orchitis.
Benedikt Fritzsching et al.
Oncoimmunology, 4(3), e990800-e990800 (2015-05-08)
Osteosarcoma is the most common primary bone tumor characterized by juvenile onset, tumor heterogeneity, and early pulmonary metastasis. Therapeutic improvement stagnates since more than two decades. Unlike major malignancies, biomarkers as prognostic factors at time of diagnosis are missing. Disease
Yue Han et al.
Biochimica et biophysica acta, 1853(5), 1165-1173 (2015-02-28)
The dysfunction of vascular endothelial cells (ECs) influenced by flow shear stress is crucial for vascular remodeling. However, the roles of nuclear envelope (NE) proteins in shear stress-induced EC dysfunction are still unknown. Our results indicated that, compared with normal
Kristell L S Chatalic et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(12), 2050-2056 (2014-11-22)
Gastrin-releasing peptide receptor (GRPR) is overexpressed in human prostate cancer and is being used as a target for molecular imaging. In this study, we report on the direct comparison of 3 novel GRPR-targeted radiolabeled tracers: Al(18)F-JMV5132, (68)Ga-JMV5132, and (68)Ga-JMV4168 (JMV5132
Yuichi Nakajima et al.
Molecular ecology, 23(24), 6029-6044 (2014-11-12)
Information on genetic diversity and differentiation of seagrass populations is essential for the conservation of coastal ecosystems. However, little is known about the seagrasses in the Indo-West Pacific Ocean, where the world's highest diversity of seagrasses occurs. The influence of
Norbert Pallua et al.
The Journal of craniofacial surgery, 26(4), 1403-1407 (2015-06-17)
Autologous fat grafting has been used for reconstructive and aesthetic surgery for more than a century. Although initial criticism involved fat resorption and later the possible radiological interference in mammographies, the most recent debate focuses on the carcinogenicity of fat
Baoming Mi et al.
Theranostics, 5(10), 1115-1121 (2015-07-23)
This pilot prospective evaluation study is to verify the efficiency of (18)F-Alfatide II, a specific PET imaging agent for integrin αvβ3, in detecting bone metastasis in human, with comparison to (18)F-FDG PET. Thirty recruited patients underwent (18)F-FDG and (18)F-alfatide II
Aanchal Ghai et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 105, 40-46 (2015-08-02)
The present study describes the optimization of (68)Ga radiolabeling with PAMAM dendrimer-DOTA conjugate. A conjugate (PAMAM-DOTA) concentration of 11.69µM, provided best radiolabeling efficiency of more than 93.0% at pH 4.0, incubation time of 30.0min and reaction temperature ranging between 90
Sun Och Yoon et al.
Clinical nuclear medicine, 40(3), e178-e182 (2015-01-22)
Extrahepatic bile duct (EHD) cancer varies in uptake of FDG. The aim of the present study was to determine the role of glucose transporter (GLUT) 1 and hexokinase (HK) 2 in the glucose metabolism of EHD cancer cells using immunohistochemistry
Parisa Khateri et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(6), 884-892 (2015-04-29)
The aim of this study is to generate a four-class magnetic resonance imaging (MRI)-based attenuation map (μ-map) for attenuation correction of positron emission tomography (PET) data of the head area using a novel combination of short echo time (STE)/Dixon-MRI and
Aya Sugyo et al.
Nuclear medicine communications, 36(3), 286-294 (2014-12-03)
Pancreatic cancer is aggressive and its prognosis remains poor; thus, effective therapy is urgently needed. Transferrin receptor (TfR) is highly expressed in pancreatic cancer and is considered to be a good candidate for molecular-targeted therapy. We radiolabeled and evaluated fully
Abdelhak Belmadani et al.
Hippocampus, 25(11), 1224-1241 (2015-02-07)
We identified a previously unknown neurogenic region at the dorsal surface of the hippocampus; (the "subhippocampal zone," SHZ) in the adult brain. Using a reporter mouse in which SHZ cells and their progeny could be traced through the expression of
Eric P Gillis et al.
Journal of medicinal chemistry, 58(21), 8315-8359 (2015-07-23)
The role of fluorine in drug design and development is expanding rapidly as we learn more about the unique properties associated with this unusual element and how to deploy it with greater sophistication. The judicious introduction of fluorine into a
Peter Laverman et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(5), 778-783 (2015-04-11)
One of the most prominent cell populations playing a role in rheumatoid arthritis (RA) is activated fibroblast-like synoviocytes. Among many other proteins, fibroblast-like synoviocytes dominantly express fibroblast activation protein (FAP). Because of the high expression of FAP in arthritic joints
Wolfgang P Fendler et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(4), 530-537 (2015-02-28)
We evaluated the prognostic accuracy of established PET and CT response criteria in patients with soft-tissue sarcoma (STS) after combined chemotherapy plus regional hyperthermia (RHT). Seventy-three patients underwent (18)F-FDG PET/CT before and after 2-4 cycles of neoadjuvant chemotherapy with RHT
Ugo De Giorgi et al.
Oncotarget, 5(23), 12448-12458 (2014-12-17)
We investigated the role of 18F-fluorocholine positron emission tomography/computed tomography (FCH-PET/CT) in the early evaluation of abiraterone and outcome prediction in patients with metastatic castration-resistant prostate cancer (CRPC). Forty-three patients with metastatic CRPC progressing after docetaxel received abiraterone 1,000 mg
Yihua Liu et al.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 34(4), 594-603 (2015-02-24)
Cardiac recovery is possible by means of mechanical unloading yet remains rare. Excessive unloading-associated myocardial atrophy and fibrosis may adversely affect the process of reverse remodeling. In this study, we sought to evaluate the effect of different intensities of chronic
Tze-Bin Song et al.
ACS applied materials & interfaces, 7(44), 24601-24607 (2015-10-22)
Solution-processed silver nanowire networks are one of the promising candidates to replace a traditional indium tin oxide as next-generation transparent and flexible electrodes due to their ease of processing, moderate flexibility, high transparency, and low sheet resistance. To date, however
Elmira H Maharramova et al.
American journal of botany, 102(1), 119-128 (2015-01-15)
• The Caucasus represents one of the world's biodiversity hotspots and includes the climatic refugia Hyrcan on the southern coast of the Caspian Sea and Colchis on the eastern coast of the Black Sea, where different species survived during the
Matthias Gawlitza et al.
PloS one, 10(8), e0134749-e0134749 (2015-08-14)
To demonstrate the feasibility of simultaneous acquisition of 18F-FDG-PET, diffusion-weighted imaging (DWI) and T1-weighted dynamic contrast-enhanced MRI (T1w-DCE) in an integrated simultaneous PET/MRI in patients with head and neck squamous cell cancer (HNSCC) and to investigate possible correlations between these
Connor A Wathen et al.
Contrast media & molecular imaging, 10(3), 188-193 (2014-08-30)
Gold nanomaterials (AuNPs) represent a promising new class of contrast agents for X-ray computed tomographic (CT) imaging in both research and clinical settings. These materials exhibit superior X-ray absorption properties compared with other iodinated agents, and thus require lower injection
Hugo J A Adams et al.
Nuclear medicine communications, 37(1), 23-29 (2015-10-07)
To directly correlate fluorine-18 fluoro-2-deoxy-D-glucose (F-FDG) uptake of the iliac crest, as determined with PET, with both spatially matched histological bone marrow parameters and laboratory markers in Hodgkin lymphoma patients without lymphomatous bone marrow involvement at bone marrow biopsy. This
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