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Katharina M Uhlig et al.
Journal of virology, 89(17), 9044-9060 (2015-06-19)
To induce and trigger innate and adaptive immune responses, antigen-presenting cells (APCs) take up and process antigens. Retroviral particles are capable of transferring not only genetic information but also foreign cargo proteins when they are genetically fused to viral structural...
Aline Dall'Oglio et al.
Journal of anatomy, 227(4), 440-459 (2015-07-29)
The medial nucleus of the amygdala (Me) is a component of the neural circuit for the interpretation of multimodal sensory stimuli and the elaboration of emotions and social behaviors in primates. We studied the presence, distribution, diverse shape, and connectivity...
Amani Makkouk et al.
Cancer immunology research, 3(4), 389-398 (2015-01-30)
In situ immunization aims at generating antitumor immune responses through manipulating the tumor microenvironment. On the basis of recent advances in the understanding of antitumor immunity, we designed a three-step approach to in situ immunization to lymphoma: (i) inducing immunogenic...
Nima Momtahan et al.
Tissue engineering. Part C, Methods, 21(11), 1148-1161 (2015-06-17)
Whole heart decellularization combined with patient-specific cells may prove to be an extremely valuable approach to engineer new hearts. Mild detergents are commonly used in the decellularization process, but are known to denature and solubilize key proteins and growth factors...
Valeria Iansante et al.
Nature communications, 6, 7882-7882 (2015-08-11)
Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood. In this study, using loss-of-function studies...
Katherine M Murphy et al.
American journal of botany, 102(11), 1931-1937 (2015-11-04)
Although anthers of Zea mays, Oryza sativa, and Arabidopsis thaliana have been studied intensively using genetic and biochemical analyses in the past 20 years, few updates to anther anatomical and ultrastructural descriptions have been reported. For example, no transmission electron...
Chiara Focaccetti et al.
PloS one, 10(2), e0115686-e0115686 (2015-02-12)
Antimetabolites are a class of effective anticancer drugs interfering in essential biochemical processes. 5-Fluorouracil (5-FU) and its prodrug Capecitabine are widely used in the treatment of several solid tumors (gastro-intestinal, gynecological, head and neck, breast carcinomas). Therapy with fluoropyrimidines is...
Kuaifei Xia et al.
Plant, cell & environment, 38(12), 2662-2673 (2015-05-28)
Cuticular wax forms a hydrophobic layer covering aerial plant organs and acting as a protective barrier against biotic and abiotic stresses. Compared with well-known wax biosynthetic pathway, molecular regulation of wax biosynthesis is less known. Here, we show that rice...
Seon-Mi Jeon et al.
Journal of microbiology and biotechnology, 25(5), 723-731 (2015-03-05)
Microalgae hold promise as producers of sustainable biomass for the production of biofuels and other biomaterials. However, the selection of strains with efficient and robust production of desirable resources remains challenging. In this study, we isolated a green microalga from...
Fumito Sakamoto et al.
Cytotechnology, 67(1), 75-84 (2013-12-07)
We compared the osteoblastic differentiation abilities of dedifferentiated fat cells (DFATs) and human bone marrow mesenchymal stem cells (hMSCs) as a cell source for bone regeneration therapies. In addition, the utility of DFATs in bone tissue engineering in vitro was...
Sophie Sagnier et al.
Journal of virology, 89(1), 615-625 (2014-10-24)
Autophagy is a ubiquitous mechanism involved in the lysosomal-mediated degradation of cellular components when they are engulfed in vacuoles called autophagosomes. Autophagy is also recognized as an important regulator of the innate and adaptive immune responses against numerous pathogens, which...
Kathy C Nguyen et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(1), 31-42 (2015-03-27)
There are an increasing number of studies indicating that mitochondria are relevant targets in nanomaterial-induced toxicity. However, the underlying mechanisms by which nanoparticles (NPs) interact with these organelles and affect their functions are unknown. The aim of this study was...
Maria Andree et al.
The EMBO journal, 33(19), 2171-2187 (2014-07-25)
The X-linked inhibitor of apoptosis protein (XIAP) is a potent caspase inhibitor, best known for its anti-apoptotic function in cancer. During apoptosis, XIAP is antagonized by SMAC, which is released from the mitochondria upon caspase-mediated activation of BID. Recent studies...
Sergio Granados-Principal et al.
Biochemical pharmacology, 90(1), 25-33 (2014-04-15)
Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and has been shown to potentiate the therapeutic effect of drugs such as doxorubicin. Doxorubicin causes significant cardiotoxicity characterized by marked increases in oxidative stress and mitochondrial...
Giulia Ruozi et al.
Nature communications, 6, 7388-7388 (2015-06-13)
Functional screening of expression libraries in vivo would offer the possibility of identifying novel biotherapeutics without a priori knowledge of their biochemical function. Here we describe a procedure for the functional selection of tissue-protective factors based on the in vivo...
Jingjing Li et al.
Marine drugs, 13(6), 3368-3387 (2015-05-30)
Hepatic ischemia reperfusion (IR) is an important issue in complex liver resection and liver transplantation. The aim of the present study was to determine the protective effect of astaxanthin (ASX), an antioxidant, on hepatic IR injury via the reactive oxygen...
Rong Zou et al.
Molecular medicine reports, 12(2), 2027-2034 (2015-05-06)
Disruption of the blood-brain barrier (BBB) and subsequent brain edema are major contributors to the pathogenesis of ischemic stroke, however, current clinical therapeutic methods remains unsatisfactory. Electroacupuncture (EA) pretreatment has a protective effect against cerebral ischemia/reperfusion (I/R). However, the underlying...
Qi Dong et al.
Journal of translational medicine, 12, 323-323 (2014-11-27)
Cardiac hypertrophy is a compensatory stage of the heart in response to stress such as pressure overload (PO), which can develop into heart failure (HF) if left untreated. Resveratrol has been reported to prevent the development of hypertrophy and contractile...
Alessandra Aparecida Vireque et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(8), 1015-1027 (2015-02-24)
Culture systems are available for human granulosa cells (GCs) that perpetuate luteinization. The present study examines the plating density effects and long-term serum-free culture on the in vitro dynamics differentiation of luteinizing human GCs. Cells were cultured in serum-free α-minimum...
Colette A Bichsel et al.
Tissue engineering. Part A, 21(15-16), 2166-2176 (2015-04-22)
The formation of blood vessels is a complex tissue-specific process that plays a pivotal role during developmental processes, in wound healing, cancer progression, fibrosis, and other pathologies. To study vasculogenesis and vascular remodeling in the context of the lung, we...
Rinrada Pattanayaiying et al.
International journal of food microbiology, 188, 135-146 (2014-08-12)
The effects of lauric arginate (LAE) and nisin Z, alone or in combination, on cell damage were investigated against Escherichia coli O157:H7, Listeria monocytogenes and Brochothrix thermosphacta, by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations, efflux of...
Papia Chakraborty et al.
Molecular endocrinology (Baltimore, Md.), 28(7), 1055-1072 (2014-05-16)
Sertoli cell tight junctions (SCTJs) of the seminiferous epithelium create a specialized microenvironment in the testis to aid differentiation of spermatocytes and spermatids from spermatogonial stem cells. SCTJs must be chronically broken and rebuilt with high fidelity to allow the...
Fan He et al.
The Journal of endocrinology, 223(2), 167-180 (2014-09-12)
Both self-renewal and lineage-specific differentiation of mesenchymal stem cells (MSCs) are triggered by their in vivo microenvironment including the extracellular matrix (ECM) and secreted hormones. The ECM may modulate the physiological functions of hormones by providing binding sites and by...
Nicolas Darville et al.
Journal of pharmaceutical sciences, 103(7), 2072-2087 (2014-05-23)
The present study aims at elucidating the intricate nature of the drug release and absorption following intramuscular (i.m.) injection of sustained-release prodrug nanocrystals/microcrystals. A paliperidone palmitate (PPP) long-acting suspension was characterized with regard to particle size (Dv,50 = 1.09 μm)...
Mayara Klimuk Uchiyama et al.
Toxicological sciences : an official journal of the Society of Toxicology, 142(2), 497-507 (2014-09-28)
Gold nanoparticle (AuNP) bioconjugates have been used as therapeutic and diagnostic tools; however, in vivo biocompatibility and cytotoxicity continue to be two fundamental issues. The effect of AuNPs (20 nm) conjugated with antibody [immunoglobulin G (IgG)], albumin, protein A, PEG4000, and citrate...
Raluca Zaganescu et al.
Microscopy research and technique, 78(9), 792-800 (2015-07-17)
This research aimed to observe the behavior of mesenchymal stem cells (MSCs) isolated from periodontal granulation tissue (gt) when manipulated ex vivo to induce three-dimensional (3D) spheroid (aggregates) formation as well as when seeded on two bone scaffolds of animal...
Boaz Arzi et al.
Stem cells and development, 24(7), 814-823 (2014-11-19)
Mesenchymal stem cells (MSCs) are a promising therapeutic option for various immune-mediated and inflammatory disorders due to their potent immunomodulatory and trophic properties. Naturally occurring diseases in large animal species may serve as surrogate animal models of human disease, as...
Moise Bendayan et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 59(10), 899-907 (2011-08-13)
Low-voltage (5-kV) transmission electron microscopy revealed a novel aspect of the pancreatic acinar cell secretory granules not previously detected by conventional (80-kV) transmission electron microscopy. Examination of ultra-thin (30-nm) sections of non-osmicated, stain-free pancreatic tissue sections by low-voltage electron microscopy...
Ji Eun Kim et al.
PloS one, 10(7), e0129664-e0129664 (2015-07-08)
To characterize the changes in global gene expression in the distal colon of constipated SD rats in response to the laxative effects of aqueous extracts of Liriope platyphylla (AEtLP), including isoflavone, saponin, oligosaccharide, succinic acid and hydroxyproline, the total RNA...
Tamara Muñoz-Caro et al.
Parasites & vectors, 8, 607-607 (2015-11-28)
Polymorphonuclear neutrophil (PMN) and eosinophil extracellular trap (ETs) formation has recently been described as an important host effector mechanism against invading pathogens. So far, scarce evidence on metazoan-triggered ET formation has been published. We here describe for the first time...
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