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Mei-Shu Chen et al.
Developmental neurobiology, 75(3), 232-248 (2014-08-12)
FGF1 is involved in multiple biological functions and exhibits the importance in neuroprotective effects. Our previous studies indicated that, in human brain and retina, the FGF1B promoter controlled the expression of FGF1. However, the exact function and regulation of FGF1
Varun Kesherwani et al.
Neuroscience letters, 576, 45-50 (2014-06-07)
Fasudil (HA-1077), a specific Rho kinase II (ROCKII) inhibitor, is in clinical trials for recovery from spinal cord injury (SCI). The primary role of Fasudil is in axonal regeneration, as it inhibits ROCKII, the key signaling molecule involved in collapse
Shawn Montpetit et al.
Forensic science international. Genetics, 17, 70-74 (2015-04-02)
Gun crimes are a significant problem facing law enforcement agencies. Traditional forensic examination of firearms involves comparisons of markings imparted to bullets and cartridge casings during the firing process. DNA testing of casings and cartridges may not be routinely done
Airie Kim et al.
Blood cells, molecules & diseases, 56(1), 31-36 (2015-11-26)
Acute and severe anemia of inflammation (AI) is a common complication of various clinical syndromes, including fulminant infections, critical illness with multiorgan failure, and exacerbations of autoimmune diseases. Building on recent data showing beneficial results with isocitrate treatment for chronic
Yanzuo Chen et al.
International journal of nanomedicine, 10, 4043-4057 (2015-07-08)
The therapeutic effect of methotrexate (MTX)-conjugated Pluronic-based polymeric mixed micelles (F127/P105-MTX) on the folate receptor-overexpressing tumors treatment was investigated in this study. Due to its high structural similarity to folic acid and the high expression of folate receptor in most
Qunying Lin et al.
Cancer epidemiology, 39(4), 539-544 (2015-07-01)
Osteopontin (OPN) and vascular endothelial growth factor (VEGF) play important roles in cancer progression and angiogenesis. In the current study we aimed to investigate the clinical significance of OPN and VEGF expression in patients with non-small-cell lung cancer (NSCLC) and
Ming Dai et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4978-4988 (2015-08-25)
Bluetongue virus (BTV), a nonenveloped double-stranded RNA virus, is a potent inducer of type Ι interferons in multiple cell systems. In this study, we report that BTV16 treatment of primary human macrophages induced both type I and III IFN expression
Xiaohu Xia et al.
ACS nano, 9(10), 9994-10004 (2015-09-04)
Peroxidase mimics with dimensions on the nanoscale have received great interest as emerging artificial enzymes for biomedicine and environmental protection. While a variety of peroxidase mimics have been actively developed recently, limited progress has been made toward improving their catalytic
Emily E Woodward et al.
Journal of environmental quality, 43(6), 1933-1941 (2015-01-21)
The increase in endocrine-disrupting compounds in the environment has generated research focused on the behavior of these compounds in natural soil and water ecosystems. To understand how estrogens behave in the soil environment as a result of 25+ yr of
A Kozłowska et al.
Journal of molecular neuroscience : MN, 54(1), 10-19 (2014-02-13)
We revealed earlier that induction of ovarian cysts in gilts by dexamethasone phosphate disodium salt (DXM) administration from the follicular phase of the estrous cycle (EC) changed the cholinergic innervation of the gonad. In the present study, the innervation of
Cyd Castro-Rojas et al.
Journal of neuroimmunology, 276(1-2), 232-235 (2014-09-18)
Immune surveillance of the CNS is critical for preventing infections; however, there is no accepted experimental model to assess the risk of infection when utilizing disease-modifying agents. We tested two approved agents for patients with multiple sclerosis (MS), glatiramer acetate
Rachel D Schrier et al.
PloS one, 10(2), e0116526-e0116526 (2015-02-27)
HIV associated neurocognitive disorders (HAND) continue to affect cognition and everyday functioning despite anti-retroviral treatment (ART). Previous studies focused on mechanisms related to monocyte/macrophage mediated inflammation. However, in the ART era, there is increasing evidence for the involvement of CD8+
Eun-Ju Yang et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 64(9), 733-746 (2015-07-25)
The ubiquitous nuclear protein, high-mobility group box 1 (HMGB1), is released by activated macrophages and human umbilical vein endothelial cells (HUVECs) and functions as a late mediator of experimental sepsis. Polyozellin, which has been reported to have a variety of
Annamalai Muthusamy et al.
International journal of radiation biology, 90(12), 1229-1239 (2014-05-17)
The purpose of the investigation was to induce somaclonal variations by gamma rays (GR), ethylmethane sulphonate (EMS) and sodium azide (SA) during in vitro organogenesis of cotton. The shoot tip explants were irradiated with 5-50 Gray (Gy) GR (Cobalt 60)
Samuel Furse et al.
Organic & biomolecular chemistry, 13(7), 2001-2011 (2014-12-18)
In this paper evidence is presented that the fatty acid component of an inositide substrate affects the kinetic parameters of the lipid phosphatase Salmonella Outer Protein B (SopB). A succinct route was used to prepare the naturally occurring enantiomer of
Lizan Kawa et al.
Journal of neurotrauma, 32(16), 1190-1199 (2014-12-20)
Exposure to improvised explosive devices can result in a unique form of traumatic brain injury--blast-induced traumatic brain injury (bTBI). At the mild end of the spectrum (mild bTBI [mbTBI]), there are cognitive and mood disturbances. Similar symptoms have been observed
Geoffrey S Williams et al.
Malaria journal, 8, 168-168 (2009-07-25)
Sero-epidemiological methods are being developed as a tool for rapid assessment of malaria transmission intensity. Simple blood collection methods for use in field settings will make this more feasible. This paper describes validation of such a method, by analysing immunoglobulins
Lucy Golden-Mason et al.
PloS one, 9(7), e103219-e103219 (2014-07-31)
Hepatitis C viral (HCV) proteins, including core, demonstrate immuno-modulatory properties; however, the effect of extracellular core on natural killer (NK) cells has not previously been investigated. To characterise NKs in acute HCV infection over time, and, to examine the effect
Kirk D C Jensen et al.
mBio, 6(2), e02280-e02280 (2015-02-26)
The intracellular parasite Toxoplasma gondii infects a wide variety of vertebrate species globally. Infection in most hosts causes a lifelong chronic infection and generates immunological memory responses that protect the host against new infections. In regions where the organism is
Monika Jusko et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 2231-2240 (2015-07-26)
Recent reports focusing on virulence factors of periodontal pathogens implicated proteinases as major determinants of remarkable pathogenicity of these species, with special emphasis on their capacity to modulate complement activity. In particular, bacteria-mediated cleavage of C5 and subsequent release of
Sheng-Hui Yang et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 185(6), 677-693 (2015-06-03)
There are essentially four different morphological types of pseudobranchs in teleosts, including lamellae-free, lamellae semi-free, covered, and embedded types. In the euryhaline silver moony (Monodactylus argenteus), the pseudobranch belongs to the lamellae semi-free type, which is characterized by one row
S Rudnick-Glick et al.
Journal of nanobiotechnology, 13, 80-80 (2015-11-19)
Bisphosphonate (BP) compounds are widely used in the treatment of bone disorders. This group of drugs with a high affinity to Ca(+2) ions is rapidly attracted to bone mineral, especially in areas of high resorption. We have engineered unique biodegradable
Gabriela Morachis-Valdez et al.
Environmental science and pollution research international, 22(12), 9159-9172 (2015-01-15)
Madín Reservoir (MR) is located on the Río Tlalnepantla in Mexico. Previous studies seeking to identify pollutants at this site evidence that MR water contains a considerable metal load as well as nonsteroidal anti-inflammatory drugs (NSAIDs) at concentrations above those
Irma Pujol-Autonell et al.
PloS one, 10(6), e0127057-e0127057 (2015-06-04)
The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes. An ideal immunotherapy should inhibit the autoimmune attack, avoid systemic side effects and allow β-cell regeneration. Based on the immunomodulatory effects
Elena Brezina et al.
Environmental science & technology, 49(17), 10449-10456 (2015-08-25)
Carbamazepine (CBZ) is a worldwide used antiepileptic drug, which is metabolized to a large extent in the human body to several metabolites, including 10,11-dihydroxy-10,11-dihydrocarbamazepine (DiOHCBZ), 2-hydroxycarbamazepine (2OHCBZ), and 3-hydroxycarbamazepine (3OHCBZ). 2OHCBZ and 3OHCBZ were previously detected in raw and treated
Mitesh Patel et al.
Brain research, 1468, 1-10 (2012-06-12)
Riboflavin is an important water soluble vitamin (B2) required for metabolic reactions, normal cellular growth, differentiation and function. Mammalian brain cells cannot synthesize riboflavin and must import from systemic circulation. However, the uptake mechanism, cellular translocation and intracellular trafficking of
Chuang Xu et al.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 34(5), 341-345 (2015-10-23)
When abrin-a was combined with several polyclonal antibodies (PAb), the detection limit could be increased. In this way, a monoclonal antibody (capture) and polyclonal antibody (detection) sandwich enzyme-linked immunosorbent assay (ELISA) and a colloidal gold-PAb conjugate-based immunochromatographic assay for detection
Koichiro Tsuboi et al.
The Journal of biological chemistry, 290(33), 20511-20526 (2015-07-08)
Genome-wide association studies of inflammatory bowel diseases identified susceptible loci containing an autophagy-related gene. However, the role of autophagy in the colon, a major affected area in inflammatory bowel diseases, is not clear. Here, we show that colonic epithelial cell-specific
Michael E Frohbergh et al.
Tissue engineering. Part A, 21(5-6), 970-981 (2014-10-23)
Our long-term goal is to develop smart biomaterials that can facilitate regeneration of critical-size craniofacial lesions. In this study, we tested the hypothesis that biomimetic scaffolds electrospun from chitosan (CTS) will promote tissue repair and regeneration in a critical size
F Kazazi-Hyseni et al.
International journal of pharmaceutics, 482(1-2), 99-109 (2014-12-17)
Poly(D,L-lactic-co-hydroxymethyl glycolic acid) (PLHMGA) is a biodegradable copolymer with potential as a novel carrier in polymeric drug delivery systems. In this study, the biocompatibility of PLHMGA microspheres (PLHMGA-ms) was investigated both in vitro in three different cell types (PK-84, HK-2
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