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71290

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Soju Chang et al.
International journal of toxicology, 22(3), 175-186 (2003-07-10)
Sodium azide, used mainly as a preservative in aqueous laboratory reagents and biologic fluids and as a fuel in automobile airbag gas generants, has caused deaths for decades. Its exposure potential for the general population increases as the use of...
Xianming Lin et al.
Channels (Austin, Tex.), 8(5), 433-443 (2014-12-09)
Connexin40 (Cx40) and connexin43 (Cx43) are co-expressed in the cardiovascular system, yet their ability to form functional heterotypic Cx43/Cx40 gap junctions remains controversial. We paired Cx43 or Cx40 stably-transfected N2a cells to examine the formation and biophysical properties of heterotypic...
Tzu-Yu Liu et al.
Current drug delivery, 12(1), 3-8 (2014-10-02)
Vaccine candidates for the treatment of human papillomavirus (HPV)-associated cancers are aimed to activate T-cells and induce development of cytotoxic anti-tumor specific responses. Peptide epitopes derived from HPV-16 E7 oncogenic protein have been identified as promising antigens for vaccine development....
Gustavo Bodelón et al.
Small (Weinheim an der Bergstrasse, Germany), 11(33), 4149-4157 (2015-05-06)
Detection technologies employing optically encoded particles have gained much interest toward clinical diagnostics and drug discovery, but the portfolio of available systems is still limited. The fabrication and characterization of highly stable surface-enhanced resonance Raman scattering (SERRS)-encoded colloids for the...
Koneni V Sashidhara et al.
ChemMedChem, 9(12), 2671-2684 (2014-09-25)
In the search for effective multifunctional agents for the treatment of Alzheimer's disease (AD), a series of novel hybrids incorporating benzofuran and chalcone fragments were designed and synthesized. These hybrids were screened by using a transgenic Caenorhabditis elegans model that...
Elizabeth V Clarke et al.
Journal of leukocyte biology, 97(1), 147-160 (2014-11-09)
A complete genetic deficiency of the complement protein C1q results in SLE with nearly 100% penetrance in humans, but the molecular mechanisms responsible for this association have not yet been fully determined. C1q opsonizes ACs for enhanced ingestion by phagocytes...
Yun-Hee Rhee et al.
Biochemical and biophysical research communications, 447(4), 557-562 (2014-02-15)
Anethole has been known to have chemopreventive activities as a suppressor of the incidence and multiplicity of both invasive and noninvasive carcinomas. The goal of this study was to understand the anti-metastatic effect of anethole through C-X-C chemokine receptor type...
Nelly Del Socorro Cruz-Cansino et al.
Ultrasonics sonochemistry, 27, 277-286 (2015-07-19)
The objective of this study was to evaluate changes in color, betalain content, browning index, viscosity, physical stability, microbiological growth, antioxidant content and antioxidant activity of purple cactus pear juice during storage after thermoultrasonication at 80% amplitude level for 15...
Hsiao-yin Yang et al.
Pharmaceutical research, 32(2), 680-690 (2014-08-29)
To develop a bio-assay for measuring long-term bioactivity of released anti-inflammatory compounds and to test the bioactivity of celecoxib (CXB) and triamcinolone acetonide (TA) released from a new PLGA-based microsphere platform. Human osteoarthritic chondrocytes were plated according to standardized procedures...
Carmine Pasquale Cerrato et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4589-4599 (2015-07-22)
Cell-penetrating peptides (CPPs) are short, nontoxic peptides with cationic and/or amphipathic properties able to cross the cellular membrane. CPPs are used for the delivery of a wide variety of cargoes, such as proteins, oligonucleotides, and therapeutic molecules. The aim of...
Hanne Frydenberg et al.
Breast cancer research : BCR, 17, 103-103 (2015-08-08)
Alcohol consumption may promote aromatization of androgens to estrogens, which may partly explain the observations linking alcohol consumption to higher breast cancer risk. Whether alcohol consumption is associated with endogenous estrogen levels, and mammographic density phenotypes in premenopausal women remains...
Nicole von Burg et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(35), 12835-12840 (2014-08-20)
Group 3 innate lymphoid cells (ILC3s) have emerged as important cellular players in tissue repair and innate immunity. Whether these cells meaningfully regulate adaptive immune responses upon activation has yet to be explored. Here we show that upon IL-1β stimulation...
J N H Stern et al.
Clinical and experimental immunology, 152(3), 472-481 (2008-04-01)
Pemphigus vulgaris (PV) is an autoimmune blistering disease that affects the skin and multiple mucous membranes, and is caused by antibodies to desmoglein (Dsg) 1 and 3. Natural killer (NK) cells have a role in autoimmunity, but their role in...
Miriam Reuschenbach et al.
Cancer immunology, immunotherapy : CII, 63(12), 1251-1259 (2014-08-22)
Humoral immune responses against tumor antigens are studied as indirect markers of antigen exposure and in cancer vaccine studies. An increasing number of tumor antigens potentially translated from mutant genes is identified by advances in genomic sequencing. They represent an...
Vinícius Leite Pedro Bom et al.
Eukaryotic cell, 14(8), 728-744 (2015-04-26)
Aspergillus fumigatus is an opportunistic pathogenic fungus able to infect immunocompromised patients, eventually causing disseminated infections that are difficult to control and lead to high mortality rates. It is important to understand how the signaling pathways that regulate these factors...
Liyi Huang et al.
Free radical biology & medicine, 53(11), 2062-2071 (2012-10-10)
Sodium azide (NaN(3)) is widely employed to quench singlet oxygen during photodynamic therapy (PDT), especially when PDT is used to kill bacteria in suspension. We observed that addition of NaN(3) (100 μM or 10 mM) to gram-positive Staphylococcus aureus and...
Yuji Motoi et al.
International immunology, 26(10), 563-573 (2014-05-27)
Toll-like receptors (TLRs) recognize a variety of microbial products and induce defense responses. Pathogen sensing by TLRs occurs either on the cell surface or in endolysosomes. TLR-dependent responses are greatly influenced by the site of pathogen sensing. TLR heterodimers TLR1/TLR2...
Ervin E Kara et al.
Nature communications, 6, 8644-8644 (2015-10-30)
IL-17-producing helper T (Th17) cells are critical for host defense against extracellular pathogens but also drive numerous autoimmune diseases. Th17 cells that differ in their inflammatory potential have been described including IL-10-producing Th17 cells that are weak inducers of inflammation...
Tang Li et al.
Journal of colloid and interface science, 555, 361-372 (2019-08-10)
Drug nanocrystals precipitated inside liposomes are of increasing interest in liposomal drug delivery. For liposomal nanocrystal formulations, the size and shape of the drug nanocrystals can influence the apparent drug release properties, providing opportunities for developing tailored liposomal drug release...
Nikki Kapp et al.
Journal of experimental botany, 66(14), 4295-4304 (2015-04-30)
Lignin is a complex polyphenolic heteropolymer that is abundant in the secondary cell walls of plants and functions in growth and defence. It is also a major barrier to the deconstruction of plant biomass for bioenergy production, but the spatiotemporal...
Teri L Wadsworth et al.
Journal of Alzheimer's disease : JAD, 14(2), 225-234 (2008-06-19)
Increasing evidence suggests that Alzheimer's disease (AD) is associated with oxidative damage that is caused in part by mitochondrial dysfunction. Here we investigated the feasibility of modifying Alzheimer pathology with the mitochondrial antioxidant coenzyme Q (CoQ). Exogenous CoQ protected MC65...
Eric Bonneau et al.
RNA (New York, N.Y.), 21(9), 1621-1632 (2015-07-01)
As part of an effort to structurally characterize the complete Neurospora VS ribozyme, NMR solution structures of several subdomains have been previously determined, including the internal loops of domains I and VI, the I/V kissing-loop interaction and the III-IV-V junction....
Michael Skwirba et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(10), 1020-1031 (2014-04-05)
Chronic allograft injury (CAI) limits the long-term success of renal transplantation. Nestin is a marker of progenitor cells, which probably contribute to its pathogenesis. We hypothesize that nestin is induced by ischemia/reperfusion injury and acute rejection, main risk factors for...
Xiaohua Sun et al.
Organic letters, 9(22), 4495-4498 (2007-10-04)
A novel intermolecular cross-double-Michael addition between nitro and carbonyl activated olefins has been developed through Lewis base catalysis. The reaction took place with a large group of beta-alkyl nitroalkenes and alpha,beta-unsaturated ketone/esters, producing an allylic nitro compound in good to...
Tessa Gargett et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 38(1), 12-23 (2014-11-22)
Cancer immunotherapy has long been used in the treatment of metastatic melanoma, and an anti-CTLA-4 monoclonal antibody treatment has recently been approved by the US Food and Drug Administration. Targeted therapies such as small molecule kinase inhibitors targeting deregulated mitogen-activated...
Ryan Matsuda et al.
Analytical and bioanalytical chemistry, 407(18), 5309-5321 (2015-04-29)
In diabetes, the elevated levels of glucose in the bloodstream can result in the nonenzymatic glycation of proteins such as human serum albumin (HSA). This type of modification has been shown to affect the interactions of some drugs with HSA...
Constantin Rüder et al.
PloS one, 9(8), e104644-e104644 (2014-08-15)
Several studies suggest that circulating bone marrow derived stem cells promote the regeneration of ischemic tissues. For hematopoietic stem cell transplantation combinatorial granulocyte-colony stimulating factor (G-CSF)/Plerixafor (AMD3100) administration was shown to enhance mobilization of bone marrow derived stem cells compared...
Jaco Franken et al.
Applied microbiology and biotechnology, 99(15), 6377-6389 (2015-04-09)
Industrial synthesis of L-carnitine is currently performed by whole-cell biotransformation of industrial waste products, mostly D-carnitine and cronobetaine, through specific bacterial species. No comparable system has been established using eukaryotic microorganisms, even though there is a significant and growing international...
Hongxu Lu et al.
Biomaterials science, 3(7), 1085-1095 (2015-07-30)
Many attempts have been made in the application of multicellular tumor spheroids (MCTS) as a 3D tumor model to investigate their biological responses upon introduction of polymeric micelles as nanocarriers for therapeutic applications. However, the micelle penetration pathways in MCTS...
Liliana Costa et al.
Journal of photochemistry and photobiology. B, Biology, 120, 10-16 (2013-02-19)
Microbial photodynamic inactivation (PDI), involving the use of a photosensitizer (PS), light and molecular oxygen, with the subsequent production of reactive oxygen species (ROS), has been considered a promising and effective technology for viral inactivation. Although singlet oxygen is generally...
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