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Sujan Badal et al.
The Journal of biological chemistry, 290(36), 22287-22297 (2015-07-25)
Fluoroquinolones (FQ) are powerful broad-spectrum antibiotics whose side effects include renal damage and, strangely, tendinopathies. The pathological mechanisms underlying these toxicities are poorly understood. Here, we show that the FQ drugs norfloxacin, ciprofloxacin, and enrofloxacin are powerful iron chelators comparable
Susanne Mueller et al.
Molecular biology of the cell, 26(14), 2596-2608 (2015-05-23)
Protein degradation is essential for cellular homeostasis. We developed a sensitive approach to examining protein degradation rates in Saccharomyces cerevisiae by coupling a SILAC approach to selected reaction monitoring (SRM) mass spectrometry. Combined with genetic tools, this analysis made it
M K Quinn et al.
Physical chemistry chemical physics : PCCP, 17(46), 31177-31187 (2015-11-07)
A complete understanding of the role of molecular anisotropy in directing the self assembly of colloids and proteins remains a challenge for soft matter science and biophysics. For proteins in particular, the complexity of the surface at a molecular level
Jaung-Geng Lin et al.
PloS one, 10(6), e0128037-e0128037 (2015-06-05)
Fibromyalgia (FM) is among the most common chronic pain syndromes encountered in clinical practice, but there is limited understanding of FM pathogenesis. We examined the contribution of transient receptor potential vanilloid 1 (TRPV1) and TRPV4 channels to chronic pain in
Nathan Wolf et al.
Rapid communications in mass spectrometry : RCM, 29(15), 1448-1456 (2015-07-07)
The eco-physiological mechanisms that govern the incorporation and routing of macronutrients from dietary sources into consumer tissues determine the efficacy of stable isotope analysis (SIA) for studying animal foraging ecology. We document how changes in the relative amounts of dietary
D Felske et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(9), 681-685 (2014-12-17)
Subclinical hypothyroidism, characterized by an isolated rise in TSH serum levels with normal thyroid function, is a pro-inflammatory state associated with insulin resistance. Adipocytes express TSH receptors, but it is not known if TSH can directly inhibit insulin signaling. Using
Jianbo Zhu et al.
Physical chemistry chemical physics : PCCP, 17(43), 28666-28673 (2015-10-08)
In this work, polypyrrole/graphene doped by p-toluenesulfonic is prepared as an active material for supercapacitors, and its capacitance performance is investigated in various aqueous electrolytes including HCl, LiCl, NaCl, and KCl with a concentration of 3 M, respectively. A rising
Hua Yang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(21), 8297-8307 (2015-05-29)
All synapses show activity-dependent changes in strength, which affect the fidelity of postsynaptic spiking. This is particularly important at auditory nerve synapses, where the presence and timing of spikes carry information about a sound's structure, which must be passed along
Kyeung A Ryu et al.
PloS one, 10(8), e0136617-e0136617 (2015-08-27)
The aim of this study was to investigate the effects of intracochlear bleeding during cochleostomy on cochlear inflammatory response and residual hearing in a guinea pig animal model. Auditory brainstem response threshold shifts were greater in blood injected ears (p<0.05).
Paolo Piatti et al.
Scientific reports, 5, 8007-8007 (2015-01-27)
The modulation of chromatin dynamics by ATP-dependent chromatin remodeling factors has been recognized as an important mechanism to regulate the balancing of self-renewal and pluripotency in embryonic stem cells (ESCs). Here we have studied the effects of a partial deletion
Alexandria T Phan et al.
The Lancet. Oncology, 16(6), 695-703 (2015-05-10)
Treatment options for advanced, well-differentiated neuroendocrine tumours (NETs) remain scarce. Pazopanib is an orally bioavailable, small molecule, multitargeted kinase inhibitor that inhibits VEGF receptors 1, 2, and 3. We did a study of the efficacy of pazopanib with depot octreotide
Shanlu Liang et al.
Nanotoxicology, 9(1), 92-105 (2014-03-14)
In the past few years, much work has been performed to explore the biomedical applications and toxicity of nano-graphene and its derivatives. However, the reproductive toxicity of those carbon nanomaterials has been rarely studied. In this study, we report on
Alex Yong Sheng Eng et al.
Nanoscale, 7(47), 20256-20266 (2015-11-19)
Chemical modification and functionalization of inherent functional groups within graphite oxide (GO) are essential aspects of graphene-based nano-materials used in wide-ranging applications. Despite extensive research, there remains some discrepancy in its structure, with current knowledge limited primarily to spectroscopic data
A Kaufmann et al.
Analytica chimica acta, 862, 41-52 (2015-02-16)
An ultra-high performance liquid chromatography based method, coupled to high resolution mass spectrometry (UHPLC-HRMS), was developed to permit the detection and quantification of various nitrofuran and chloramphenicol residues in a number of animal based food products. This method is based
N K Chang et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(6), 1692-1700 (2015-02-04)
Here we introduce a novel method of transplanting human fetal kidneys into adult rats. To overcome the technical challenges of fetal-to-adult organ transplantation, we devised an arterial flow regulator (AFR), consisting of a volume adjustable saline-filled cuff, which enables low-pressure
Simeon Springer et al.
Breast cancer research and treatment, 152(2), 313-321 (2015-06-24)
Chromosomal amplifications are among the most common genetic alterations found in human cancers. However, experimental systems to study the processes that lead to specific, recurrent amplification events in human cancers are lacking. Moreover, some common amplifications, such as that at
Daniel Rycroft et al.
PloS one, 10(2), e0117847-e0117847 (2015-02-18)
Interferon alpha (IFNα) is used for the treatment of hepatitis B virus infection, and whilst efficacious, it is associated with multiple adverse events caused by systemic exposure to interferon. We therefore hypothesise that targeting IFN directly to the intended site
Karolien Hollanders et al.
Investigative ophthalmology & visual science, 56(2), 1335-1348 (2015-01-30)
Rho kinase (ROCK) is associated with VEGF-driven angiogenesis, as well as with inflammation and fibrosis. Therefore, the effect of AMA0428, a novel ROCK inhibitor, was studied in these processes, which highly contribute to the pathogenesis of neovascular AMD. The effect
Enamel color modifications by controlled hydrochloric acid pumice abrasion: a review with case summaries.
T C Adams
Journal (Indiana Dental Association), 66(5), 23-26 (1987-09-01)
Elizabeth A Ennis et al.
ACS chemical neuroscience, 6(3), 417-427 (2015-01-07)
The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and manipulation of synaptic cholinergic signaling. To expand CHT pharmacology, we pursued a high-throughput screen for
Miyeoun Song et al.
Cell transplantation, 24(2), 183-190 (2014-01-02)
The long-term effect of magnetically targeted neural stem cells in a rat focal cerebral ischemia model was investigated. In middle cerebral artery occlusion (MCAO) stroke model rats, ferumoxide-labeled human neural stem cells (hNSCs) were injected into the tail vein. MCAO
Evelien A W Smits et al.
Journal of liposome research, 25(1), 46-57 (2014-07-02)
Besides the development of sample preparation methods for the determination of separate liposomal-encapsulated prednisolone phosphate and non-encapsulated prednisolone concentrations in murine plasma and blood, this article also presents the first description of an accurate sample preparation method for the determination
Marta Cigognetti et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 28(8), 1043-1057 (2015-05-30)
The distinction between malignant mesothelioma and reactive mesothelial proliferation can be challenging both on histology and cytology. Recently, variants of the BRCA1-associated protein 1 (BAP1) gene resulting in nuclear protein loss were reported in hereditary and sporadic mesothelioma. Using immunohistochemistry
Nahid Moghbel et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 997, 142-145 (2015-06-27)
A reversed-phase HPLC-UV method was developed, optimized, and validated for the separation and quantitation of six target alkaloids from leaves of Nicotiana species (nicotine, nornicotine, anatabine, anabasine, myosmine, and cotinine). A bidentate reversed-phase C18 column was used as stationary phase
Davide R Ceratti et al.
Advanced materials (Deerfield Beach, Fla.), 27(34), 4958-4962 (2015-07-23)
A new, simple bi-phasic dip-coating method is developed. This method is considered as a great improvement of the technique for research, development and production, since expensive, rare, harmful, or time-evolving solutions can now be easily deposited on large surfaces and
Jorge M Santos et al.
Stem cell research & therapy, 6, 90-90 (2015-05-10)
The secretion of trophic factors by mesenchymal stromal cells has gained increased interest given the benefits it may bring to the treatment of a variety of traumatic injuries such as skin wounds. Herein, we report on a three-dimensional culture-based method
Enkhtuul Tsogtbaatar et al.
Journal of experimental botany, 66(14), 4267-4277 (2015-02-26)
Pennycress (Thlaspi arvense L.), a plant naturalized to North America, accumulates high levels of erucic acid in its seeds, which makes it a promising biodiesel and industrial crop. The main carbon sinks in pennycress embryos were found to be proteins
Stefanie H Grimm et al.
ChemMedChem, 10(6), 1027-1039 (2015-04-23)
We herein present label-free, mass-spectrometry-based binding assays (MS Binding Assays) for the human dopamine, norepinephrine, and serotonin transporters (hDAT, hNET, and hSERT). Using this approach both enantiomers of the triple reuptake inhibitor indatraline as well as its cis-configured diastereomer were
Dallas L Matz et al.
Dalton transactions (Cambridge, England : 2003), 44(27), 12210-12224 (2015-04-16)
Synthetic details for 4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.5.2]pentadecane, the dimethyl ethylene cross-bridged homocyclen ligand are presented for the first time. Its novel Mn(2+), Fe(2+), Mn(3+), and Fe(3+) complexes have been synthesized and characterized. X-ray crystal structures were obtained for both manganese complexes, along with
Johanna Kaartinen et al.
Veterinary journal (London, England : 1997), 202(2), 353-360 (2014-09-10)
The haemodynamic interactions of a step infusion with medetomidine (MED) and the peripherally acting alpha-2 antagonist MK-467 (MK) were compared with MED infused alone in isoflurane-anaesthetised dogs. Eight purposely-bred Beagles were used in a randomised crossover study. Anaesthesia was induced
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