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Po-Chung Chen et al.
Molecular & cellular proteomics : MCP, 14(3), 510-518 (2014-12-30)
To profile plasma antibodies of patients with bipolar disorder (BD), an E. coli proteome microarray comprising ca. 4200 proteins was used to analyze antibody differences between BD patients and mentally healthy controls (HCs). The plasmas of HCs and patients aged
Stella Liong et al.
Journal of physiology and biochemistry, 71(4), 703-717 (2015-09-27)
Gestational diabetes mellitus (GDM) is characterised by maternal peripheral insulin resistance and inflammation. Sterile inflammation and bacterial infection are key mediators of this enhanced inflammatory response. Adenosine monophosphate (AMP)-activated kinase (AMPK), which is decreased in insulin resistant states, possesses potent
Zhengkui Sun et al.
Molecular medicine reports, 11(5), 3235-3542 (2015-01-15)
The stem cell populations in cancerous tissues and cell lines vary widely and are often associated with aggressive cases of breast cancer. Despite research on the topic, the mechanism underlying the regulation of the breast cancer stem cell (BCSC) population
Angélica Maciel Gomes et al.
Journal of cellular biochemistry, 116(8), 1668-1679 (2015-03-05)
The development of the mammary gland involves formation of a branched arboreal structure resulting from the penetration and proliferation of epithelial cells into the fat pad. The mammary cells invade by remodeling their surrounding extracellular matrix (ECM), which are rich
Huanyu Xu et al.
Scientific reports, 5, 12453-12453 (2015-07-28)
Among the identified thousands of circular RNAs (circRNA) in humans and animals, Cdr1as (also known as CiRS-7) was recently demonstrated to act as a powerful miR-7 sponge/inhibitor in developing midbrain of zebrafish, suggesting a novel mechanism for regulating microRNA functions.
Anne J J Roussel et al.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 79(1), 46-51 (2015-02-13)
Epidermal tight junctions (TJ) have been well-described in human medicine and are involved in many skin diseases such as atopic dermatitis (AD). In dogs, there are no data regarding the implication of TJ in skin diseases including canine AD. The
Sandeep Gupta et al.
The Journal of infectious diseases, 211(1), 45-52 (2014-05-23)
The time to acquisition of simian immunodeficiency virus (SIV) infection following low-dose repeated rectal challenge correlated inversely with the number of transmitted/founder strains among macaques vaccinated with ALVAC-SIV/gp120 or gp120 alone. We determined if the ability of postvaccination, prechallenge sera
Yiting Tang et al.
Scientific reports, 5, 9476-9476 (2015-03-31)
Radioresistance has been an important factor in restricting efficacy of radiotherapy for non-small cell lung cancer (NSCLC) patients and new approaches to inhibit cancer growth and sensitize irradiation were warranted. Despite the important role of ubiquitin/proteasome system (UPS) during cancer
Kalpana Sriraman et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(7), 884-903 (2015-03-18)
This study was undertaken to investigate stem cells in adult mouse ovary, the effect of chemotherapy on them and their potential to differentiate into germ cells. Very small embryonic-like stem cells (VSELs) that were SCA-1+/Lin-/CD45-, positive for nuclear octamer-binding transforming
Didem Seven et al.
Oncology letters, 10(3), 1927-1931 (2015-12-02)
Several studies have suggested that Ras-associated binding 25 protein (Rab25) is involved in the pathogenesis of human cancer. Although it has been demonstrated that the development of head and neck squamous cell carcinoma (HNSCC) is the result of an accumulation
Yunshuo Tang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(51), 18339-18344 (2014-12-10)
GABAergic inhibition has been shown to play an important role in the opening of critical periods of brain plasticity. We recently have shown that transplantation of GABAergic precursors from the embryonic medial ganglionic eminence (MGE), the source of neocortical parvalbumin-
Mogher Khamaisi et al.
Kidney international, 87(4), 761-770 (2014-12-04)
Renal endothelin-converting enzyme (ECE)-1 is induced in experimental diabetes and following radiocontrast administration, conditions characterized by renal hypoxia, hypoxia-inducible factor (HIF) stabilization, and enhanced endothelin synthesis. Here we tested whether ECE-1 might be a HIF-target gene in vitro and in
Jie Lu et al.
PloS one, 10(9), e0137595-e0137595 (2015-09-10)
Small molecule inhibitors against protein geranylgeranyltransferase-I such as P61A6 have been shown to inhibit proliferation of a variety of human cancer cells and exhibit antitumor activity in mouse models. Development of these inhibitors could be dramatically accelerated by conferring tumor
Xu Liu et al.
Brain, behavior, and immunity, 46, 121-131 (2015-02-01)
Alzheimer's disease (AD) is a neurodegenerative disease characterized by extracellular deposits of amyloid β peptide (Aβ) and microglia-dominated neuroinflammation. The therapeutic options for AD are currently limited. In this study, we investigated the antiinflammatory effects and the underlying molecular mechanisms
Christoph Gerhardt et al.
The Journal of cell biology, 210(1), 115-133 (2015-07-08)
Mutations in RPGRIP1L result in severe human diseases called ciliopathies. To unravel the molecular function of RPGRIP1L, we analyzed Rpgrip1l(-/-) mouse embryos, which display a ciliopathy phenotype and die, at the latest, around birth. In these embryos, cilia-mediated signaling was
J Gu et al.
European review for medical and pharmacological sciences, 19(13), 2354-2358 (2015-07-28)
The correlation of the embryo matrix metalloproteinase-9 (MMP-9) secretion, embryonic development and clinical pregnancy was investigated. The embryo culture from in vitro fertilization-embryo transfer (IVF-ET) patients were collected in the Xuzhou Central Hospital from January 2013 to September 2014. At
Heyke C Diddens-Tschoeke et al.
Lasers in surgery and medicine, 47(5), 452-461 (2015-06-09)
In an attempt to develop a new therapeutic approach for highly localized thermal destruction of tissue targets that lack natural pigmentation, the potential of in-vivo dye-enhanced photothermal therapy (PTT) was investigated. PTT involves the application of an exogenous absorber, which
Hyo Jin Lee et al.
Molecules (Basel, Switzerland), 20(6), 11604-11616 (2015-06-26)
The present study tested the hypothesis that Korean red ginseng (KRG) provides a protective effect against alcoholic fatty liver. Male Sprague-Dawley rats were divided into four groups and fed a modified Lieber-DeCarli diet containing 5% (w/v) alcohol or an isocaloric
Jenny Freitag et al.
PloS one, 9(10), e109199-e109199 (2014-10-09)
Transgenic expression of B- and T-cell receptors (BCRs and TCRs, respectively) has been a standard tool to study lymphocyte development and function in vivo. The generation of transgenic mice is time-consuming and, therefore, a faster method to study the biology
Hope F Douglas et al.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 25(4), 528-537 (2015-06-05)
To evaluate the poly (ADP-ribose) polymerase-1 (PARP1) enzyme and its inhibition in horses and explore its potential as a novel therapeutic target for equine intestinal ischemia-reperfusion injury by (1) identifying poly (ADP-ribose) (PAR) as an indication of PARP1 activation in
Xingxing Wang et al.
Journal of neurotrauma, 31(24), 1955-1966 (2014-06-26)
Axonal growth and neurological recovery after traumatic spinal cord injury (SCI) is limited by the presence of inhibitory proteins in myelin, several of which act via the NgR1 protein in neurons. A truncated soluble ligand-binding fragment of NgR1 serves as
Tu'uhevaha J Kaitu'u-Lino et al.
Pregnancy hypertension, 4(4), 287-295 (2015-06-25)
Soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng) are the most studied molecules in preeclampsia. However, most trophoblast cell lines do not secrete both these factors. Thus, we set out to characterize protocols to functionally investigate sFlt-1 and sEng
Haiyan Hao et al.
European journal of obstetrics, gynecology, and reproductive biology, 194, 85-91 (2015-09-08)
It is well documented that an imbalance in immune tolerance at the maternal-fetal interface is likely to play an essential role in the etiology of preeclampsia. However, the mechanisms underlying immune tolerance during preeclampsia are still poorly understood. Tim-3, a
James W Wynne et al.
Genome biology, 15(11), 532-532 (2014-11-16)
Bats are a major reservoir of emerging infectious viruses. Many of these viruses are highly pathogenic to humans however bats remain asymptomatic. The mechanism by which bats control viral replication is unknown. Here we utilize an integrated approach of proteomics
Ines Fasolino et al.
Molecular nutrition & food research, 59(3), 434-442 (2014-12-10)
Inflammatory bowel disease (IBD) is an incurable disease which affects millions of people. Garlic (Allium sativum) preparations have been traditionally employed for the treatment of diseases affecting the digestive tract. Here, we have investigated the effect of diallyl sulfide (DAS)
M K N Sai Varsha et al.
Nutrition (Burbank, Los Angeles County, Calif.), 31(10), 1284-1292 (2015-09-04)
Vitamin K is a potent regulator of vascular dynamics and prevents vascular calcification. Vitamin K is increasingly being recognized for its antioxidant and antiinflammatory properties. Recently we demonstrated that vitamin K1 (5 mg/kg) protects against streptozotocin-induced type 1 diabetes and
Paula Szalai et al.
Experimental cell research, 333(1), 21-38 (2015-02-17)
LC3, a mammalian homologue of yeast Atg8, is assumed to play an important part in bulk sequestration and degradation of cytoplasm (macroautophagy), and is widely used as an indicator of this process. To critically examine its role, we followed the
Xiaoyong Dai et al.
Applied microbiology and biotechnology, 99(14), 5997-6007 (2015-03-12)
Nogo-66, a hydrophilic loop of 66 amino acids flank two hydrophobic domains of the Nogo-A C terminus, interacts with the Nogo-66 receptor (NgR) to exert numerous functions in the central nervous system (CNS). Nogo-66 has important roles in aspects of
Jasmin Balmer et al.
International journal of molecular sciences, 16(7), 15086-15103 (2015-07-08)
Herein, we have investigated retinal cell-death pathways in response to the retina toxin sodium iodate (NaIO3) both in vivo and in vitro. C57/BL6 mice were treated with a single intravenous injection of NaIO3 (35 mg/kg). Morphological changes in the retina
Josephine M J Stoffels et al.
Glia, 63(2), 242-256 (2014-08-27)
Central nervous system remyelination by oligodendrocyte progenitor cells (OPCs) ultimately fails in the majority of multiple sclerosis (MS) lesions. Remyelination benefits from transient expression of factors that promote migration and proliferation of OPCs, which may include fibronectin (Fn). Fn is
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