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So Hee Dho et al.
Oncotarget, 6(36), 39235-39246 (2015-10-30)
The NADPH oxidase, NOX5, is known to stimulate cell proliferation in some cancers by generating reactive oxygen species (ROS). We show here that the long form of NOX5 (NOX5-L) also promotes cell death, and thus determines the balance of proliferation
Atsuhiko Toyoshima et al.
PloS one, 10(6), e0127302-e0127302 (2015-06-16)
Intra-arterial stem cell transplantation exerts neuroprotective effects for ischemic stroke. However, the optimal therapeutic time window and mechanisms have not been completely understood. In this study, we investigated the relationship between the timing of intra-arterial transplantation of allogeneic mesenchymal stem
Xiao-Hui Ma et al.
The International journal of neuroscience, 125(2), 140-146 (2014-04-16)
Hundreds of previous studies demonstrated the cytoprotective effect of trichostatin-A (TSA), a kind of histone deacetylases inhibitors (HDACIs), against cerebral ischemia/reperfusion insult. Meanwhile, phosphatidylinositol-3 kinase/Akt (PI3K/Akt) is a well-known, important signaling pathway that mediates neuroprotection. However, it should be remains
Yinghua Jiang et al.
Neuroscience letters, 602, 73-78 (2015-07-08)
We previously have shown that tissue type plasminogen activator (tPA) in combination with its receptor annexin A2 (rA2) protein significantly improved tPA thrombolytic efficacy. In this study we aimed to examine the therapeutic effects of the combination when treated at
Pei-Pei Zhai et al.
Neuropharmacology, 95, 1-11 (2015-03-10)
This study was designed to evaluate the neuroprotective effect of l-serine and the underlying mechanisms in mice after traumatic brain injury (TBI) induced using a weight drop model. The mice were intraperitoneally injected with l-serine 3 h after TBI and
Jun Guo et al.
Inflammation, 38(2), 664-671 (2014-07-13)
The aim of the study was to investigate the anti-apoptotic potency of TNFR:Fc gene in ischemia/reperfusion-induced myocardial cell injury and hypoxia/reoxygenation-induced H9c2 rat cardiomyocytes injury. Rats were randomly divided into the following groups (n=8): (1) sham operation group; (2) ischemia-reperfusion
Feng Gao et al.
Chemical & pharmaceutical bulletin, 60(3), 415-418 (2012-03-03)
A selective intramolecular transacylation from C-4 to C-5 of taxoids, which occurred simultaneously with the oxetane D-ring opening and was promoted by TiCl4, was presented. The optimal condition was found to be treatment of substrates in double dose of dichloromethane
Shoko Yamazaki et al.
The Journal of organic chemistry, 76(15), 6432-6437 (2011-06-21)
Lewis acid-catalyzed cyclization of aminoacetals 2 and triethyl ethenetricarboxylate (1a) has been examined. The reaction of 3-aminopropionaldehyde diethyl acetal (2a) and 1a in the presence of 1 equiv of TiCl(4) at room temperature gave 4-ethoxypiperidine-2,3,3-tricarboxylate 3a in 92% yield with
Mércia Beluzi et al.
PloS one, 10(3), e0122660-e0122660 (2015-03-26)
Cachexia is a multifactorial syndrome characterized by profound involuntary weight loss, fat depletion, skeletal muscle wasting, and asthenia; all symptoms are not entirely attributable to inadequate nutritional intake. Adipose tissue and skeletal muscle loss during cancer cachexia development has been
Rita Lh Yim et al.
Oncotarget, 5(20), 9770-9782 (2014-09-12)
Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin's lymphoma (NHL). In cancers, tumor suppressive microRNAs may be silenced by DNA hypermethylation. By microRNA profiling of representative EBV-negative MCL cell lines before and after demethylation treatment, miR-155-3p was found significantly
Li-Jun Xu et al.
Experimental neurology, 264, 1-7 (2014-11-30)
miR-181 has deleterious effects on stroke outcome, and reducing miR-181a levels prior to middle cerebral artery occlusion (MCAO) was shown previously to be protective. Here we tested the effect of post-ischemic treatment with miR-181a antagomir by intracerebroventricular and intravenous routes
Y X Zhao et al.
Journal of hazardous materials, 187(1-3), 495-501 (2011-02-12)
The growth, breakage and regrowth nature of flocs formed by Titanium tetrachloride (TiCl(4)) and polyaluminum chloride (PACl) was comparatively evaluated with surface water treatment. A series of jar experiments were conducted to investigate the impacts of different operating parameters such
Y Chen et al.
British journal of anaesthesia, 114(2), 327-335 (2014-09-04)
Sevoflurane preconditioning has a neuroprotective effect, but the underlying mechanism is not fully understood. The aim of the present investigation was to evaluate whether sevoflurane-induced cerebral preconditioning involves inhibition of carboxy-terminal modulator protein (CTMP), an endogenous inhibitor of Akt, in
Dan Wu et al.
Journal of molecular medicine (Berlin, Germany), 93(12), 1311-1325 (2015-07-04)
C1q/tumor necrosis factor-related protein-3 (CTRP3) is a novel adipokine with modulation effects on metabolism, inflammation, and cardiovascular system. This study aimed to investigate the effect of CTRP3 on cardiac fibrosis and its underlying mechanism. The myocardial expression of CTRP3 was
A Vercelli et al.
Cell death & disease, 6, e1854-e1854 (2015-08-14)
Excitotoxicity following cerebral ischemia elicits a molecular cascade, which leads to neuronal death. c-Jun-N-terminal kinase (JNK) has a key role in excitotoxic cell death. We have previously shown that JNK inhibition by a specific cell-permeable peptide significantly reduces infarct size
Magdalena Stevanović et al.
Colloids and surfaces. B, Biointerfaces, 132, 208-215 (2015-06-07)
In the bone tissue engineering field, there is a growing interest in the application of bioactive glass scaffolds (45S5Bioglass(®)) due to their bone bonding ability, osteoconductivity and osteoinductivity. However, such scaffolds still lack some of the required functionalities to enable
Gulnaz Begum et al.
Stroke, 46(7), 1956-1965 (2015-06-13)
WNK kinases, including WNK3, and the associated downstream Ste20/SPS1-related proline-alanine-rich protein kinase (SPAK) and oxidative stress responsive 1 (OSR1) kinases, comprise an important signaling cascade that regulates the cation-chloride cotransporters. Ischemia-induced stimulation of the bumetanide-sensitive Na(+)-K(+)-Cl(-) cotransporter (NKCC1) plays an
Manohar Puppala et al.
Chemical communications (Cambridge, England), 48(46), 5778-5780 (2012-05-03)
A TiCl(4)-promoted domino semipinacol-Schmidt reaction of oxaspiropentane-azide provides an easy access to bridged azatricyclic ring systems, which possess the azaquaternary center, present in the immunosupressant FR901483 and platelet aggregation inhibitor daphlongeranine B.
Jing Hu et al.
Cardiovascular toxicology, 15(3), 241-249 (2014-11-08)
Apigenin (Api), a mainly bioactive component of Apium graveolens L. var. dulce DC. (a traditional Chinese medicinal herb), possesses a wide range of biological activities, including antioxidant effects. It also has been shown to associate with lower prevalence of cardiovascular
Amber J Marty et al.
PLoS pathogens, 11(6), e1004959-e1004959 (2015-06-27)
In response to temperature, Blastomyces dermatitidis converts between yeast and mold forms. Knowledge of the mechanism(s) underlying this response to temperature remains limited. In B. dermatitidis, we identified a GATA transcription factor, SREB, important for the transition to mold. Null
Elizabeth D Ellis et al.
American journal of industrial medicine, 56(3), 282-291 (2012-11-13)
A cohort of 3,607 workers employed in three DuPont titanium dioxide production facilities was followed from 1935 through 2006. Combined and plant-specific cohort mortality was compared with the overall US population and other DuPont employees. The relationships between selected causes
Ya Wen et al.
Molecular medicine (Cambridge, Mass.), 21, 197-209 (2015-03-27)
Inflammatory responses play a critical role in ischemic brain injury. MicroRNA-155 (miR-155) induces the expression of inflammatory cytokines, and acetylbritannilactone (ABL) exerts potent antiinflammatory actions by inhibiting expression of inflammation-related genes. However, the functions of miR-155 and the actual relationship
Hong-Shuo Sun et al.
Experimental neurology, 263, 161-171 (2014-12-03)
Neonatal hypoxic-ischemic brain injury and its related illness hypoxic-ischemic encephalopathy (HIE) are major causes of nervous system damage and neurological morbidity in children. Hypoxic preconditioning (HPC) is known to be neuroprotective in cerebral ischemic brain injury. K(ATP) channels are involved
Bhavisha Bakrania et al.
International journal of cardiology, 202, 27-33 (2015-09-21)
Unconjugated bilirubin (UCB), an endogenous antioxidant, may protect the heart against ischemia-reperfusion (I-R) injury. However, the 'cardioprotective' potential of bilirubin therapy remains unclear. We tested whether pre- or post-ischemic treatment of ex vivo perfused hearts with bilirubin ditaurate (BRT) improves
Hai Xia Hu et al.
Molecular medicine reports, 12(1), 1321-1327 (2015-03-31)
The aim of the present study was to explore the neuroprotective effects of Gualou Guizhi decoction (GLGZD) in a rat model of middle cerebral artery occlusion (MCAO). Sprague-Dawley rats were divided into three groups: Sham (no MCAO), MCAO (MCAO with
Haipeng Zhu et al.
International journal of molecular medicine, 36(2), 595-601 (2015-06-18)
The present study aimed to reveal the association between insulin-like growth factor binding protein-2 (IGFBP-2) and the sensitivity of bladder cancer cells to cisplatin, and determine the underlying mechanism involving maspin. A total of 32 bladder cancer tissue samples were
Jing Wang et al.
Environmental technology, 37(1), 39-45 (2015-06-27)
Bioreduced graphene oxide (BRGO) has been proven to be capable of accelerating nitrobenzene (NB) biotransformation by anaerobic sludge (AS). To realize its application, in the present study, two continuous anaerobic reactors (R1 with BRGO/AS composite; R2 with AS) were employed
Masaki Izumo et al.
Echocardiography (Mount Kisco, N.Y.), 32(11), 1608-1613 (2015-04-18)
Although takotsubo cardiomyopathy (TTC) has been reported to have a favorable outcome, many complications may occur in the acute phase. Heart failure is the most common clinical complication in patients with TTC. We aimed to investigate determinants of secondary pulmonary
Wayne Pilgrim et al.
The Journal of organic chemistry, 75(20), 6747-6755 (2010-09-15)
The quantification of factors that influence both rates and stereoselectivity of anomerization reactions catalyzed by SnCl(4) and TiCl(4) and how this has informed the synthesis of α-O- and α-S-glycolipids is discussed. The SnCl(4)-catalyzed anomerization reactions of β-S- and β-O-glycosides of
Niloofar Moghadas-Sharif et al.
Drug development and industrial pharmacy, 41(3), 445-450 (2014-01-11)
The aim of the present study was to assess the in vitro antimicrobial activities of nanoliposomal formulations loaded with vancomycin or/and rifampin against the biofilm formed by Staphylococcus epidermidis at 37 °C under aerobic condition. Liposomal formulations were prepared by dehydration-rehydration
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