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Nam-Gyoon Kim
Perceptual and motor skills, 120(3), 906-927 (2015-05-20)
As an object approaches an observer, the visual angle subtended by any two texture elements on the object surface expands, as does the solid angle corresponding to the object's contour. The inverse of the relative rate of each of these...
Bo-ding Tong et al.
Molecular vision, 21, 324-334 (2015-04-16)
This study aimed to determine the role of miR-21 in orbital fibroblasts obtained from donors with thyroid-associated ophthalmopathy (TAO) and to elucidate the regulation of fibrosis by miR-21 in the pathological process of TAO. The expression of miR-21 was investigated...
Bahman Khameneh et al.
Drug development and industrial pharmacy, 41(6), 989-994 (2014-05-21)
Antibiotic resistance has stimulated the research for developing novel strategies that can prevent bacterial growth. Methicillin-resistant Staphylococcus aureus (MRSA), regarded as one of the most serious antibiotic-resistant bacteria which has been conventionally recognized as a nosocomial pathogen. Nanoliposomal formulations of...
Ivan Kocic et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(1), 79-86 (2014-10-26)
This study evaluated the therapeutic potential of masitinib, an oral tyrosine kinase inhibitor with activity against c-Kit and platelet-derived growth factor receptors (PDGFR), to reduce ischemic brain area and neurological deficit. Using a well-established filament model of ischemic stroke in...
Harri Heikkinen et al.
Solid state nuclear magnetic resonance, 43-44, 36-41 (2012-03-20)
In this study, solid state (13)C NMR spectroscopy was utilised to characterize and identify the metal-ester coordination in active fourth generation (phthalate) Ziegler-Natta catalysts. It is known that different donors affect the active species in ZN catalysts. However, there is...
Jianjuan Ke et al.
Journal of cardiovascular pharmacology, 66(1), 25-34 (2015-02-24)
This study was undertaken to determine and confer the cardioprotective effects of the adenosine A2 receptor (A2AR) and its impact on myocardial autophagy in the setting of reperfusion. We established a rat ischemia model by subjecting rats to 30 minutes...
Bo Yang et al.
Neurotoxicity research, 28(1), 1-7 (2015-02-24)
Cystatin C (CysC) has been used as a renal function indicator and a strong predictor of cardiovascular events. In this study, we determined the prognostic value of serum CysC in patients with acute ischemic stroke (AIS) and examined its protective...
Ying Li et al.
Toxicology and applied pharmacology, 286(1), 53-63 (2015-03-21)
Curcumin is a natural polyphenolic compound in Curcuma longa with beneficial effects on neuronal protection. This study aims to investigate the action of curcumin in the hippocampus subjected to glutamate neurotoxicity. Glutamate stimulation induced reactive oxygen species (ROS), endoplasmic reticulum...
Tao Luo et al.
Archives of biochemistry and biophysics, 586, 1-9 (2015-06-21)
Calpain plays an important role in myocardial ischemia/reperfusion (I/R) injury. PD150606, a nonpeptide, cell-permeable and noncompetitive calpain inhibitor, has been shown to have protective properties in ischemic disease. The aims of the present study were to investigate whether PD150606 could...
Zhi Li et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 14(6), 1197-1206 (2015-05-23)
Recently, porous carbons have showed great potential in many areas. In this study, TiO2-doped mesoporous carbonaceous (TiO2@C) nanoparticles were obtained by a simple one-pot hydrothermal treatment, folic acid (FA) was conjugated to TiO2@C through an amide bond, then Mitoxantrone HCl...
Hua Dock et al.
Translational stroke research, 6(4), 296-300 (2015-04-01)
5-Aza-deoxycytidine (5-aza-dC) confers neuroprotection in ischemic mice by inhibiting DNA methylation. Zebularine is another DNA methylation inhibitor, less toxic and more stable in aqueous solutions and, therefore more biologically suitable. We investigated Zebularine's effects on brain ischemia in a rat...
Mingbao Lin et al.
PloS one, 10(4), e0124558-e0124558 (2015-04-22)
Methylophiopogonanone A (MO-A), an active homoisoflavonoid of the Chinese herb Ophiopogon japonicus which has been shown to have protective effects on cerebral ischemia/reperfusion (I/R) injury, has been demonstrated to have anti-inflammatory and anti-oxidative properties. However, little is known about its...
Fei Zhou et al.
Stem cell research & therapy, 6, 92-92 (2015-05-10)
Growing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived stem cells (ADSCs) are considered as one of the most appropriate for stroke treatment. However, previous experimental...
Hongqiu Li et al.
Molecular medicine reports, 12(1), 1561-1567 (2015-03-31)
Previous studies have suggested that microRNAs (miRNAs/miRs) may positively or negatively control osteogenic differentiation and mineralization by targeting negative regulators of osteogenesis or important osteogenic factors. miR-21 is important in osteoblast differentiation and Smad7 is a critical regulator of osteogenic...
Kasumi Ishida et al.
BMC microbiology, 14, 330-330 (2014-12-22)
Pathogenic chlamydiae are obligate intracellular pathogens and have adapted successfully to human cells, causing sexually transmitted diseases or pneumonia. Chlamydial outer protein N (CopN) is likely a critical effector protein secreted by the type III secretion system in chlamydiae, which...
Y X Zhao et al.
Journal of hazardous materials, 198, 70-77 (2011-10-28)
Characteristics of flocs formed by charge neutralization and sweep coagulation using titanium tetrachloride (TiCl(4)) were investigated with humic acid-kaolin suspension by continuous optical monitoring. This paper focused on the regrowth ability of broken flocs after addition of second TiCl(4) dose....
Grace Wong et al.
PloS one, 10(7), e0131701-e0131701 (2015-07-07)
Many modern molecular diagnostic assays targeting nucleic acids are typically confined to developed countries or to the national reference laboratories of developing-world countries. The ability to make technologies for the rapid diagnosis of infectious diseases broadly available in a portable...
Chin-Yi Cheng et al.
BMC complementary and alternative medicine, 15, 241-241 (2015-07-19)
This study aimed to determine the effects of electroacupuncture stimulation at the Baihui (GV20) and Fengfu (GV16) acupoints, at frequencies of 5Hz (EA-5Hz) and 25Hz (EA-25Hz), 7 days after cerebral ischemia-reperfusion (I/R) injury, and to evaluate the possible signaling mechanisms...
Kei Miyagi et al.
Biological & pharmaceutical bulletin, 38(11), 1747-1751 (2015-11-03)
Regulation of blood glucose levels as a therapeutic strategy for cerebral ischemia plays an important role in suppressing neuronal damage. In particular, suppression of post-ischemic glucose intolerance improves cerebral ischemia. We have reported that cerebral ischemia induces glucose intolerance and...
Maja Kozarski et al.
Food & function, 6(6), 1875-1886 (2015-05-07)
The methanolic extract of the wild edible mushroom Cantharellus cibarius Fr. (chanterelle) was analyzed for in vitro antioxidative, cytotoxic, antihypertensive and antibacterial activities. Various primary and secondary metabolites were found. Phenols were the major antioxidant components found in the extract...
Xiang-pen Li et al.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 23(10), 2671-2680 (2014-10-14)
The effect of changing temperature on an individual's cerebrovascular risk is both biologically plausible and supported by epidemiologic evidence. We used a global proteomic-based approach to analyze the expression alterations of proteins in artificial cold exposure (ACE)-induced hypertensive stroke in...
Yinhua Dong et al.
International journal of endocrinology, 2015, 903186-903186 (2015-08-22)
Alpha-lipoic acid (ALA) has various pharmacological effects such as antioxidative, anti-inflammatory, and antiapoptotic properties. In the present study, administration of ALA (40 mg/kg, i.p.) for 3 days resulted in a significant decrease in neuronal deficit score and infarct volume and a...
Soji Shimizu et al.
Chemical communications (Cambridge, England), 49(16), 1621-1623 (2013-01-23)
Pyrrolopyrrole aza-BODIPY analogues were synthesized from diketopyrrolopyrrole and heteroaromatic amines in the presence of titanium tetrachloride. These novel compounds exhibit intense absorption in the visible region and strong emission with high fluorescence quantum yields greater than 0.8.
Annie Y Chou et al.
The Canadian journal of cardiology, 31(8), 1073-1073 (2015-07-28)
Spontaneous coronary artery dissection (SCAD) and Takotsubo cardiomyopathy (TTC) can both cause myocardial infarction with subsequent normalization of wall motion abnormality. Angiograms of patients with TTC at Vancouver General Hospital were reviewed for SCAD. Clinical and investigational characteristics were recorded....
Xue Jiang et al.
Apoptosis : an international journal on programmed cell death, 20(8), 1033-1047 (2015-04-22)
sRAGE can protect cardiomyocytes from apoptosis induced by ischemia/reperfusion (I/R). However, the signaling mechanisms in cardioprotection by sRAGE are currently unknown. We investigated the cardioprotective effect and potential molecular mechanisms of sRAGE inhibition on apoptosis in the mouse myocardial I/R...
Jeffrey A Kline et al.
Thrombosis research, 136(4), 769-774 (2015-09-05)
Pulmonary embolism (PE) can cause intracardiac hemolysis and increased plasma hemoglobin and arginase-1, which can worsen pulmonary vasoconstriction. We test the hypothesis that patients with PE that causes tricuspid regurgitation (TR), indicative of higher pulmonary arterial pressures, have decreased leukocyte...
Zhao Yang et al.
Experimental and molecular pathology, 98(2), 219-224 (2015-02-11)
Much evidence demonstrated that autophagy played an important role in neural inflammation response after ischemia stroke. However, the specific effect of microglia autophagy in cerebral ischemia is still unknown. In the current study, we constructed focal cerebral ischemia model by...
Shan-Wen Chen et al.
Inflammation, 38(1), 375-383 (2014-10-27)
Lipopolysaccharide was found to be elevated in the plasma of necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD) patients and may play an important role in the pathogenesis and propagation of these intestinal diseases. To illustrate the destructive effect of...
Tyson Howell et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 127(12), 2695-2709 (2014-10-18)
This study identifies a small distal region of the 1RS chromosome from rye that has a positive impact on wheat yield. The translocation of the short arm of rye (Secale cereale L.) chromosome one (1RS) onto wheat (Triticum aestivum L.)...
Chen-Huan Lin et al.
Stem cells (Dayton, Ohio), 33(4), 1153-1172 (2014-12-20)
Understanding stem cell homing, which is governed by environmental signals from the surrounding niche, is important for developing effective stem cell-based repair strategies. The molecular mechanism by which the brain under ischemic stress recruits bone marrow-derived cells (BMDCs) to the...
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