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C Murat Songur et al.
The heart surgery forum, 17(5), E263-E268 (2014-11-05)
We sought to investigate the effects of the angiotension II receptor blocker candesartan on ischemia-reperfusion injury using a cardioplegia arrested isolated rat heart model. Ischemia-reperfusion injury was induced in isolated rat hearts with 40 minutes of global ischemia followed by
Ikuo Yamamiya et al.
The Journal of pharmacy and pharmacology, 66(12), 1686-1697 (2014-08-15)
Tegafur (FT), a pro-drug of 5-fluorouracil (5-FU), is a racemate consisting of two enantiomers, R and S-FT. The aim of this study was to clarify interspecies variation in the enantioselective metabolism of FT. Plasma concentrations of FT enantiomers were determined
Kazuko Inoue et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1326-1333 (2014-06-11)
Lenvatinib is a multityrosine kinase inhibitor that inhibits vascular endothelial growth factor receptors, and is being developed as an anticancer drug. P450s are involved in one of the elimination pathways of lenvatinib, and mono-oxidized metabolites, such as N-oxide (M3) and
Qing Wang et al.
Talanta, 129, 438-447 (2014-08-17)
In the current study, zirconia (ZrO2) and its composite, magnesia-zirconia (MgO-ZrO2), were prepared as the hydrophilic interaction chromatographic (HILIC) stationary phases (SPs). Different experimental variables including water content, pH and buffer concentration in the mobile phase (MP) as well as
Liang Yang et al.
Archives of pharmacal research, 37(12), 1554-1559 (2014-08-15)
The present study aimed to develop an effective oral formulation of tranilast (TL), a poorly soluble anti-inflammatory drug, via the formation of drug complex with 3-aminopropyl functionalized magnesium phyllosilicate (AMP clay) and improve the pH-dependent drug dissolution and bioavailability of
Joseph T Morott et al.
Journal of pharmaceutical sciences, 104(1), 124-134 (2014-11-21)
The primary aim of this research was to produce successfully taste masked formulations of Sildenafil Citrate (SC) using hot-melt extrusion (HME) technology. Multiple screw configurations and polymeric carriers were evaluated for their effects on taste masking efficiency, which was assessed
Yi Deng et al.
Analytica chimica acta, 868, 45-52 (2015-03-31)
Rapid and ultrasensitive detection of trace heavy metal mercury(II) ions (Hg(2+)) are of significant importance due to the induced serious risks for environment and human health. This presented article reports the gold nanoparticle-based dual labeling colorimetric method (Dual-COLO) for ultrasensitive
Günther Gratzl et al.
Colloids and surfaces. B, Biointerfaces, 126, 98-105 (2014-12-30)
The availability of polymeric antimicrobially active surfaces, which are mainly based on cationic surface effects, is limited. We have previously reported the discovery that, in addition to cationic surfaces, anionic surfaces based on poly(acrylic acid) (PAA) copolymers have a bactericidal
Niina Tani et al.
Bioorganic & medicinal chemistry, 22(23), 6655-6664 (2014-12-03)
Inhibition of CYP2A6-mediated nicotine metabolism can reduce cigarette smoking. We sought potent and selective CYP2A6 inhibitors to be used as leads for drugs useful in smoking reduction therapy, by evaluating CYP2A6 inhibitory effect of novel formyl, alkyl amine or carbonitrile
Marina Makrecka et al.
Molecular and cellular biochemistry, 395(1-2), 1-10 (2014-06-01)
In the heart, a nutritional state (fed or fasted) is characterized by a unique energy metabolism pattern determined by the availability of substrates. Increased availability of acylcarnitines has been associated with decreased glucose utilization; however, the effects of long-chain acylcarnitines
Johanna Troberg et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 107-118 (2014-10-11)
Understanding drug glucuronidation in the dog, a preclinical animal, is important but currently poorly characterized at the level of individual enzymes. We have constructed cDNAs for the 10 dog UDP-glucuronosyltransferases of subfamily 1A (dUGT1As), expressed them in insect cells, and
Heleen Kraan et al.
Vaccine, 33(17), 2030-2037 (2015-03-17)
In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV
Therese Ericsson et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(7), 615-626 (2014-01-10)
1. Cytochrome P450 enzyme system is the most important contributor to oxidative metabolism of drugs. Modification, and more specifically inhibition, of this system is an important determinant of several drug-drug interactions (DDIs). 2. Effects of the antimalarial agent artemisinin and
J E Brooks
Methods in enzymology, 152, 113-129 (1987-01-01)
It is clear that we have still not exhausted all the restriction endonuclease specificities to be found in nature. Recently discovered BsmI is the first endonuclease recognizing a nonpalindromic sequence that cleaves within the site. Certainly other endonucleases belonging to
Yi-Ling Hsieh et al.
Pharmaceutical research, 32(2), 549-561 (2014-08-26)
The aim of this study was to investigate how factors such as temperature, relative humidity and particle size impact the extent of disproportionation (salt to free base conversion) in powder blends of miconazole, benzocaine or sertraline mesylate salts mixed with
Mehmet Gumustas et al.
Biomedical chromatography : BMC, 28(10), 1409-1417 (2014-05-28)
Fulvestrant is used for the treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. Several reversed-phase columns with variable silica materials, diameters, lengths, etc., were tested for the optimization study. A good chromatographic
Fu-Chen Kung et al.
Materials science & engineering. C, Materials for biological applications, 45, 578-588 (2014-12-11)
Electrospun fiber sheets with various orientations (random, partially aligned, and aligned) and smooth and roughened casted membranes were prepared. Hydroxyapatite (HA) crystals were in situ formed on these material surfaces via immersion in 10× simulated body fluid solution. The size
Liang Yang et al.
International journal of pharmaceutics, 471(1-2), 258-263 (2014-05-20)
Telmisartan (TEL) belongs to BCS class II (low solubility/high permeability) and exhibits the pH-dependent drug release. Since 3-aminopropyl functionalized magnesium phyllosilicate (aminoclay) can intercalate or adsorb the negatively charged molecules via the electrostatic interaction, TEL-aminoclay complex was synthesized to improve
Iyekhoetin Matthew Omoruyi et al.
International journal of environmental research and public health, 11(8), 8347-8367 (2014-08-26)
Food and drinking water are poorly delineated sources of human exposure to chemical food mutagens and endocrine-disrupting chemicals. In this study, we investigated the presence of mutagens and chemicals exhibiting estrogenic activity in the daily diet of Nigerians, using in
Monica Mazzarino et al.
Analytica chimica acta, 837, 70-82 (2014-07-09)
This article describes a liquid chromatographic/tandem mass spectrometric method, based on the use of precursor ion scan as the acquisition mode, specifically developed to detect indole-derived cannabinoids (phenylacetylindoles, naphthoylindoles and benzoylindoles) in biological fluids (saliva, urine and blood). The method
Diana Zhang et al.
Nucleic acids research, 42(21), 13422-13429 (2014-11-13)
We have determined the 1.50 Å crystal structure of the DNA decamer, d(CCA(CNV)KGCGTGG) ((CNV)K, 3-cyanovinylcarbazole), which forms a G-quadruplex structure in the presence of Ba(2+). The structure contains several unique features including a bulged nucleotide and the first crystal structure
Yashpal S Chhonker et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 127-132 (2014-07-13)
Nonoxynol-9 (N-9), a microbicidal spermicide, has been in use as an over-the-counter contraceptive since the 1960s. A detailed account of its pharmacokinetic profile using highly sensitive detection method has not been reported yet. We developed and validated a rapid, selective
Hardik Chandasana et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 180-188 (2015-02-16)
Apocynin is a major active constituent of Picrorhiza kurroa that exhibits potent anti-inflammatory activity by inhibiting superoxide-generating NADPH oxidase enzyme. To elucidate detailed pharmacokinetic profile of apocynin, high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed in
Ikuo Yamamiya et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1485-1492 (2014-07-09)
Tegafur (FT), a prodrug of 5-fluorouracil, is a chiral molecule, a racemate of R- and S-isomers, and CYP2A6 plays an important role in the enantioselective metabolism of FT in human liver microsomes (R-FT > S-FT). This study examined the enantioselective
Heleen Kraan et al.
Pharmaceutical research, 31(10), 2618-2629 (2014-04-25)
The aim of current study was to develop a dried inactivated polio vaccine (IPV) formulation with minimal loss during the drying process and improved stability when compared with the conventional liquid IPV. Extensive excipient screening was combined with the use
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