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Mingyue Shen et al.
Journal of food science, 80(6), T1432-T1437 (2015-04-29)
Furan, a possible carcinogen, is commonly produced by thermal processing in a number of heated foods. The existence of furan levels in foods has attracted considerable attention worldwide. Recent research of furan in food has focused on the possible influences
Eun-Yeong Jeon et al.
Applied microbiology and biotechnology, 99(15), 6267-6275 (2015-02-01)
Enzyme fusion was investigated as a strategy to improve productivity of a two-step whole-cell biocatalysis. The biotransformation of long-chain sec-alcohols into esters by an alcohol dehydrogenase (ADH) and Baeyer-Villiger monooxygenases (BVMOs) was used as the model reaction. The recombinant Escherichia
M Hilal Sehitoglu et al.
Journal of enzyme inhibition and medicinal chemistry, 30(2), 264-269 (2014-06-19)
In the present study, in order to evaluate antioxidant and radical scavenging properties of Pistachio gum (P-Gum), different bioanalytical methods such as DPPH(•) scavenging activity, DMPD(•+) radical scavenging activity, total antioxidant activity determination by ferric thiocyanate, reducing ability Fe(3+)-Fe(2+) transformation
Dong Chang et al.
Journal of the American College of Nutrition, 33(5), 406-411 (2014-08-01)
To evaluate and compare the levels of free fatty acids between senile cataract patients and normal controls. Fifty consecutive patients with newly diagnosed senile cataract and 50 age- and gender-matched controls were evaluated. Subjects/patients were randomized according to selection criteria.
Yaping Zhang et al.
Clinica chimica acta; international journal of clinical chemistry, 437, 31-37 (2014-07-13)
Changes in the levels of lipids are associated with breast cancer (BC). Disease-specific serum free fatty acids (FFAs) were quantified using chip-based direct-infusion nanoelectrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry (CBDInanoESI-FTICR MS) in the negative ion mode. Multiple point
Yunbao Liu et al.
Journal of natural products, 73(7), 1193-1195 (2010-06-23)
Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH is the basis of established in vitro cell viability assays. An antioxidant assay
Jihye Baek et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(4), 572-583 (2015-02-03)
Meniscus injury and degeneration have been linked to the development of secondary osteoarthritis (OA). Therapies that successfully repair or replace the meniscus are, therefore, likely to prevent or delay OA progression. We investigated the novel approach of building layers of
S Toomey et al.
Biochemical Society transactions, 31(Pt 5), 1075-1079 (2003-09-25)
Conjugated linoleic acid (CLA) refers to a group of positional and geometric isomers of linoleic acid that has been shown to suppress the development of atherosclerosis in a rabbit model. We investigated whether CLA acts as a cyclo-oxygenase (COX) inhibitor
G Imokawa et al.
The Journal of clinical investigation, 94(1), 89-96 (1994-07-01)
Pseudo-acylceramides with different acyl properties were investigated for their capacity to restore diminished barrier function in essential fatty acid-deficient rats. Daily topical applications of synthetic pseudo-acylceramides containing ester-linked linoleic acid caused a dose-dependent, significant reduction of transepidermal water loss (TEWL).
Yurong Liu et al.
Tissue engineering. Part A, 20(21-22), 3050-3062 (2014-05-03)
A therapy for regenerating large cartilaginous lesions within the articular surface of osteoarthritic joints remains elusive. While tissue engineering strategies such as matrix-assisted autologous chondrocyte implantation can be used in the repair of focal cartilage defects, extending such approaches to
Kathrine B Christensen et al.
Journal of natural products, 72(5), 933-937 (2009-04-21)
Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPARgamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was
Kevin L Fritsche
Missouri medicine, 111(1), 41-43 (2014-03-22)
Should we listen to warnings that linoleic acid (LA) promotes inflammation and that Americans would be healthier if they restricted their intake of LA (i.e., vegetable oils)? A recently published systematic review of 15 clinical trials failed to find any
William S Harris
Prostaglandins, leukotrienes, and essential fatty acids, 79(3-5), 169-171 (2008-10-28)
The extent to which higher intakes of linoleic acid (LA) affect risk for coronary heart disease (CHD) is examined by reviewing a wide variety of study types, mostly in humans. In experimental studies, LA has been shown to lower serum
Wan Mohd Nuzul Hakimi Salleh et al.
Natural product communications, 10(11), 2005-2008 (2016-01-12)
The chemical composition of the essential oil and antioxidant and anti-inflammatory activities of the extracts from Piper miniatum were determined. GC and GC-MS analysis of the essential oil resulted in the identification of 64 components, accounting for 89.2% of the
Christina N Robitaille et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 126-135 (2014-10-18)
Several pesticides suspected or known to have endocrine disrupting effects were screened for pro- or antiandrogenic properties by determining their effects on proliferation, prostatic-specific antigen (PSA) secretion and androgen receptor (AR) expression, and AR phosphorylation in androgen-dependent LNCaP human prostate
S Grimsgaard et al.
Hypertension (Dallas, Tex. : 1979), 34(3), 478-483 (1999-09-18)
The role of individual fatty acids in blood pressure regulation is unclear. We studied the cross-sectional relationship of blood pressure, total plasma phospholipid fatty acid concentrations, and proportions of individual fatty acids among participants in a population study. Blood pressure
Youichirou Nishida et al.
Pharmaceutical biology, 52(10), 1351-1357 (2014-07-16)
Scilla scilloides Druce (Liliaceae) is a folk medicine to treat dermal inflammation; however, the medicinal properties of this plant have not been completely established. The current study investigates the potent anti-inflammatory effects of S. scilloides bulbs for its traditional usage
Sandip B Bharate et al.
Bioorganic & medicinal chemistry letters, 18(24), 6357-6361 (2008-11-11)
In this letter, we report discovery of diacylphloroglucinol compounds as a new class of GPR40 (FFAR1) agonists. Several diacylphloroglucinols with varying length of acyl functionality and substitution on aromatic hydroxyls were synthesized and evaluated for GPR40 agonism using functional calcium-flux
Xian-Guo Zou et al.
Journal of agricultural and food chemistry, 62(43), 10594-10603 (2014-10-10)
In the present study, a human milk fat substitute (HMFS) enriched in medium-chain fatty acids (MCFAs) was synthesized through acidolysis reaction from Cinnamomum camphora seed oil (CCSO) with oleic acid in a solvent-free system. A commercial immobilized lipase, Lipozyme RM
Stephen D Anton et al.
Journal of integrative medicine, 11(1), 2-10 (2013-03-08)
According to the classic "diet-heart" hypothesis, high dietary intake of saturated fats and cholesterol combined with low intake of polyunsaturated fats can increase levels of serum cholesterol and lead to the development of atherogenic plaques and ultimately cardiovascular diseases. Recently
J P Casazza et al.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1, 607-609 (1987-01-01)
Plasma 1,2-propanediol, D,L,-2,3-butanediol and 2,3-meso-butanediol were measured in 29 patients with biopsy proven alcoholic cirrhosis and 10 control subjects, none of whom had measurable blood alcohol levels. None of these compounds were present in control subjects at level above 5
P Monica Lind et al.
Environment international, 55, 1-8 (2013-03-05)
Environmental contaminants have previously been linked to components of the Metabolic Syndrome (MetS). However, exposure to environmental contaminants is in part determined by various lifestyle factors. Using an "Environmental Wide Association Study" (ELWAS) integrating environmental contaminants and lifestyle factors, we
D F Horrobin
The American journal of clinical nutrition, 71(1 Suppl), 367S-372S (2000-01-05)
Research from the 1930s to the 1950s established that a deficit of n-6 essential fatty acids (EFAs) leads to an inflammatory skin condition in both animals and humans. In a common inherited skin condition, atopic dermatitis (eczema), there was evidence
Maik Dahlhoff et al.
FEBS letters, 589(12), 1376-1382 (2015-04-19)
The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile
Marie-Louise R W Hansen et al.
Microbiology (Reading, England), 161(10), 1990-1998 (2015-07-23)
Probiotics are bacteria used in the food industry due to their potential health benefits. In this study, the plasma membrane of the probiotic Lactobacillus acidophilus La-5 was investigated using state-of-the-art high-resolution shotgun lipidomics. Comparisons of the lipidome of the plasma
Yuan Xiao et al.
Life sciences, 112(1-2), 33-40 (2014-07-25)
The present study was to investigate the effect of hydrogen peroxide (H2O2) on bone marrow stem cells and their endothelial differentiation and the underlying mechanisms in vitro. Rat bone marrow multipotent adult progenitor cells (MAPCs) were used as the source
Ankita Misra et al.
BMC research notes, 8, 324-324 (2015-08-01)
Roscoea purpurea (Zingiberaceae) is commonly known as "kakoli". Traditionally, various parts like leaves, roots and flower etc. are used for the treatment of diabetic, hypertension, diarrhea, fever, inflammation etc. In Nepal tubers are boiled for edible purpose and also used
Chen-Yuan Chung et al.
Annals of biomedical engineering, 43(12), 2991-3003 (2015-06-17)
Tissue-engineered (TE) cartilage constructs tend to develop inhomogeneously, thus, to predict the mechanical performance of the tissue, conventional biomechanical testing, which yields average material properties, is of limited value. Rather, techniques for evaluating regional and depth-dependent properties of TE cartilage
C Löser et al.
Pancreas, 5(2), 119-127 (1990-03-01)
We investigated the total, free, and acetylated polyamine concentrations in pancreatic tissue, serum, and urine of 20 patients with pancreatic cancer, 30 healthy volunteers, and 40 patients with nonmalignant, gastrointestinal diseases by reversed-phase liquid chromatography. Tissue concentrations in carcinoma compared
Aaron T Wecksler et al.
Bioorganic & medicinal chemistry, 17(18), 6534-6539 (2009-09-01)
Recently, it has been shown that lipoxygenase (LO) products affect the substrate specificity of human 15-LO. In the current paper, we demonstrate that soybean LO-1 (sLO-1) is not affected by its own products, however, inhibitors which bind the allosteric site
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