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P S Anjaneyulu et al.
International journal of peptide and protein research, 30(1), 117-124 (1987-07-01)
N-Hydroxysulfosuccinimide esters are reactive functional groups employed in a variety of protein modification reagents, especially cross-linking reagents. For these compounds, hydrolysis is the most important reaction competing for reaction of the esters with nucleophilic groups in proteins. We have employed
Galina Nifontova et al.
Frontiers in chemistry, 7, 34-34 (2019-02-15)
Imaging agents and drug carriers are commonly targeted toward cancer cell through functionalization with specific recognition molecules. Quantum dots (QDs) are fluorescent semiconductor nanocrystals whose extraordinary brightness and photostability make them attractive for direct fluorescent labeling of biomolecules or optical
Kai Cheng et al.
ACS nano, 8(10), 9884-9896 (2014-10-07)
Development of multifunctional nanoparticle-based probes for dual T1- and T2-weighted magnetic resonance imaging (MRI) could allow us to image and diagnose the tumors or other abnormalities in an exceptionally accurate and reliable manner. In this study, by fusing distinct nanocrystals
Xiaokang Li et al.
Lab on a chip, 17(13), 2208-2217 (2017-06-07)
Cell secretion dynamics plays a central role in physiological and disease processes. Due to its various temporal profiles, it is essential to implement a precise detection scheme for continuous monitoring of secretion in real time. The current fluorescent and colorimetric
Trinh Thi Thuy Tien et al.
International journal of molecular sciences, 19(10) (2018-10-04)
Human respiratory syncytial virus (RSV) is one of the most common viruses infecting the respiratory tracts of infants. The rapid and sensitive detection of RSV is important to minimize the incidence of infection. In this study, novel monoclonal antibodies (mAbs;
María A Ortega et al.
Lab on a chip, 19(15), 2568-2580 (2019-06-28)
Despite the increasing number of organs-on-a-chip that have been developed in the past decade, limited efforts have been made to integrate a sensing system for in situ continual measurements of biomarkers from three-dimensional (3D) tissues. Here, we present a custom-made
Jiadi Sun et al.
Biosensors & bioelectronics, 70, 239-245 (2015-04-02)
A novel DNA sensor for the detection of the Escherichia coli O157:H7 (E. coli O157:H7) eaeA gene was constructed using surface enhanced fluorescence (SEF). The spacing distance dependence nature of Au@Ag nanorods surface enhanced fluorescence was investigated when the cy3-labled
Md Zakir Hossain et al.
Biosensors & bioelectronics, 101, 245-252 (2017-11-03)
A rapid, sensitive and multiplexed imaging surface plasmon resonance (iSPR) biosensor assay was developed and validated for three Fusarium toxins, deoxynivalenol (DON), zearalenone (ZEA) and T-2 toxin. The iSPR assay was based on a competitive inhibition format with secondary antibodies
Zahra Jamali et al.
Photodiagnosis and photodynamic therapy, 23, 190-201 (2018-07-04)
In this study, antibody-conjugated biodegradable polymeric nanoparticles were developed to enhance the photodaynamic efficiency of curcumin (CUR) on glioblastoma tumor cells. Poly (D, l-lactic-co-glycolic acid) nanoparticles (PLGA NPs) were synthesized and stabilized by polyvinyl alcohol (PVA). Poly(ethylene-alt-maleic anhydride) (PEMA) was
Shengnan Zhan et al.
Journal of agricultural and food chemistry, 67(32), 9104-9111 (2019-07-25)
Gold nanoflowers (GNFs) exhibit stronger light scattering ability than gold nanospheres (GNSs) with the same diameter, thereby contributing to enhancing the sensitivity of the scattering-based sensing method. However, the application of GNFs in biosensors based on dynamic light scattering (DLS)
Enrique Valera et al.
Lab on a chip, 18(10), 1461-1470 (2018-04-18)
Sepsis, an adverse auto-immune response to an infection often causing life-threatening complications, results in the highest mortality and treatment cost of any illness in US hospitals. Several immune biomarker levels, including Interleukin 6 (IL-6), have shown a high correlation to
Menachem Motiei et al.
ACS nano, 10(3), 3469-3477 (2016-02-18)
One of the main limitations of the highly used cancer imaging technique, PET-CT, is its inability to distinguish between cancerous lesions and post treatment inflammatory conditions. The reason for this lack of specificity is that [(18)F]FDG-PET is based on increased
Zhen Lu Yang et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(5), 1700847-1700847 (2018-06-08)
Oxygen (O2) plays a critical role during photodynamic therapy (PDT), however, hypoxia is quite common in most solid tumors, which limits the PDT efficacy and promotes the tumor aggression. Here, a safe and multifunctional oxygen-evolving nanoplatform is costructured to overcome
Ronald Carnemolla et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(2), 761-770 (2016-11-12)
Endothelial thrombomodulin (TM) regulates coagulation and inflammation via several mechanisms, including production of activated protein C (APC). Recombinant APC and soluble fragments of TM (sTM) have been tested in settings associated with insufficiency of the endogenous TM/APC pathway, such as
Laura Rodriguez-Lorenzo et al.
Colloids and surfaces. B, Biointerfaces, 171, 579-589 (2018-08-12)
The lack of understanding of fundamental nano-bio interactions, and difficulties in designing particles stable in complex biological environments are major limitations to their translation into biomedical clinical applications. Here we present a multi-parametric approach to fully characterize targeted nanoparticles, and
Gustavo Frindt et al.
The Journal of physiology, 596(16), 3585-3602 (2018-05-09)
Dietary Na restriction, through the mineralocorticoid aldosterone, acts on epithelial Na channels via both fast (24 h) and slow (5-7 days) mechanisms in the kidney. The fast effect entails increased proteolytic processing and trafficking of channel protein to the apical membrane. It
Yu Mi et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(19), 1900809-1900809 (2019-10-09)
Peritoneal adhesion occurs in a majority of patients following abdominal surgery and can result in significant side effects and complications. Current strategies to minimize adhesions involve the use of nontargeted anatomical barriers that are either inefficient in protecting injured areas
Jing Jing et al.
Biomacromolecules, 16(3), 715-722 (2015-01-30)
In this work, cell-responsive polysaccharide hydrogels were prepared by a simple procedure based on the sequential bioconjugation and cross-linking of the polysaccharide backbone with bioactive peptides and poly(ethylene glycol)-bis(thiol) (PEG-(SH)2), respectively. Using thiol-ene reactions, we successfully functionalized hyaluronic acid (HA)
Hyundoo Hwang et al.
Analytica chimica acta, 1061, 92-100 (2019-03-31)
We propose a new immunoassay technique, called magnetic-force assisted electrochemical sandwich immunoassay (MESIA), where serum biomarkers can be determined by magnetic actuation and electrochemical detection of gold-coated iron oxide nanoparticles as probes for immunocomplex formation. In MESIA, neither washing buffer
Patrick Kelly et al.
International journal of environmental research and public health, 12(10), 12543-12555 (2015-10-17)
The potency, selectivity, and decreased side effects of bioactive peptides have propelled these agents to the forefront of pharmacological research. Peptides are especially promising for the treatment of neurological disorders and pain. However, delivery of peptide therapeutics often requires invasive
Chuda Chittasupho et al.
Current drug delivery, 14(8), 1060-1070 (2017-02-22)
CXCR4 possesses a critical role in several intracellular events such as chemotaxis, invasion and adhesion, which are associated with metastasis of cancer cell. In this study, CXCR4 targeted polymeric nanoparticle was developed for delivering cytotoxic drug and blocking the chemokine
Yin-Chih Fu et al.
Acta biomaterialia, 10(11), 4583-4596 (2014-07-23)
Nanoparticles (NP) that target bone tissue were developed using PLGA-PEG (poly(lactic-co-glycolic acid)-polyethylene glycol) diblock copolymers and bone-targeting moieties based on aspartic acid, (Asp)(n(1,3)). These NP are expected to enable the transport of hydrophobic drugs. The molecular structures were examined by
Kaixian Liu et al.
Molecular cell, 74(2), 310-319 (2019-03-11)
Multi-domain proteins, containing several structural units within a single polypeptide, constitute a large fraction of all proteomes. Co-translational folding is assumed to simplify the conformational search problem for large proteins, but the events leading to correctly folded, functional structures remain
Danni Hao et al.
Biosensors & bioelectronics, 100, 23-27 (2017-08-30)
We report on the design and fabrication of a hybrid sensor that integrates transmission-mode localized surface plasmonic resonance (LSPR) into a quartz crystal microbalance (QCM) for studying biochemical surface reactions. The coupling of LSPR nanostructures and a QCM allows optical
A New Theranostic System Based on Endoglin Aptamer Conjugated Fluorescent Silica Nanoparticles.
Juntao Tan et al.
Theranostics, 7(19), 4862-4876 (2017-12-01)
Madelane Teran et al.
Analytical biochemistry, 564-565, 21-31 (2018-10-08)
Angiogenesis is a highly regulated process orchestrated, in large part, by the vascular endothelial growth factor-A (VEGF-A) system of ligands and receptors. Considerable effort has been invested in finding optimal ways to modulate VEGF-A activity to treat disease, however, the
Rhea J Longley et al.
Malaria journal, 16(1), 178-178 (2017-04-30)
Thailand is aiming to eliminate malaria by the year 2024. Plasmodium vivax has now become the dominant species causing malaria within the country, and a high proportion of infections are asymptomatic. A better understanding of antibody dynamics to P. vivax
Shahid Hussain et al.
Scientific reports, 8(1), 15785-15785 (2018-10-27)
Spontaneously occurring canine mammary tumours (CMTs) are the most common neoplasms of female unspayed dogs and are of potential importance as models for human breast cancer as well. Mortality rates are thrice higher in dogs as compared to humans with
Kuldeep Rajpoot et al.
Artificial cells, nanomedicine, and biotechnology, 46(6), 1236-1247 (2017-08-30)
Colorectal cancer (CRC) ranked second in females and third in males among all type of cancers diagnosed. About 1.4 million cases took place with 693,900 deaths in 2012. It can occur either in colon or rectum. Thus, we aimed to
E Breard et al.
Transboundary and emerging diseases, 64(6), 1837-1847 (2016-09-27)
Bluetongue viruses (BTV) are arboviruses responsible for infections in ruminants. The confirmation of BTV infections is based on rapid serological tests such as enzyme-linked immunosorbent assays (ELISAs) using the BTV viral protein 7 (VP7) as antigen. The determination of the
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