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Amie J Moyes et al.
The Journal of clinical investigation, 124(9), 4039-4051 (2014-08-12)
The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing factors that regulate local blood flow, systemic blood pressure, and the reactivity of leukocytes and platelets. Accordingly, endothelial dysfunction underpins many cardiovascular diseases, including hypertension, myocardial infarction, and
Karina Lopes Dornelas et al.
Analytica chimica acta, 858, 82-90 (2015-01-20)
This paper presents a simple and low-cost method for patterning poly(dimethylsiloxane) (PDMS) barriers in porous support such as paper for the construction of flexible microfluidic paper-based analytical devices (μPADs). The fabrication method consisted of contact-printing a solution of PDMS and
Nabanita Chatterjee et al.
Journal of leukocyte biology, 96(2), 325-336 (2014-04-04)
The use of live, attenuated, or genetically modified microbes or their cellular component(s) or metabolites has begun to emerge as a potential new approach in medicinal research to deliver biologically active entities. Thus, advancing our knowledge of such microbe-mediated therapy
Yiye Li et al.
ACS nano, 8(11), 11529-11542 (2014-11-07)
Near-infrared plasmonic nanoparticles demonstrate great potential in disease theranostic applications. Herein a nanoplatform, composed of mesoporous silica-coated gold nanorods (AuNRs), is tailor-designed to optimize the photodynamic therapy (PDT) for tumor based on the plasmonic effect. The surface plasmon resonance of
S R Kim et al.
Cell death & disease, 5, e1498-e1498 (2014-10-31)
Abnormality in mitochondria has been suggested to be associated with development of allergic airway disorders. In this study, to evaluate the relationship between mitochondrial reactive oxygen species (ROS) and NLRP3 inflammasome activation in allergic asthma, we used a newly developed
Ayse Nur Aksoy et al.
Indian journal of pharmacology, 46(6), 622-626 (2014-12-30)
To explore the protective effect of progesterone on inflammation and oxidative stress in a rat model of sepsis created by cecal ligation and puncture (CLP). Rats were randomly divided into 4 groups: Overiectomy group (OVX), sham operated (control), sepsis (CLP)
Kamil Wojciechowski et al.
Biochimica et biophysica acta, 1838(7), 1931-1940 (2014-04-22)
The interactions between a model phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and a biosurfactant Quillaja Bark Saponin (QBS) obtained from the bark of Quillaja saponaria Molina were studied using simple models of biological membranes. QBS is known to interact strongly with the latter
Trinidad Montero-Melendez et al.
The American journal of pathology, 184(8), 2333-2341 (2014-07-01)
Because there is clinical evidence for an association between periodontal disease and rheumatoid arthritis, it is important to develop suitable experimental models to explore pathogenic mechanisms and therapeutic opportunities. The K/BxN serum model of inflammatory arthritis was applied using distinct
Lei Wu et al.
Biosensors & bioelectronics, 62, 13-18 (2014-06-29)
As thiocyanate (SCN(-)) acts as an important biomarker in human health assessment, there remains an urgent need to realize rapid and reproducible analysis of SCN(-) in body fluids. Here, a droplet microfluidic device has been designed and fabricated for SCN(-)
Mateus Fortes Rossato et al.
Inflammation, 38(2), 606-615 (2014-08-15)
Vitamin E (vit-E) is a lipophilic antioxidant, and its anti-inflammatory activity is still not full characterized. Thus, our goal was to investigate the anti-inflammatory effect of repeated vit-E treatment in the arthritis induced by the intraplantar injection of complete Freund's
Paul J Ackerman et al.
Nature communications, 6, 6012-6012 (2015-01-22)
Some of the most exotic condensed matter phases, such as twist grain boundary and blue phases in liquid crystals and Abrikosov phases in superconductors, contain arrays of topological defects in their ground state. Comprised of a triangular lattice of double-twist
Xiao Xiao et al.
Food chemistry, 167, 438-446 (2014-08-26)
With the prevalence of inflammatory bowel disease (IBD) and its associated risk for development of colorectal cancer, it is of great importance to prevent and treat IBD. However, due to the complexity of etiology and potentially serious adverse effects, treatment
Verónica Ramírez-Alcántara et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(11), G1002-G1010 (2014-04-20)
Pharmacotherapy based on 5-aminosalicylic acid (5-ASA) is a preferred treatment for ulcerative colitis, but variable patient response to this therapy is observed. Inflammation can affect therapeutic outcomes by regulating the expression and activity of drug-metabolizing enzymes; its effect on 5-ASA
Zengyan Wei et al.
Nature communications, 5, 3870-3870 (2014-05-16)
The shape-controlled synthesis of nanoparticles was established in single-phase solutions by controlling growth directions of crystalline facets on seed nanocrystals kinetically; however, it was difficult to rationally predict and design nanoparticle shapes. Here we introduce a methodology to fabricate nanoparticles
Yujie Zhang et al.
Dalton transactions (Cambridge, England : 2003), 42(15), 5485-5490 (2013-02-22)
A simple, rapid colorimetric detection method for Pb(2+) in aqueous solution has been developed by using sodium thiosulfate (Na2S2O3) and hexadecyl trimethyl ammonium bromide (CTAB) modified gold nanoparticles (Au NPs). Na2S2O3 was added into the Au NP solution and thiosulfate
Attila Gaspar et al.
Electrophoresis, 34(8), 1249-1252 (2013-02-13)
This paper demonstrates the use of surface plasmon resonance to study adsorption (either reversible or irreversible) of detergents on PDMS surfaces in real time. The surface plasmon resonance measurements can directly provide information about the adsorption/desorption processes of detergents on
Cristian C Villa et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(14), 3097-3109 (2014-07-22)
The behavior of water entrapped in reverse micelles (RMs) formed by two catanionic ionic liquid-like surfactants, benzyl-n-hexadecyldimethylammonium 1,4-bis-2-ethylhexylsulfosuccinate (AOT-BHD) and cetyltrimethylammonium 1,4-bis-2-ethylhexylsulfosuccinate (AOT-CTA), was investigated by using dynamic (DLS) and static (SLS) light scattering, FTIR, and (1)H NMR spectroscopy techniques.
Esther Navarro-Escobar et al.
Journal of applied oral science : revista FOB, 21(1), 74-79 (2013-04-06)
To assess the influence of final irrigation protocols with chlorhexidine in the coronal leakage of Enterococcus faecalis in filled root canals. Seventy single-root canals from extracted teeth were prepared using ProTaper instruments. The irrigation protocol accomplished an alternating irrigation with
Ali Modir-Rousta et al.
Electrophoresis, 36(7-8), 1016-1023 (2015-02-03)
We recently introduced a pressure-assisted sweeping-reversed migration-EKC (RM-EKC) method for preconcentration of neutral polar N-nitrosamines with low affinity for the micellar phase. The type of surfactant and phase ratio are dominant factors in dictating the magnitude of interactions between analyte
Carmen E DeMarco et al.
Antimicrobial agents and chemotherapy, 51(9), 3235-3239 (2007-06-20)
Efflux is an important resistance mechanism in Staphylococcus aureus, but its frequency in patients with bacteremia is unknown. Nonreplicate bloodstream isolates were collected over an 8-month period, and MICs of four common efflux pump substrates, with and without the broad-spectrum
Wanzhen Li et al.
The Analyst, 139(16), 3926-3931 (2014-06-21)
A thin film consisting of highly ordered and vertically oriented silica mesochannels (SMCs) was prepared on the indium tin oxide (ITO) coated glass electrode surface by chronopotentiometry. The mesochannel has a uniform pore size of 2-3 nm in diameter and
Yin-Ming Li et al.
Environmental technology, 35(17-20), 2556-2568 (2014-08-26)
This study was carried out to develop a cost-effective and practicable sorbent for application in abrupt perfluorooctane sulphonate (PFOS) pollution accidents. The main merit of this work was that a waste material, namely construction and demolition (C&D) waste, was employed
Limei Tian et al.
Biosensors & bioelectronics, 59, 208-215 (2014-04-15)
Printable multi-marker biochips that enable simultaneous quantitative detection of multiple target biomarkers in point-of-care and resource-limited settings are a holy grail in the field of biodiagnostics. However, preserving the functionality of biomolecules, which are routinely employed as recognition elements, during
Xiaojun Zhou et al.
Dalton transactions (Cambridge, England : 2003), 43(31), 11834-11842 (2014-06-25)
This paper presents a facile method for the fabrication of uniform hollow mesoporous silica nanoparticles (HMSNs) with tunable shell thickness and pore size. In this method, a series of amphiphilic block copolymers of polystyrene-b-poly (acrylic acid) (PS-b-PAA) with different hydrophobic
Sandra L Orellana et al.
Journal of pharmaceutical sciences, 104(3), 1141-1152 (2015-01-06)
The association efficiency of oxytetracycline (OTC) to pharmaceutical available, ionic oil-in-water nanoemulsions is studied. Theoretical mathematical developments allowed us to differentiate by diafiltration (DF) between thermodynamically and kinetically controlled binding of the drug to the nanoemulsions, and relate these important
Abdulrazaq Bidemi Nafiu et al.
Pharmaceutical biology, 53(5), 662-671 (2014-11-29)
Carica papaya L. (Caricaceae) fruit was shown to exhibit wound healing properties. We investigated anti-inflammatory and antioxidant potential of papaya fruit phosphate-buffered saline extract (PE) during wound healing and enhancement of the potentials due to trace ions addition. Rat excision
Yongqian Xu et al.
Chemical communications (Cambridge, England), 49(70), 7732-7734 (2013-07-24)
A simple self-assembly platform based on squaraine-embedded CTAB micelles can readily discriminate between Cys and Hcy with different absorption and fluorescence signals. The recognition mechanism is attributed to the fact that analyte adducts trigger the CTAB micelles to undergo sphere-to-rod
Annemie Deiteren et al.
Gut, 63(12), 1873-1882 (2014-02-25)
Substantial evidence implicates mast cells and their main constituent histamine in the pathogenesis of visceral hypersensitivity. We explored the specific contribution of histamine H4 (H4R) and H1 (H1R) receptors to visceral hypersensitivity in a postinflammatory rat model. Trinitrobenzenesulfonic acid (TNBS)-colitis
Leandra Naira Z Ramalho et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 74, 270-278 (2014-12-03)
Rosmarinic acid (RosmA) demonstrates antioxidant and anti-inflammatory properties. We investigated the effect of RosmA on liver ischemia/reperfusion injury. Rats were submitted to 60 min of ischemia plus saline or RosmA treatment (150 mg/kg BW intraperitoneally) followed by 6 h of reperfusion. Hepatocellular injury
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this
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