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Muhammad H Zaman et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(29), 10889-10894 (2006-07-13)
Cell migration on 2D surfaces is governed by a balance between counteracting tractile and adhesion forces. Although biochemical factors such as adhesion receptor and ligand concentration and binding, signaling through cell adhesion complexes, and cytoskeletal structure assembly/disassembly have been studied
John Midkiff et al.
PloS one, 6(9), e25395-e25395 (2011-10-04)
The ability of the pathogenic yeast Candida albicans to interconvert between budded and hyphal growth states, herein termed the budded-to-hyphal transition (BHT), is important for C. albicans development and virulence. The BHT is under the control of multiple cell signaling
Monica A Serban et al.
Acta biomaterialia, 4(1), 67-75 (2007-11-06)
In vitro cell culture is a vital research tool for cell biology, pharmacology, toxicology, protein production, systems biology and drug discovery. Traditional culturing methods on plastic surfaces do not accurately represent the in vivo environment, and a paradigm shift from
Hongmei Jiang et al.
Molecular biology of the cell, 16(11), 5070-5076 (2005-08-19)
Fibroblast-3D collagen matrix culture provides a physiologically relevant model to study cell-matrix interactions. In tissues, fibroblasts are phagocytic cells, and in culture, they have been shown to ingest both fibronectin and collagen-coated latex particles. Compared with cells on collagen-coated coverslips
Hynda K Kleinman et al.
Seminars in cancer biology, 15(5), 378-386 (2005-06-25)
The basement membrane extracellular matrix contacts epithelial, endothelial, fat and smooth muscle cells. Because this extracellular matrix is so thin, it had been hard to study its composition, structure, and function. An extract of a tumor was found to contain
Karen A Beningo et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(52), 18024-18029 (2004-12-17)
Fibroblasts in 2D cultures differ dramatically in behavior from those in the 3D environment of a multicellular organism. However, the basis of this disparity is unknown. A key difference is the spatial arrangement of anchored extracellular matrix (ECM) receptors to
Alba Iglesias et al.
European journal of pharmacology, 800, 63-69 (2017-02-22)
Different ligands differentially activate phospholipase A2 (PLA2) and phospholipase C (PLC) signalling pathways that are coupled to the serotonin 2A (5-HT2A) receptor, a class-A G-protein coupled receptor (GPCR). The serotonin 5-HT2A receptor has been shown to be expressed as a
Salome Boroda et al.
Biochemical pharmacology, 123, 29-39 (2016-12-16)
Diacylglycerol kinase alpha (DGKα) catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). Recently, DGKα was identified as a therapeutic target in various cancers, as well as in immunotherapy. Application of small-molecule DGK inhibitors, R59022 and R59949, induces cancer
Bing-Chang Chen et al.
The Journal of biological chemistry, 279(20), 20889-20897 (2004-03-10)
In this study, we investigated the signaling pathway involved in cyclooxygenase-2 (COX-2) expression caused by peptidoglycan (PGN), a cell wall component of the Gram-positive bacterium Staphylococcus aureus, in RAW 264.7 macrophages. PGN caused dose- and time-dependent increases in COX-2 expression
Christian Ledig et al.
Scientific reports, 8(1), 11258-11258 (2018-07-28)
Magnetic resonance (MR) imaging is a powerful technique for non-invasive in-vivo imaging of the human brain. We employed a recently validated method for robust cross-sectional and longitudinal segmentation of MR brain images from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
L Minchiotti et al.
European journal of biochemistry, 228(1), 155-159 (1995-02-15)
A slow migrating variant of human serum albumin, present in lower amount than the normal protein, has been detected by routine clinical electrophoresis at pH 8.6 in two members of a family living in Asola (Lombardia, Italy). Ion-exchange chromatography of
Marzena Grden et al.
Journal of cellular physiology, 215(1), 151-160 (2007-10-18)
Recently it was demonstrated that the elevated concentration of glucose but not lack of insulin is responsible for suppression of equilibrative nucleoside transporter (ENT1) in diabetic rat cardiac fibroblasts (CFs). The present study was undertaken to determine the signaling pathway
Xu Yue et al.
European journal of pharmacology, 584(2-3), 272-277 (2008-03-11)
Recent studies suggest that sustained morphine-mediated paradoxical pain may play an important role in the development of analgesic tolerance. The intracellular signal transduction pathways involved in sustained opioid mediated augmentation of spinal pain neurotransmitter (such as calcitonin gene-related peptide (CGRP))
A K Batta et al.
Cancer research, 58(8), 1684-1687 (1998-05-01)
We recently showed that feeding the cytoprotective bile acid ursodeoxycholic acid (UDCA) to rats resulted in significant reduction in polyps and especially cancers, both in number and size (D. L. Earnest et al., Cancer Res., 54: 5071-5074, 1994). Because fecal
Xiaorong Zhu et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(16), 10293-10298 (2002-07-30)
The subtilisin-like proprotein convertases PC1/3 (SPC3) and PC2 (SPC2) are believed to be the major endoproteolytic processing enzymes of the regulated secretory pathway. They are expressed together or separately in neuroendocrine cells throughout the brain and dispersed endocrine system in
Hong Luo et al.
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 25(8), 342-346 (2011-07-19)
To investigate the changes of leukotriene D4 (LTD4) in nasal discharge and plasma of patients with persistent allergic rhinitis (AR) and the effects of antihistamine. The investigation was a prospective, randomized controlled trial. Forty AR patients (group C) were divided
Robert S Haworth et al.
The Biochemical journal, 399(3), 493-501 (2006-07-13)
In cardiac myocytes, sustained (3 min) intracellular acidosis activates the ERK1/2 (extracellular-signal-regulated kinase 1/2) pathway and, through this pathway, increases sarcolemmal NHE (Na+/H+ exchanger) activity [Haworth, McCann, Snabaitis, Roberts and Avkiran (2003) J. Biol. Chem. 278, 31676-31684]. In the present
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