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Noriaki Kitada et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(4), 479-482 (2013-07-16)
The current status of treatment with sorafenib, and factors affecting the duration of treatment in patients started on sorafenib for hepatocellular carcinoma from July 2009 until April 2011 in the Department of Gastroenterology at Kobe City Medical Center General Hospital
E V Zinov'ev et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(4), 39-44 (2013-06-15)
Survival rate, average life expectancy of victims, parameters of the acid - base balance, gas composition of blood, and morphological structure of internal organs have been studied in acute experiments on a group of 120 rats with burn injury of
T Pan et al.
Clinical radiology, 69(12), e553-e561 (2014-10-12)
To evaluate the safety and efficacy of combined therapy with transarterial chemoembolization (TACE) and sorafenib for hepatocellular carcinoma (HCC) with portal venous tumour thrombus (PVTT). This study was approved by the institutional review board. From May 2009 to May 2012
Weirong Wang et al.
Experimental cell research, 319(10), 1523-1533 (2013-04-23)
The ligand-activated transcription factor peroxisome proliferator-activated receptor-α (PPARα) participates in the regulation of cellular inflammation. More recent studies indicated that sirtuin1 (SIRT1), a NAD(+)-dependent deacetylase, regulates the inflammatory response in adipocytes. However, whether the role of PPARα in inflammation is
K Schulpis et al.
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 17(5), 443-448 (2004-09-11)
Low folate and vitamin B(12) concentrations during pregnancy are implicated with neural tube defects (NTD) and neurological manifestations in the neonates. To compare serum concentrations of folate and vitamin B(12) in 1025 Greek mothers, 908 immigrant Albanian mothers at delivery
Elisabeth Smolle et al.
Anticancer research, 34(4), 1519-1530 (2014-04-03)
Ovarian cancer (OC) is ranked as the eighth most common gynecological malignancy and is the leading cause of gynecological cancer-related deaths in women worldwide. The response to platinum- and taxane-based chemotherapy is very often poor, and targeted-therapeutics are currently being
Evaluation of analytical tools and multivariate methods for quantification of co-former crystals in ibuprofen-nicotinamide co-crystals
Soares FLF and Carneiro RL
Journal of Pharmaceutical and Biomedical Analysis, 89, 166-175 (2014)
Hisateru Komatsu et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(12), 1672-1674 (2014-01-08)
Case 1 involved a 63-year-old woman who had multiple hepatocellular carcinomas (HCC) associated with hepatitis C virus infection. She was treated with hepatic arterial infusion chemotherapy (HAIC) and transcatheter arterial chemoembolization (TACE), followed by oral administration of sorafenib (200 mg/day).
Makoto Shioya et al.
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 111(7), 1424-1432 (2014-07-08)
Erythema multiforme (EM) is a known side effect of sorafenib therapy in cancer patients; at onset, the causative medication should be permanently discontinued. Here we report two cases of hepatocellular carcinoma (HCC) that developed sorafenib-induced EM. In both cases, retreatment
Faqi Li et al.
Current medicinal chemistry, 13(8), 883-895 (2006-04-14)
Nicotinamide, the amide form of niacin (vitamin B(3)), is the precursor for the coenzyme beta-nicotinamide adenine dinucleotide (NAD(+)) and plays a significant role during the enhancement of cell survival as well as cell longevity. Yet, these abilities of nicotinamide appear
Roberto Iacovelli et al.
Cancer treatment reviews, 40(2), 271-275 (2013-09-28)
Antiangiogenic agents (AAs) have reported grater efficacy compared to interferon. Despite these advances, radiological complete response to therapy is rare. We meta-analyzed the incidence of complete response in patients treated with AAs and in controls in main randomized clinical trials
Liyuan Yang et al.
Zhonghua fu chan ke za zhi, 37(11), 660-662 (2002-12-19)
To investigate the expression of nicotinamide edenine dinucleotide (NADH) dehydrogenase gene in the placenta of patients with pregnancy induced hypertension (PIH) and the role of NADH dehydrogenase in PIH pathogenesis. Using (32)P dATP labeled human NADH dehydrogenase cDNA probe, the
Zoe Diana Draelos et al.
Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 8(2), 96-101 (2006-06-13)
The presence of sebum on the face is responsible for both facial shine and the formation of comedonal and inflammatory acne lesions. Sebum control is a goal of many OTC skin care products; however, most currently available products function by
M Moehler et al.
European journal of cancer (Oxford, England : 1990), 50(18), 3125-3135 (2014-12-03)
Since sorafenib has shown activity in different tumour types and gemcitabine regimens improved the outcome for biliary tract cancer (BTC) patients, we evaluated first-line gemcitabine plus sorafenib in a double-blind phase II study. 102 unresectable or metastatic BTC patients with
Yu-Yun Shao et al.
Oncology, 85(5), 312-316 (2013-11-13)
A germline BIM deletion polymorphism has been proposed to predict a poor treatment efficacy of certain kinase inhibitors. The current study aimed to explore whether the BIM deletion polymorphism predicts the treatment efficacy of sorafenib for advanced hepatocellular carcinoma (HCC).
Cheuk Him Man et al.
Blood, 123(16), 2530-2539 (2014-03-13)
Internal tandem duplication (ITD) of fms-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia (AML) is associated with inferior clinical prognosis. Sorafenib is effective in clearing leukemic blasts in chemorefractory FLT3-ITD(+) AML, but leukemia progression invariably occurs. Mechanisms of drug
N Baeza et al.
Diabetes & metabolism, 22(4), 229-234 (1996-07-01)
Beta-cell regeneration in adult pancreas is usually considered to be limited. However, various animal models suggest that this tissue is still capable of regeneration under certain conditions. Reg protein could be responsible for this replicative process. The reg gene codes
Kenneth Maiese et al.
Molecules (Basel, Switzerland), 14(9), 3446-3485 (2009-09-29)
Nicotinamide, the amide form of vitamin B(3) (niacin), is changed to its mononucleotide compound with the enzyme nicotinic acide/nicotinamide adenylyltransferase, and participates in the cellular energy metabolism that directly impacts normal physiology. However, nicotinamide also influences oxidative stress and modulates
Neil M Niren
Cutis, 77(1 Suppl), 11-16 (2006-07-29)
Various skin disorders with an inflammatory component often have been treated with steroids and/or oral antibiotics. However, long-term use of these agents has drawbacks: steroids may induce numerous serious side effects such as hypertension, immunosuppression, and osteoporosis, and overuse of
Jan Peveling-Oberhag et al.
Clinical science (London, England : 1979), 128(1), 29-37 (2014-06-25)
Sorafenib is the standard treatment for patients with advanced hepatocellular carcinoma (HCC). However, the median overall survival (OS) benefit is only ~3 months, and sufficient biomarkers predicting treatment response are not available. The aim of the present study was to
Ivana Cristina Fernandez et al.
Journal of pediatric endocrinology & metabolism : JPEM, 26(3-4), 347-355 (2013-06-07)
Abstract Objectives: The aim was to evaluate the treatment with acetyl-L-carnitine (50 mg/kg/day) and nicotinamide (25 mg/kg/day) in children at risk of type 1 diabetes. This treatment was effective and harmless in experimental type 1 diabetes in mice. Nine out
M M Kirstein et al.
Acta gastro-enterologica Belgica, 77(4), 386-388 (2015-02-17)
The multi-kinase inhibitor sorafenib still remains the only approved agent for advanced HCC. Its benefits typically involve disease stabilisation, whereas an induction of response is rare. We report a series of five cases with extraordinary response to sorafenib. For two
Chiara Paglino et al.
Anticancer research, 33(11), 4999-5004 (2013-11-14)
the ideal sequence of targeted agents for advanced kidney cancer is still unknown. In the present study we assessed the clinical benefit of two different sequential approaches, namely sorafenib, an inhibitor of mammalian target of rapamycin (mTORi) and sunitinib, or
Sina Bartfeld et al.
Gastroenterology, 148(1), 126-136 (2014-10-14)
We previously established long-term, 3-dimensional culture of organoids from mouse tissues (intestine, stomach, pancreas, and liver) and human intestine and pancreas. Here we describe conditions required for long-term 3-dimensional culture of human gastric stem cells. The technology can be applied
Sun Young Shin et al.
International journal of clinical pharmacology and therapeutics, 51(11), 837-846 (2013-10-01)
The purpose of this study was to identify the correlation of skin toxicity and hypertension with clinical benefit in advanced hepatocellular carcinoma (HCC) patients treated with sorafenib by analyzing medical records retrospectively. Data from medical records was statistically analyzed to
Kengo Nomura et al.
Journal of the American Society of Nephrology : JASN, 25(4), 761-772 (2013-11-23)
Marked hypophosphatemia is common after major hepatic resection, but the pathophysiologic mechanism remains unknown. We used a partial hepatectomy (PH) rat model to investigate the molecular basis of hypophosphatemia. PH rats exhibited hypophosphatemia and hyperphosphaturia. In renal and intestinal brush-border
Mellissa Hicks et al.
Biochemical and biophysical research communications, 450(1), 19-24 (2014-05-27)
Chemotherapy resistance is a major obstacle to achieving durable progression-free-survival in breast cancer patients. Identifying resistance mechanisms is crucial to the development of effective breast cancer therapies. Immediate early genes (IEGs) function in the initial cellular reprogramming response to alterations
[Niacin, niacinamide and blood sugar].
L Mainardi
Acta vitaminologica et enzymologica, 21(4), 139-159 (1967-01-01)
S Karovic et al.
Clinical pharmacology and therapeutics, 96(1), 27-35 (2014-03-19)
Hypertension after treatment with vascular endothelial growth factor (VEGF) receptor inhibitors is associated with superior treatment outcomes for advanced cancer patients. To determine whether increased sorafenib doses cause incremental increases in blood pressure (BP), we measured 12-h ambulatory BP in
Katrina L Bogan et al.
Annual review of nutrition, 28, 115-130 (2008-04-24)
Although baseline requirements for nicotinamide adenine dinucleotide (NAD+) synthesis can be met either with dietary tryptophan or with less than 20 mg of daily niacin, which consists of nicotinic acid and/or nicotinamide, there is growing evidence that substantially greater rates
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