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Hideyuki Takeshima et al.
Carcinogenesis, 36(2), 192-201 (2014-12-06)
Alterations of epigenetic modifications are promising targets for cancer therapy, and several epigenetic drugs are now being clinically utilized. At the same time, individual epigenetic modifications have physiological functions in normal cells, and cancer cell specificity is considered difficult to
Cristina Pavan et al.
Particle and fibre toxicology, 11, 76-76 (2014-12-20)
The hemolytic activity of inhaled particles such as silica has been widely investigated in the past and represents a usual toxicological endpoint to characterize particle reactivity despite the fact that red blood cells (RBCs) are not involved in the pathogenesis
Kevork Hagopian et al.
PloS one, 10(4), e0124204-e0124204 (2015-04-17)
Shc proteins interact with the insulin receptor, indicating a role in regulating glycolysis. To investigate this idea, the activities of key glycolytic regulatory enzymes and metabolites levels were measured in skeletal muscle from mice with low levels of Shc proteins
Nadège Minois et al.
PloS one, 9(7), e102435-e102435 (2014-07-11)
Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating
Zhi Zou et al.
BMC genomics, 16, 1001-1001 (2015-11-27)
Natural rubber, an important industrial raw material, is specifically synthesized in laticifers located inside the rubber tree (Hevea brasiliensis Muell. Arg.) trunk. Due to the absence of plasmodesmata, the laticifer water balance is mediated by aquaporins (AQPs). However, to date
Masaya Yasui et al.
Glia, 62(9), 1407-1417 (2014-05-24)
Patients with chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS) display multiple symptoms, such as chronic widespread pain, fatigue, sleep disturbance, and cognitive dysfunction. Abnormal pain sensation may be the most serious of these symptoms; however, its pathophysiology remains unknown.
Ariel Alperstein et al.
PloS one, 9(10), e110842-e110842 (2014-10-23)
The predatory bacterium Bdellovibrio bacteriovorus preys on other Gram-negative bacteria and was predicted to be an asparagine auxotroph. However, despite encoding asparaginyl-tRNA synthetase and glutaminyl-tRNA synthetase, B. bacteriovorus also contains the amidotransferase GatCAB. Deinococcus radiodurans, and Thermus thermophilus also encode
David Goodwin et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 19(6), 517-529 (2014-07-26)
Mild injury of the exocrine pancreas is often asymptomatic and can be under- or mis-diagnosed. The pancreas-enriched microRNAs miR-216a and miR-217 were evaluated as potential serum biomarkers of exocrine pancreas injury in rodent models of acute pancreatitis induced by caerulein
Agnieszka Konopacka et al.
eLife, 4 (2015-11-13)
In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3' poly(A) tail of the AVP mRNA, and the up-regulation of the expression
Amir Sherman et al.
BMC plant biology, 15, 277-277 (2015-11-18)
Germplasm collections are an important source for plant breeding, especially in fruit trees which have a long duration of juvenile period. Thus, efforts have been made to study the diversity of fruit tree collections. Even though mango is an economically
Farhadul Islam et al.
Phytotherapy research : PTR, 29(4), 573-581 (2015-01-15)
Anticancer activities of p-menth-1-ene-4,7-diol (EC-1) isolated from Eucalyptus camaldulensis Dhnh. were studied on Ehrlich ascites carcinoma (EAC) cells by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. Anticancer activities also analyzed in EAC-bearing mice by assessment of cancer growth inhibition, changes in
Éder Costa Oliveira et al.
Talanta, 127, 59-67 (2014-06-11)
Hollow fiber liquid phase microextraction (HFLPME) and solid phase microextraction (SPME) methods for pre-concentration of contaminants (toluene, benzophenone, tetracosane and chloroform) in food simulants were investigated. For HFLPME 1-heptanol, 2-octanone and dibutyl-ether were studied as extracting solvents. Analysis by gas
Stine A Danielsen et al.
Neuro-oncology, 17(1), 63-69 (2014-07-20)
Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A
Miyeoun Song et al.
Cell transplantation, 24(2), 183-190 (2014-01-02)
The long-term effect of magnetically targeted neural stem cells in a rat focal cerebral ischemia model was investigated. In middle cerebral artery occlusion (MCAO) stroke model rats, ferumoxide-labeled human neural stem cells (hNSCs) were injected into the tail vein. MCAO
Dong-Kuk Lee et al.
Biochemistry, 54(10), 1897-1907 (2015-02-26)
Multidrug resistance against the existing antibiotics is becoming a global threat, and any potential drug that can be designed using cationic antimicrobial peptides (AMP) could be an alternate solution to alleviate this existing problem. The mechanism of action of killing
Jessica P Otis et al.
Disease models & mechanisms, 8(3), 295-309 (2015-01-31)
Improved understanding of lipoproteins, particles that transport lipids throughout the circulation, is vital to developing new treatments for the dyslipidemias associated with metabolic syndrome. Apolipoproteins are a key component of lipoproteins. Apolipoproteins are proteins that structure lipoproteins and regulate lipid
Mina Mirzaian et al.
Journal of lipid research, 56(4), 936-943 (2015-01-30)
Sulfatides are found in brain as components of myelin, oligodendrocytes, and neurons but are also present in various visceral tissues. Metachromatic leukodystrophy (MLD) is an inherited lysosomal storage disorder caused by a deficiency of arylsulfatase A, leading to severe white
J Fawell
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 38(1 Suppl), S91-S95 (2000-03-16)
Chlorine, used as an important disinfectant for drinking water, can react with naturally occurring organic matter to form chloroform, bromodichloromethane, chlorodibromomethane and bromoform. Chloroform and other trihalomethanes have been shown to increase tumours of the liver, kidney or large intestine
Jianhui Zhu et al.
Journal of proteome research, 13(6), 2986-2997 (2014-05-09)
We have developed herein a quantitative mass spectrometry-based approach to analyze the etiology-related alterations in fucosylation degree of serum haptoglobin in patients with liver cirrhosis and hepatocellular carcinoma (HCC). The three most common etiologies, including infection with hepatitis B virus
Isamu Hoshino et al.
Anticancer research, 35(3), 1353-1359 (2015-03-10)
Although conventional staging laparoscopy (SL) has improved the diagnostic accuracy of peritoneal dissemination, novel technology is needed to increase the sensitivity of SL. We herein describe a new imaging method employing near-infrared (NIR) fluorescence imaging using a liposomal synthesized indocyanine
Coilín Boland et al.
Cellular and molecular life sciences : CMLS, 71(24), 4895-4910 (2014-07-12)
Membrane proteins are key elements in cell physiology and drug targeting, but getting a high-resolution structure by crystallographic means is still enormously challenging. Novel strategies are in big demand to facilitate the structure determination process that will ultimately hasten the
Hannah E Rockwell et al.
ASN neuro, 7(2) (2015-04-16)
Sandhoff disease (SD) is an autosomal recessive neurodegenerative disease caused by a mutation in the gene for the β-subunit of β-N-acetylhexosaminidase (Hex), resulting in the inability to catabolize ganglioside GM2 within the lysosomes. SD presents with an accumulation of GM2
Stefano Menini et al.
Diabetologia, 58(4), 845-853 (2014-12-05)
AGEs are involved in diabetic complications and might be responsible for the phenomenon of 'hyperglycaemic memory'. D-Carnosine-octylester (DCO) has been shown to attenuate AGE formation and vascular and renal injury induced by high-fat diet in Apoe-null mice. This study aimed
Adeolu B Adewoye et al.
Nature communications, 6, 6684-6684 (2015-03-27)
The ability to predict the genetic consequences of human exposure to ionizing radiation has been a long-standing goal of human genetics in the past 50 years. Here we present the results of an unbiased, comprehensive genome-wide survey of the range
Sung Nam Kang et al.
Biomaterials, 44, 1-10 (2015-01-27)
A drug-eluting stent (DES) is one of the commonly used treatment techniques in percutaneous coronary intervention (PCI). Sirolimus (SRL) has been widely used for DES as a drug for suppressing neointimal hyperplasia causing restenosis. Phytoncides (PTC) are compounds released from
Helena Aguilar et al.
Breast cancer research : BCR, 16(3), R53-R53 (2014-06-03)
Endocrine therapies targeting cell proliferation and survival mediated by estrogen receptor α (ERα) are among the most effective systemic treatments for ERα-positive breast cancer. However, most tumors initially responsive to these therapies acquire resistance through mechanisms that involve ERα transcriptional
Leigh J Ellmers et al.
Journal of cardiovascular pharmacology, 65(3), 269-275 (2015-02-07)
The impact of chronic urocortin 2 (Ucn2) treatment after myocardial infarction (MI) has not previously been investigated. In this study, we examined the effects of 30-day Ucn2 administration (415 μg·kg·d SC per day) in mice post-MI. Compared with surgical sham
Mosin S Khan et al.
Endocrine, 47(2), 449-455 (2014-06-15)
Promoter hypermethylation of multiple genes have been identified to play a role in thyroid cancers and most prominent among them is TSHR gene promoter hypermethylation in particular showing a close association with BRAF gene-altered status. Thus, the aim of this
Sigmund Brabrand et al.
Neoplasia (New York, N.Y.), 17(2), 167-174 (2015-03-10)
Intratubular germ cell neoplasia, the precursor of testicular germ cell tumors (TGCTs), is hypothesized to arise during embryogenesis from developmentally arrested primordial germ cells (PGCs) or gonocytes. In early embryonal life, the PGCs migrate from the yolk sac to the
Bilal Yilmaz et al.
Journal of chromatographic science, 53(7), 1037-1043 (2015-01-27)
A sensitive and efficient method was developed for determination of tramadol and its metabolite (O-desmethyltramadol) in human urine by gas chromatography-mass spectrometry. Tramadol, O-desmethyltramadol and medazepam (internal standard) were extracted from human urine with a mixture of ethylacetate and diethylether
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