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471348

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Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation.

Jared M Fine et al.

Neuroscience letters, 584, 362-367 (2014-12-03)

In addition to the hallmark accumulation of amyloid and hyper-phosphorylation of tau, brain changes in Alzheimer's disease are multifactorial including inflammation, oxidative stress, and metal dysregulation. Metal chelators have been explored as a less well known approach to treatment. One

Desferrioxamine as an appropriate chelator for 90Nb: comparison of its complexation properties for M-Df-Octreotide (M = Nb, Fe, Ga, Zr).

Valery Radchenko et al.

Nuclear medicine and biology, 41(9), 721-727 (2014-08-05)

The niobium-90 radioisotope ((90)Nb) holds considerable promise for use in immuno-PET, due to its decay parameters (t½ = 14.6h, positron yield=53%, Eß(+)(mean) = 0.35 MeV and Eß(+)(max) = 1.5 MeV). In particular, (90)Nb appears well suited to detect in vivo

Methane Sulphonic Acid is Green Catalyst in Organic Synthesis.

Kulkarni P.

Orient. J. Chem., 31(1), 447-451 (2015)

Cannabinoid CB1 receptors mediate the effects of dipyrone.

Fernanda Crunfli et al.

Clinical and experimental pharmacology & physiology, 42(3), 246-255 (2014-11-29)

Dipyrone is a non-steroidal anti-inflammatory drug used primarily as an analgesic and antipyretic. Some hypothesize that dipyrone activity can modulate other pathways, including endocannabinoid signalling. Thus, the aim of the present study was to evaluate the possible role of endocannabinoids

Real-Time detection and mixing state of methanesulfonate in single particles at an inland urban location during a phytoplankton bloom.

Cassandra J Gaston et al.

Environmental science & technology, 44(5), 1566-1572 (2010-02-04)

Dimethyl sulfide (DMS), produced by oceanic phytoplankton, is oxidized to form methanesulfonic acid (MSA) and sulfate, which influence particle chemistry and hygroscopicity. Unlike sulfate, MSA has no known anthropogenic source making it a useful tracer for ocean-derived biogenic sulfur. Despite

AG4, a compound isolated from Radix Ardisiae Gigantifoliae, induces apoptosis in human nasopharyngeal cancer CNE cells through intrinsic and extrinsic apoptosis pathways.

Xian-Zhe Dong et al.

Anti-cancer drugs, 26(3), 331-342 (2014-12-19)

3β-O-{α-L-Pyran rhamnose-(1→3)-[β-D-xylopyranose-(1→2)]-β-D-glucopyranose-(1→4)-[β-D-lucopyranose-(1→2)]-α-L-pyran arabinose}-cyclamiretin A (AG4) is a saponin component obtained from the Giantleaf Ardisia Rhizome (Rhizoma Ardisiae Gigantifoliae). The present study aimed to investigate the antitumor potential of AG4 and its possible mechanisms in human nasopharyngeal carcinoma cells (CNE). We

A highly stable, efficient visible-light driven water photoelectrolysis system using a nanocrystalline WO3 photoanode and a methane sulfonic acid electrolyte.

Renata Solarska et al.

Nanoscale, 4(5), 1553-1556 (2012-02-01)

Nanostructuring of semiconductor films offers the potential means for producing photoelectrodes with improved minority charge carrier collection. Crucial to the effective operation of the photoelectrode is also the choice of a suitable electrolyte. The behaviour of the nanostructured WO(3) photoanodes

In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs.

Tsung-Ming Shih et al.

Chemico-biological interactions, 187(1-3), 207-214 (2010-03-13)

This study compared the ability of nine oximes (HI-6, HLö7, MMB-4, TMB-4, carboxime, ICD585, ICD692, ICD3805, and 2-PAM) to reactivate in vivo cholinesterase (ChE) in blood, brain, and peripheral tissues in guinea pigs intoxicated by one of four organophosphorus nerve

Isolation and structure characterization of related impurities in 10-O-(N,N-dimethylaminoethyl)-ginkgolide B methanesulfonate (XQ-1H) bulk drug and quantitation by a validated RP-LC.

Wenyuan Liu et al.

Journal of pharmaceutical and biomedical analysis, 52(4), 603-608 (2010-02-09)

10-O-(N,N-dimethylaminoethyl)-ginkgolide B methanesulfonate (XQ-1H), a novel active derivative of ginkgolide B, is a platelet-activating factor antagonist which is being under clinical trial. Two unknown related impurities were observed in analysis of XQ-1H bulk drug. A scaling up preparative liquid chromatography

Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate.

Jae Hong Seo et al.

Drug design, development and therapy, 9, 3961-3968 (2015-08-08)

Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution

Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety.

Xuan Zhao et al.

Oncotarget, 6(8), 5582-5596 (2015-02-26)

Anti-apoptotic protein Mcl-1 plays an important role in protecting cell from death in acute myeloid leukemia (AML). The apoptosis blocking activity of Mcl-1 is inhibited by BH3-only protein Noxa. We found that dihydroartemisinin (DHA) and its derivative X-11 are potent

Hydroxamate production as a high affinity iron acquisition mechanism in Paracoccidioides spp.

Mirelle Garcia Silva-Bailão et al.

PloS one, 9(8), e105805-e105805 (2014-08-27)

Iron is a micronutrient required by almost all living organisms, including fungi. Although this metal is abundant, its bioavailability is low either in aerobic environments or within mammalian hosts. As a consequence, pathogenic microorganisms evolved high affinity iron acquisition mechanisms

Total polyphenol of Anemarrhena asphodeloides ameliorates advanced glycation end products-induced endothelial dysfunction by regulation of AMP-Kinase.

Qianwen Zhao et al.

Journal of diabetes, 6(4), 304-315 (2013-11-20)

Anemarrhena asphodeloides Bunge is widely used in China for the treatment of diabetes and the polyphenol components are responsible for its anti-diabetic action. This study aimed to investigate the effect of total polyphenol of Anemarrhena asphodeloides (TPAA) on endothelial dysfunction and

Environmental benefits of methanesulfonic acid. Comparative properties and advantages.

Gernon MD.

Green Chemistry, 1(3), 127-140 (1999)

Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells.

Junna Song et al.

Metabolism: clinical and experimental, 64(3), 428-437 (2014-12-17)

Endothelial dysfunction is tightly associated with cardiovascular complications in diabetic patients. This study aims to investigate the effects of mangiferin on the regulation of endothelial homeostasis under endoplasmic reticulum stress (ER stress) conditions. High glucose (25 mmol/L) exposure induced ER

Salt Stability - The Effect of pHmax on Salt to Free Base Conversion.

Yi-Ling Hsieh et al.

Pharmaceutical research, 32(9), 3110-3118 (2015-04-16)

The aim of this study was to investigate how the disproportionation process can be impacted by the properties of the salt, specifically pHmax. Five miconazole salts and four sertraline salts were selected for this study. The extent of conversion was

Statistically sound calibration curves for chromatographic methods involving negative response data.

L E Vanatta et al.

Journal of chromatographic science, 49(8), 610-611 (2011-08-24)

A statistical procedure is presented for calibrating chromatographic methods that generate negative chromatographic peaks. The technique is illustrated via data collected during the ion-chromatographic analysis of the ammonium ion in methansulfonic-acid solutions. A peak-integration protocol is explained and subsequent regression

Chemical structure-related mechanisms underlying in vivo genotoxicity induced by nitrofurantoin and its constituent moieties in gpt delta rats.

Aki Kijima et al.

Toxicology, 331, 125-135 (2015-03-17)

Nitrofurans are antimicrobial compounds containing a nitro group at the 5-position of the furan ring and an amine or hydrazide side chain derivative. One member of the nitrofurans, nitrofurantoin (NFT), is a renal carcinogen in male rats despite its still

Synergistic effect of reductive and ligand-promoted dissolution of goethite.

Zimeng Wang et al.

Environmental science & technology, 49(12), 7236-7244 (2015-05-13)

Ligand-promoted dissolution and reductive dissolution of iron (hydr)oxide minerals control the bioavailability of iron in many environmental systems and have been recognized as biological iron acquisition strategies. This study investigated the potential synergism between ligands (desferrioxamine B (DFOB) or N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic

Mechanism of the hydroxyl radical oxidation of methacryloyl peroxynitrate (MPAN) and its pathway toward secondary organic aerosol formation in the atmosphere.

Tran B Nguyen et al.

Physical chemistry chemical physics : PCCP, 17(27), 17914-17926 (2015-06-23)

Methacryloyl peroxynitrate (MPAN), the acyl peroxynitrate of methacrolein, has been suggested to be an important secondary organic aerosol (SOA) precursor from isoprene oxidation. Yet, the mechanism by which MPAN produces SOA through reaction with the hydroxyl radical (OH) is unclear.

Interfacial molecular organization at aqueous solution surfaces of atmospherically relevant dimethyl sulfoxide and methanesulfonic Acid using sum frequency spectroscopy and molecular dynamics simulation.

Xiangke Chen et al.

The journal of physical chemistry. B, 114(47), 15546-15553 (2010-11-11)

The molecular organization at the aqueous dimethyl sulfoxide (DMSO) and methanesulfonic acid (MSA) surfaces was investigated using vibrational sum frequency generation (VSFG) spectroscopy and molecular dynamics (MD) simulation. The molecular orientation of surface DMSO and MSA is deduced based on

Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.

Kimiko Ishiguro et al.

Biochemical pharmacology, 91(3), 312-322 (2014-08-19)

Triapine, currently being evaluated as an antitumor agent in phase II clinical trials, and its terminally dimethylated derivative Dp44mT share the α-pyridyl thiosemicarbazone backbone that functions as ligands for transition metal ions. Yet, Dp44mT is approximately 100-fold more potent than

Synthesis and chromatographic enantioresolution of anti-HIV quinolone derivatives.

Benedetto Natalini et al.

Talanta, 85(3), 1392-1397 (2011-08-03)

The successful enantioseparation of five 6-desfluoroquinolones with three polysaccharide-based stationary phases (namely, the cellulose-based Chiralpak IB and the two amylose-based Chiralpak AD-H and Lux Amylose-2) is herein described. The investigated species differ for the nature of substituents and/or the position

Synthesis of aryl ethers via a sulfonyl transfer reaction.

Neal W Sach et al.

Organic letters, 14(15), 3886-3889 (2012-07-18)

A general synthesis of aryl ethers from primary and secondary alcohols and aryl mesylates is presented. The reaction proceeds via a sulfonyl-transfer mechanism. In this paper, we compare the sulfonyl transfer reaction to Mitsunobu ether formation. The reaction can be

Suppression of peak tailing of phosphate prodrugs in reversed-phase liquid chromatography.

Jin Zhang et al.

Journal of pharmaceutical and biomedical analysis, 98, 247-252 (2014-06-20)

Peak tailing of phosphate prodrugs in acidic mobile phases was thoroughly investigated. The results indicated that both metal-phosphate interactions and silanophilic interactions contributed to the observed peak tailing. Column pretreatment with phosphate buffers was demonstrated to be an effective and

Indoline-3-propionate and 3-aminopropyl carbamates reduce lung injury and pro-inflammatory cytokines induced in mice by LPS.

E Finkin-Groner et al.

British journal of pharmacology, 172(4), 1101-1113 (2014-10-18)

In the search for safer and effective anti-inflammatory agents, we investigated the effect of methyl indoline-3-propionate and indoline-3-(3-aminopropyl) carbamates on LPS-induced lung injury and pro-inflammatory cytokines in mice. Their mechanism of action was determined in murine peritoneal macrophages. Lung injury

Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats.

José-Ángel García-Pedraza et al.

Clinical and experimental pharmacology & physiology, 42(6), 640-647 (2015-04-10)

5-HT is a powerful vasoconstrictor substance in renal vasculature (mainly by 5-HT₂ activation). Nevertheless, 5-HT is notable for its dual cardiovascular effects, producing both vasodilator and vasoconstrictor actions. This study aimed to investigate whether, behind the predominant serotonergic vasoconstrictor action

The gas-phase reaction of methane sulfonic acid with the hydroxyl radical without and with water vapor.

Solvejg Jørgensen et al.

Physical chemistry chemical physics : PCCP, 15(14), 5140-5150 (2013-03-02)

The gas phase reaction between methane sulfonic acid (CH3SO3H; MSA) and the hydroxyl radical (HO), without and with a water molecule, was investigated with DFT-B3LYP and CCSD(T)-F12 methods. For the bare reaction we have found two reaction mechanisms, involving proton

In vivo transcription kinetics of a synthetic gene uninvolved in stress-response pathways in stressed Escherichia coli cells.

Anantha-Barathi Muthukrishnan et al.

PloS one, 9(9), e109005-e109005 (2014-10-01)

The fast adaptation of Escherichia coli to stressful environments includes the regulation of gene expression rates, mainly of transcription, by specific and global stress-response mechanisms. To study the effects of mechanisms acting on a global level, we observed with single

Cyclo[6]pyridine[6]pyrrole: a dynamic, twisted macrocycle with no meso bridges.

Zhan Zhang et al.

Journal of the American Chemical Society, 136(21), 7591-7594 (2014-05-13)

A large porphyrin analogue, cyclo[6]pyridine[6]pyrrole, containing no meso bridging atoms, has been synthesized through Suzuki coupling. In its neutral form, this macrocycle exists as a mixture of two figure-eight conformers that undergo fast exchange in less polar solvents. Upon protonation

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