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Li-Hui An et al.
Marine pollution bulletin, 89(1-2), 59-66 (2014-12-03)
The transcriptomes of Zhikong scallop exposed to 17β-estradiol were determined using the Roche/454. A total of 51,997 unigenes, representing 45,030 contigs and 6967 singlets were obtained. And 14,028, 19,798 and 14,981 of these unigenes were annotated from the non-redundant nucleic
Yiming Zhang et al.
Journal of immunotoxicology, 12(1), 81-91 (2014-05-16)
Innate defenses against environmental particulate exposures can become deficient when physiological background of the organism is unbalanced. Even those exposures considered innocuous may then become harmful. For example, one of the important inherent risks of pregnancy is increased inflammatory responsiveness
Islam M Saadeldin et al.
Indian journal of experimental biology, 53(2), 75-81 (2015-03-12)
The bidirectional communication between oocytes and granulosa cells are mediated by several factors via a local feedback loop(s). The current model was carried out to study the spatial mutual interaction of porcine denuded oocytes and granulosa cells either in direct
Raifish E Mendoza-Villarroel et al.
Biology of reproduction, 91(1), 26-26 (2014-06-06)
Testosterone production is dependent on cholesterol transport within the mitochondrial matrix, an essential step mediated by a protein complex containing the steroidogenic acute regulatory (STAR) protein. In steroidogenic Leydig cells, Star expression is hormonally regulated and involves several transcription factors.
María Salomé Gachet et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 976-977, 6-18 (2014-12-02)
Free arachidonic acid is functionally interlinked with different lipid signaling networks including those involving prostanoid pathways, the endocannabinoid system, N-acylethanolamines, as well as steroids. A sensitive and specific LC-MS/MS method for the quantification of arachidonic acid, prostaglandin E2, thromboxane B2
Uterine fibroids.
Serdar E Bulun
The New England journal of medicine, 369(14), 1344-1355 (2013-10-04)
Pablo B Martínez de Morentin et al.
Endocrinology, 156(3), 947-960 (2014-12-24)
During gestation, hyperphagia is necessary to cope with the metabolic demands of embryonic development. There were three main aims of this study: Firstly, to investigate the effect of pregnancy on hypothalamic fatty acid metabolism, a key pathway for the regulation
Mette Petri Lauritsen et al.
Clinical endocrinology, 82(4), 584-591 (2014-09-30)
To evaluate revised criteria for polycystic ovarian morphology (PCOM) in the diagnosis of polycystic ovary syndrome (PCOS) in anovulatory infertility. Prospective cohort study. WHO Group II anovulatory infertile women (n = 75). Clinical, sonographic and endocrine parameters, including anti-Müllerian hormone (AMH). The
B Martinez de Tejada et al.
BJOG : an international journal of obstetrics and gynaecology, 122(1), 80-91 (2014-09-12)
To evaluate the effectiveness of 200 mg of daily vaginal natural progesterone to prevent preterm birth in women with preterm labour. Multicentre, randomised, double-blind, placebo-controlled trial. Twenty-nine centres in Switzerland and Argentina. A total of 385 women with preterm labour
Mariana S Parahuleva et al.
Thrombosis research, 135(2), 260-266 (2014-12-30)
Atherosclerosis, as an inflammatory disease, is characterized by pathologically altered levels of cytokines. We investigated whether smoking and/or oral contraceptives (OCs) affect the CD40/CD40L plasma levels and expression in young females without other risk factors for atherosclerosis. A case-control single-center
Charalampos Siristatidis et al.
Journal of assisted reproduction and genetics, 32(4), 563-570 (2015-01-27)
To compare the outcomes of embryos selected via time lapse monitoring (TLM) versus those selected with conventional methods of selection in subfertile women undergoing ICSI. The study population (239 women) was classified into two groups, based on the monitoring method
Leo Doherty et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(9), 1067-1092 (2014-05-14)
Uterine fibroids (leiomyomata) are extremely common lesions that are associated with detrimental effects including infertility and abnormal uterine bleeding. Fibroids cause molecular changes at the level of endometrium. Abnormal regulation of growth factors and cytokines in fibroid cells may contribute
Bo Zhang et al.
The Journal of steroid biochemistry and molecular biology, 141, 135-143 (2014-01-18)
Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3) has an essential role in the inactivation of 5α-dihydrotestosterone (DHT). Notably, human 3α-HSD3 shares 97.8% sequence identity with human 20-alpha hydroxysteroid dehydrogenase (20α-HSD) and there is only one amino acid difference (residue 54)
Waël Zeinyeh et al.
European journal of medicinal chemistry, 45(6), 2480-2488 (2010-03-09)
The syntheses of new N-polysubstituted imidazo[4,5-b]pyridine-7-one (IP, 5 and 8a-8f) and indazole-4,7-dione (ID, 9 and 10) derivatives are described. The binding affinity of IP and ID towards the recombinant Nucleotide Binding Domain NBD1 of Cryptosporidium parvum CpABC3 was evaluated by
Jessica D K Kresowik et al.
Biology of reproduction, 91(1), 17-17 (2014-05-24)
The window of implantation of human embryos into the endometrium spans Cycle Days 20-24 of the 28-day menstrual cycle. However, uterine receptivity may not be reliably replicated in infertile patients throughout this span. Thus, it is of importance to be
Baljit Singh et al.
Breast cancer research : BCR, 16(6), 463-463 (2014-11-12)
Estrogen inhibition is effective in preventing breast cancer in only up to 50% of women with precancerous lesions and many experience side effects that are poorly tolerated. As insulin-like growth factor I (IGF-I) underlies both estrogen and progesterone actions and
Cathrin Brisken
Nature reviews. Cancer, 13(6), 385-396 (2013-05-25)
Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase
D-z Yuan et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(11), 761-767 (2014-07-10)
Under normal conditions, progesterone inhi-bits the estrogen-induced proliferation of endometrial epithelium. Our previous studies have shown that cyclin G1 was progesterone-dependent in mouse endometrial epithelium at peri-implantation, and exogenous cyclin G1 suppressed the proliferation of endometrial cancer cells. The objectives
Sirwan M Hadad et al.
Breast cancer research and treatment, 150(1), 149-155 (2015-02-16)
Metformin has therapeutic potential against breast cancer, but the mechanisms of action in vivo remain uncertain. This study examined biomarker effects of metformin in primary breast cancer in a preoperative window of opportunity trial. Non-diabetic women with operable invasive breast
Noriaki Hashimoto et al.
BMC cancer, 14, 722-722 (2014-09-28)
Cancer stem cells (CSCs) are thought to play important roles in therapy-resistance. In this study, we induced cancer stem-like cells from hepatocellular carcinoma (HCC) cell lines using a unique medium, and examined their potential for resistance to anti-cancer drugs. The
A W Jones et al.
Forensic science international, 37(4), 277-285 (1988-06-01)
Headspace gas chromatography was used to determine the concentration of ethanol and methanol in blood samples from 519 individuals suspected of drinking and driving in Sweden where the legal alcohol limit is 0.50 mg/g in whole blood (11 mmol/l). The
Clayton J Underwood et al.
American journal of physiology. Heart and circulatory physiology, 307(2), H152-H164 (2014-05-13)
The details of the mechanical factors that modulate angiogenesis remain poorly understood. Previous in vitro studies of angiogenesis using microvessel fragments cultured within collagen constructs demonstrated that neovessel alignment can be induced via mechanical constraint of the boundaries (i.e., boundary
Untangling BRCA mutations, sex hormones, and cancer risk.
Martha Hickey
The Lancet. Oncology, 14(12), 1151-1152 (2013-10-22)
Rodolfo C Cardoso et al.
The Journal of endocrinology, 223(3), 289-298 (2014-10-19)
Feeding a high-concentrate diet to heifers during the juvenile period, resulting in increased body weight (BW) gain and adiposity, leads to early-onset puberty. In this study, we tested the hypothesis that the increase in GnRH/LH release during nutritional acceleration of
Artem Cherkasov et al.
Journal of medicinal chemistry, 51(7), 2047-2056 (2008-03-12)
A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data set by adding a number of nonsteroidal SHBG ligands identified
Shinichi Nakagawa et al.
Development (Cambridge, England), 141(23), 4618-4627 (2014-11-02)
Neat1 is a non-protein-coding RNA that serves as an architectural component of the nuclear bodies known as paraspeckles. Although cell-based studies indicate that Neat1 is a crucial regulator of gene expression, its physiological relevance remains unclear. Here, we find that
Vivian Chi Yan Lee et al.
Fertility and sterility, 101(5), 1288-1293 (2014-03-08)
To assess the incidence of P elevation (PE) in natural cycles and evaluate its effect on frozen-thawed embryo transfer cycles performed in natural cycles (FET-NC). Retrospective analysis. A tertiary assisted reproductive unit. Subfertile woman who did not conceive in their
M E Reichman et al.
Journal of the National Cancer Institute, 85(9), 722-727 (1993-05-05)
Most epidemiologic studies of the relationship between alcohol consumption and breast cancer risk over the past decade have shown that persons who consume a moderate amount of alcohol are at 40%-100% greater risk of breast cancer than those who do
Hsiao-Li Wu et al.
Fertility and sterility, 103(4), 1098-1106 (2015-02-17)
To determine whether berberine (BBR), a naturally occurring plant-derived alkaloid, inhibits the proliferation of human uterine leiomyoma (UtLM) cells. Laboratory research. Laboratory. UtLM and normal human uterine smooth muscle (UtSMC) cell lines. Treatment with [1] BBR (10, 20, and 50
Christian Laggner et al.
Journal of medicinal chemistry, 48(15), 4754-4764 (2005-07-22)
ERG2, emopamil binding protein (EBP), and sigma-1 receptor (sigma(1)) are enzymes of sterol metabolism and an enzyme-related protein, respectively, that share high affinity for various structurally diverse compounds. To discover novel high-affinity ligands, pharmacophore models were built with Catalyst based
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