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Wenhao Dai et al.
Small (Weinheim an der Bergstrasse, Germany), 11(33), 4158-4164 (2015-06-03)
Molybdenum disulfide (MoS2 ) quantum dots (QDs) (size <10 nm) possess attractive new properties due to the quantum confinement and edge effects as graphene QDs. However, the synthesis and application of MoS2 QDs has not been investigated in great detail.
Laura A Merriam et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(10), 4614-4622 (2013-03-08)
After G-protein-coupled receptor activation and signaling at the plasma membrane, the receptor complex is often rapidly internalized via endocytic vesicles for trafficking into various intracellular compartments and pathways. The formation of signaling endosomes is recognized as a mechanism that produces
Fan Hu et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(12), 1051-1058 (2012-08-15)
Danshen (Salviae Miltiorrhizae Radix) and Gegen (Puerariae Lobatae Radix) have been widely used in treating cardiovascular diseases for thousands of years in China. The present study was carried out to evaluate the effects of a Danshen and Gegen decoction (DG)
Caroline Zanotto et al.
Brain research, 1491, 14-22 (2012-11-13)
Aquaporin-4 (AQP-4) is the principal brain water channel and is predominantly expressed in astrocytes suggesting its dynamic involvement in water homeostasis in brain tissue. Due to the co-localization of AQP-4 and inward rectifier K(+) channels Kir 4.1, a functional coupling
Gisela Di Giusto et al.
Journal of cellular biochemistry, 113(12), 3721-3729 (2012-07-13)
We have previously demonstrated that in renal cortical collecting duct cells (RCCD(1)) the expression of the water channel Aquaporin 2 (AQP2) raises the rate of cell proliferation. In this study, we investigated the mechanisms involved in this process, focusing on
Group 17 (H, F, Cl, Br, I) Alkaline Earth Compounds
Encyclopedia of the Alkaline Earth Compounds, 25-104 (2013)
Nathalie M Goodfellow et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(17), 5804-5809 (2012-04-28)
The 5-HT(5A) receptor is the least understood serotonin (5-HT) receptor. Here, we electrophysiologically identify and characterize a native 5-HT(5A) receptor current in acute ex vivo brain slices of adult rodent prefrontal cortex. In the presence of antagonists for the previously
Hanna Heikkinen et al.
Investigative ophthalmology & visual science, 53(9), 5653-5664 (2012-06-30)
To examine the amplification and kinetics of murine rod photoresponses by recording ERG flash responses in vivo and ex vivo from the same retina. We also aimed to evaluate the two available methods for isolating the rod signal from the
Alice E McGovern et al.
British journal of pharmacology, 171(15), 3633-3650 (2014-04-26)
Subtypes of the hyperpolarization-activated cyclic nucleotide-gated (HCN) family of cation channels are widely expressed on nerves and smooth muscle cells in many organ systems, where they serve to regulate membrane excitability. Here we have assessed whether HCN channel inhibitors alter
Pimluck Kijjanapanich et al.
Environmental technology, 35(13-16), 1989-1996 (2014-06-25)
Construction and demolition debris (CDD) is a product of construction, renovation or demolition activities. It has a high gypsum content (52.4% of total gypsum), concentrated in the CDD sand (CDDS) fraction. To comply with the posed limit of the maximum
Patcharin Tep-Areenan et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 95 Suppl 12, S63-S68 (2013-03-22)
To investigate the effects of gamma-mangostin on vascular tone and its mechanisms in the isolated rat aorta. Aortic rings from male Wistar rats were precontracted with methoxamine. Changes in tension were measured using an isometric force transducer and recorded on
Anne R Crecelius et al.
The Journal of physiology, 590(21), 5349-5359 (2012-07-11)
Circulating ATP possesses unique vasomotor properties in humans and has been hypothesized to play a role in vascular control under a variety of physiological conditions. However, the primary downstream signalling mechanisms underlying ATP-mediated vasodilatation remain unclear. The purpose of the
Sanjay Sarkhel et al.
International journal of pharmaceutics, 477(1-2), 469-475 (2014-12-03)
In vitro estimation of release kinetics from drug delivery systems is needed in formulation development. Cost-effective methods of assessment for delivery systems are needed particularly in the case of biologicals and drug administration routes that are difficult to screen in
Rajani M George et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(46), 18549-18554 (2013-10-31)
The adaptor protein Numb has been implicated in the switch between cell proliferation and differentiation made by satellite cells during muscle repair. Using two genetic approaches to ablate Numb, we determined that, in its absence, muscle regeneration in response to
Virginia Bay et al.
Glia, 60(4), 651-660 (2012-02-01)
Uptake of K(+) released by axons during action potential propagation is a major function of astrocytes. Here, we demonstrate the importance of glial inward rectifying potassium channels (Kir) in regulating extracellular K(+) ([K(+)](o)) and axonal electrical activity in CNS white
Javiera F Rubilar et al.
Carbohydrate polymers, 123, 27-38 (2015-04-07)
The objective of this research was to study the effect of the film microstructure of oil-in-water emulsions stabilized by hydroxypropyl methyl cellulose/whey protein isolate (HPMC/WPI) with or without sodium dodecyl sulfate (SDS) over physical properties of HPMC/WPI emulsion-based films. The
Hyung Seok Ahn et al.
Pharmacology, 87(5-6), 331-340 (2011-06-08)
In the present study, we examined the uterine relaxant activity of 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid (TBIC), a putative opener of the large conductance Ca(2+)-activated K(+) (BK(Ca)) channel. TBIC concentration-dependently inhibited spontaneous uterine contractions (EC(50) = 4.63 μmol/l; E(max) = 94.85 ± 1.85%;
Puneet Mahajan et al.
Journal of cardiovascular pharmacology, 60(1), 23-32 (2012-03-24)
The effect of high salt diet on β-adrenoceptor-mediated response was assessed in rat-isolated pulmonary arteries. Isoprenaline-induced relaxations were not different in tissues from rats on either, high salt or regular diets. However, acidic buffer (pH 6.4) alone and in combination
Haiyan Lu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(10), 3344-3355 (2011-06-24)
CC chemokine ligand 2 (CCL2), a ligand of CC chemokine receptor 2 (CCR2), is essential to mount an adequate inflammatory response to repair acute skeletal muscle injury. We studied the mechanisms by which CCL2 regulates muscle inflammation and regeneration. Mobilization
Kechun Yang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(48), 15888-15897 (2014-11-28)
Although evidence suggests that DA modulates hippocampal function, the mechanisms underlying that dopaminergic modulation are largely unknown. Using perforated-patch electrophysiological techniques to maintain the intracellular milieu, we investigated how the activation of D1-type DA receptors regulates spike timing-dependent plasticity (STDP)
Sarah E Pierce et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 15(42), 11244-11255 (2009-09-12)
Isoguanine (2-oxo-6-amino-guanine), a natural but non-standard base, exhibits unique self-association properties compared to its isomer, guanine, and results in formation of different higher order DNA structures. In this work, the higher order structures formed by oligonucleotides containing guanine repeats or
Ying Lv et al.
American journal of physiology. Lung cellular and molecular physiology, 305(11), L856-L865 (2013-10-01)
Chronic hypoxia pulmonary hypertension (CH-PHT) in adulthood is likely to be of fetal origin following intrauterine growth retardation (IUGR). Oxygen (O₂)-sensitive voltage-gated potassium channels (Kv channels) in resistance pulmonary artery smooth muscle cells (PASMCs) play an important role in scaling
Jun-Yih Chen et al.
The Kaohsiung journal of medical sciences, 27(12), 538-543 (2012-01-03)
This study investigated whether KMUP-1, a xanthine-based derivative, inhibits L-type Ca(2+) currents (I(Ca,L)) in rat basilar artery smooth muscle cells (RBASMCs). We used whole cell patch-clamp recording to monitor Ba(2+) currents (I(Ba)) through L-type Ca(2+) channels (LTCCs). Under voltage-clamp conditions
Alastair M Mathewson et al.
PloS one, 9(11), e111977-e111977 (2014-11-06)
The present study examined the hypothesis that potassium ions act as an endothelium-derived hyperpolarizing factor (EDHF) released in response to ACh in small mesenteric arteries displaying myogenic tone. Small mesenteric arteries isolated from rats were set up in a pressure
Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy
Wikstrom J, et al.
Biomaterials, 29(7), 869-876 (2008)
Eiji Ohmae et al.
Biochimica et biophysica acta, 1834(12), 2782-2794 (2013-10-22)
To investigate the contribution of solvent environments to the enzymatic function of Escherichia coli dihydrofolate reductase (DHFR), the salt-, pH-, and pressure-dependence of the enzymatic function of the wild-type protein were compared with those of the active-site mutant D27E in
Ruben Ragg et al.
ACS nano, 8(5), 5182-5189 (2014-04-08)
Sulfite oxidase is a mitochondria-located molybdenum-containing enzyme catalyzing the oxidation of sulfite to sulfate in the amino acid and lipid metabolism. Therefore, it plays a major role in detoxification processes, where defects in the enzyme cause a severe infant disease
Michaela E Levin et al.
Journal of neurophysiology, 108(1), 175-186 (2012-04-13)
Inner ear hair cells respond to mechanical stimuli with graded receptor potentials. These graded responses are modulated by a host of voltage-dependent currents that flow across the basolateral membrane. Here, we examine the molecular identity and the function of a
T Mesallati et al.
European cells & materials, 30, 163-185 (2015-09-29)
Arthroplasty is currently the only surgical procedure available to restore joint function following articular cartilage and bone degeneration associated with diseases such as osteoarthritis (OA). A potential alternative to this procedure would be to tissue-engineer a biological implant and use
Anja Veronovski et al.
International journal of pharmaceutics, 454(1), 58-66 (2013-07-16)
The presented research was oriented towards the preparation of dry biodegradable alginate aerogels with multi-membranes using a multi-step sol-gel process with potential applications as carriers during oral drug delivery. First alginate spherical hydrogels were formed in CaCl2 or BaCl2 solutions
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