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Paresh A Parmar et al.
Biomaterials, 54, 213-225 (2015-04-25)
Regenerative medicine strategies for restoring articular cartilage face significant challenges to recreate the complex and dynamic biochemical and biomechanical functions of native tissues. As an approach to recapitulate the complexity of the extracellular matrix, collagen-mimetic proteins offer a modular template
Liang-Feng Liu et al.
Scientific reports, 5, 16862-16862 (2015-11-19)
Tianma Gouteng Yin (TGY) is a traditional Chinese medicine (TCM) decoction widely used to treat symptoms associated with typical Parkinson's disease (PD). In this study, the neuroprotective effects of water extract of TGY were tested on rotenone-intoxicated and human α-synuclein
Krysti Todd et al.
Biochimica et biophysica acta, 1842(12 Pt A), 2457-2467 (2014-09-28)
Familial British dementia (FBD) is an early-onset non-amyloid-β (Aβ) cerebral amyloidosis that presents with severe cognitive decline and strikingly similar neuropathological features to those present in Alzheimer's disease (AD). FBD is associated with a T to A single nucleotide transition
Saeed Shahrokhian et al.
Materials science & engineering. C, Materials for biological applications, 53, 134-141 (2015-06-05)
A novel voltammetric sensor based on glassy carbon electrode (GCE) modified with a thin film of multi-walled carbon nanotubes (MWCNTs) coated with an electropolymerized layer of tiron-doped polypyrrole was developed and the resulting electrode was applied for the determination of
Jae-Yeon Shin et al.
Biomolecules & therapeutics, 23(4), 313-319 (2015-07-15)
P7C3 and its derivatives, 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(p-tolylamino)propan-2-ol (1) and N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-hydroxypropyl)-N-(3-methoxyphenyl)-4-methylbenzenesulfonamide (2), were previously reported to increase neurogenesis in rat neural stem cells (NSCs). Although P7C3 is known to increase neurogenesis by protecting newborn neurons, it is not known whether its derivatives also
Alessia Colombo et al.
Dalton transactions (Cambridge, England : 2003), 44(26), 11788-11796 (2015-06-09)
The synthesis of two new thiocyanate free Ru(II) complexes with different pyrid-2-yl tetrazolate ligands is reported, along with their electrochemical, spectroscopic and theoretical characterization. The corresponding dye-sensitized solar cell devices were prepared, leading to 3.4% conversion efficiency, promising data, considering
Anna W Sromek et al.
Journal of labelled compounds & radiopharmaceuticals, 57(14), 725-729 (2014-11-18)
Aporphines are attractive candidates for imaging D2 receptor function because, as agonists rather than antagonists, they are selective for the receptor in the high affinity state. In contrast, D2 antagonists do not distinguish between the high and low affinity states
Mikhail A Kabeshov et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(34), 12026-12033 (2015-07-07)
Comprehensive mechanistic studies on the enantioselective aldol reaction between isatin (1 a) and acetone, catalyzed by L-leucinol (3 a), unraveled that isatin, apart from being a substrate, also plays an active catalytic role. Conversion of the intermediate oxazolidine 4 into the reactive
Andreas Reisch et al.
ACS nano, 9(5), 5104-5116 (2015-04-22)
Ultrasmall polymer nanoparticles are rapidly gaining importance as nanocarriers for drugs and contrast agents. Here, a straightforward modular approach to efficiently loaded and stable sub-20-nm polymer particles is developed. In order to obtain ultrasmall polymer nanoparticles, we investigated the influence
Shing Fung Chow et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 462-471 (2014-07-16)
The relative performance of two specially designed mixers for nanoparticle production, namely, two-stream confined impinging jets with dilution mixer (CIJ-D-M) and four-stream multi-inlet vortex mixer (MIVM), was evaluated using the model compound, curcumin (CUR), under defined conditions of varying mixing
Hongjie An et al.
Enzyme and microbial technology, 68, 15-22 (2014-12-02)
Immobilization of the enzymes on nano-structured materials is a promising approach to enhance enzyme stabilization, activation and reusability. This study aimed to develop polystyrene fiber-enzyme assembles to catalyze model formaldehyde to methanol dehydrogenation reaction, which is an essential step for
Takashi Toyao et al.
ChemSusChem, 8(22), 3905-3912 (2015-09-24)
Various N-doped nanoporous carbons containing metal species were prepared by direct thermal conversion of zeolitic imidazolate frameworks (ZIFs; ZIF-7, -8, -9, and -67) at different temperatures (600, 800, and 1000 °C). These materials were utilized as bifunctional acid-base catalysts to promote
Şerife Tokalıoğlu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 149, 378-384 (2015-05-15)
In this study, a fast and simple vortex assisted solid phase extraction method was developed for the separation/preconcentration of basic fuchsin in various water samples. The determination of basic fuchsin was carried out at a wavelength of 554 nm by
Poonam Srivastava et al.
Nature communications, 6, 7789-7789 (2015-07-25)
Artificial metalloenzymes (ArMs) formed by incorporating synthetic metal catalysts into protein scaffolds have the potential to impart to chemical reactions selectivity that would be difficult to achieve using metal catalysts alone. In this work, we covalently link an alkyne-substituted dirhodium
Sawanta S Mali et al.
Scientific reports, 5, 11424-11424 (2015-06-23)
Development of ternary metal oxide (TMO) based electron transporting layer (ETL) for perovskite solar cell open a new approaches toward efficient a unique strategy for solid state dye-sensitized solar cells (ssDSSCs). In the present investigation, highly porous zinc tin oxide
A Bianchi et al.
Organic & biomolecular chemistry, 13(27), 7530-7541 (2015-06-16)
Integrins are associated with tumour cell survival and progression, and their expression has been shown to be increased in tumours. Thus, four novel conjugates of the tripeptide integrin ligand Arg-Gly-Asp (RGD) and the cytotoxic agent paclitaxel (cRGD-PTX) were prepared to
Yang Wang et al.
The Analyst, 139(23), 6197-6203 (2014-10-10)
In this work, a novel chemically modified electrode is constructed based on metal-organic frameworks and β-cyclodextrin (Cu3(BTC)2/β-CD, BTC = benzene-1,3,5-tricarboxylate) composite material. The electrode was used for simultaneous determination of guanine and adenine in a sequential injection lab-on-valve format and
Sun-Young Kong et al.
PloS one, 10(2), e0118188-e0118188 (2015-02-24)
Neural stem cells (NSCs) have the ability to proliferate and differentiate into neurons and glia. Regulation of NSC fate by small molecules is important for the generation of a certain type of cell. The identification of small molecules that can
Laila Arzuman et al.
Anticancer research, 35(5), 2783-2794 (2015-05-13)
With the idea that platinum compounds that bind with DNA differently than cisplatin may be better-able to overcome platinum resistance in ovarian tumor, the monofunctional platinum complex tris(imidazo(1,2-α)pyridine) chloroplatinum(II) chloride (coded as LH6) has been synthesized and investigated for its
Ming-Lung Hsieh et al.
Journal of chromatography. A, 1358, 208-216 (2014-07-23)
A vancomycin-bonded silica monolithic column for capillary electrochromatography (CEC) was prepared by a single-step in situ sol-gel approach. This sol-gel process incorporates a synthetic sol-gel precursor which contains a macrocyclic antibiotic, vancomycin, to form a porous silica network inside a
Farzad Foroutan et al.
Biomedical materials (Bristol, England), 10(4), 045025-045025 (2015-08-27)
In the present study, we report a new and facile sol-gel synthesis of phosphate-based glasses with the general formula of (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x , where x = 0, 5, 10 or 15, for bone tissue engineering applications. The sol-gel synthesis method
Jixian Xu et al.
Nature communications, 6, 7081-7081 (2015-05-09)
Solution-processed planar perovskite devices are highly desirable in a wide variety of optoelectronic applications; however, they are prone to hysteresis and current instabilities. Here we report the first perovskite-PCBM hybrid solid with significantly reduced hysteresis and recombination loss achieved in
Jian Li et al.
Journal of chromatographic science, 53(4), 641-645 (2014-07-06)
A new capillary electrophoresis (CE) method was developed by using graphene oxide (GO) as a stationary phase for the separation of brucine and strychnine. The separation performance, reproducibility and stability of GO-coated capillary were investigated for the analysis of brucine
Makhsud I Saidaminov et al.
Nature communications, 6, 7586-7586 (2015-07-07)
Single crystals of methylammonium lead trihalide perovskites (MAPbX3; MA = CH3NH3(+), X = Br(-) or I(-)) have shown remarkably low trap density and charge transport properties; however, growth of such high-quality semiconductors is a time-consuming process. Here we present a
Elisabetta Schievano et al.
Talanta, 140, 36-41 (2015-06-07)
The first step in caffeine metabolism is mediated for over 95% by the CYP1A2 isoform of cytochrome P450. Therefore, CYP1A2 activity is most conveniently measured through the determination of caffeine clearance. The HPLC quantification of caffeine is fully validated and
Purushothaman Kuppan et al.
Journal of biomedical materials research. Part A, 103(7), 2236-2250 (2014-10-28)
Poly(ɛ-caprolactone) (PCL) and PCL-gelatin random and aligned nanofibers with diameters in the range of 200-400 nm were developed through electrospinning. Mechanical properties of aligned PCL and PCL-gelatin nanofibers were compared, and it was found that aligned PCL nanofibers showed significantly
Eddie Y Chung et al.
Nano letters, 15(8), 5025-5032 (2015-07-24)
We developed a quantum-dot-based fluorescence resonance energy transfer (QD-FRET) nanosensor to visualize the activity of matrix metalloproteinase (MT1-MMP) at cell membrane. A bended peptide with multiple motifs was engineered to position the FRET pair at a close proximity to allow
Kunitoshi Kobayashi et al.
International immunology, 27(7), 333-344 (2015-02-28)
Dimethyl fumarate (DMF) is a modifier of the nuclear factor (erythroid-derived 2)-2 (Nrf2)-kelch-like ECH-associated protein 1 (Keap1) pathway. DMF treatment in the effector phase significantly suppressed the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) both clinically and histologically.
Matthew D Overturf et al.
Aquatic toxicology (Amsterdam, Netherlands), 161, 33-40 (2015-02-11)
Pharmaceuticals are routinely detected in the environment; and several of these compounds have been extensively researched due to their potential impacts to the endocrine system of aquatic organisms. The negative reproductive consequences of synthetic progestins in teleost species have only
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