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Eun Joung Lim et al.
PloS one, 7(4), e33361-e33361 (2012-04-10)
Breast cancer is the most aggressive form of all cancers, with high incidence and mortality rates. The purpose of the present study was to investigate the molecular mechanism by which methylsulfonylmethane (MSM) inhibits breast cancer growth in mice xenografts. MSM
David S Wishart et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 871(2), 164-173 (2008-05-27)
With continuing improvements in analytical technology and an increased interest in comprehensive metabolic profiling of biofluids and tissues, there is a growing need to develop comprehensive reference resources for certain clinically important biofluids, such as blood, urine and cerebrospinal fluid
Youn Hee Joung et al.
PloS one, 7(10), e47477-e47477 (2012-10-17)
Methylsulfonylmethane (MSM) is a naturally occurring sulfur compound with well-known anti-oxidant properties and anti-inflammatory activities. But, its effects on bone are unknown. Growth hormone (GH) is regulator of bone growth and bone metabolism. GH activates several signaling pathways such as
S E Rose et al.
Magnetic resonance imaging, 18(1), 95-98 (2000-01-21)
We wish to report the detection of dimethyl sulfone (methylsulfonylmethane, C2H6O2S) in the brain of a normal 62-year-old male using in vivo proton magnetic resonance spectroscopy. The presence of this exogenous metabolite resulted from ingestion of a dietary supplement containing
Bing Zheng et al.
Organic letters, 15(7), 1690-1693 (2013-03-23)
A direct and efficient approach for palladium-catalyzed arylation of aryl and alkyl methyl sulfones with aryl bromides has been developed. The catalytic system affords arylated sulfones in good to excellent yields (73-90%).
Babak Nakhostin-Roohi et al.
The Journal of pharmacy and pharmacology, 63(10), 1290-1294 (2011-09-09)
This study was conducted to assess the effects of chronic daily methylsulfonylmethane (MSM) supplementation on known markers of oxidative stress following acute bouts of exercise in untrained healthy young men. Eighteen untrained men volunteered for this study. Participants were randomized
S Brien et al.
Osteoarthritis and cartilage, 16(11), 1277-1288 (2008-04-18)
Conventional treatment of osteoarthritis (OA) with non-steroidal anti-inflammatory drugs is associated with serious gastrointestinal side effects and in view of the recent withdrawal of some cyclo-oxygenase-2 inhibitors, identifying safer alternative treatment options is needed. The objective of this systematic review
Teresa Tsui et al.
BMC complementary and alternative medicine, 12, 198-198 (2012-10-31)
Over 30% of individuals use natural health products (NHPs) for osteoarthritis-related pain. The Deficit Model for the Public Understanding of Science suggests that if individuals are given more information (especially about scientific evidence) they will make better health-related decisions. In
A Lin et al.
Toxicology letters, 123(2-3), 169-177 (2001-10-20)
Methylsulfonylmethane (MSM) is a widely available 'alternative' medicine. In vivo magnetic resonance spectroscopy (MRS) was used to detect and quantify MSM in the brains of four patients with memory loss and in three normal volunteers all of who had ingested
Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy.
Jarrow L Rogovin
Toxicology letters, 129(3), 263-263 (2002-03-13)
R Tripathi et al.
Cellular and molecular biology (Noisy-le-Grand, France), 57(1), 62-69 (2011-03-04)
No pharmacological treatment exists for lower extremity pitting edema, characterized by inflammation, found in chronic venous insufficiency. Treatment with EDTA, an effective metal chelator, was explored because it can modulate free calcium and iron and prevent further free radical production.
Eytan M Debbi et al.
BMC complementary and alternative medicine, 11, 50-50 (2011-06-29)
Patients with osteoarthritis (OA) take a variety of health supplements in an attempt to reduce pain and improve function. The aim of this study was to determine the efficacy of methylsulfonylmethane (MSM) in treating patients with knee OA. This study
Xiaoxue Li et al.
Immunity, 52(2), 374-387 (2020-02-23)
Animals require complex metabolic and physiological adaptations to maintain the function of vital organs in response to environmental stresses and infection. Here, we found that infection or injury in Drosophila induced the excretion of hemolymphatic lipids by Malpighian tubules, the
K Amirshahrokhi et al.
Toxicology and applied pharmacology, 253(3), 197-202 (2011-04-06)
Methylsulfonylmethane (MSM), naturally occurring in green plants, fruits and vegetables, has been shown to exert anti-inflammatory and antioxidant effects. MSM is an organosulfur compound and a normal oxidative metabolite of dimethyl sulfoxide. This study was carried out to investigate the
Dawn T Gulick et al.
Journal of strength and conditioning research, 26(9), 2478-2483 (2011-11-10)
Athletes are on an endless quest to enhance performance and are frequently barraged by products that purport to contribute to various components of athletic activity. The purpose of this study was to determine if MagPro™ influenced muscle flexibility or muscle
Caitlin M Quinn et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 222, 1-7 (2012-07-24)
We demonstrate the determination of quantitative rates of molecular reorientation in the solid state with rotating frame (R(1ρ)) relaxation measurements. Reorientation of the carbon chemical shift anisotropy (CSA) tensor was used to probe site-specific conformational exchange in a model system
A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance - part 25.
B Lundy et al.
British journal of sports medicine, 45(13), 1077-1078 (2011-09-20)
Burkhard Kloesch et al.
Life sciences, 89(13-14), 473-478 (2011-08-09)
Reactive oxygen species (ROS) are highly diffusable and reactive molecules which modulate gene transcription, particularly of pro-inflammatory cytokines which play a crucial role in the nascency and progression of chronic inflammatory diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA).
Min Zhang et al.
Journal of toxicology and environmental health. Part A, 74(6), 380-391 (2011-01-29)
Oxidative stress plays a critical role in cataractogenesis, the leading cause of blindness worldwide. Since transition metals generate reactive oxygen species (ROS) formation, metal chelation therapy has been proposed for treatment of cataracts. However, the effectiveness of most chelators is
Youn Hee Joung et al.
International journal of oncology, 44(3), 883-895 (2014-01-10)
Human urinary bladder cancer is the fifth most common cancer, with a worldwide estimate of about two million patients. Recurrence after complete transurethral prostatic resection is the most important problem in therapy. Combination therapy is a new approach in the
Joan McIntyre Caron et al.
PloS one, 5(8), e11788-e11788 (2010-08-10)
The most deadly form of cancer is not lung or colon, breast or prostate; it is any cancer that has become metastatic. Mortality due to metastatic melanoma, one of the most aggressive and deadly cancers, has increased steadily over the
Make and break-Facile synthesis of cocrystals and comprehensive dissolution studies
Batzdorf.L, et al.
Journal of Molecular Structure, 1133, 18-23 (2017)
Yao-Hua Zhang et al.
Chemical senses, 36(2), 125-135 (2010-10-28)
Olfactory cues play a vital role in kin recognition and mate choice of the rat. Here, using 2 inbred strains of rats, Brown Norway (BN) and Lewis, as models to simulate kinship via genetic distance, we examined whether urine-derived volatiles
Why are dimethyl sulfoxide and dimethyl sulfone such good solvents?
Clark T, et al.
Journal of Molecular Modeling, 14, 689-697 (2008)
Jan Bergman et al.
The Journal of organic chemistry, 76(6), 1546-1553 (2011-02-24)
Tetraphosphorus decasulfide (P(4)S(10)) in pyridine has been used as a thionating agent for a long period of time. The moisture-sensitive reagent has now been isolated in crystalline form, and the detailed structure has been determined by X-ray crystallography. The thionating
Angela Notarnicola et al.
Advances in therapy, 29(9), 799-814 (2012-08-28)
Extracorporeal shockwave therapy (ESWT) produces good results in the treatment of insertional Achilles tendinopathy. The efficacy of combined administration of dietary supplements with ESWT has not yet been studied. In this prospective, randomized clinical trial, Shock Waves therapy and Arginine
N Joksimovic et al.
Updates in surgery, 64(3), 195-201 (2012-04-12)
Topical formulations are widely used in anti-haemorrhoidal treatment, but often lacking controlled clinical trials. Here, we report the results from a controlled clinical trial performed with a new gel medical device (Proctoial) containing hyaluronic acid with tea tree oil and
Nadia Ms Arafa et al.
Toxicology and industrial health, 29(2), 187-201 (2011-12-17)
The study aimed to investigate the effect of the oral administration for 15 days of either Echinacea (E) or genuphil (a composite of chondroitin sulphate, glucosamine and methyl sulfonyl methane [GCM]) nutraceutical supplements on female rat model of acute or
S Gumina et al.
Current medical research and opinion, 28(11), 1767-1774 (2012-10-10)
Arthroscopic rotator cuff repair generally provides satisfactory result, in terms of decreasing shoulder pain, resulting in improvement in range of motion. Unfortunately, imaging studies have shown that after surgical repair re-rupture rate is potentially high. Literature data indicate that each
Virginia Pérez-Fernández et al.
Chirality, 24(7), 577-583 (2012-05-23)
The potential of three capillary columns based on β-cyclodextrin (i.e., Chirasil-Dex, BGB-172, and BGB-176SE) has been studied for the simultaneous enantiomeric separation of polychlorinated biphenyls (PCBs) and methylsulfonyl metabolites of PCBs (MeSO(2)-PCBs) employing a heart-cut multidimensional gas chromatographic system (heart-cut
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