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Ludivine Renaud et al.
Circulation. Heart failure, 8(6), 1094-1104 (2015-09-16)
MicroRNAs (miRNAs) and histone deacetylases (HDACs) serve a significant role in the pathogenesis of a variety of cardiovascular diseases. The transcriptional regulation of miRNAs is poorly understood in cardiac hypertrophy. We investigated whether the expression of miR-133a is epigenetically regulated
Gulcin Tezcan et al.
Cellular and molecular neurobiology, 35(2), 175-187 (2014-09-13)
Glioblastoma multiforme (GBM) is one of the deadliest human malignancies. A cure for GBM remains elusive, and the overall survival time is less than 1 year. Thus, the development of more efficient therapeutic approaches for the treatment of these patients
Qing Lin et al.
Oncology reports, 32(6), 2405-2410 (2014-09-19)
Tumor treatment requires a long-term regimen of chemotherapy, and both surgical tumor resection and radiation therapy are also used. The present study aimed to develop a novel method for 5-fluorouracil (5-FU)-loaded microspheres which enhance the therapeutic effects of chemotherapy, the
Gui-Peng Tian et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 70(12), 1934-1940 (2014-12-19)
1,4-Dioxane is a probable human carcinogenic and refractory substance that is widely detected in aquatic environments. Traditional wastewater treatment processes, including activated sludge, cannot remove 1,4-dioxane. Removing 1,4-dioxane with a reaction kinetic constant of 0.32 L/(mol·s) by using ozone, a
Lydia N Wamalwa et al.
Journal of agricultural and food chemistry, 63(1), 335-342 (2014-11-25)
Furanoterpenoid accumulation in response to microbial attack in rotting sweetpotatoes has long been linked to deaths and lung edema of cattle in the world. However, it is not known whether furanoterpenoid ipomeamarone accumulates in the healthy-looking parts of infected sweetpotato
Julian P Sachs et al.
PloS one, 10(11), e0141643-e0141643 (2015-11-18)
The hydrogen isotope (2H/1H) ratio of lipids from phytoplankton is a powerful new tool for reconstructing hydroclimate variations in the geologic past from marine and lacustrine sediments. Water 2H/1H changes are reflected in lipid 2H/1H changes with R2 > 0.99
Ana Penko et al.
Food chemistry, 168, 372-382 (2014-08-31)
The oxidation processes were studied in chicken patties, enriched with n-3 fatty acids, after 8days of storage at 4°C, under different aerobic conditions, and following heat treatment. Significant effects were seen on lipid and cholesterol oxidation and the sensory qualities
Laura Golsteijn et al.
Environment international, 71, 36-45 (2014-06-28)
The present paper describes a method that accounts for variation in indoor chemical exposure settings and accompanying human toxicity in life cycle assessment (LCA). Metal degreasing with dichloromethane was used as a case study to show method in practice. We
Ben Newland et al.
Scientific reports, 5, 17478-17478 (2015-12-02)
Externally controlled site specific drug delivery could potentially provide a means of reducing drug related side effects whilst maintaining, or perhaps increasing therapeutic efficiency. The aim of this work was to develop a nanoscale drug carrier, which could be loaded
Anna W Sromek et al.
Journal of labelled compounds & radiopharmaceuticals, 57(14), 725-729 (2014-11-18)
Aporphines are attractive candidates for imaging D2 receptor function because, as agonists rather than antagonists, they are selective for the receptor in the high affinity state. In contrast, D2 antagonists do not distinguish between the high and low affinity states
Huan Dang et al.
American journal of cancer research, 5(1), 243-254 (2015-01-30)
Ardipusilloside I (ADS-I) is a natural compound that can be isolated from the Chinese medicinal herb Ardisiapusilla A.DC, and has been reported to inhibit the growth of glioblastoma cells in cultures. This study was designed to test its efficacy by
Attractors in Sequence Space: Peptide Morphing by Directed Simulated Evolution.
Jan A Hiss et al.
Molecular informatics, 34(11-12), 709-714 (2016-01-19)
Hyun Su Min et al.
Theranostics, 5(12), 1402-1418 (2015-12-19)
Theranostic nanoparticles hold great promise for simultaneous diagnosis of diseases, targeted drug delivery with minimal toxicity, and monitoring of therapeutic efficacy. However, one of the current challenges in developing theranostic nanoparticles is enhancing the tumor-specific targeting of both imaging probes
Aina Ramsay et al.
Journal of agricultural and food chemistry, 63(43), 9471-9479 (2015-10-21)
Little information exists on the effects of ensiling on condensed tannins or proanthocyanidins. The acetone-butanol-HCl assay is suitable for measuring proanthocyanidin contents in a wide range of samples, silages included, but provides limited information on proanthocyanidin composition, which is of
Eshwar Jagerdeo et al.
Journal of analytical toxicology, 39(2), 83-88 (2014-11-30)
The abuse of gamma-hydroxybutyric acid (GHB) and its suspicion in cases of suspected drug-facilitated sexual assault is of keen interest to forensic toxicology laboratories. This paper reports an extraction, separation and detection procedure for GHB in hair utilizing a combination
Murat Topal et al.
Environmental monitoring and assessment, 187(12), 750-750 (2015-11-15)
The aims of this study are to investigate the fate of tetracycline (TC) and degradation products (DPs) in municipal biological wastewater treatment plant (MBWWTP) located in Elazığ City (Turkey) and to determine the occurrence and transport of TC and DPs
Jorge O Oña-Ruales et al.
Analytical and bioanalytical chemistry, 407(30), 9165-9176 (2015-10-10)
We applied a combination of normal-phase liquid chromatography (NPLC) with ultraviolet-visible spectroscopy and gas chromatography with mass spectrometry (GC/MS) for the fractionation, identification, and quantification of six ring C26H16 cata-condensed polycyclic aromatic hydrocarbons, PAHs, in the Standard Reference Material 1597a
Jordan L Knight et al.
Workplace health & safety, 61(4), 153-160 (2013-03-26)
This study analyzed data from the Occupational Safety and Health Administration's (OSHA) Chemical Exposure Health Database to assess contaminant exposures in general medical and surgical hospitals. Seventy-five inspections conducted in these hospitals from 2005 through 2009 were identified. Five categories
Darina Lankova et al.
Analytica chimica acta, 854, 61-69 (2014-12-07)
In the present study, a novel analytical approach for the simultaneous determination of 27 brominated flame retardants (BFRs), namely polybrominated diphenyl ethers (PBDEs), isomers of hexabromocyclododecane (HBCD), tetrabromobisphenol A (TBBPA) and several novel BFRs (NBFRs), together with 18 perfluoroalkyl substances
S Marquette et al.
International journal of pharmaceutics, 470(1-2), 41-50 (2014-05-06)
Antibodies (Abs) require the development of stable formulations and specific delivery strategies given their susceptibility to a variety of physical and chemical degradation pathways. In this study, the encapsulation of an antibody into polylactide-co-glycolide (PLGA) based microspheres was explored to
Vicente Ferreira et al.
Journal of agricultural and food chemistry, 62(41), 10015-10027 (2014-10-07)
Samples from 16 Spanish red wines have been stored for 6 months at 25 °C under different levels of oxygen (0-56 mg/L). Amino acids, metals, and phenolic compounds were analyzed and related to the production or depletion of key oxidation-
Mette Thing et al.
Journal of pharmaceutical sciences, 103(12), 4021-4029 (2014-10-31)
Long-acting nonsteroidal anti-inflammatory drug formulations for intra-articular injection might be effective in the management of joint pain and inflammation associated sports injuries and osteoarthritis. In this study, a prodrug-based delivery system was evaluated. The synthesized diclofenac ester prodrug, a weak
Zulin Zhang et al.
Journal of separation science, 37(24), 3699-3705 (2014-10-02)
A simple and rapid method was developed for the simultaneous analysis of nine different pesticides in water samples by gas chromatography with mass spectrometry. A number of parameters that may affect the recovery of pesticides, such as the type of
Bettina Gohlke et al.
Hormone research in paediatrics, 84(5), 331-337 (2015-10-07)
Events during foetal or early extrauterine life may affect bodily structure and/or functions and even pave the way for adult diseases. To find whether extremely low birth weight (ELBW) infants differ from healthy controls regarding the excretion of steroid metabolites.
Mauricio Mora-Pale et al.
Biotechnology and bioengineering, 112(12), 2417-2428 (2015-06-26)
Plant polyphenols are known to have varying antimicrobial potencies, including direct antibacterial activity, synergism with antibiotics and suppression of bacterial virulence. We performed the in vitro oligomerization of resveratrol catalyzed by soybean peroxidase, and the two isomers (resveratrol-trans-dihydrodimer and pallidol)
Jian Kang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 141-147 (2014-06-08)
A novel method has been developed to protect Recombinant Human Growth Hormone (rhGH) in poly (lactic-co-glycolic acid) (PLGA) microspheres using an aqueous phase/aqueous phase emulsion and S/O/W multi-emulsion method. This method develops a novel rhGH sustained-release system, which is based
L Mousnier et al.
International journal of pharmaceutics, 471(1-2), 10-17 (2014-05-20)
Ultrasound contrast agents (UCAs) composed of a liquid perfluorocarbon (PFC) core surrounded by a polymer shell have shown promising echogenicity as well as stability. In a strategy to optimize the ultrasound properties of these systems, encapsulating a liquid PFC with
Kari L Organtini et al.
Journal of chromatography. A, 1369, 138-146 (2014-12-03)
A comprehensive approach was taken to characterize the polyhalogenated dibenzo-p-dioxin and dibenzofuran contents of fire debris. Household and electronics fire simulations were performed to create samples representative of those firefighters most typically come in contact with. Sample analysis was performed
Elizabeth N Ndunda et al.
Environmental science. Processes & impacts, 17(12), 2101-2109 (2015-11-13)
The need for continuous monitoring of polychlorinated biphenyls (PCBs) has necessitated the development of analytical techniques that are sensitive and selective with minimal reagent requirement. In light of this, we developed a column for clean-up of soil and sediment extracts
Gennara Cavallaro et al.
International journal of pharmaceutics, 495(2), 719-727 (2015-09-28)
Nanocarriers of amphiphilic polymeric materials represent versatile delivery systems for poorly water soluble drugs. In this work the technique of solvent evaporation from multiple emulsions was applied to produce nanovectors based on new amphiphilic copolymer, the α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-polylactic acid (PHEA-PLA), purposely
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