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Caroline Übel et al.
Scientific reports, 4, 5865-5865 (2014-08-12)
In a murine model of allergic asthma, we found that Tyk-2((-/-)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the lung, IRF4 and hyperproliferative lung Th2 CD4(+) effector T cells over-expressing IL-3, IL-4, IL-5, IL-10 and
Anna W Sromek et al.
Journal of labelled compounds & radiopharmaceuticals, 57(14), 725-729 (2014-11-18)
Aporphines are attractive candidates for imaging D2 receptor function because, as agonists rather than antagonists, they are selective for the receptor in the high affinity state. In contrast, D2 antagonists do not distinguish between the high and low affinity states
Kathryn N Lister et al.
Aquatic toxicology (Amsterdam, Netherlands), 161, 61-72 (2015-02-11)
Legacy pollutants, including polycyclic aromatic hydrocarbons (PAHs) and metals, can occur in high concentrations in some Antarctic marine environments, particularly near scientific research stations. Oxidative stress is an important unifying feature underlying the toxicity of many chemical contaminants to aquatic
Yung-Chih Kuo et al.
International journal of pharmaceutics, 473(1-2), 334-344 (2014-07-08)
CRM197-grafted liposomes containing cardiolipin (CL) (CRM197/CL-liposomes) were used to enhance the permeability of neuron growth factor (NGF) across the blood-brain barrier (BBB) for promoting the neuroprotective effect of NGF. CRM197/CL-liposoms were incubated with a monolayer of human astrocyte (HA)-regulated human
Claire D Bourke et al.
International journal for parasitology, 45(4), 215-224 (2015-01-13)
Keratinocytes constitute the majority of cells in the skin's epidermis, the first line of defence against percutaneous pathogens. Schistosome larvae (cercariae) actively penetrate the epidermis to establish infection, however the response of keratinocytes to invading cercariae has not been investigated.
Hisanobu Ota et al.
PloS one, 10(4), e0123733-e0123733 (2015-04-16)
Relationship between microalbuminuria and worse outcome of coronary artery disease patients is discussed, but its underlying pathophysiological mechanism remains unclear. We investigated the role of microalbuminuria to the function of endothelial progenitor cells (EPCs), that might affect to outcome of
Venkata Krishna Bayineni et al.
Biochemical and biophysical research communications, 453(4), 784-786 (2014-12-03)
An autobiographic method based on the thin layer chromatogram was developed by using the chemical system that comprises p-Nitrophenyl butyrate and bromothymol blue for detecting the lipase inhibitor. Lipase inhibitory zones were visualized as blue spots against the greenish yellow
Junji Kurashige et al.
Carcinogenesis, 36(1), 133-141 (2014-11-21)
Cancer-associated fibroblasts (CAFs) have recently been linked to the invasion and metastasis of gastric cancer. In addition, the microRNA (miR)-200 family plays a central role in the regulation of the epithelial-mesenchymal transition process during cancer metastasis, and aberrant DNA methylation
Yu Zheng et al.
Nature communications, 5, 5772-5772 (2014-12-17)
The self-assembly of nanoscale materials to form hierarchically ordered structures promises new opportunities in drug delivery, as well as magnetic materials and devices. Herein, we report a simple means to promote the self-assembly of two polymers with functional groups at
João Cleverson Gasparetto et al.
PloS one, 10(3), e0118922-e0118922 (2015-03-11)
For decades guaco species have been empirically used for the treatment of respiratory diseases. However, studies have shown that the toxic and therapeutic effects of the main guaco metabolites are dose-dependent, and none clinical study was done to evaluate the
Tereza Kunická et al.
PloS one, 9(7), e101740-e101740 (2014-08-01)
ATP-Binding Cassette (ABC) transporters may cause treatment failure by transporting of anticancer drugs outside of the tumor cells. Multidrug resistance-associated protein 1 coded by the ABCC1 gene has recently been suggested as a potential prognostic marker in breast cancer patients.
Irene T Ma et al.
Pediatric research, 77(4), 500-505 (2015-01-15)
Vascular endothelial growth factor (VEGF), a well-characterized regulator of angiogenesis, has been mechanistically implicated in retinal neovascularization and in the pathogenesis of retinopathy of prematurity. However, the ontogeny of VEGF expression in the human fetal retina is not well known.
Maria Chiara Mimmi et al.
Journal of proteome research, 14(3), 1465-1471 (2015-01-28)
Fetal endoscopic tracheal occlusion has been proposed as a prenatal intervention to ameliorate congenital diaphragmatic hernia (CDH) prognosis. Tracheal occlusion (TO) prevents pulmonary fluid egress, leading to tissue expansion, reversal of lung hypoplasia, and potential maturation. Fetal lung maturity strongly
Werner Stenzel et al.
Neurology, 84(13), 1346-1354 (2015-03-10)
To analyze antisynthetase syndrome-associated myositis by modern myopathologic methods and to define its place in the spectrum of idiopathic inflammatory myopathies (IIMs). Skeletal muscle biopsies from antisynthetase syndrome-associated myositis and other IIMs from different institutions worldwide were analyzed by histopathology
Mariana Segovia-Mendoza et al.
BMC cancer, 15, 21-21 (2015-01-28)
Over the past few years, the concurrent use of cisplatin-based chemotherapy and radiation therapy has dramatically improved the local response and increased overall survival in early-stage cervical cancer. However, for the advanced stages of the disease this standard treatment has
Evan Markegard et al.
PloS one, 6(9), e25540-e25540 (2011-10-04)
In contrast to the well-characterized T cell receptor (TCR) signaling pathways that induce genes that drive T cell development or polarization of naïve CD4 T cells into the diverse T(H)1, T(H)2, T(H)17 and T(reg) lineages, it is unclear what signals
Steven A Lopez et al.
The Journal of organic chemistry, 78(4), 1576-1582 (2013-01-26)
The transition structures for the 1,3-dipolar cycloadditions of phenyl azide to enamines derived from acetophenone or phenylacetaldehyde and piperidine, morpholine, or pyrrolidine were located using quantum mechanical methods. These cycloadditions were studied experimentally in 1975 by Meilahn, Cox, and Munk
P Farinelli et al.
Cell death & disease, 5, e1558-e1558 (2014-12-06)
Retinitis pigmentosa (RP) defines a group of inherited degenerative retinal diseases causing progressive loss of photoreceptors. To this day, RP is still untreatable and rational treatment development will require a thorough understanding of the underlying cell death mechanisms. Methylation of
Ana Penko et al.
Food chemistry, 168, 372-382 (2014-08-31)
The oxidation processes were studied in chicken patties, enriched with n-3 fatty acids, after 8days of storage at 4°C, under different aerobic conditions, and following heat treatment. Significant effects were seen on lipid and cholesterol oxidation and the sensory qualities
Katrien Forier et al.
Journal of controlled release : official journal of the Controlled Release Society, 195, 21-28 (2014-08-16)
Encapsulation of antibiotics into nanoparticles is a potential strategy to eradicate biofilms. To allow further optimization of nanomedicines for biofilm eradication, the influence of the nanoparticle size on the penetration into dense biofilm clusters needs to be investigated. In the
Jacobus J van Franeker et al.
Nature communications, 6, 6229-6229 (2015-02-07)
The photoactive layer of organic solar cells consists of a nanoscale blend of electron-donating and electron-accepting organic semiconductors. Controlling the degree of phase separation between these components is crucial to reach efficient solar cells. In solution-processed polymer-fullerene solar cells, small
Chung Wah Wu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(11), 2994-3002 (2014-04-03)
Detecting microRNA (miRNA) in stool is a novel approach for colorectal cancer (CRC) screening. This study aimed to identify stool-based miRNA as noninvasive biomarkers for detection of CRC and adenoma. A miRNA expression array covering 667 human miRNAs was performed
Indri Erliandri et al.
Nucleic acids research, 42(18), 11502-11516 (2014-09-18)
In human chromosomes, centromeric regions comprise megabase-size arrays of 171 bp alpha-satellite DNA monomers. The large distances spanned by these arrays preclude their replication from external sites and imply that the repetitive monomers contain replication origins. However, replication within these
Valerie L Colley et al.
Drug testing and analysis, 7(3), 241-246 (2014-10-11)
South American 'crack' cocaine, produced directly from coca leaf, can be distinguished from US domestically produced crack on the basis of occluded solvent profiles. In addition, analysis of domestically produced crack indicates the solvents that were used for cocaine hydrochloride
Jie Zhang et al.
Biotechnology for biofuels, 8, 36-36 (2015-03-13)
Clostridium cellulolyticum and other cellulolytic Clostridium strains are natural producers of lignocellulosic biofuels and chemicals via the consolidated bioprocessing (CBP) route, and systems metabolic engineering is indispensable to meet the cost-efficient demands of industry. Several genetic tools have been developed
An investigation into the sample preparation procedure and analysis of cyanoacrylate adhesives using capillary electrophoresis.
Whitaker G, et al.
International Journal of Adhesion and Adhesives, 27(7), 604-609 (2007)
Juliana I G da S Ferreira et al.
Systematic parasitology, 91(1), 63-70 (2015-04-12)
Trypanosomes of anurans and fish are grouped into the Aquatic Clade which includes species isolated from fish, amphibians, turtles and platypus, usually transmitted by leeches and phlebotomine sand flies. Trypanosomes from Brazilian frogs are grouped within the Aquatic Clade with
Nuria Roldan et al.
Biochimica et biophysica acta, 1848(1 Pt A), 184-191 (2014-10-14)
Surfactant protein C (SP-C) has been regarded as the most specific protein linked to development of mammalian lungs, and great efforts have been done to understand its structure-function relationships. Previous evidence has outlined the importance of SP-C palmitoylation to sustain
Bamaprasad Dutta et al.
Molecular & cellular proteomics : MCP, 13(9), 2183-2197 (2014-05-17)
The chromatin-associated proteome (chromatome) regulates cellular gene expression by restricting access of transcriptional machinery to template DNA, and dynamic re-modeling of chromatin structure is required to regulate critical cell functions including growth and replication, DNA repair and recombination, and oncogenic
Behnam Behnoush et al.
Medicine, 94(14), e640-e640 (2015-04-11)
The aim of this study was to compare system efficiency and analysis duration regarding the solvent consumption and system maintenance in high-pressure liquid chromatography (HPLC) and ultra high-pressure liquid chromatography (UHPLC). In a case-control study, standard solutions of 7 benzodiazepines
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