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36541

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Naomi L Kruhlak et al.
Toxicology mechanisms and methods, 18(2-3), 217-227 (2008-01-01)
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development...
Dennis J Pelletier et al.
Journal of chemical information and modeling, 47(3), 1196-1205 (2007-04-13)
The identification of phospholipidosis (PPL) during preclinical testing in animals is a recognized problem in the pharmaceutical industry. Depending on the intended indication and dosing regimen, PPL can delay or stop development of a compound in the drug discovery process....
Arun Kumar Yadawa et al.
Pesticide biochemistry and physiology, 153, 106-115 (2019-02-13)
Paraquat (PQ) is a herbicide and well characterized pneumotoxicant which is also known to induce neurodegeneration in organisms. Aim of this study was to investigate the effect of PQ on hypothalamic - pituitary - adrenal (HPA) axis. PQ was administered...
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds...
Marion Robin et al.
Autophagy, 15(5), 771-784 (2018-12-20)
The tumor suppressor TP53/p53 is a known regulator of apoptosis and macroautophagy/autophagy. However, the molecular mechanism by which TP53 regulates 2 apparently incompatible processes remains unknown. We found that Drosophila lacking p53 displayed impaired autophagic flux, higher caspase activation and...
Metabolism of short-chain fatty acid propionate induces surface expression of NKG2D ligands on cancer cells.
H?gh, et al.
Faseb Journal, 34, 15531-15546 (2021)
Inhibition of c-Src protects paraquat induced microvascular endothelial injury by modulating caveolin-1 phosphorylation and caveolae mediated transcellular permeability
Yu H and Qing H
Environmental Toxicology and Pharmacology, 52, 62-68 (2017)
Nigel Greene et al.
Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential...
Vijaya Bharathi Srinivasan et al.
Antimicrobial agents and chemotherapy, 53(12), 5312-5316 (2009-09-23)
In this study, a chromosomally encoded putative drug efflux pump of the SMR family, named AbeS, from a multidrug-resistant strain of Acinetobacter baumannii was characterized to elucidate its role in antimicrobial resistance. Expression of the cloned abeS gene in hypersensitive...
Kriti Chaplot et al.
Disease models & mechanisms, 12(2) (2019-01-13)
Familial amyotrophic lateral sclerosis (ALS) is an incurable, late-onset motor neuron disease, linked strongly to various causative genetic loci. ALS8 codes for a missense mutation, P56S, in VAMP-associated protein B (VAPB) that causes the protein to misfold and form cellular...
Jeongsu Han et al.
Oxidative medicine and cellular longevity, 2019, 4174803-4174803 (2019-09-20)
Paraquat (PQ), an herbicide considered an environmental contributor to the development of Parkinson's disease (PD), induces dopaminergic neuronal loss through reactive oxygen species (ROS) production and oxidative stress by mitochondrial complex I. Most patients with PQ-induced PD are affected by...
Haixia Zou et al.
ACS chemical neuroscience, 6(3), 464-475 (2014-12-30)
Endoplasmic reticulum (ER) stress causes neuronal dysfunction followed by cell death and is recognized as a feature of many neurodegenerative diseases. Using a phenotypic screen, we recently identified benzodiazepinone derivatives that reduce ER stress-mediated apoptosis in a rat neuronal progenitor...
Erika C Anderson et al.
Developmental cell, 51(2), 192-207 (2019-09-10)
Mechanisms establishing higher-order chromosome structures and their roles in gene regulation are elusive. We analyzed chromosome architecture during nematode X chromosome dosage compensation, which represses transcription via a dosage-compensation condensin complex (DCC) that binds hermaphrodite Xs and establishes megabase-sized topologically...
Richa Soni et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 224, 108568-108568 (2019-07-16)
Paraquat (PQ) being a potent herbicide, causes toxic effect on growth, development and reproduction of plant as well as in animals. In this study we have mainly focused on the toxic effect of PQ on photoperception via different photoreceptors present...
Prasanna V Ramachandran et al.
Developmental cell, 48(5), 685-696 (2019-02-05)
Lysosomes and mitochondria are both crucial cellular organelles for metabolic homeostasis and organism health. However, mechanisms linking their metabolic activities to promote organism longevity remain poorly understood. We discovered that the induction of specific lysosomal signaling mediated by a LIPL-4...
Ben Zhou et al.
Cell, 177(2), 299-314 (2019-04-02)
Autophagy is required in diverse paradigms of lifespan extension, leading to the prevailing notion that autophagy is beneficial for longevity. However, why autophagy is harmful in certain contexts remains unexplained. Here, we show that mitochondrial permeability defines the impact of...
Sumith A Kularatne et al.
Journal of medicinal chemistry, 53(21), 7767-7777 (2010-10-13)
Ligand-targeted therapeutics have increased in prominence because of their potential for improved potency and reduced toxicity. However, with the advent of personalized medicine, a need for greater versatility in ligand-targeted drug design has emerged, where each tumor-targeting ligand should be...
Myrielle Dupont et al.
Antimicrobial agents and chemotherapy, 51(9), 3190-3198 (2007-07-04)
Bacterial adaptation to external stresses and toxic compounds is a key step in the emergence of multidrug-resistant strains that are a serious threat to human health. Although some of the proteins and regulators involved in antibiotic resistance mechanisms have been...
Joe Turner et al.
Behavioural processes, 157, 532-539 (2018-06-14)
Individuals are known to differ consistently in various aspects of their behaviour in many animal species, a phenomenon that has come to be referred to as animal personalities. These individual differences are likely to have evolutionary and ecological significance, and...
Field Dissiation Kinetics of Paraquat in Acid Soil as Function of Concentration and its Residues in Tea Leaves
Janaki.P and Chinnusamy.C
Asian Journal of Chemistry, 28, 1639-1639 (2016)
Diego Herrero et al.
Redox biology, 22, 101156-101156 (2019-03-10)
Adult progenitor cells reside in specialized microenvironments which maintain their undifferentiated cell state and trigger regenerative responses following injury. Although these environments are well described in several tissues, the cellular components that comprise the cardiac environment where progenitor cells are...
Julia M D Grandjean et al.
ACS chemical biology, 14(4), 784-795 (2019-03-02)
Cellular proteostasis is maintained by stress-responsive signaling pathways such as the heat shock response (HSR), the oxidative stress response (OSR), and the unfolded protein response (UPR). Activation of these pathways results in the transcriptional upregulation of select subsets of stress-responsive...
Xiang Li et al.
Nucleic acids research, 47(10), 5074-5085 (2019-06-05)
In microorganisms, a number of metalloproteins including PerR are found to regulate gene expression in response to environmental reactive oxygen species (ROS) changes. However, discovery of similar regulatory mechanisms remains elusive within mammalian cells. As an antioxidant metalloenzyme that maintains...
Feng Long et al.
Antimicrobial agents and chemotherapy, 52(9), 3052-3060 (2008-07-02)
Active efflux of antimicrobial agents is one of the most important adapted strategies that bacteria use to defend against antimicrobial factors that are present in their environment. The NorM protein of Neisseria gonorrhoeae and the YdhE protein of Escherichia coli...