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34998

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Jerald E Dumas et al.
Tissue engineering. Part A, 20(1-2), 115-129 (2013-08-15)
There is a compelling clinical need for bone grafts with initial bone-like mechanical properties that actively remodel for repair of weight-bearing bone defects, such as fractures of the tibial plateau and vertebrae. However, there is a paucity of studies investigating...
Amadeu Gavaldà et al.
Pulmonary pharmacology & therapeutics, 28(2), 114-121 (2014-06-15)
This study characterised the in vitro and in vivo profiles of two novel long-acting muscarinic antagonists, aclidinium bromide and glycopyrronium bromide, using tiotropium bromide and ipratropium bromide as comparators. All four antagonists had high affinity for the five muscarinic receptor sub-types (M1-M5);...
Christine Cahyadi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 90, 30-37 (2014-12-03)
The Supercell coater was developed as an in-line small batch tablet coater which uses air-fluidization for tablet coating. Coating time is very much reduced, with improved heat and mass transfer. It was hypothesized that the quasi-continuous Supercell coating process was...
Anna Maria Sniecinska-Cooper et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 18-23 (2014-12-23)
Human sleep is a natural part of every individual's life. Clear relationship between sleep and endocrine system has been already established. In particular, melatonin and cortisol are known to affect and regulate sleep/wake patterns. Here we report the development of...
Gulcin Tezcan et al.
Cellular and molecular neurobiology, 35(2), 175-187 (2014-09-13)
Glioblastoma multiforme (GBM) is one of the deadliest human malignancies. A cure for GBM remains elusive, and the overall survival time is less than 1 year. Thus, the development of more efficient therapeutic approaches for the treatment of these patients...
Clara Coscollà et al.
Journal of chromatography. A, 1368, 132-142 (2014-10-15)
A comprehensive strategy for the analysis of current airborne pesticides has been developed using liquid chromatography coupled to high resolution mass spectrometry. The methodology includes both quantitative target analysis and post-run target screening analysis. The quantitative method was validated after...
Yuanyuan Li et al.
Biochemical and biophysical research communications, 457(2), 177-182 (2015-01-03)
Non-small cell lung cancer (NSCLC) is a common malignant disease, and in ~10-20% of patients, pleural effusion is the first symptom. The pleural effusion proteome contains information on pulmonary disease that directly or indirectly reflects pathophysiological status. However, the proteome...
Sarah Zanon Agapito-Tenfen et al.
BMC plant biology, 14, 346-346 (2014-12-11)
The safe use of stacked transgenic crops in agriculture requires their environmental and health risk assessment, through which unintended adverse effects are examined prior to their release in the environment. Molecular profiling techniques can be considered useful tools to address...
Maximiliano J Jiménez-Dalmaroni et al.
Innate immunity, 21(2), 175-193 (2014-03-05)
TLRs are key innate immune receptors that recognize conserved features of biological molecules that are found in microbes. In particular, TLR2 has been reported to be activated by different kinds of microbial ligands. To advance our understanding of the interaction...
Suzanne L Parker et al.
Journal of pharmaceutical and biomedical analysis, 105, 39-45 (2014-12-22)
A high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, using hydrophilic interaction liquid chromatography (HILIC) chromatography for the analysis of fosfomycin in human plasma and urine, has been developed and validated. The plasma method uses a simple protein precipitation using...
Thierry K Ngouana et al.
Mycoses, 58(1), 33-39 (2014-10-08)
Minor species of the Candida albicans complex may cause overestimation of the epidemiology of C. albicans, and misidentifications could mask their implication in human pathology. Authors determined the occurrence of minor species of the C. albicans complex (C. africana, C....
Forrest T Smith et al.
Talanta, 129, 171-182 (2014-08-17)
This report compares the GC-MS and FTIR properties of all 6 regioisomeric benzoyl substituted-1-n-pentylindoles. These compounds have the benzoyl-group attached at each of the possible ring substituent positions of the indole ring. The six compounds have the same elemental composition...
Shijie Yao et al.
Cancer chemotherapy and pharmacology, 75(4), 719-728 (2015-01-31)
Camptothecins contain a lactone ring that is necessary for antitumor activity, and hydrolysis of the lactone ring yields an inactive carboxylate species. Human serum albumin (HSA) and alpha-1 acid glycoprotein (AGP) are clinically significant plasma proteins thought to have important...
Sun-Young Kong et al.
PloS one, 10(2), e0118188-e0118188 (2015-02-24)
Neural stem cells (NSCs) have the ability to proliferate and differentiate into neurons and glia. Regulation of NSC fate by small molecules is important for the generation of a certain type of cell. The identification of small molecules that can...
Lydia N Wamalwa et al.
Journal of agricultural and food chemistry, 63(1), 335-342 (2014-11-25)
Furanoterpenoid accumulation in response to microbial attack in rotting sweetpotatoes has long been linked to deaths and lung edema of cattle in the world. However, it is not known whether furanoterpenoid ipomeamarone accumulates in the healthy-looking parts of infected sweetpotato...
Qiqing Chen et al.
The Science of the total environment, 496, 453-460 (2014-08-12)
The potential transfer of fullerene aqueous suspension (nC₆₀) associated contaminants in vivo is one of the most significant and currently not well-understood environmental risks. In this study, the carrier function of nC₆₀ for ibuprofen (IBU) was examined through whole-body and...
Lígia Marquez Andrade et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(1), 40-47 (2014-05-13)
The aim of this study was to develop lipid nanoparticles to deliver genistein (GEN) to deeper skin layers. To do so, the impact of lipid dynamic behavior (nanoparticle flexibility) on stability, release and skin permeation studies was verified. GEN-loaded solid...
Paulo Magalhães et al.
Bioanalysis, 6(22), 3025-3038 (2014-12-17)
A new high-performance liquid chromatography-fluorescence detection assay based on microextraction by packed sorbent as sample preparation approach is described to quantify venlafaxine (VEN) and its main metabolite [O-desmethylvenlafaxine (ODV)]in human plasma. Chromatographic separation of the target analytes (VEN and ODV)...
Tidjani Amza et al.
Journal of food science and technology, 52(5), 2770-2778 (2015-04-22)
The antioxidant capacity of gingerbread plum kernel protein fraction (albumin, globulin and glutelin) hydrolysates (GPKH) was studied. Gingerbread plum kernel protein fractions were hydrolyzed through a combined action of two digestive enzymes (pespsin and trypsin). The hydrolyzed fractions were subjected...
Peng Liu et al.
Pharmaceutical research, 32(2), 628-639 (2014-08-26)
The lack of effective screening methods and systemic understanding of interaction mechanisms complicates the stabilizer selection process for nanocrystallization. This study focuses on the efficiency of stabilizers with various molecular compositions and structures to stabilize drug nanocrystals. Five structurally different...
Rui Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1646-1655 (2014-08-06)
A previously developed physiologically based pharmacokinetic model for hepatic transporter substrates was extended to an organic anion transporting polypeptide substrate, telmisartan. Predictions used in vitro data from sandwich culture human hepatocyte and human liver microsome assays. We have developed a...
M Stefanič et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 8-15 (2014-05-23)
The purpose of this research was to predict the in vivo dissolution of lansoprazole from enteric coated pellets in the fasted state using a biorelevant flow-through dissolution method with low flow rates and volumes close to those in vivo. Additionally...
A-ram Kang et al.
Biochimica et biophysica acta, 1854(5), 356-364 (2015-02-03)
Spinocerebellar ataxia type 1 (SCA1), an autosomal-dominant neurodegenerative disorder, is caused by expansion of the polyglutamine tract within ataxin-1 (ATXN1). The AXH domain of ATXN1 can mediate neurodegeneration through its interaction with other proteins. We have previously showed that the...
Shu-Ping Zou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 111-117 (2014-12-30)
Echinocandin B (ECB), an echinocandin type of lipopeptide antibiotic produced by Aspergillus nidulans, is a precursor for the synthesis of novel anti-fungal drug - anidulafungin. In this work, a separation strategy involving one-step macroporous resin adsorption chromatography was established for...
Le Ngoc Tran et al.
Journal of chromatography. A, 1356, 289-293 (2014-07-20)
An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clindamycin phosphate (CLIP) as a chiral selector. A sol solution consisting of 6 × 10(-3)M of polyethylene glycol...
Shujiao Li et al.
Journal of pharmaceutical and biomedical analysis, 107, 456-463 (2015-02-11)
The compatibility of Angelicae Sinensis Radix (Danggui, DG) and Flos Carthami (Honghua, HH), a famous herb pair Gui-Hong (GH), can produce synergistic and promoting blood effects. Although some physiological and pathological function parameters of the acute blood stasis have been...
Tianshi Feng et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 1086-1093 (2014-10-12)
PLGA porous microspheres loaded with doxorubicin (DOX) and paclitaxel (PTX) were developed for in situ treatment of metastatic lung cancer. The synergistic effect of the combined drugs was investigated against B16F10 cells to obtain the optimal prescription for in vivo...
Rong-Jie Zeng et al.
Biomedical chromatography : BMC, 29(3), 459-464 (2014-07-30)
Boldine is a potential anti-inflammatory agent found in several different plants. Published bioanalytical methods using HPLC with ultraviolet and fluorescent detection lacked enough sensitivity and required tedious sample preparation procedures. Herein, we describe the development of a novel ultra-high performance...
Jing Han et al.
British journal of pharmacology, 171(23), 5252-5264 (2014-07-22)
The short biological half-life limits the therapeutic use of glucagon-like peptide-1 (GLP-1) and chemical modification to improve the interaction of peptides with serum albumin represents an effective strategy to develop long-acting peptide analogues. Coumarin, a natural product, is known to...
Ali Mehdinia et al.
Journal of chromatography. A, 1364, 12-19 (2014-09-07)
In order to resolve the low adsorption capacity of the surface molecularly imprinting methods, an approach was developed for the preparation of magnetic imprinted polymers by pre-grafting the amino functional material, 3-aminopropyltriethoxysilane (APTES), on the surface of the silica coated...
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