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34854

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Caroline Übel et al.
Scientific reports, 4, 5865-5865 (2014-08-12)
In a murine model of allergic asthma, we found that Tyk-2((-/-)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the lung, IRF4 and hyperproliferative lung Th2 CD4(+) effector T cells over-expressing IL-3, IL-4, IL-5, IL-10 and...
Xiaojian Li et al.
Journal of pharmaceutical sciences, 103(9), 2937-2949 (2014-04-18)
Dry powder inhalation aerosols of antibiotic drugs (a first-line aminoglycoside, tobramycin, and a first-line macrolide, azithromycin) and a sugar alcohol mucolytic agent (mannitol) as co-spray dried (co-SD) particles at various molar ratios of drug:mannitol were successfully produced by organic solution...
Arlette Bochud et al.
Biochimica et biophysica acta, 1851(5), 629-640 (2015-02-18)
Five yeast enzymes synthesizing various glycerophospholipids belong to the CDP-alcohol phosphatidyltransferase (CAPT) superfamily. They only share the so-called CAPT motif, which forms the active site of all these enzymes. Bioinformatic tools predict the CAPT motif of phosphatidylinositol synthase Pis1 as...
Katrien Forier et al.
Journal of controlled release : official journal of the Controlled Release Society, 195, 21-28 (2014-08-16)
Encapsulation of antibiotics into nanoparticles is a potential strategy to eradicate biofilms. To allow further optimization of nanomedicines for biofilm eradication, the influence of the nanoparticle size on the penetration into dense biofilm clusters needs to be investigated. In the...
Jacobus J van Franeker et al.
Nature communications, 6, 6229-6229 (2015-02-07)
The photoactive layer of organic solar cells consists of a nanoscale blend of electron-donating and electron-accepting organic semiconductors. Controlling the degree of phase separation between these components is crucial to reach efficient solar cells. In solution-processed polymer-fullerene solar cells, small...
Chung Wah Wu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(11), 2994-3002 (2014-04-03)
Detecting microRNA (miRNA) in stool is a novel approach for colorectal cancer (CRC) screening. This study aimed to identify stool-based miRNA as noninvasive biomarkers for detection of CRC and adenoma. A miRNA expression array covering 667 human miRNAs was performed...
Indri Erliandri et al.
Nucleic acids research, 42(18), 11502-11516 (2014-09-18)
In human chromosomes, centromeric regions comprise megabase-size arrays of 171 bp alpha-satellite DNA monomers. The large distances spanned by these arrays preclude their replication from external sites and imply that the repetitive monomers contain replication origins. However, replication within these...
Taylor R Jay et al.
The Journal of experimental medicine, 212(3), 287-295 (2015-03-04)
Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer's disease (AD) and other neurodegenerative diseases. However, the cell types and mechanisms underlying TREM2's involvement in neurodegeneration remain to be established. Here, we report that...
Maja Lozić et al.
British journal of pharmacology, 171(19), 4385-4398 (2014-05-20)
The paraventricular nucleus (PVN) of the hypothalamus is an important integrative site for neuroendocrine control of the circulation. We investigated the role of oxytocin receptors (OT receptors) in PVN in cardiovascular homeostasis. Experiments were performed in conscious male Wistar rats...
Ana Penko et al.
Food chemistry, 168, 372-382 (2014-08-31)
The oxidation processes were studied in chicken patties, enriched with n-3 fatty acids, after 8days of storage at 4°C, under different aerobic conditions, and following heat treatment. Significant effects were seen on lipid and cholesterol oxidation and the sensory qualities...
Steven A Lopez et al.
The Journal of organic chemistry, 78(4), 1576-1582 (2013-01-26)
The transition structures for the 1,3-dipolar cycloadditions of phenyl azide to enamines derived from acetophenone or phenylacetaldehyde and piperidine, morpholine, or pyrrolidine were located using quantum mechanical methods. These cycloadditions were studied experimentally in 1975 by Meilahn, Cox, and Munk...
P Farinelli et al.
Cell death & disease, 5, e1558-e1558 (2014-12-06)
Retinitis pigmentosa (RP) defines a group of inherited degenerative retinal diseases causing progressive loss of photoreceptors. To this day, RP is still untreatable and rational treatment development will require a thorough understanding of the underlying cell death mechanisms. Methylation of...
Mariana Segovia-Mendoza et al.
BMC cancer, 15, 21-21 (2015-01-28)
Over the past few years, the concurrent use of cisplatin-based chemotherapy and radiation therapy has dramatically improved the local response and increased overall survival in early-stage cervical cancer. However, for the advanced stages of the disease this standard treatment has...
Evan Markegard et al.
PloS one, 6(9), e25540-e25540 (2011-10-04)
In contrast to the well-characterized T cell receptor (TCR) signaling pathways that induce genes that drive T cell development or polarization of naïve CD4 T cells into the diverse T(H)1, T(H)2, T(H)17 and T(reg) lineages, it is unclear what signals...
Tereza Kunická et al.
PloS one, 9(7), e101740-e101740 (2014-08-01)
ATP-Binding Cassette (ABC) transporters may cause treatment failure by transporting of anticancer drugs outside of the tumor cells. Multidrug resistance-associated protein 1 coded by the ABCC1 gene has recently been suggested as a potential prognostic marker in breast cancer patients....
Irene T Ma et al.
Pediatric research, 77(4), 500-505 (2015-01-15)
Vascular endothelial growth factor (VEGF), a well-characterized regulator of angiogenesis, has been mechanistically implicated in retinal neovascularization and in the pathogenesis of retinopathy of prematurity. However, the ontogeny of VEGF expression in the human fetal retina is not well known....
Maria Chiara Mimmi et al.
Journal of proteome research, 14(3), 1465-1471 (2015-01-28)
Fetal endoscopic tracheal occlusion has been proposed as a prenatal intervention to ameliorate congenital diaphragmatic hernia (CDH) prognosis. Tracheal occlusion (TO) prevents pulmonary fluid egress, leading to tissue expansion, reversal of lung hypoplasia, and potential maturation. Fetal lung maturity strongly...
Werner Stenzel et al.
Neurology, 84(13), 1346-1354 (2015-03-10)
To analyze antisynthetase syndrome-associated myositis by modern myopathologic methods and to define its place in the spectrum of idiopathic inflammatory myopathies (IIMs). Skeletal muscle biopsies from antisynthetase syndrome-associated myositis and other IIMs from different institutions worldwide were analyzed by histopathology...
Yu Zheng et al.
Nature communications, 5, 5772-5772 (2014-12-17)
The self-assembly of nanoscale materials to form hierarchically ordered structures promises new opportunities in drug delivery, as well as magnetic materials and devices. Herein, we report a simple means to promote the self-assembly of two polymers with functional groups at...
João Cleverson Gasparetto et al.
PloS one, 10(3), e0118922-e0118922 (2015-03-11)
For decades guaco species have been empirically used for the treatment of respiratory diseases. However, studies have shown that the toxic and therapeutic effects of the main guaco metabolites are dose-dependent, and none clinical study was done to evaluate the...
Claire D Bourke et al.
International journal for parasitology, 45(4), 215-224 (2015-01-13)
Keratinocytes constitute the majority of cells in the skin's epidermis, the first line of defence against percutaneous pathogens. Schistosome larvae (cercariae) actively penetrate the epidermis to establish infection, however the response of keratinocytes to invading cercariae has not been investigated....
Hisanobu Ota et al.
PloS one, 10(4), e0123733-e0123733 (2015-04-16)
Relationship between microalbuminuria and worse outcome of coronary artery disease patients is discussed, but its underlying pathophysiological mechanism remains unclear. We investigated the role of microalbuminuria to the function of endothelial progenitor cells (EPCs), that might affect to outcome of...
Venkata Krishna Bayineni et al.
Biochemical and biophysical research communications, 453(4), 784-786 (2014-12-03)
An autobiographic method based on the thin layer chromatogram was developed by using the chemical system that comprises p-Nitrophenyl butyrate and bromothymol blue for detecting the lipase inhibitor. Lipase inhibitory zones were visualized as blue spots against the greenish yellow...
Junji Kurashige et al.
Carcinogenesis, 36(1), 133-141 (2014-11-21)
Cancer-associated fibroblasts (CAFs) have recently been linked to the invasion and metastasis of gastric cancer. In addition, the microRNA (miR)-200 family plays a central role in the regulation of the epithelial-mesenchymal transition process during cancer metastasis, and aberrant DNA methylation...
Anna W Sromek et al.
Journal of labelled compounds & radiopharmaceuticals, 57(14), 725-729 (2014-11-18)
Aporphines are attractive candidates for imaging D2 receptor function because, as agonists rather than antagonists, they are selective for the receptor in the high affinity state. In contrast, D2 antagonists do not distinguish between the high and low affinity states...
Kathryn N Lister et al.
Aquatic toxicology (Amsterdam, Netherlands), 161, 61-72 (2015-02-11)
Legacy pollutants, including polycyclic aromatic hydrocarbons (PAHs) and metals, can occur in high concentrations in some Antarctic marine environments, particularly near scientific research stations. Oxidative stress is an important unifying feature underlying the toxicity of many chemical contaminants to aquatic...
Yung-Chih Kuo et al.
International journal of pharmaceutics, 473(1-2), 334-344 (2014-07-08)
CRM197-grafted liposomes containing cardiolipin (CL) (CRM197/CL-liposomes) were used to enhance the permeability of neuron growth factor (NGF) across the blood-brain barrier (BBB) for promoting the neuroprotective effect of NGF. CRM197/CL-liposoms were incubated with a monolayer of human astrocyte (HA)-regulated human...
Arfat Idrees et al.
Acta poloniae pharmaceutica, 71(2), 287-295 (2014-10-03)
This study was aimed to determine effects of penetration enhancers and plasticizers on drug release from rationally designed formulations of flurbiprofen based transdermal drug delivery system. Matrix type transdermal patches were formulated with ethyl cellulose (EC) as a polymer by...
Kei Takahashi et al.
Journal of biological engineering, 9, 3-3 (2015-05-15)
The cytosol of amoeba cells controls the membrane deformation during their motion in vivo. To investigate such ability of the cytosol of amoeba cell, Dictyostelium discoideum (Dictyostelium), in vitro, we used lipids extracted from Dictyostelium and commercially available phospholipids, and...
Jonathan Wanagat et al.
Experimental gerontology, 61, 15-19 (2014-12-03)
Mitochondrial DNA (mtDNA) deletion mutations are proposed contributors to aging-related muscle fiber loss and atrophy, but evidence of a causal role for these mutations in muscle aging is lacking. Elucidating the etiology of in vivo mtDNA deletion mutations will help...
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