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Zhaoqiang Ding et al.
Materials science & engineering. C, Materials for biological applications, 48, 469-479 (2015-01-13)
A novel molecularly imprinted optosensing material based on multi-walled carbon nanotube-quantum dots (MWCNT-QDs) has been designed and synthesized for its high selectivity, sensitivity and specificity in the recognition of a target protein bovine serum albumin (BSA). Molecularly imprinted polymer coated
Katharina Bell et al.
BMC ophthalmology, 15, 64-64 (2015-06-28)
Previous studies demonstrate changes of autoantibody concentrations against retinal and optic nerve head antigens in the serum of glaucoma patients in comparison to healthy persons. These antibodies belong to the natural autoimmunity. Previous studies showed up regulated, but also significantly
Davide Carta et al.
ChemMedChem, 10(11), 1846-1862 (2015-10-09)
A small library of 3-ethylpyrrolo[3,2-f]quinoline derivatives was synthesized to identify a novel class of dyes for use in biological studies. According to the spectroscopic analyses performed to evaluate the fluorimetric parameters of quantum yield and brightness, 7-methyl- and 6,7-dimethylpyrroloquinolin(9)one derivatives
Zivile Pranskuniene et al.
Acta poloniae pharmaceutica, 70(4), 727-736 (2013-08-08)
The aim of this study was to evaluate the effect of different capsule filling manufacturing techniques and storage conditions on the release of the active ingredients from herbal capsules during the dissolution test in vitro. Different techniques for the preparation
Joon Seo Lim et al.
Neurobiology of disease, 81, 203-213 (2014-12-03)
Excessive entry of zinc ions into the soma of neurons and glial cells results in extensive oxidative stress and necrosis of cortical cells, which underlies acute neuronal injury in cerebral ischemia and epileptic seizures. Here, we show that angiopoietin-1 (Ang1)
Guillaume A Schoch et al.
IUCrJ, 2(Pt 2), 177-187 (2015-04-14)
Nuclear hormone receptors are cytoplasm-based transcription factors that bind a ligand, translate to the nucleus and initiate gene transcription in complex with a co-activator such as TIF2 (transcriptional intermediary factor 2). For structural studies the co-activator is usually mimicked by
Hang Yang et al.
Scientific reports, 5, 17257-17257 (2015-11-27)
The increasing emergence of multi-drug resistant streptococci poses a serious threat to public health worldwide. Bacteriophage lysins are promising alternatives to antibiotics; however, their narrow lytic spectrum restricted to closely related species is a central shortcoming to their translational development.
Y Lei et al.
PloS one, 10(7), e0132122-e0132122 (2015-07-25)
DENV envelope glycoprotein (E) is responsible for interacting with host cell receptors and is the main target for the development of a dengue vaccine based on an induction of neutralizing antibodies. It is well known that DENV E glycoprotein has
Rokhsana Mortuza et al.
Journal of cellular and molecular medicine, 19(8), 1857-1867 (2015-03-11)
In diabetes, hyperglycaemia causes up-regulation of endothelin 1 (ET-1) and transforming growth factor beta 1 (TGF-β1). Previously we showed glucose reduces sirtuin1 (SIRT1), a class III histone deacetylase. Here, we investigated the regulatory role of SIRT1 on ET-1 and TGF-β1
Andrew Godwin et al.
Shock (Augusta, Ga.), 43(1), 24-30 (2014-09-05)
Cold-inducible RNA-binding protein (CIRP) is a nuclear protein that has been recently identified as a novel inflammatory mediator in hemorrhagic shock and sepsis. We hypothesized that CIRP acts as a potent inflammatory mediator in hepatic ischemia-reperfusion (I/R), and thus blocking
Yasushi Itoh et al.
PLoS pathogens, 10(6), e1004192-e1004192 (2014-06-20)
Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype often cause severe pneumonia and multiple organ failure in humans, with reported case fatality rates of more than 60%. To develop a clinical antibody therapy, we generated a human-mouse chimeric
Jessica P Otis et al.
Disease models & mechanisms, 8(3), 295-309 (2015-01-31)
Improved understanding of lipoproteins, particles that transport lipids throughout the circulation, is vital to developing new treatments for the dyslipidemias associated with metabolic syndrome. Apolipoproteins are a key component of lipoproteins. Apolipoproteins are proteins that structure lipoproteins and regulate lipid
Aquagenic wrinkling: a unique facial presentation.
Christopher Stamey et al.
Journal of the American Academy of Dermatology, 71(4), e150-e152 (2014-09-16)
Zhenfei Chen et al.
International journal of clinical and experimental pathology, 8(5), 4614-4626 (2015-07-21)
MicroRNA-22 (miR-22) was previously reported to elicit cardiac myocyte hypertrophy and had an anti-apoptotic effect on neurons. However, its effects on cardiac myocyte apoptosis and cardiac function during ischemia and reperfusion (I/R) are not clear. In the present study, we
Ying Li et al.
Lab on a chip, 15(16), 3300-3306 (2015-07-15)
Quantitative assays are of great importance for point-of-care (POC) diagnostics because they can offer accurate information on the analytes. However, current POC devices often require an accessory instrument to give quantitative readouts for protein biomarkers, especially for those at very
Nguyen Thuy Tram et al.
Journal of water and health, 12(4), 896-900 (2014-12-05)
The study was done to assess the level of fecal (Escherichia coli) and protozoan parasite (Cryptosporidium spp. and Giardia spp.) contamination in water used by traders to moisten vegetables at markets in Hanoi, Vietnam. A total of 200 splashing water
Pooneh Khoshakhlagh et al.
Journal of pharmaceutical sciences, 104(7), 2213-2224 (2015-05-13)
A set of biorelevant media "fasted-state simulated intestinal fluid with cholesterol (FaSSIF-C)" for the in vitro study of intestinal drug dissolution in the duodenum was developed. These contain cholesterol at the same levels as in human bile: the cholesterol content
William J Rayfield et al.
Biotechnology progress, 31(3), 765-774 (2015-04-29)
Controlling viral contamination is an important issue in the process development of monoclonal antibodies (MAbs) produced from mammalian cell lines. Virus filtration (VF) has been demonstrated to be a robust and effective clearance step which can provide ≥4 logs of
Mateus B Pereira et al.
Journal of AOAC International, 97(4), 987-994 (2014-08-26)
Pollution of water sources by pesticides is a result of intensive use of these compounds, and the establishment of analytical methods for monitoring programs is very important. This paper presents a method for the determination of multiclass pesticide residues in
A new wrinkle.
Walter H C Burgdorf et al.
JAMA dermatology, 151(1), 14-14 (2015-01-15)
Abbas M Walji et al.
ChemMedChem, 10(2), 245-252 (2014-12-04)
Developing new antiretroviral therapies for HIV-1 infection with potential for less frequent dosing represents an important goal within drug discovery. Herein, we present the discovery of ethyl (1-((4-((4-fluorobenzyl)carbamoyl)-1-methyl-2-(2-(5-methyl- 1,3,4-oxadiazole-2-carboxamido)propan-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)ethyl) carbonate (MK-8970), a highly optimized prodrug of raltegravir (Isentress). Raltegravir is a
Yu Huang et al.
Bioresource technology, 181, 224-230 (2015-02-07)
In this study, steam explosion pretreatment was performed in cotton stalks, leading to 5-6 folds enhancements on biomass enzymatic saccharification distinctive in Gossypium barbadense and Gossypium hirsutum species. Sequential 1% H2SO4 pretreatment could further increase biomass digestibility of the steam-exploded
Felicity Yaqin Han et al.
Behavioural pharmacology, 25(8), 732-740 (2014-10-18)
Chemotherapy-induced peripheral neuropathy (CIPN) is the major dose-limiting side-effect of many front-line anticancer drugs. This study was designed to establish and pharmacologically characterize a refined rat model of cisplatin-induced CIPN. Adult male Sprague-Dawley rats received four (n=18) or five (n=18)
Xiao-jun Chen et al.
BMC medical genetics, 16, 11-11 (2015-05-01)
Polymorphisms of the CC chemokine receptor 6 (CCR6) and RNASET2 tag SNP have been shown to be associated with the susceptibility to several immune-related diseases. This study was conducted to identify the association of CCR6 and RNASET2 tag SNP with
Jasenka Kraljevic et al.
Medicine and science in sports and exercise, 47(12), 2504-2512 (2015-06-10)
Exercise training reduces pathological remodeling and improves cardiac function in ischemic heart failure; however, causal mechanisms underlying the cardiac benefits of exercise are poorly understood. Because opening of adenosine triphosphate (ATP)-sensitive K ⁺(KATP) channels protects the heart during myocardial stress
Stefan Opitz et al.
Analytical and bioanalytical chemistry, 407(4), 1107-1118 (2014-11-27)
Triton X-100 has been widely used in many analytical and preparative protocols for a long time. Nevertheless, mass spectrometry, chromatographic separation, and spectrophotometric readout may be considerably hampered by this detergent due to signal suppression, complex formation, and high blank
Eric Durandau et al.
BMC biology, 13, 55-55 (2015-08-02)
Mitogen activated protein kinases (MAPK) play an essential role in integrating extra-cellular signals and intra-cellular cues to allow cells to grow, adapt to stresses, or undergo apoptosis. Budding yeast serves as a powerful system to understand the fundamental regulatory mechanisms
Johan Courjon et al.
Toxins, 7(10), 4131-4142 (2015-10-27)
It is crucial to define risk factors that contribute to host invasion by Staphylococcus aureus. Here, we demonstrate that the chromosomally encoded EDIN-B isoform from S. aureus contributes to the onset of bacteremia during the course of pneumonia. Deletion of
Julien Haran et al.
PloS one, 10(7), e0134126-e0134126 (2015-07-30)
Mountain ranges may delimit the distribution of native species as well as constitute potential barriers to the spread of invasive species. The invasive pinewood nematode, Bursaphelenchus xylophilus, is a severe forest pest inducing pine wilt disease. It is vectored in
Hamid M Said
American journal of physiology. Gastrointestinal and liver physiology, 305(9), G601-G610 (2013-08-31)
This review focuses on recent advances in our understanding of the mechanisms and regulation of water-soluble vitamin (WSV) transport in the large intestine and pancreas, two important organs of the digestive system that have only recently received their fair share
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