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George R Kracke et al.
ChemMedChem, 10(1), 62-67 (2014-11-26)
Clinically there is a need for local anesthetics with a greater specificity of action on target cells and longer duration. We have synthesized a series of local anesthetic derivatives we call boronicaines in which the aromatic phenyl ring of lidocaine
Chemistry (Weinheim An Der Bergstrasse, Germany), 12, 5657-5657 (2006)
Santos Fustero et al.
Organic letters, 8(18), 4129-4132 (2006-08-25)
The synthesis of new beta,beta-difluorinated cyclic quaternary alpha-amino acid derivatives 1 in which a ring-closing metathesis reaction (RCM) constitutes the key step is described. The approach employs imidoyl chlorides 3 as fluorinated building blocks, and the overall process involves the
Wolfe, J. P.; Wagaw, S.; Buchwald, S. L.
Journal of the American Chemical Society, 118, 7215-7215 (1996)
Crystal and molecular structure of tris (dibenzylideneacetone) dipalladium (0).
Pierpont CG and Mazza MC
Inorganic Chemistry, 13(8), 1891-1895 (1974)
Zhouen Zhang et al.
Journal of labelled compounds & radiopharmaceuticals, 57(8), 540-549 (2014-07-06)
The nucleosides zidovudine (AZT), stavudine (d4T), and telbivudine (LdT) are approved for use in the treatment of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. To promote positron emission tomography (PET) imaging studies on their pharmacokinetics, pharmacodynamics, and
Tetrahedron Letters, 33, 4859-4859 (1992)
Chung-Yao Wu et al.
Journal of immunology (Baltimore, Md. : 1950), 204(6), 1448-1461 (2020-02-16)
Tris (dibenzylideneacetone) dipalladium (Tris DBA), a small-molecule palladium complex, has been shown to inhibit cell growth and proliferation in pancreatic cancer, lymphocytic leukemia, and multiple myeloma. In the current study, we examined the therapeutic effects of Tris DBA on glomerular
Xiaoqiang Shen et al.
Journal of the American Chemical Society, 132(40), 14076-14078 (2010-09-23)
The palladium-catalyzed conversion of aryl and vinyl triflates to aryl and vinyl halides (bromides and chlorides) has been developed using dialkylbiaryl phosphine ligands. A variety of aryl, heteroaryl, and vinyl halides can be prepared via this method in good to
Palladium-catalyzed β arylation of carboxylic esters.
Alice Renaudat et al.
Angewandte Chemie (International ed. in English), 49(40), 7261-7265 (2010-08-21)
Anant R Kapdi et al.
Journal of the American Chemical Society, 135(22), 8388-8399 (2013-05-25)
Pd(0)2(dba)3 (dba = E,E-dibenzylidene acetone) is the most widely used Pd(0) source in Pd-mediated transformations. Pd(0)2(dba-Z)3 (Z = dba aryl substituents) complexes exhibit remarkable and differential catalytic performance in an eclectic array of cross-coupling reactions. The precise structure of these
European Journal of Inorganic Chemistry, 6, 1262-1269 (2004)
Littke, A. F.; Dai, C.; Fu, G.C.
Journal of the American Chemical Society, 122, 4020-4020 (2000)
Matthew H Katcher et al.
Journal of the American Chemical Society, 132(49), 17402-17404 (2010-11-23)
The enantioselective fluorination of readily available cyclic allylic chlorides with AgF has been accomplished using a Pd(0) catalyst and Trost bisphosphine ligand. The reactions proceed with unprecedented ease of operation for Pd-mediated nucleophilic fluorination, allowing access to highly enantioenriched cyclic
Martin Arthuis et al.
Chemical communications (Cambridge, England), 46(41), 7810-7812 (2010-09-21)
A novel and fully chemo- and stereoselective three component strategy leading to Z-α-chloroacrylates by a Pd(0)-catalyzed reaction of CO (1 atm) with 1,1-dichloro-1-alkenes and various alcohols is disclosed. This catalytic approach compares favourably with the Wittig type strategies as α-chloroacrylates
Satoshi Suetsugu et al.
Organic letters, 16(3), 996-999 (2014-01-28)
The total synthesis of (-)-aurantioclavine (1) was accomplished based on an intramolecular asymmetric amination of allyl carbonate 3 containing a p-tosylamide group. The reaction using tris(dibenzylideneacetone)dipalladium(0), tBu-phosphinooxazoline, and Bu4NCl in CH2Cl2 gave azepane 2 in 77% yield with 95% enantiomeric
Michael J Ardolino et al.
Tetrahedron, 71(37), 6409-6413 (2015-08-19)
While Pd-catalyzed allyl-allyl cross-couplings in the presence of small-bite-angle bidentate ligands reliably furnish the branched regioisomer with high levels of selectivity, cross-couplings in the presence of large-bite-angle bidentate ligands give varying, often unpredictable, levels of selectivity. In a combined computational
Kawatsura, M.; Hartwig, J. F.
Journal of the American Chemical Society, 121, 1473-1473 (1999)
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