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322415

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Laurence C Cadalbert et al.
PloS one, 10(6), e0131066-e0131066 (2015-06-27)
Barth syndrome is an X-linked mitochondrial disease, symptoms of which include neutropenia and cardiac myopathy. These symptoms are the most significant clinical consequences of a disease, which is increasingly recognised to have a variable presentation. Mutation in the Taz gene
Weilin Guo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 157-165 (2015-03-18)
Intranasal delivery is emerging as a promising alternative for oral or intravenous administration of central nervous system (CNS) drugs, such as pramipexole which is widely used for the treatment of Parkinson's disease. To evaluate the effectiveness of intranasal delivery of
Sabiha Kazim et al.
Molecular cancer therapeutics, 14(7), 1570-1581 (2015-05-03)
Pancreatic cancer is an aggressive and deadly malignancy responsible for the death of over 37,000 Americans each year. Gemcitabine-based therapy is the standard treatment for pancreatic cancer but has limited efficacy due to chemoresistance. In this study, we evaluated the
Cristina Pavan et al.
Particle and fibre toxicology, 11, 76-76 (2014-12-20)
The hemolytic activity of inhaled particles such as silica has been widely investigated in the past and represents a usual toxicological endpoint to characterize particle reactivity despite the fact that red blood cells (RBCs) are not involved in the pathogenesis
Carsten Skarke et al.
Journal of lipid research, 56(9), 1808-1820 (2015-07-17)
Resolvins, maresins, and protectins can be formed from fish oils. These specialized pro-resolving mediators (SPMs) have been implicated in the resolution of inflammation. Synthetic versions of such SPMs exert anti-inflammatory effects in vitro and when administered to animal models. However
Emin Ozbek et al.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 13(3), 262-272 (2014-12-30)
Mesenchymal stem cells hold promise for renal disease treatment. Vascular endothelial growth factor may heal tubule-interstitial fibrosis in unilateral ureteral obstruction by inhibiting epithelial-mesenchymal transition. We investigated the protective effect of vascular endothelial growth factor in transfected mesenchymal stem cells
Soile Ae Pakkanen et al.
Veterinary anaesthesia and analgesia, 42(5), 527-536 (2014-12-23)
To investigate MK-467 as part of premedication in horses anaesthetized with isoflurane. Experimental, crossover study with a 14 day wash-out period. Seven healthy horses. The horses received either detomidine (20 μg kg(-1) IV) and butorphanol (20 μg kg(-1) IV) alone (DET) or with MK-467 (200 μg kg(-1)
Anne Scheffler et al.
Toxicology letters, 234(2), 81-91 (2015-02-24)
After consumption of red clover-based dietary supplements, plasma concentrations of the isoflavone irilone (IRI) equal that of the well-investigated daidzein. Since some isoflavones are genotoxic, the potential of IRI to induce mutations was investigated. Gene mutations were determined by hypoxanthine-guanine
Shotaro Uehara et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(10), 1408-1416 (2015-08-01)
The common marmoset (Callithrix jacchus), a small New World monkey, has the potential for use in human drug development due to its evolutionary closeness to humans. Four novel cDNAs, encoding cytochrome P450 (P450) 2C18, 2C19, 2C58, and 2C76, were cloned
Magdalena Poplawska et al.
Journal of pharmaceutical and biomedical analysis, 94, 45-53 (2014-02-18)
The new compound - flibanserin - begun to appear as a synthetic adulterant in counterfeit herbal supplements used to stimulate women sexual drive. It was detected in two samples submitted to the Polish National Medicines Institute for analysis. The second
Anja Hartmann et al.
Journal of photochemistry and photobiology. B, Biology, 149, 149-155 (2015-06-13)
Extremophilic green algae and cyanobacteria are the most abundant species in high mountain habitats, where rough climate conditions such as temperature differences, limited water retention and high ultraviolet (UV) radiation are the cause for a restricted biological diversity in favor
Agnieszka Szuba et al.
Journal of proteomics, 126, 200-217 (2015-06-14)
The presented study verified the possibility of using proteomics as a tool for investigating poplars growing on obviously separate plots. The examination covered poplars planted on grassland irrigated for 40 years with potato industry wastewater and in a plot appropriate
Mônica Siqueira Ferreira et al.
International journal for parasitology, 45(6), 385-391 (2015-03-31)
Finding specific molecular targets and the mechanism of action of praziquantel in the treatment of schistosomiasis remains a challenging task. Our efforts were focused on obtaining further information on worm composition before and after exposure to praziquantel in the treatment
Rocchina Sabia et al.
Journal of chromatography. A, 1363, 144-149 (2014-08-21)
Diazepam and the structurally related 1,4-benzodiazepin-2-ones tetrazepam, prazepam and flunitrazepam are chiral molecules because they adopt a ground state conformation featuring a non-planar seven membered ring devoid of any reflection-symmetry element. The two conformational enantiomers of this class of benzodiazepines
Bernhard Kluger et al.
Analytical chemistry, 86(23), 11533-11537 (2014-11-06)
An untargeted metabolomics workflow for the detection of metabolites derived from endogenous or exogenous tracer substances is presented. To this end, a recently developed stable isotope-assisted LC-HRMS-based metabolomics workflow for the global annotation of biological samples has been further developed
Anastasia Koltsakidou et al.
Journal of chromatography. A, 1377, 46-54 (2014-12-30)
In the present report, a simple and cost-effective method for the determination of twelve US EPA priority polycyclic aromatic hydrocarbons (PAHs) in honey samples after salting-assisted liquid-liquid extraction and UHPLC with fluorescence detection is proposed. The sample treatment is based
Maxime Favier et al.
Chemosphere, 136, 32-41 (2015-05-04)
Phenazone-type pharmaceuticals, such as aminopyrine, metamizole, phenazone and propyphenazone, are widely used analgesics that have been detected in wastewater treatment plant effluents in μg L(-1) concentrations. Acetamido antipyrine (AAA) and formyl aminoantipyrine (FAA) - the main metabolites of aminopyrine and
Nadège Minois et al.
PloS one, 9(7), e102435-e102435 (2014-07-11)
Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating
Ce Zhang et al.
The Kaohsiung journal of medical sciences, 31(8), 398-404 (2015-08-01)
The purpose of this study was to investigate the combined effects of Ginkgo biloba extract and phenytoin (PHT) sodium as a dose regimen simulating the clinical treatment of patients with epilepsy, on P-glycoprotein (P-GP) overexpression in a pentylenetetrazole-kindled mouse model
Sujan Badal et al.
The Journal of biological chemistry, 290(36), 22287-22297 (2015-07-25)
Fluoroquinolones (FQ) are powerful broad-spectrum antibiotics whose side effects include renal damage and, strangely, tendinopathies. The pathological mechanisms underlying these toxicities are poorly understood. Here, we show that the FQ drugs norfloxacin, ciprofloxacin, and enrofloxacin are powerful iron chelators comparable
Yadi Yang et al.
Journal of ethnopharmacology, 168, 279-286 (2015-04-12)
Seeds of Peganum harmala Linn are traditionally used as folk medical herb in Uighur medicine in China to treat disorders of hemiplegia and amnesia. Previously studies have proved that dominating alkaloids in P. harmala show significant inhibitory activities on the
Yiming Zhang et al.
Journal of immunotoxicology, 12(1), 81-91 (2014-05-16)
Innate defenses against environmental particulate exposures can become deficient when physiological background of the organism is unbalanced. Even those exposures considered innocuous may then become harmful. For example, one of the important inherent risks of pregnancy is increased inflammatory responsiveness
Ming Lei et al.
Journal of pharmaceutical sciences, 104(3), 995-1004 (2014-12-30)
The biopharmaceutical industry increasingly demands thorough characterization of protein conformation and conformational dynamics to ensure product quality and consistency. Here, we present a chromatography-based method that is able to characterize protein conformation and conformational dynamics at peptide level resolution in
Baolian Wang et al.
Biomedical chromatography : BMC, 29(9), 1393-1398 (2015-02-14)
A simple, rapid and sensitive method was developed for the simultaneous quantification of curdione, furanodiene and germacrone in rabbit plasma using a LC-MS/MS analysis. The plasma sample preparation was a simple deproteinization by the addition of 3 vols of acetonitrile
Anna Scislowska-Czarnecka et al.
Journal of biomedical materials research. Part A, 103(12), 3965-3977 (2015-05-28)
Here, we report on modification of one of the model biomedical polymers, poly L-lactide-co-glycolide (PLGA; 85:15), by reactive ion etching (RIE) oxygen plasma treatment. PLGA's major disadvantage is high hydrophobicity which restrains binding of cell-adhesive proteins and host cells. In
Satoshi Kofuji et al.
Cancer discovery, 5(7), 730-739 (2015-04-18)
Inositol polyphosphate 4-phosphatase B (INPP4B) has been identified as a tumor suppressor mutated in human breast, ovary, and prostate cancers. The molecular mechanism underlying INPP4B's tumor-suppressive role is currently unknown. Here, we demonstrate that INPP4B restrains tumor development by dephosphorylating
Hui Xiong et al.
Fitoterapia, 103, 33-45 (2015-03-12)
The phytochemical investigation of the ethanol extract from the stems of Entada phaseoloides (L.) Merr (also called "Guo Gang Long") led to the isolation of eleven triterpene saponins (1-11). Their structures were elucidated by extensive spectroscopic methods including 1D- ((1)H
Gema Pereira-Caro et al.
Free radical biology & medicine, 84, 206-214 (2015-03-25)
Orange juice (OJ) flavanones are bioactive polyphenols that are absorbed principally in the large intestine. Ingestion of probiotics has been associated with favorable changes in the colonic microflora. The present study examined the acute and chronic effects of orally administered
Sachine Yoshida et al.
Journal of neuroscience methods, 243, 63-67 (2015-02-04)
Mouse pups are invaluable model animals for understanding the molecular and neural basis underlying behavioral development. Stereotaxic operations with anesthetic control are useful tools in systems neuroscience. However, there are no commercially available anesthetic or stereotaxic devices for mouse pups.
W Leconet et al.
Oncogene, 33(47), 5405-5414 (2013-11-19)
AXL receptor tyrosine kinase (RTK) is implicated in proliferation and invasion of many cancers, particularly in pancreatic ductal adenocarcinoma (PDAC), for which new therapeutic options are urgently required. We investigated whether inhibition of AXL activity by specific monoclonal antibodies (mAbs)
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