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31642

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Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet.

Pan Yongming et al.

Cardiovascular diabetology, 14, 6-6 (2015-01-17)

A long-term high-fat/cholesterol (HFC) diet leads to insulin resistance (IR), which is associated with inflammation, atherosclerosis (AS), cardiac sympathovagal imbalance, and cardiac dysfunction. Peroxisome proliferator-activated receptors (PPARs) and nuclear factor ĸB (NF-κB) are involved in the development of IR-AS. Thus

Anti-leishmanial, anti-inflammatory and antimicrobial activities of phenolic derivatives from Tibouchina paratropica.

María I Tracanna et al.

Phytotherapy research : PTR, 29(3), 393-397 (2014-11-25)

A new phenolic derivative, 2,8-dihydroxy-7H-furo[2,3-f]chromen-7-one (1), together with isoquercitrin (2), was isolated from the aerial parts of Tibouchina paratropica. Compound structures were elucidated by spectroscopic methods. Both compounds show antimicrobial activity towards a panel of bacterial and fungal pathogens, and

Identification of NDUFAF1 in mediating K-Ras induced mitochondrial dysfunction by a proteomic screening approach.

Peng Wang et al.

Oncotarget, 6(6), 3947-3962 (2015-02-26)

Increase in aerobic glycolysis and mitochondrial dysfunction are important biochemical features observed in human cancers. Recent studies suggest oncogenic K-Ras can cause suppression of mitochondrial respiration and up-regulation of glycolytic activity through a yet unknown mechanism. Here we employed proteomic

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition.

Aaron Goldman et al.

Nature communications, 6, 6139-6139 (2015-02-12)

Understanding the emerging models of adaptive resistance is key to overcoming cancer chemotherapy failure. Using human breast cancer explants, in vitro cell lines, mouse in vivo studies and mathematical modelling, here we show that exposure to a taxane induces phenotypic

Responses of solid tumor cells in DMEM to reactive oxygen species generated by non-thermal plasma and chemically induced ROS systems.

Neha Kaushik et al.

Scientific reports, 5, 8587-8587 (2015-02-27)

In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma

Carthamus, Salvia and Stachys species protect neuronal cells against oxidative stress-induced apoptosis.

Marjan Tavakkoli et al.

Pharmaceutical biology, 52(12), 1550-1557 (2014-09-23)

Finding effective therapies for neurodegenerative diseases is of utmost importance for the aging population. Plants growing in Iran are rich sources of antioxidants and active phytochemicals. The protective capacity of plants, with a special focus on those with reported antioxidant

Endometriosis impairs bone marrow-derived stem cell recruitment to the uterus whereas bazedoxifene treatment leads to endometriosis regression and improved uterine stem cell engraftment.

Sharif Sakr et al.

Endocrinology, 155(4), 1489-1497 (2014-02-04)

Endometriosis is a disease defined by the ectopic growth of uterine endometrium. Stem cells contribute to the generation of endometriosis as well as to repair and regeneration of normal endometrium. Here we demonstrate that the selective estrogen receptor modulator bazedoxifene

Cloning, expression and characterization of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Wolbachia endosymbiont of human lymphatic filarial parasite Brugia malayi.

Mohd Shahab et al.

PloS one, 9(6), e99884-e99884 (2014-06-19)

Wolbachia, an endosymbiont of filarial nematode, is considered a promising target for treatment of lymphatic filariasis. Although functional characterization of the Wolbachia peptidoglycan assembly has not been fully explored, the Wolbachia genome provides evidence for coding all of the genes

Intracellular delivery of cytochrome c by galactosylated albumin to hepatocarcinoma cells.

Tzyy-Harn Yeh et al.

Journal of drug targeting, 22(6), 528-535 (2014-04-16)

In some cancer cells, translocation of cytochrome c (Cyt c) from mitochondria to the cytoplasma is inhibited. This inhibition prevents cells from undergoing apoptotic cell death and can lead to uncontrolled cell growth. Increasing cytoplasmic concentration of Cyt c can

Tungsten carbide nanotubes supported platinum nanoparticles as a potential sensing platform for oxalic acid.

Thandavarayan Maiyalagan et al.

Analytical chemistry, 86(15), 7849-7857 (2014-07-16)

Supported tungsten carbide is an efficient and vital nanomaterial for the development of high-performance, sensitive, and selective electrochemical sensors. In this work, tungsten carbide with tube-like nanostructures (WC NTs) supported platinum nanoparticles (PtNPs) are synthesized and explored as an efficient

Brain malformations associated with Knobloch syndrome--review of literature, expanding clinical spectrum, and identification of novel mutations.

Ahmet Okay Caglayan et al.

Pediatric neurology, 51(6), 806-813 (2014-12-03)

Knobloch syndrome is a rare, autosomal recessive, developmental disorder characterized by stereotyped ocular abnormalities with or without occipital skull deformities (encephalocele, bone defects, and cutis aplasia). Although there is clear heterogeneity in clinical presentation, central nervous system malformations, aside from

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration.

Sam Chen et al.

Journal of controlled release : official journal of the Controlled Release Society, 196, 106-112 (2014-10-07)

Recently developed lipid nanoparticle (LNP) formulations of siRNA have proven to be effective agents for hepatocyte gene silencing following intravenous administration with at least three LNP-siRNA formulations in clinical trials. The aim of this work was to develop LNP-siRNA systems

"FoxP3 Hunting" during infection with Francisella tularensis.

R V D'Elia et al.

International journal of immunopathology and pharmacology, 27(4), 585-595 (2015-01-13)

Francisella tularensis is a Gram-negative intracellular bacterium that can cause acute disease in mouse models of infection when administered via the inhalational route. The immune response to a pulmonary infection is typified by an initial lack of pro-inflammatory cytokines, followed

Renal tight junction proteins are decreased in cisplatin-induced nephrotoxicity in rats.

Joyce Trujillo et al.

Toxicology mechanisms and methods, 24(7), 520-528 (2014-07-24)

Cisplatin (CP) is an antineoplastic agent that induces nephrotoxicity and oxidative stress. It is unknown whether renal tight junction (TJ) proteins expression and localization are modified in CP-induced nephrotoxicity. To study if the expression of the TJ proteins occludin, claudin-2

Diagnostic performance study of an antigen microarray for the detection of antiphospholipid antibodies in human serum.

Aline R Schindler et al.

Clinical chemistry and laboratory medicine, 53(5), 801-808 (2014-10-03)

The parallelization of clinically relevant antigens in a microarray format is of growing importance due to the ability to measure multiple antigen-antibody interactions. With the development of a microarray for the detection of antiphospholipid antibodies we focussed on one important

Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats.

Jang-Won Lee et al.

Neurobiology of aging, 36(1), 505-518 (2014-09-02)

Mutations in leucine-rich repeated kinase 2 (LRRK2) cause autosomal dominant late-onset Parkinson's disease (PD), and the G2019S mutation in the kinase domain of LRRK2 is the most common genetic cause of familial PD. Enhanced kinase activity of G2019S LRRK2 is

NLRP3 inflammasome activation is essential for paraquat-induced acute lung injury.

Zhenning Liu et al.

Inflammation, 38(1), 433-444 (2014-10-24)

The innate immune response is important in paraquat-induced acute lung injury, but the exact pathways involved are not elucidated. The objectives of this study were to determine the specific role of the NLRP3 inflammasome in the process. Acute lung injury

Inorganic/organic hybrid solar cells: optimal carrier transport in vertically aligned silicon nanowire arrays.

Keisuke Sato et al.

Nanoscale, 6(11), 6092-6101 (2014-05-03)

Inorganic/organic hybrid radial heterojunction solar cells that combine vertically-aligned n-type silicon nanowires (SiNWs) with poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS) have great potential for replacing commercial Si solar cells. The chief advantage of such solar cells is that they exhibit higher absorbance for a

Gravimetric preparation and characterization of primary reference solutions of molybdenum and rhodium.

Angela Kaltenbach et al.

Analytical and bioanalytical chemistry, 407(11), 3093-3102 (2014-12-19)

Gravimetrically prepared mono-elemental reference solutions having a well-known mass fraction of approximately 1 g/kg (or a mass concentration of 1 g/L) define the very basis of virtually all measurements in inorganic analysis. Serving as the starting materials of all standard/calibration solutions, they

Inactivation of human salivary glutathione transferase P1-1 by hypothiocyanite: a post-translational control system in search of a role.

Raffaele Fabrini et al.

PloS one, 9(11), e112797-e112797 (2014-11-14)

Glutathione transferases (GSTs) are a superfamily of detoxifying enzymes over-expressed in tumor tissues and tentatively proposed as biomarkers for localizing and monitoring injury of specific tissues. Only scarce and contradictory reports exist about the presence and the level of these

REVOLUTA and WRKY53 connect early and late leaf development in Arabidopsis.

Yakun Xie et al.

Development (Cambridge, England), 141(24), 4772-4783 (2014-11-15)

As sessile organisms, plants have to continuously adjust growth and development to ever-changing environmental conditions. At the end of the growing season, annual plants induce leaf senescence to reallocate nutrients and energy-rich substances from the leaves to the maturing seeds.

Apoptotic cells ameliorate chronic intestinal inflammation by enhancing regulatory B-cell function.

Md Mesbah Uddin Ansary et al.

Inflammatory bowel diseases, 20(12), 2308-2320 (2014-10-31)

Apoptosis is a programmed physiological death of unwanted cells, and handling of apoptotic cells (ACs) is thought to have profound effects on immune-mediated disorders. However, there is scant information regarding the role of ACs in intestinal inflammation, in which immune

Nox1 upregulates the function of vascular T-type calcium channels following chronic nitric oxide deficit.

Lauren Howitt et al.

Pflugers Archiv : European journal of physiology, 467(4), 727-735 (2014-06-14)

Cardiovascular disease is characterised by reduced nitric oxide bioavailability resulting from oxidative stress. Our previous studies have shown that nitric oxide deficit per se increases the contribution of T-type calcium channels to vascular tone through increased superoxide from NADPH oxidase

Increased interleukin 21 and follicular helper T-like cells and reduced interleukin 10+ B cells in patients with new-onset systemic lupus erythematosus.

Li Wang et al.

The Journal of rheumatology, 41(9), 1781-1792 (2014-07-17)

To elucidate the potential role of follicular helper T cells (TFH) and interleukin 10 (IL-10)+ B cells in the development of systemic lupus erythematosus (SLE). The numbers of peripheral blood CD27+, CD38+, CD86+, CD95+, IL-10+ B cells, and inducible T

Morphology and gene expression profile of the submandibular gland of androgen-receptor-deficient mice.

Kannika Adthapanyawanich et al.

Archives of oral biology, 60(2), 320-332 (2014-12-02)

In the submandibular gland (SMG) of mice, the granular convoluted tubule (GCT) develops preferentially in males dependent on androgens. To clarify the molecular mechanism of androgen action in SMG, we examined the SMG of mice deficient for the androgen receptor

Correlation of EGFR expression, gene copy number and clinicopathological status in NSCLC.

Rania Gaber et al.

Diagnostic pathology, 9, 165-165 (2014-09-18)

Epidermal Growth Factor Receptor (EGFR) targeting therapies are currently of great relevance for the treatment of lung cancer. For this reason, in addition to mutational analysis immunohistochemistry (IHC) of EGFR in lung cancer has been discussed for the decision making

The pharmacological chaperone AT2220 increases the specific activity and lysosomal delivery of mutant acid alpha-glucosidase, and promotes glycogen reduction in a transgenic mouse model of Pompe disease.

Richie Khanna et al.

PloS one, 9(7), e102092-e102092 (2014-07-19)

Pompe disease is an inherited lysosomal storage disorder that results from a deficiency in acid α-glucosidase (GAA) activity due to mutations in the GAA gene. Pompe disease is characterized by accumulation of lysosomal glycogen primarily in heart and skeletal muscles

Hide and seek: a comparative autoradiographic in vitro investigation of the adenosine A3 receptor.

D Haeusler et al.

European journal of nuclear medicine and molecular imaging, 42(6), 928-939 (2015-03-06)

Since the adenosine A3 receptor (A3R) is considered to be of high clinical importance in the diagnosis and treatment of ischaemic conditions (heart and brain), glaucoma, asthma, arthritis, cancer and inflammation, a suitable and selective A3R PET tracer such as

Microscopic analysis of molar--incisor malformation.

Hyo-Seol Lee et al.

Oral surgery, oral medicine, oral pathology and oral radiology, 119(5), 544-552 (2014-12-30)

Molar-incisor malformation (MIM) is a newly discovered type of dental anomaly that involves a characteristic root malformation of the permanent first molars. The aim of this study was to reveal the microstructure of MIM teeth in order to determine their

A non-pediocin low molecular weight antimicrobial peptide produced by Pediococcus pentosaceus strain IE-3 shows increased activity under reducing environment.

Pradip K Singh et al.

BMC microbiology, 14, 226-226 (2014-08-28)

Species of the genus Pediococcus are known to produce antimicrobial peptides such as pediocin-like bacteriocins that contain YGNGVXC as a conserved motif at their N-terminus. Until now, the molecular weight of various bacteriocins produced by different strains of the genus

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