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Pan Yongming et al.
Cardiovascular diabetology, 14, 6-6 (2015-01-17)
A long-term high-fat/cholesterol (HFC) diet leads to insulin resistance (IR), which is associated with inflammation, atherosclerosis (AS), cardiac sympathovagal imbalance, and cardiac dysfunction. Peroxisome proliferator-activated receptors (PPARs) and nuclear factor ĸB (NF-κB) are involved in the development of IR-AS. Thus
María I Tracanna et al.
Phytotherapy research : PTR, 29(3), 393-397 (2014-11-25)
A new phenolic derivative, 2,8-dihydroxy-7H-furo[2,3-f]chromen-7-one (1), together with isoquercitrin (2), was isolated from the aerial parts of Tibouchina paratropica. Compound structures were elucidated by spectroscopic methods. Both compounds show antimicrobial activity towards a panel of bacterial and fungal pathogens, and
Peng Wang et al.
Oncotarget, 6(6), 3947-3962 (2015-02-26)
Increase in aerobic glycolysis and mitochondrial dysfunction are important biochemical features observed in human cancers. Recent studies suggest oncogenic K-Ras can cause suppression of mitochondrial respiration and up-regulation of glycolytic activity through a yet unknown mechanism. Here we employed proteomic
Aaron Goldman et al.
Nature communications, 6, 6139-6139 (2015-02-12)
Understanding the emerging models of adaptive resistance is key to overcoming cancer chemotherapy failure. Using human breast cancer explants, in vitro cell lines, mouse in vivo studies and mathematical modelling, here we show that exposure to a taxane induces phenotypic
Neha Kaushik et al.
Scientific reports, 5, 8587-8587 (2015-02-27)
In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to cell death in T98G, A549, HEK293 and MRC5 cell lines. For a comparison with plasma
Marjan Tavakkoli et al.
Pharmaceutical biology, 52(12), 1550-1557 (2014-09-23)
Finding effective therapies for neurodegenerative diseases is of utmost importance for the aging population. Plants growing in Iran are rich sources of antioxidants and active phytochemicals. The protective capacity of plants, with a special focus on those with reported antioxidant
Sharif Sakr et al.
Endocrinology, 155(4), 1489-1497 (2014-02-04)
Endometriosis is a disease defined by the ectopic growth of uterine endometrium. Stem cells contribute to the generation of endometriosis as well as to repair and regeneration of normal endometrium. Here we demonstrate that the selective estrogen receptor modulator bazedoxifene
Mohd Shahab et al.
PloS one, 9(6), e99884-e99884 (2014-06-19)
Wolbachia, an endosymbiont of filarial nematode, is considered a promising target for treatment of lymphatic filariasis. Although functional characterization of the Wolbachia peptidoglycan assembly has not been fully explored, the Wolbachia genome provides evidence for coding all of the genes
Tzyy-Harn Yeh et al.
Journal of drug targeting, 22(6), 528-535 (2014-04-16)
In some cancer cells, translocation of cytochrome c (Cyt c) from mitochondria to the cytoplasma is inhibited. This inhibition prevents cells from undergoing apoptotic cell death and can lead to uncontrolled cell growth. Increasing cytoplasmic concentration of Cyt c can
Thandavarayan Maiyalagan et al.
Analytical chemistry, 86(15), 7849-7857 (2014-07-16)
Supported tungsten carbide is an efficient and vital nanomaterial for the development of high-performance, sensitive, and selective electrochemical sensors. In this work, tungsten carbide with tube-like nanostructures (WC NTs) supported platinum nanoparticles (PtNPs) are synthesized and explored as an efficient
Ahmet Okay Caglayan et al.
Pediatric neurology, 51(6), 806-813 (2014-12-03)
Knobloch syndrome is a rare, autosomal recessive, developmental disorder characterized by stereotyped ocular abnormalities with or without occipital skull deformities (encephalocele, bone defects, and cutis aplasia). Although there is clear heterogeneity in clinical presentation, central nervous system malformations, aside from
Sam Chen et al.
Journal of controlled release : official journal of the Controlled Release Society, 196, 106-112 (2014-10-07)
Recently developed lipid nanoparticle (LNP) formulations of siRNA have proven to be effective agents for hepatocyte gene silencing following intravenous administration with at least three LNP-siRNA formulations in clinical trials. The aim of this work was to develop LNP-siRNA systems
R V D'Elia et al.
International journal of immunopathology and pharmacology, 27(4), 585-595 (2015-01-13)
Francisella tularensis is a Gram-negative intracellular bacterium that can cause acute disease in mouse models of infection when administered via the inhalational route. The immune response to a pulmonary infection is typified by an initial lack of pro-inflammatory cytokines, followed
Joyce Trujillo et al.
Toxicology mechanisms and methods, 24(7), 520-528 (2014-07-24)
Cisplatin (CP) is an antineoplastic agent that induces nephrotoxicity and oxidative stress. It is unknown whether renal tight junction (TJ) proteins expression and localization are modified in CP-induced nephrotoxicity. To study if the expression of the TJ proteins occludin, claudin-2
Aline R Schindler et al.
Clinical chemistry and laboratory medicine, 53(5), 801-808 (2014-10-03)
The parallelization of clinically relevant antigens in a microarray format is of growing importance due to the ability to measure multiple antigen-antibody interactions. With the development of a microarray for the detection of antiphospholipid antibodies we focussed on one important
Jang-Won Lee et al.
Neurobiology of aging, 36(1), 505-518 (2014-09-02)
Mutations in leucine-rich repeated kinase 2 (LRRK2) cause autosomal dominant late-onset Parkinson's disease (PD), and the G2019S mutation in the kinase domain of LRRK2 is the most common genetic cause of familial PD. Enhanced kinase activity of G2019S LRRK2 is
Zhenning Liu et al.
Inflammation, 38(1), 433-444 (2014-10-24)
The innate immune response is important in paraquat-induced acute lung injury, but the exact pathways involved are not elucidated. The objectives of this study were to determine the specific role of the NLRP3 inflammasome in the process. Acute lung injury
Keisuke Sato et al.
Nanoscale, 6(11), 6092-6101 (2014-05-03)
Inorganic/organic hybrid radial heterojunction solar cells that combine vertically-aligned n-type silicon nanowires (SiNWs) with poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS) have great potential for replacing commercial Si solar cells. The chief advantage of such solar cells is that they exhibit higher absorbance for a
Angela Kaltenbach et al.
Analytical and bioanalytical chemistry, 407(11), 3093-3102 (2014-12-19)
Gravimetrically prepared mono-elemental reference solutions having a well-known mass fraction of approximately 1 g/kg (or a mass concentration of 1 g/L) define the very basis of virtually all measurements in inorganic analysis. Serving as the starting materials of all standard/calibration solutions, they
Raffaele Fabrini et al.
PloS one, 9(11), e112797-e112797 (2014-11-14)
Glutathione transferases (GSTs) are a superfamily of detoxifying enzymes over-expressed in tumor tissues and tentatively proposed as biomarkers for localizing and monitoring injury of specific tissues. Only scarce and contradictory reports exist about the presence and the level of these
Yakun Xie et al.
Development (Cambridge, England), 141(24), 4772-4783 (2014-11-15)
As sessile organisms, plants have to continuously adjust growth and development to ever-changing environmental conditions. At the end of the growing season, annual plants induce leaf senescence to reallocate nutrients and energy-rich substances from the leaves to the maturing seeds.
Md Mesbah Uddin Ansary et al.
Inflammatory bowel diseases, 20(12), 2308-2320 (2014-10-31)
Apoptosis is a programmed physiological death of unwanted cells, and handling of apoptotic cells (ACs) is thought to have profound effects on immune-mediated disorders. However, there is scant information regarding the role of ACs in intestinal inflammation, in which immune
Lauren Howitt et al.
Pflugers Archiv : European journal of physiology, 467(4), 727-735 (2014-06-14)
Cardiovascular disease is characterised by reduced nitric oxide bioavailability resulting from oxidative stress. Our previous studies have shown that nitric oxide deficit per se increases the contribution of T-type calcium channels to vascular tone through increased superoxide from NADPH oxidase
Li Wang et al.
The Journal of rheumatology, 41(9), 1781-1792 (2014-07-17)
To elucidate the potential role of follicular helper T cells (TFH) and interleukin 10 (IL-10)+ B cells in the development of systemic lupus erythematosus (SLE). The numbers of peripheral blood CD27+, CD38+, CD86+, CD95+, IL-10+ B cells, and inducible T
Kannika Adthapanyawanich et al.
Archives of oral biology, 60(2), 320-332 (2014-12-02)
In the submandibular gland (SMG) of mice, the granular convoluted tubule (GCT) develops preferentially in males dependent on androgens. To clarify the molecular mechanism of androgen action in SMG, we examined the SMG of mice deficient for the androgen receptor
Rania Gaber et al.
Diagnostic pathology, 9, 165-165 (2014-09-18)
Epidermal Growth Factor Receptor (EGFR) targeting therapies are currently of great relevance for the treatment of lung cancer. For this reason, in addition to mutational analysis immunohistochemistry (IHC) of EGFR in lung cancer has been discussed for the decision making
Richie Khanna et al.
PloS one, 9(7), e102092-e102092 (2014-07-19)
Pompe disease is an inherited lysosomal storage disorder that results from a deficiency in acid α-glucosidase (GAA) activity due to mutations in the GAA gene. Pompe disease is characterized by accumulation of lysosomal glycogen primarily in heart and skeletal muscles
D Haeusler et al.
European journal of nuclear medicine and molecular imaging, 42(6), 928-939 (2015-03-06)
Since the adenosine A3 receptor (A3R) is considered to be of high clinical importance in the diagnosis and treatment of ischaemic conditions (heart and brain), glaucoma, asthma, arthritis, cancer and inflammation, a suitable and selective A3R PET tracer such as
Hyo-Seol Lee et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 119(5), 544-552 (2014-12-30)
Molar-incisor malformation (MIM) is a newly discovered type of dental anomaly that involves a characteristic root malformation of the permanent first molars. The aim of this study was to reveal the microstructure of MIM teeth in order to determine their
Pradip K Singh et al.
BMC microbiology, 14, 226-226 (2014-08-28)
Species of the genus Pediococcus are known to produce antimicrobial peptides such as pediocin-like bacteriocins that contain YGNGVXC as a conserved motif at their N-terminus. Until now, the molecular weight of various bacteriocins produced by different strains of the genus
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