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T Jickells et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368(1621), 20130115-20130115 (2013-05-29)
Atmospheric organic nitrogen (ON) appears to be a ubiquitous but poorly understood component of the atmospheric nitrogen deposition flux. Here, we focus on the ON components that dominate deposition and do not consider reactive atmospheric gases containing ON such as...
Carsten Skarke et al.
Journal of lipid research, 56(9), 1808-1820 (2015-07-17)
Resolvins, maresins, and protectins can be formed from fish oils. These specialized pro-resolving mediators (SPMs) have been implicated in the resolution of inflammation. Synthetic versions of such SPMs exert anti-inflammatory effects in vitro and when administered to animal models. However...
Baojing Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(28), 8792-8797 (2015-07-01)
Reactive nitrogen (Nr) plays a central role in food production, and at the same time it can be an important pollutant with substantial effects on air and water quality, biological diversity, and human health. China now creates far more Nr...
Kevork Hagopian et al.
PloS one, 10(4), e0124204-e0124204 (2015-04-17)
Shc proteins interact with the insulin receptor, indicating a role in regulating glycolysis. To investigate this idea, the activities of key glycolytic regulatory enzymes and metabolites levels were measured in skeletal muscle from mice with low levels of Shc proteins...
Ji-Hye Yun et al.
Biochimica et biophysica acta, 1848(6), 1294-1302 (2015-03-11)
The melanocortin receptors (MCRs) are members of the G protein-coupled receptor (GPCR) 1 superfamily with seven transmembrane (TM) domains. Among them, the melanocortin-4 receptor (MC4R) subtype has been highlighted recently by genetic studies in obese humans. In particular, in a...
Christabelle J Darcy et al.
Critical care (London, England), 18(4), R163-R163 (2014-08-03)
Impaired T cell function in sepsis is associated with poor outcome, but the mechanisms are unclear. In cancer, arginase-expressing myeloid derived suppressor cells (MDSCs) deplete arginine, impair T cell receptor CD3 zeta-chain expression and T cell function and are linked...
Naci Cine et al.
Oncology reports, 32(3), 1078-1086 (2014-06-28)
Breast cancer is the most common cancer among women and accounts for 23% of all female types of cancers. It is well recognized that breast cancer represents a heterogeneous group of tumors, and the molecular events involved in the progression...
Xiaoyuan He et al.
PloS one, 10(8), e0136185-e0136185 (2015-08-27)
To study the main molecular mechanisms responsible for itraconazole resistance in clinical isolates of Candida krusei. The 14α-demethylases encoded by ERG11 gene in the 16 C.krusei clinical isolates were amplified by polymerase chain reaction (PCR), and their nucleotide sequences were...
Ying Yu et al.
Oncology reports, 34(1), 407-414 (2015-05-09)
Cisplatin (CDDP) is a chemotherapeutic drug that is often used for the treatment of hepatoblastoma. However, many patients acquire resistance to therapeutic agents leading to local and distant treatment failure. It has been shown that suppression survivin contributed to the...
Wally C van Heeswijk et al.
Microbiology and molecular biology reviews : MMBR, 77(4), 628-695 (2013-12-04)
We present a comprehensive overview of the hierarchical network of intracellular processes revolving around central nitrogen metabolism in Escherichia coli. The hierarchy intertwines transport, metabolism, signaling leading to posttranslational modification, and transcription. The protein components of the network include an...
Yan Li et al.
Experimental eye research, 135, 174-181 (2015-03-11)
Retinal ischemia is a common risk factor for visual impairment and blindness. Two common changes after retinal ischemia are retinal ganglion cell (RGC) loss and Müller glial cell (MGC)-mediated endogenous repair. Matrix metalloproteinase 9 (MMP-9) has been shown to be...
Nassrene Y Elmadhun et al.
The Journal of surgical research, 193(2), 536-542 (2014-06-26)
Epidemiologic studies have demonstrated that daily low to moderate alcohol consumption is cardioprotective as compared with abstainers and high alcohol consumption. Our group reported that alcohol consumption improves angiogenesis in chronically ischemic myocardium. We developed a clinically relevant follow-up study...
Majambu Mbikay et al.
Journal of diabetes, 7(1), 74-84 (2014-02-20)
Proprotein convertase subtilisin/kexin-type 9 (PCSK9) downregulates clearance of plasma cholesterol by liver. Its inactivation increases this clearance, reducing cardiovascular risk. However, a lack of PCSK9 could also lead to cholesterol accumulation in pancreatic islet beta cells, impairing insulin secretion. We...
Aaron M Reedy et al.
General and comparative endocrinology, 208, 57-63 (2014-08-27)
Hormones play key, functional roles in mediating the tradeoff between survival and reproduction. Glucocorticoid hormones can inhibit reproduction and improve chances of survival during periods of stress. However, glucocorticoid hormones are, at times, also associated with successfully engaging in energetically...
Tatsuro Nakamura et al.
Nature communications, 6, 7514-7514 (2015-07-15)
Prostaglandin D2 (PGD2) is a major prostanoid secreted mainly by mast cells. Although PGD2 has been identified as a modulator of allergic inflammation, its precise role remains unclear. Here we investigate the role of PGD2 in food allergy. Oral administration...
Katherine M Murphy et al.
American journal of botany, 102(11), 1931-1937 (2015-11-04)
Although anthers of Zea mays, Oryza sativa, and Arabidopsis thaliana have been studied intensively using genetic and biochemical analyses in the past 20 years, few updates to anther anatomical and ultrastructural descriptions have been reported. For example, no transmission electron...
Erin Collins et al.
Journal of immunology (Baltimore, Md. : 1950), 193(9), 4381-4390 (2014-10-03)
Mesenchymal stem cells (MSCs) are useful in tissue repair but also possess immunomodulatory properties. Murine and uncontrolled human trials suggest efficacy of MSCs in treating lupus. Autologous cells are preferable; however, recent studies suggest that lupus-derived MSCs lack efficacy in...
Joshua Edgell et al.
Journal of environmental quality, 44(6), 1861-1870 (2015-12-08)
Organic agricultural systems are often assumed to be more sustainable than conventional farming, yet there has been little work comparing surface water quality from organic and conventional production, especially under the same cropping sequence. Our objective was to compare nutrient...
Kathrin M Scherer et al.
Journal of biomedical optics, 20(5), 051004-051004 (2014-10-28)
The photoisomerization of relatively nontoxic E-combretastatins to clinically active Z-isomers is shown to occur in solution through both one- and two-photon excitations at 340 and 625 nm, respectively. The photoisomerization is also demonstrated to induce mammalian cell death by a...
Victoria Gascón et al.
Molecules (Basel, Switzerland), 19(6), 7057-7071 (2014-06-03)
Siliceous ordered mesoporous materials (OMM) are gaining interest as supports for enzyme immobilization due to their uniform pore size, large surface area, tunable pore network and the introduction of organic components to mesoporous structure. We used SBA-15 type silica materials...
Zhicheng Jin et al.
The Journal of biological chemistry, 290(30), 18671-18677 (2015-06-14)
We investigated the compartmentation of the catabolism of dodecanedioate (DODA), azelate, and glutarate in perfused rat livers, using a combination of metabolomics and mass isotopomer analyses. Livers were perfused with recirculating or nonrecirculating buffer containing one fully (13)C-labeled dicarboxylate. Information...
Karen V Ambrose et al.
Scientific reports, 5, 10939-10939 (2015-06-10)
Epichloë spp. are symbiotic fungal endophytes of many cool season grasses. The presence of the fungal endophytes often confers insect, drought, and disease tolerance to the host grasses. The presence of the fungal endophytes within the host plants does not...
Su Chen et al.
Oncology reports, 33(5), 2207-2218 (2015-03-05)
Chordomas are locally destructive tumors with high rates of recurrence and a poor prognosis. The mechanisms involved in chordoma recurrence remain largely unknown. In the present study, we examined the proteomic profile of a chordoma primary tumor (CSO) and a...
Huan Ren et al.
Biochemical and biophysical research communications, 463(4), 504-509 (2015-05-25)
The repressor element-1 (RE1) silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) has an irreplaceable role during the differentiation of neurons. REST has multiple splice variants which link to various types of cancer. Previous work had highlighted the role of REST in...
Seong-wook Seo et al.
Journal of immunology (Baltimore, Md. : 1950), 195(4), 1732-1743 (2015-07-03)
The adenosine A2b receptor (Adora2b) has been implicated in cardioprotection from myocardial ischemia. As such, Adora2b was found to be critical in ischemic preconditioning (IP) or ischemia/reperfusion (IR) injury of the heart. Whereas Adora2b is present on various cells types...
Yoshiyuki Hattori et al.
International journal of pharmaceutics, 476(1-2), 289-298 (2014-10-08)
In this study, we developed novel siRNA transfer method to the liver by sequential intravenous injection of anionic polymer and cationic liposome/cholesterol-modified siRNA complex (cationic lipoplex). When cationic lipoplex was intravenously injected into mice, the accumulation of siRNA was mainly...
Brenda Oppert et al.
BMC genomics, 16, 968-968 (2015-11-20)
Phosphine is a valuable fumigant to control pest populations in stored grains and grain products. However, recent studies indicate a substantial increase in phosphine resistance in stored product pests worldwide. To understand the molecular bases of phosphine resistance in insects...
Ene Reimann et al.
Human genomics, 8, 20-20 (2014-12-17)
Osteosarcoma (OS) is a prevalent primary malignant bone tumour with unknown etiology. These highly metastasizing tumours are among the most frequent causes of cancer-related deaths. Thus, there is an urgent need for different markers, and with our study, we were...
Elina Esmaeilzadeh Gharehdaghi et al.
Nucleic acid therapeutics, 24(6), 420-427 (2014-10-02)
Chitosan nanoparticles were prepared using ultrasonication methodology at specific amplitudes and times of sonication. Subsequently, small interfering RNA (siRNA) was added to the solution at predetermined values of nitrogen to phosphorous ratio (N/P), and stirring time. Employing response surfaces generated...
Weimin Li et al.
Acta biochimica et biophysica Sinica, 47(2), 73-79 (2015-01-15)
Cholesterol-rich regions are attractive targets for studying metabolic disorders that involve accumulation of cholesterol. Despite efforts to develop probes for labelling cholesterol-rich regions in cells, few of these reagents have a low molecular weight. Previous studies have shown that the...