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270997

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Weilin Guo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 157-165 (2015-03-18)
Intranasal delivery is emerging as a promising alternative for oral or intravenous administration of central nervous system (CNS) drugs, such as pramipexole which is widely used for the treatment of Parkinson's disease. To evaluate the effectiveness of intranasal delivery of...
Marina Shestakova et al.
Chemosphere, 93(7), 1258-1267 (2013-08-21)
Dichloromethane (DCM) is a toxic volatile compound which is found in the ground waters and wastewaters of the pharmaceutical, chemical, textile, metal-working and petroleum industries. DCM inhibits the growth of aquatic organisms, induces cancer in animals and is potentially carcinogenic...
Anja Hartmann et al.
Journal of photochemistry and photobiology. B, Biology, 149, 149-155 (2015-06-13)
Extremophilic green algae and cyanobacteria are the most abundant species in high mountain habitats, where rough climate conditions such as temperature differences, limited water retention and high ultraviolet (UV) radiation are the cause for a restricted biological diversity in favor...
Rocchina Sabia et al.
Journal of chromatography. A, 1363, 144-149 (2014-08-21)
Diazepam and the structurally related 1,4-benzodiazepin-2-ones tetrazepam, prazepam and flunitrazepam are chiral molecules because they adopt a ground state conformation featuring a non-planar seven membered ring devoid of any reflection-symmetry element. The two conformational enantiomers of this class of benzodiazepines...
Anastasia Koltsakidou et al.
Journal of chromatography. A, 1377, 46-54 (2014-12-30)
In the present report, a simple and cost-effective method for the determination of twelve US EPA priority polycyclic aromatic hydrocarbons (PAHs) in honey samples after salting-assisted liquid-liquid extraction and UHPLC with fluorescence detection is proposed. The sample treatment is based...
Byeongtaek Oh et al.
Molecular pharmaceutics, 12(9), 3226-3236 (2015-07-15)
This study was aimed to develop and evaluate a smart nanosystem that targeted photothermal ablation of inflammatory macrophages in atherosclerotic plaque. Mannosylated-reduced graphene oxide (Man-rGO) was synthesized using three step procedures: (1) preparation of ox-GOs, (2) microwave-assisted synthesis of PEI-rGOs...
Weiwei Zhang et al.
Marine pollution bulletin, 99(1-2), 28-34 (2015-08-25)
Microplastics provide a mechanism for the long-range transport of hydrophobic chemical contaminants to remote coastal and marine locations. In this study, plastic resin pellets were collected from Zhengmingsi Beach and Dongshan Beach in China. The collected pellets were analyzed for...
Estefanía Concha-Graña et al.
Journal of chromatography. A, 1406, 19-26 (2015-06-25)
In this work a matrix solid-phase dispersion extraction method, followed by programmed temperature vaporization-gas chromatography-tandem mass spectrometry determination is proposed for the analysis of polycyclic aromatic hydrocarbons (PAHs) in moss samples. A devitalized, cultivated Sphagnum palustre L. moss clone obtained...
Poonam Saraf et al.
Pharmaceutical research, 32(9), 3087-3101 (2015-06-13)
The objective of this work was to compare the efficacy of self-assembling cyclic and linear RGD peptide amphiphiles as carriers for delivering paclitaxel to αvβ3 integrin overexpressing tumors. Linear (C18-ADA5-RGD) and cyclic (C18-ADA5-cRGDfK) peptide amphiphiles were synthesized and characterized for...
Yu Bon Man et al.
The Science of the total environment, 505, 261-268 (2014-12-03)
This study was to investigate removal efficiencies and profiles of 14 polybrominated diphenyl ether (PBDE) congeners by two different types of sewage treatment work (STW) in Hong Kong: Stonecutters Island STW (SCISTW) which uses chemically enhanced primary treatment (CEPT) process...
Estelle Bastien et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 14(12), 2203-2212 (2015-10-27)
There is currently great interest in the development of efficient and specific carrier delivery platforms for systemic photodynamic therapy. Therefore, we aimed to develop covalent conjugates between the photosensitizer chlorin e6 (Ce6) and PAMAM G4.5 dendrimers. Singlet oxygen generation (SOG)...
John Marshall et al.
The Journal of biological chemistry, 290(36), 22030-22048 (2015-06-24)
It is widely accepted that overactivation of NMDA receptors, resulting in calcium overload and consequent mitochondrial dysfunction in retinal ganglion neurons, plays a significant role in promoting neurodegenerative disorders such as glaucoma. Calcium has been shown to initiate a transient...
Malcolm E Tessensohn et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(1), 160-168 (2014-11-25)
Voltammetric experiments with 9,10-anthraquinone and 1,4-benzoquinone performed under controlled moisture conditions indicate that the hydrogen-bond strengths of alcohols in aprotic organic solvents can be differentiated by the electrochemical parameter ΔEp (red) =|Ep (red(1)) -Ep (red(2)) |, which is the potential...
Jiong Zou et al.
Biomaterials science, 3(7), 1078-1084 (2015-07-30)
Using the 3(rd) generation Grubbs' catalyst as the initiator, diblock brush polymer drug conjugates (BPDCs) were synthesized by sequential ring-opening metathesis polymerization (ROMP) of a hydrophilic poly(ethylene glycol) (PEG)-based norbornene (NB)-functionalized macromonomer and a hydrophobic paclitaxel (PTXL)-based NB-functionalized monomer. These...
Marco Nestola et al.
Analytical and bioanalytical chemistry, 407(1), 297-308 (2014-09-07)
An online normal-phase liquid chromatography-gas chromatography-mass spectrometry (HPLC-GC-MS) method was developed for the determination of vitamins D2 and D3 in selected food matrices. Transfer of the sample from HPLC to GC was realized by large volume on-column injection; detection was...
Yuanbo Li et al.
Talanta, 140, 81-87 (2015-06-07)
One of the hypotheses that may help explain the loss of honey bee colonies worldwide is the increasing potential for exposure of honey bees to complex mixtures of pesticides. To better understand this phenomenon, two multi-residue methods based on different...
Enkhtuul Tsogtbaatar et al.
Journal of experimental botany, 66(14), 4267-4277 (2015-02-26)
Pennycress (Thlaspi arvense L.), a plant naturalized to North America, accumulates high levels of erucic acid in its seeds, which makes it a promising biodiesel and industrial crop. The main carbon sinks in pennycress embryos were found to be proteins...
Gurpreet Kaur et al.
Extremophiles : life under extreme conditions, 19(2), 327-344 (2014-12-18)
Microbial adaptations to environmental extremes, including high temperature and low pH conditions typical of geothermal settings, are of interest in astrobiology and origin of life investigations. The lipid biomarkers preserved in silica deposits associated with six geothermal areas in the...
Heshmatollah Ebrahimi-Najafabadi et al.
Journal of chromatography. A, 1358, 225-231 (2014-07-19)
Thermodynamic parameters of ΔH(T0), ΔS(T0), and ΔCP for 156 compounds comprising alkanes, alkyl halides and alcohols were determined for a 5% phenyl 95% methyl stationary phase. The determination of thermodynamic parameters relies on a Nelder-Mead simplex optimization to rapidly obtain...
Kyu-Won Hwang et al.
Journal of agricultural and food chemistry, 63(30), 6675-6680 (2015-07-15)
The dissipation and removal of the etofenprox residue was studied in spring onion grown under greenhouse conditions. Samples of spring onion were collected at 0, 1, 2, 4, 6, 8, 10, 12, and 14 days after last application, and removal...
Vivek Bansal et al.
Vaccine, 33(42), 5623-5632 (2015-09-08)
Delivery of antigen through admixture formulation containing poly caprolactone (PCL) and aluminum phosphate was studied as a promising strategy to generate antigen specific immune response. The present study demonstrates the synergistic effect of admixture formulation of PCL with reduced aluminum...
Maedeh Zamani et al.
International journal of pharmaceutics, 473(1-2), 134-143 (2014-07-08)
Biodegradable polymeric particles have been extensively investigated for controlled drug delivery of various therapeutic agents. 'Coaxial' electrospraying was successfully employed in this study, to fabricate core-shell PLGA particles containing bovine serum albumin (BSA) as the model protein, and the results...
Sung Nam Kang et al.
Biomaterials, 44, 1-10 (2015-01-27)
A drug-eluting stent (DES) is one of the commonly used treatment techniques in percutaneous coronary intervention (PCI). Sirolimus (SRL) has been widely used for DES as a drug for suppressing neointimal hyperplasia causing restenosis. Phytoncides (PTC) are compounds released from...
Bilal Yilmaz et al.
Journal of chromatographic science, 53(7), 1037-1043 (2015-01-27)
A sensitive and efficient method was developed for determination of tramadol and its metabolite (O-desmethyltramadol) in human urine by gas chromatography-mass spectrometry. Tramadol, O-desmethyltramadol and medazepam (internal standard) were extracted from human urine with a mixture of ethylacetate and diethylether...
María J Trujillo-Rodríguez et al.
Analytical and bioanalytical chemistry, 407(29), 8753-8764 (2015-09-26)
The use of mixed hemimicelles of ionic liquid (IL)-based surfactants in a magnetic-based micro-dispersive solid-phase extraction (m-μdSPE) approach is described. Not only is the symmetric monocationic IL-based surfactant 1,3-didodecylimidazolium bromide (C12C12Im-Br) studied for first time in m-μdSPE, but double-salt (DS)...
Mateus B Pereira et al.
Journal of AOAC International, 97(4), 987-994 (2014-08-26)
Pollution of water sources by pesticides is a result of intensive use of these compounds, and the establishment of analytical methods for monitoring programs is very important. This paper presents a method for the determination of multiclass pesticide residues in...
Martyna Kielmas et al.
Analytical and bioanalytical chemistry, 407(9), 2557-2567 (2015-02-01)
Glycation of α-crystallin is responsible for age- and diabetic-related cataracts, which are the main cause of blindness worldwide. We optimized the method of identification of lysine residues prone to glycation using the combination of LC-MS, isotopic labeling, and modified synthetic...
Takanobu Nishizuka et al.
PloS one, 9(8), e104603-e104603 (2014-08-12)
Almost all of the currently available fracture fixation devices for metaphyseal fragility fractures are made of hard metals, which carry a high risk of implant-related complications such as implant cutout in severely osteoporotic patients. We developed a novel fracture fixation...
Cesar R Rodriguez-Saona
Journal of visualized experiments : JoVE, (58)(58), doi:10-doi:10 (2012-01-05)
Herbivore-induced plant volatiles (HIPVs) are commonly emitted from plants after herbivore attack. These HIPVs are mainly regulated by the defensive plant hormone jasmonic acid (JA) and its volatile derivative methyl jasmonate (MeJA). Over the past 3 decades researchers have documented...
Zhen Wei et al.
Applied microbiology and biotechnology, 99(17), 7369-7377 (2015-07-05)
Metabolic synthesis of single cell oils (SCOs) for biodiesel application by heterotrophic oleaginous microorganisms is being hampered by the high cost of culture media. This study investigated the possibility of using loblolly pine and sweetgum autohydrolysates as economic feedstocks for...
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