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Jerald E Dumas et al.
Tissue engineering. Part A, 20(1-2), 115-129 (2013-08-15)
There is a compelling clinical need for bone grafts with initial bone-like mechanical properties that actively remodel for repair of weight-bearing bone defects, such as fractures of the tibial plateau and vertebrae. However, there is a paucity of studies investigating
Amadeu Gavaldà et al.
Pulmonary pharmacology & therapeutics, 28(2), 114-121 (2014-06-15)
This study characterised the in vitro and in vivo profiles of two novel long-acting muscarinic antagonists, aclidinium bromide and glycopyrronium bromide, using tiotropium bromide and ipratropium bromide as comparators. All four antagonists had high affinity for the five muscarinic receptor sub-types (M1-M5);
Mònica Rosa et al.
Journal of proteome research, 14(8), 3162-3173 (2015-06-20)
Human μ-opioid receptor (hMOR) is a class-A G-protein-coupled receptor (GPCR), a prime therapeutic target for the management of moderate and severe pain. A chimeric form of the receptor has been cocrystallized with an opioid antagonist and resolved by X-ray diffraction;
Christine Cahyadi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 90, 30-37 (2014-12-03)
The Supercell coater was developed as an in-line small batch tablet coater which uses air-fluidization for tablet coating. Coating time is very much reduced, with improved heat and mass transfer. It was hypothesized that the quasi-continuous Supercell coating process was
Xiuhong Wu et al.
Biomedical chromatography : BMC, 29(8), 1184-1189 (2015-01-23)
The metabolism of swertiamarin in vivo was studied by LC-MS following 2,4-dinitrophenylhydrazine derivatization. The ionization efficiency of the main metabolite erythrocentaurin was greatly enhanced by the new analytical method developed, and erythrocentaurin was successfully detected for the first time in
Gamma Chi et al.
European biophysics journal : EBJ, 44(7), 589-598 (2015-08-04)
The mechanosensitive channel of large conductance MscL is a well-characterized mechanically gated non-selective ion channel, which often serves as a prototype mechanosensitive channel for mechanotransduction studies. However, there are some discrepancies between MscL constructs used in these studies, most notably
Anna Maria Sniecinska-Cooper et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 18-23 (2014-12-23)
Human sleep is a natural part of every individual's life. Clear relationship between sleep and endocrine system has been already established. In particular, melatonin and cortisol are known to affect and regulate sleep/wake patterns. Here we report the development of
Gulcin Tezcan et al.
Cellular and molecular neurobiology, 35(2), 175-187 (2014-09-13)
Glioblastoma multiforme (GBM) is one of the deadliest human malignancies. A cure for GBM remains elusive, and the overall survival time is less than 1 year. Thus, the development of more efficient therapeutic approaches for the treatment of these patients
Clara Coscollà et al.
Journal of chromatography. A, 1368, 132-142 (2014-10-15)
A comprehensive strategy for the analysis of current airborne pesticides has been developed using liquid chromatography coupled to high resolution mass spectrometry. The methodology includes both quantitative target analysis and post-run target screening analysis. The quantitative method was validated after
Yuanyuan Li et al.
Biochemical and biophysical research communications, 457(2), 177-182 (2015-01-03)
Non-small cell lung cancer (NSCLC) is a common malignant disease, and in ~10-20% of patients, pleural effusion is the first symptom. The pleural effusion proteome contains information on pulmonary disease that directly or indirectly reflects pathophysiological status. However, the proteome
Ali Aghazadeh-Habashi et al.
Journal of pharmaceutical and biomedical analysis, 110, 12-19 (2015-03-24)
Eicosanoids are biologically active lipid-derived oxidative metabolites of arachidonic acid. We, herein, present an improved sensitive, selective and robust high performance liquid chromatography (HPLC)-fluorescence assay for simultaneous quantification of eicosanoids in human plasma and rat tissues. Aliquots of 200 μL
Sarah Zanon Agapito-Tenfen et al.
BMC plant biology, 14, 346-346 (2014-12-11)
The safe use of stacked transgenic crops in agriculture requires their environmental and health risk assessment, through which unintended adverse effects are examined prior to their release in the environment. Molecular profiling techniques can be considered useful tools to address
Han Young Eom et al.
Journal of pharmaceutical and biomedical analysis, 117, 380-389 (2015-10-07)
A method for fast chiral separation of cetirizine and quantitation of levocetirizine in human plasma using subcritical fluid chromatography with tandem mass spectrometry was developed and validated. The chromatographic separation was performed using a Chiralpak IE column (2.1 mm×150 mm
Maximiliano J Jiménez-Dalmaroni et al.
Innate immunity, 21(2), 175-193 (2014-03-05)
TLRs are key innate immune receptors that recognize conserved features of biological molecules that are found in microbes. In particular, TLR2 has been reported to be activated by different kinds of microbial ligands. To advance our understanding of the interaction
Suzanne L Parker et al.
Journal of pharmaceutical and biomedical analysis, 105, 39-45 (2014-12-22)
A high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, using hydrophilic interaction liquid chromatography (HILIC) chromatography for the analysis of fosfomycin in human plasma and urine, has been developed and validated. The plasma method uses a simple protein precipitation using
Michael Hellwig et al.
Journal of agricultural and food chemistry, 63(30), 6723-6730 (2015-07-18)
Maillard reaction products (MRPs) are taken up in substantial amounts with the daily diet, but the majority are not transported across the intestinal epithelium. The aim of this study was to obtain first insights into the stability of dietary MRPs
Thierry K Ngouana et al.
Mycoses, 58(1), 33-39 (2014-10-08)
Minor species of the Candida albicans complex may cause overestimation of the epidemiology of C. albicans, and misidentifications could mask their implication in human pathology. Authors determined the occurrence of minor species of the C. albicans complex (C. africana, C.
Chris M Maragos et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(7), 1164-1174 (2015-04-03)
Patulin is a mycotoxin commonly found in certain fruit and fruit products. For this reason many countries have established regulatory limits pertaining to, in particular, apple juice and apple products. Fruit leathers are produced by dehydrating fruit puree, leaving a
Forrest T Smith et al.
Talanta, 129, 171-182 (2014-08-17)
This report compares the GC-MS and FTIR properties of all 6 regioisomeric benzoyl substituted-1-n-pentylindoles. These compounds have the benzoyl-group attached at each of the possible ring substituent positions of the indole ring. The six compounds have the same elemental composition
Shijie Yao et al.
Cancer chemotherapy and pharmacology, 75(4), 719-728 (2015-01-31)
Camptothecins contain a lactone ring that is necessary for antitumor activity, and hydrolysis of the lactone ring yields an inactive carboxylate species. Human serum albumin (HSA) and alpha-1 acid glycoprotein (AGP) are clinically significant plasma proteins thought to have important
Sun-Young Kong et al.
PloS one, 10(2), e0118188-e0118188 (2015-02-24)
Neural stem cells (NSCs) have the ability to proliferate and differentiate into neurons and glia. Regulation of NSC fate by small molecules is important for the generation of a certain type of cell. The identification of small molecules that can
Lydia N Wamalwa et al.
Journal of agricultural and food chemistry, 63(1), 335-342 (2014-11-25)
Furanoterpenoid accumulation in response to microbial attack in rotting sweetpotatoes has long been linked to deaths and lung edema of cattle in the world. However, it is not known whether furanoterpenoid ipomeamarone accumulates in the healthy-looking parts of infected sweetpotato
Qiqing Chen et al.
The Science of the total environment, 496, 453-460 (2014-08-12)
The potential transfer of fullerene aqueous suspension (nC₆₀) associated contaminants in vivo is one of the most significant and currently not well-understood environmental risks. In this study, the carrier function of nC₆₀ for ibuprofen (IBU) was examined through whole-body and
Lígia Marquez Andrade et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(1), 40-47 (2014-05-13)
The aim of this study was to develop lipid nanoparticles to deliver genistein (GEN) to deeper skin layers. To do so, the impact of lipid dynamic behavior (nanoparticle flexibility) on stability, release and skin permeation studies was verified. GEN-loaded solid
Paulo Magalhães et al.
Bioanalysis, 6(22), 3025-3038 (2014-12-17)
A new high-performance liquid chromatography-fluorescence detection assay based on microextraction by packed sorbent as sample preparation approach is described to quantify venlafaxine (VEN) and its main metabolite [O-desmethylvenlafaxine (ODV)]in human plasma. Chromatographic separation of the target analytes (VEN and ODV)
Milica M Fotirić Akšić et al.
Journal of agricultural and food chemistry, 63(34), 7476-7486 (2015-08-19)
The European pear psylla, Cacopsylla pyri L. (Hemiptera: Psyllidae), is one of the most serious arthropod pests of pear. Since proper control of this pest is essential, better understanding of the complex plant-pest relationship is mandatory. This research deals with
F I Al-Jenoobi et al.
Drug research, 65(6), 312-316 (2014-07-06)
The present study was conducted to investigate the effect of commonly used herb Commiphora myrrha on the pharmacokinetic profile of theophylline (narrow therapeutic index drug) in rabbits. In the experimental groups, theophylline (16 mg/kg) was given orally to the rabbits.
Tidjani Amza et al.
Journal of food science and technology, 52(5), 2770-2778 (2015-04-22)
The antioxidant capacity of gingerbread plum kernel protein fraction (albumin, globulin and glutelin) hydrolysates (GPKH) was studied. Gingerbread plum kernel protein fractions were hydrolyzed through a combined action of two digestive enzymes (pespsin and trypsin). The hydrolyzed fractions were subjected
Peng Liu et al.
Pharmaceutical research, 32(2), 628-639 (2014-08-26)
The lack of effective screening methods and systemic understanding of interaction mechanisms complicates the stabilizer selection process for nanocrystallization. This study focuses on the efficiency of stabilizers with various molecular compositions and structures to stabilize drug nanocrystals. Five structurally different
Samantha N McNulty et al.
Molecular & cellular proteomics : MCP, 14(12), 3224-3233 (2015-10-17)
Improved diagnostic methods are needed to support ongoing efforts to eliminate onchocerciasis (river blindness). This study used an integrated approach to identify adult female Onchocerca volvulus antigens that can be explored for developing serodiagnostic tests. The first step was to
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