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T R Dinesen et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 132(1), 19-24 (1998-06-06)
Measurements of 7Li nuclear spin-lattice relaxation times are made at applied magnetic field strengths from 0.25 mT to 7.05 T, in order to determine directly the form of the frequency-dependent spectral densities that modulate relaxation. This magnetic resonance dispersion (MRD)
U G Eriksson et al.
Magnetic resonance in medicine, 5(1), 73-77 (1987-07-01)
Nitroxides, paramagnetic compounds with demonstrated effectiveness as contrast agents in proton magnetic resonance imaging, shorten the relaxation times of protons and therefore cause an increase in image intensity in tissues into which they distribute. In this study, the metabolic fate
V Quaresima et al.
Biochemical and biophysical research communications, 183(2), 829-835 (1992-03-16)
Low frequency (280 MHz) electron paramagnetic resonance spectroscopy has been used to follow uptake, distribution and reduction of the nitroxyl spin label PCA in the rat. No difference of half life was found in seven rats submitted to three administrations
S Zöllner et al.
The Journal of biological chemistry, 272(37), 23076-23080 (1997-09-12)
Nitroxides are known to exert superoxide dismutase-mimetic properties and to decrease O-2- and H2O2-mediated cytotoxicity. However, the effect of nitroxides on .NO homeostasis has not been studied yet. The present study investigates the effect of nitroxides on the detectable amount
M Alecci et al.
Biophysical journal, 67(3), 1274-1279 (1994-09-01)
A radio frequency (RF) (280 MHz) electron paramagnetic resonance (EPR) spectroscopy and imaging apparatus has been used to localize a pyrrolidine nitroxide free radical in the rat abdomen and thorax. The nitroxide 2,2.5.5,-tetramethylpyrrolidine-1-oxyl-3- carboxylic acid (PCA) had a whole body
Mian Qi et al.
Journal of the American Chemical Society, 136(43), 15366-15378 (2014-10-18)
Distance measurement in the nanometer range by electron paramagnetic resonance spectroscopy (EPR) in combination with site-directed spin labeling is a very powerful tool to monitor the structure and dynamics of biomacromolecules in their natural environment. However, in-cell application is hampered
Nathan C Winn et al.
American journal of physiology. Endocrinology and metabolism, 313(4), E402-E412 (2017-06-29)
Females are typically more insulin sensitive than males, which may be partly attributed to greater brown adipose tissue (BAT) activity and uncoupling protein 1 (UCP1) content. Accordingly, we tested the hypothesis that UCP1 deletion would abolish sex differences in insulin
Barney L Bales et al.
The journal of physical chemistry. A, 115(40), 10903-10910 (2011-08-26)
A stable, monoprotic nitroxide spin probe is utilized as a model to study molecular collisions in aqueous electrolyte solutions. The rate constants of bimolecular collisions, K(col) for 2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-carboxylic acid (CP) when it is uncharged (at low pH) and K(col)⁻ when
M Gonet et al.
Computers & electrical engineering : an international journal, 74, 130-137 (2019-03-02)
We present the concept of image registration using ultrasound (US) and electron paramagnetic resonance (EPR) imaging and discuss the benefits of this solution, as well as its limitations. Both phantoms and murine tumors were used to test US and EPR
M Ferrari et al.
Biochemical and biophysical research communications, 166(1), 168-173 (1990-01-15)
The in vivo uptake distribution and reduction of the oxygen-sensitive nitroxide spin label PCA in the mouse monitored by low frequency electron paramagnetic resonance (EPR) spectroscopy are reported. Spectra were obtained from the head and liver regions of pentobarbital anesthetized
K Mäder et al.
Pharmaceutical research, 14(6), 820-826 (1997-06-01)
The purpose of this study was to compare drug release and polymer erosion from biodegradable P(FAD-SA) polyanhydrides in vitro and in vivo in real time and with minimal disturbance of the investigated system. P(FAD-SA) 20:80 and P(FAD-SA) 50:50 polymer tablets
John P Gotham et al.
Free radical biology & medicine, 154, 84-94 (2020-05-08)
Electron Paramagnetic Resonance (EPR) spectroscopy coupled with spin traps/probes enables quantitative determination of reactive nitrogen and oxygen species (RNOS). Even with numerous studies using spin probes, the methodology has not been rigorously investigated. The autoxidation of spin probes has been
Shruthi Hamsanathan et al.
Biophysical journal, 113(12), 2650-2668 (2017-12-21)
The Tat machinery catalyzes the transport of folded proteins across the bacterial cytoplasmic membrane and the thylakoid membrane in plants. Using fluorescence quenching and cross-linking approaches, we demonstrate that the Escherichia coli TatBC complex catalyzes insertion of a pre-SufI signal
M Alecci et al.
Physics in medicine and biology, 43(7), 1899-1905 (1998-08-14)
The use of RF (100 to 300 MHz) PEDRI and CW-EPR techniques allows the in vivo study of large animals such as whole rats and rabbits. Recently a PEDRI instrument was modified to also allow CW-EPR spectroscopy with samples of
Sandra Rodemeister et al.
Biochemical and biophysical research communications, 493(3), 1184-1189 (2017-09-30)
The anticancer potential of ascorbic acid (AA) has been controversially discussed for decades. Although the cytotoxic effect of pharmacologic concentrations of ascorbic acid has already been successfully demonstrated in numerous studies in vitro, it could not be verified to the same
D Mustafi et al.
Free radical research communications, 10(1-2), 95-101 (1990-01-01)
Spin-label nitroxyl derivatives of tetramethylpyrroline and tetramethylpyrrolidine in frozen solutions of perdeuterated methanol have been characterized by electron nucleus double resonance (ENDOR spectroscopy). With use of selectively deuterated derivatives of 2,2,5,5-tetramethylpyrroline-1-oxyl-3-carboxamide, proton ENDOR resonance features have been assigned to the
M A Foster et al.
Physics in medicine and biology, 43(7), 1893-1897 (1998-08-14)
Proton-electron double-resonance imaging (PEDRI) has considerable value for study of the distribution and elimination pathways of nitroxide free radicals (NFRs). This has been illustrated by its use in studies of kidney function in the living rat in which the NFR
M Koter
Cytobios, 58(234-35), 165-170 (1989-01-01)
The effect of elevated temperatures on the transport of electrolyte spin labels anionic c-TEMPIR and cationic TEMPO-choline character across the porcine lymphocyte plasma membrane was investigated. Breaks in the Arrhenius plot for permeability of both spin-labels occurred at 42 to
A Sotgiu et al.
Cellular and molecular biology (Noisy-le-Grand, France), 43(6), 813-823 (1997-11-14)
Electron paramagnetic resonance imaging (EPRI) is currently being developed at frequencies between 200 MHz and 2 GHz. EPRI can map the in vivo distribution of paramagnetic species, such as water soluble free radicals; nitroxide free radicals are commonly used. EPR
V Quaresima et al.
Physics in medicine and biology, 43(7), 1937-1947 (1998-08-14)
Much outstanding progress concerning the application of ESR spectroscopy/imaging in the biomedical field has been made in recent years. The literature in this field has already been specifically covered by several reviews. The aim of this article is to provide
Chemistry Letters (Jpn), 33, 460-460 (2004)
M A Pals et al.
Investigative radiology, 22(6), 497-501 (1987-06-01)
Contrast agents have been investigated in an effort to increase the differences between the proton relaxation times of normal and pathologic tissue, and thus improve the ability to detect regions of pathology. Data on the oxygen-dependent metabolism of three nitroxides
Guo-Xing Zhang et al.
Hypertension (Dallas, Tex. : 1979), 43(1), 117-124 (2003-11-26)
The relations among hypertensive response, oxidative stress, and mitogen-activated protein kinase (MAPK) in cardiovascular tissues have not been fully established. We investigated the involvement of reactive oxygen species on changes in the hemodynamics and cardiovascular MAPKs activities induced by acutely
J Buitink et al.
Biophysical journal, 76(6), 3315-3322 (1999-06-04)
The relationship between molecular mobility (tauR) of the polar spin probe 3-carboxy-proxyl and water content and temperature was established in pea axes by electron paramagnetic resonance (EPR) and saturation transfer EPR. At room temperature, tauR increased during drying from 10(-11)
B L Bales et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 132(2), 279-286 (1998-06-20)
A simple expression is derived to compute the total Gaussian linewidth of a Voigt line that is broadened by sinusoidal magnetic-field modulation as follows: delta HPPG(Hm)2 = delta HPPG(0)2 + kappa 2Hm2, where delta HPPG(Hm) is the Gaussian linewidth observed
I Katzhendler et al.
Pharmaceutical research, 17(10), 1299-1308 (2001-01-06)
The present study was conducted in order to investigate the correlation between the hydration properties of HPMC and EA matrices, gel microstructure and mobility, crystalline changes occurring in the gel and CBZ release kinetics. The influence of HPMC and EA
J. Chem. Soc., Faraday, 87, 947-947 (1991)
K Takeshita et al.
Biochemical and biophysical research communications, 177(2), 874-880 (1991-06-14)
Clearance of the nitroxide radicals, hydroxy-TEMPO and carboxy-PROXYL, in whole-mouse lung was directly measured by in vivo ESR. After injecting a nitroxide radical, distribution of the nitroxide radical all over the lung was confirmed by ESR imaging. The ESR signal
Wendi Zhang et al.
Toxicology letters, 237(2), 61-71 (2015-06-07)
The promising broad applications of graphene oxide (GO) derivatives in biomedicine have raised concerns about their safety on biological organisms. However, correlations between the physicochemical properties, especially oxidation degree of GOs and their toxicity, and the underlying mechanisms are not
Lianet Monzote et al.
Parasitology, 142(9), 1239-1248 (2015-06-02)
Nemorosone (Nem) and guttiferone A (GutA) are acyl phloroglucinol derivatives (APD) that are present in different natural products. For both compounds anti-cancer and anti-microbial properties have been reported. In particular, an anti-leishmanial activity of both compounds was demonstrated. The aim
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