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Shuhua Zhao et al.
Journal of cellular physiology, 230(11), 2706-2717 (2015-03-27)
Epithelial-to-mesenchymal transition (EMT) has been implicated in embryonic development and various pathological events. However, the involvement of microRNA in the process of EMT remains to be fully defined in hepatocyte. ZEB1 is a well-known transcriptional repressor of E-cadherin and plays
Zhushi Li et al.
Oncology research, 21(6), 325-331 (2013-01-01)
It was revealed by our previous research that sodium selenite repressed autophagy accompanied by the induction of apoptosis in human leukemia NB4 cells. The inhibition of autophagy exerted a facilitative effect on apoptosis. In the present study, we further explored
Selim Doganay et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 55, 371-377 (2013-01-26)
This study was designed in order to investigate whether sun dried apricots have a preventive effect on the experimental cataract model formed by sodium selenite in rats. Fifty-nine Spraque-Dawley rat pups were divided into three groups. Group 1 (control group)
Emil Rudolf et al.
Toxicology letters, 231(1), 29-37 (2014-09-11)
Effects of chronic exposure to supranutritional sodium selenite (Se) were investigated in colonic fibroblasts. Initially, Se did not produce any gross changes in exposed cells; however, basal levels of autophagy were transiently increased and p38 activity was stimulated. From the
Yu-Chi Chen et al.
International journal of cancer, 133(9), 2054-2064 (2013-04-25)
The survival rate for breast cancer drops dramatically once the disease progresses to the metastatic stage. Selenium (Se) is an essential micronutrient credited with having high anticancer and chemopreventive properties. In our study, we investigated if dietary Se supplementation modified
Fuiyee Lee et al.
PloS one, 9(7), e103254-e103254 (2014-07-23)
Graft versus host disease (GvHD) is one of the main complications after hematological stem cell transplantation (HSCT). CAMPATH-1H is used in the pre-transplant conditioning regimen to effectively reduce GvHD by targeting CD52 antigens on T cells resulting in their depletion.
Hongjie Chen et al.
Toxicology letters, 216(2-3), 181-188 (2012-12-01)
Selenite cataract, as an experimental animal model of nuclear cataract to mimic human senile cataract, is produced only when overdose selenite is injected to neonatal rats before eyelid opening. To clarify the cause of age differences on selenite cataract formation
Tao Qin et al.
Carbohydrate polymers, 92(1), 645-650 (2012-12-12)
Chinese angelica polysaccharide (CAP) was extracted by water decoction and ethanol precipitation, purified through eliminating protein by Sevage method and column chromatography of Sephadex G-200, then selenizingly modified by nitric acid-sodium selenite method according to L(9)(3(4)) orthogonal design of three-factors
Ying Li et al.
Electromagnetic biology and medicine, 33(4), 264-275 (2013-08-07)
Biological effects of extra-low-frequency (ELF) magnetic fields (MFs) have lacked a credible mechanism of interaction between MFs and living material. To examine the effect of ELF-MFs on cancer cells. Five cancer cell lines were exposed to ELF-MFs within the range
Natalia Mendelev et al.
PloS one, 7(10), e47910-e47910 (2012-10-31)
Supplementation of selenium has been shown to protect cells against free radical mediated cell damage. The objectives of this study are to examine whether supplementation of selenium stimulates mitochondrial biogenesis signaling pathways and whether selenium enhances mitochondrial functional performance. Murine
Noriaki Hashimoto et al.
BMC cancer, 14, 722-722 (2014-09-28)
Cancer stem cells (CSCs) are thought to play important roles in therapy-resistance. In this study, we induced cancer stem-like cells from hepatocellular carcinoma (HCC) cell lines using a unique medium, and examined their potential for resistance to anti-cancer drugs. The
Christina N Robitaille et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 126-135 (2014-10-18)
Several pesticides suspected or known to have endocrine disrupting effects were screened for pro- or antiandrogenic properties by determining their effects on proliferation, prostatic-specific antigen (PSA) secretion and androgen receptor (AR) expression, and AR phosphorylation in androgen-dependent LNCaP human prostate
Steven J Ressler et al.
The American journal of pathology, 184(11), 2951-2964 (2014-09-16)
WFDC1/ps20 is a whey acidic protein four-disulfide core member that exhibits diverse growth and immune-associated functions in vitro. In vivo functions are unknown, although WFDC1 is lower in reactive stroma. A Wfdc1-null mouse was generated to assess core functions. Wfdc1-null mice exhibited
Prashant S Daundkar et al.
Environmental toxicology and pharmacology, 38(3), 711-719 (2014-10-10)
In the present investigation, ameliorative effect of selenium on carbendazim induced oral sub chronic toxicity in bucks was assessed by studying various indices of antioxidant defense system. Bucks were randomly divided into four groups of four animals each. Group I
Alper Yazici et al.
International journal of ophthalmology, 8(2), 263-268 (2015-05-06)
To investigate the effects of selenium in rat retinal ischemia reperfusion (IR) model and compare pre-treatment and post-treatment use. Selenium pre-treatment group (n=8) was treated with intraperitoneal (i.p.) selenium 0.5 mg/kg for 7d and terminated 24h after the IR injury.
Paola Castro-Garcia et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1480-1492 (2015-02-01)
We studied potential changes in the subventricular zone (SVZ) stem cell niche of the senescence-accelerated mouse prone-8 (SAM-P8) aging model. Bromodeoxyuridine (BrdU) assays with longtime survival revealed a lower number of label-retaining stem cells in the SAM-P8 SVZ compared with
Yuxuan Wu et al.
Cell research, 25(1), 67-79 (2014-12-06)
Spermatogonial stem cells (SSCs) can produce numerous male gametes after transplantation into recipient testes, presenting a valuable approach for gene therapy and continuous production of gene-modified animals. However, successful genetic manipulation of SSCs has been limited, partially due to complexity
Kaiyan Hui et al.
Cancer letters, 354(1), 189-199 (2014-08-17)
Supranutritional selenite has anti-cancer therapeutic effects in vivo; however, the detailed mechanisms underlying these effects are not clearly understood. Further studies would broaden our understanding of the anti-cancer effects of this compound and provide a theoretical basis for its clinical
P S P Gupta et al.
PloS one, 9(6), e100201-e100201 (2014-06-18)
Follicular development occurs in wave like patterns in monotocous species such as cattle and humans and is regulated by a complex interaction of gonadotropins with local intrafollicular regulatory molecules. To further elucidate potential mechanisms controlling dominant follicle selection, granulosa cell
Iris Sawitza et al.
Scientific reports, 5, 13320-13320 (2015-08-26)
Mesenchymal stem cells (MSC) have the potential to differentiate into multiple cell lineages and their therapeutic potential has become obvious. In the liver, MSC are represented by stellate cells which have the potential to differentiate into hepatocytes after stimulation with
T Bayril et al.
Asian-Australasian journal of animal sciences, 28(8), 1133-1139 (2015-06-25)
This study aimed to determine the effects of parenteral selenium (Se) and vitamin E supplementation on economic impact, milk yield, and some reproductive parameters in high-yield dairy cows in the dry period and in those at the beginning of lactation.
Eun Hui Bae et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 15(4), 348-361 (2013-02-20)
This study aimed to examine the protective effects of aliskiren on gentamicin-induced nephropathy. Rats were injected with gentamicin (100 mg/kg per day) for 14 days. Aliskiren was infused for two weeks. Human proximal tubular epithelial cell lines (HK-2) were cultured
M Mathieu et al.
European cells & materials, 28, 82-96 (2014-09-03)
Because of poor self-healing ability, joint cartilage can undergo irreversible degradation in the course of various diseases or after injury. A promising approach for cartilage engineering consists of using of mesenchymal stem cells (MSC) and a differentiation factor combined with
DE-Geng Zhang et al.
Oncology letters, 9(1), 47-54 (2014-12-02)
Recently, an increasing number of studies have demonstrated that lung cancer is a stem cell disease. However, ideal cell surface markers for isolating stem cells in lung cancer are yet to be identified. In the present study, a cell population
James W Foster et al.
Scientific reports, 5, 10839-10839 (2015-06-04)
The avascular cornea is a uniquely-isolated organ, with its stroma constituting a nutrient-poor environment. Consequently, the availability of metabolites such as glucose to corneal stromal cells is considerably reduced compared with other tissues, or indeed with media commonly used to
Takuya Kitamura et al.
Molecular carcinogenesis, 54(6), 459-472 (2014-05-20)
Although very few studies have addressed the molecular and cellular mechanisms underlying the development of biliary tract cancer (BTC), several lines of evidence suggest a role for the erbB receptor family. Overexpression and activation of erbB2 has been reported in
K J Kelly et al.
PloS one, 10(7), e0131677-e0131677 (2015-07-03)
Autosomal recessive polycystic kidney disease is a truly catastrophic monogenetic disease, causing death and end stage renal disease in neonates and children. Using PCK female rats, an orthologous model of autosomal recessive polycystic kidney disease harboring mutant Pkhd1, we tested
Ece Bayir et al.
International journal of biological macromolecules, 126, 1002-1013 (2019-01-01)
There are several blood-brain barrier (BBB) models available for pharmaceutical research, but none of those are able to properly imitate the permeability of this special barrier. In this study, it is aimed to produce different BBB models with different cellular
Saeed Salman et al.
Archives of animal nutrition, 67(1), 48-61 (2013-01-10)
Dietary selenium (Se) can be supplemented from organic or inorganic sources and this may affect Se metabolism and functional outcome such as antioxidative status and immune functions in dairy cows. A feeding trial was performed with 16 Holstein-Friesian dairy cows
Cagri Sakalar et al.
Journal of immunology research, 2015, 630287-630287 (2015-12-01)
Anti-Müllerian hormone receptor, type II (AMHR2), is a differentiation protein expressed in 90% of primary epithelial ovarian carcinomas (EOCs), the most deadly gynecologic malignancy. We propose that AMHR2 may serve as a useful target for vaccination against EOC. To this
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