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Zilu Li et al.
ACS nano, 9(11), 10778-10789 (2015-10-06)
We have optimized mesoporous silica nanoparticles (MSNs) functionalized with pH-sensitive nanovalves for the delivery of the broad spectrum fluoroquinolone moxifloxacin (MXF) and demonstrated its efficacy in treating Francisella tularensis infections both in vitro and in vivo. We compared two different
Mohammad Mahdi Najafpour et al.
Dalton transactions (Cambridge, England : 2003), 42(4), 879-884 (2012-11-28)
In this communication, we report the synthesis, characterization, and electrochemistry of a 2-(2-hydroxyphenyl)-1H-benzimidazole-manganese oxide hybrid. Our results suggest that this compound is a promising model for the manganese cluster together with tyrosine-161 and histidine-190 in photosystem II of plants, algae
Mar Oroval et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(6), 1353-1360 (2016-11-20)
We describe herein the preparation of glucose-sensitive capped mesoporous silica nanoparticles for insulin delivery. The new material consists of an expanded-pore nanometric silica support grafted with 1-propyl-1-H-benzimidazole groups, loaded with fluorescein isothiocyanate-labeled insulin (FITC-Ins) and capped by the formation of
Tamara Muñoz-Caro et al.
Parasites & vectors, 8, 607-607 (2015-11-28)
Polymorphonuclear neutrophil (PMN) and eosinophil extracellular trap (ETs) formation has recently been described as an important host effector mechanism against invading pathogens. So far, scarce evidence on metazoan-triggered ET formation has been published. We here describe for the first time
Michele Macrelli et al.
Veterinary parasitology, 270, 1-6 (2019-06-20)
In 2016 suspected reduced ivermectin (IVM) efficacy in Oesophagostomum species in pigs was reported in England. Following this initial report, APHA raised awareness amongst private pig veterinary practitioners of the need to monitor the efficacy of the worm control on
Atul Ranjan et al.
Radiation research, 179(6), 647-662 (2013-05-07)
Radiation-induced DNA damage initiates a series of overlapping responses that include DNA damage recognition and repair, induction of cell cycle checkpoints, senescence and/or apoptosis. This study assessed the DNA damage response and whole genome expression profile in two mammalian cell
Jing-Kai Huang et al.
ACS nano, 12(1), 836-843 (2018-01-05)
Ultrathin two-dimensional (2D) polymeric layers are capable of separating gases and molecules based on the reported size exclusion mechanism. What is equally important but missing today is an exploration of the 2D layers with charge functionality, which enables applications using
Nour T Abdel-Ghani et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 104, 134-142 (2012-12-26)
[NiL(1,2)Cl(2)(OH(2))(3)]·zH(2)O and [ZnL(1,2)(CH(3)CO(2))(2)] (L(1)=(1H-benzimidazol-2-ylmethyl)-N-phenyl amine, z=0 and L(2)=2-[(1H-Benzimidazol-2-ylmethyl)-amino]-benzoic acid methyl ester, z=1) complexes have been synthesized and characterized by a variety of physico-chemical techniques. The central Ni(II) ion is coordinated by only the pyridine-type nitrogen (N(py)) of benzimidazole ring, three
Jingjin Yang et al.
Laboratory investigation; a journal of technical methods and pathology, 96(12), 1279-1300 (2016-10-25)
Silicosis is an occupational pulmonary fibrosis caused by inhalation of silica (SiO
Kapil Juvale et al.
Scientific reports, 9(1), 190-190 (2019-01-19)
Helicobacter pylori (H. pylori), the major cause of several gastric disorders has been recognied as a type I carcinogen. By virtue of resistance developed by H. pylori strains, currently used antibiotic based treatments rather demonstrate high failure rates. Hence, there
Hans Matter et al.
Bioorganic & medicinal chemistry letters, 23(6), 1817-1822 (2013-02-12)
The discovery of potent benzimidazole stearoyl-CoA desaturase (SCD1) inhibitors by ligand-based virtual screening is described. ROCS 3D-searching gave a favorable chemical motif that was subsequently optimized to arrive at a chemical series of potent and promising SCD1 inhibitors. In particular
Dan Zhao et al.
ACS nano, 13(1), 125-133 (2019-01-04)
Marine mussel inspired polydopamine (PDA) has received increased attention due to its good thermal and chemical stability as well as strong adhesion on most materials. In this work, high-performance nanofiltration membranes based on interpenetrating polymer networks (IPN) incorporating PDA and
Jiumao Lin et al.
BMC cancer, 14, 729-729 (2014-10-01)
The development of hepatic cancer is tightly regulated by multiple intracellular signaling pathways. Therefore, most currently-used anti-tumor agents, which typically target single intracellular pathway, might not always be therapeutically effective. Additionally, long-term use of these agents probably generates drug resistance
Neil D Sargison et al.
International journal for parasitology. Drugs and drug resistance, 10, 92-100 (2019-08-20)
Anthelmintic resistant gastrointestinal helminths have become a major cause of poor health in sheep and goats. Sensitive and specific molecular markers are needed to monitor the genotypic frequency of resistance in field parasite populations. Gastrointestinal nematode resistance to benzimidazole is
Fabian López-Vallejo et al.
Bioorganic & medicinal chemistry, 15(2), 1117-1126 (2006-11-01)
Comparative molecular field analysis (CoMFA) was performed on a set of 1H-benzimidazole derivatives. Molecular modeling and 3D-QSAR were employed to determine the tautomeric form that would probably fit a target receptor in Entamoeba histolytica. CoMFA results suggest that the antiamoebic
Venkatasubramanian Ulaganathan et al.
Journal of the American Chemical Society, 135(6), 2263-2272 (2013-01-12)
Human kinesin Eg5 is a target for drug development in cancer chemotherapy with compounds in phase II clinical trials. These agents bind to a well-characterized allosteric pocket involving the loop L5 region, a structural element in kinesin-5 family members thought
C-H Yuan et al.
Cell death & disease, 7, 2060-2060 (2016-01-23)
High-risk human papillomaviruses (HR-HPVs) cause nearly all cases of cervical cancer, as well as approximately 30% of head and neck cancers. HPV 16 E6, one of two major viral oncogenes, protects cells from apoptosis by binding to and accelerating the
Gabriel J Rocklin et al.
The Journal of chemical physics, 138(8), 085104-085104 (2013-03-08)
Orientational restraints can improve the efficiency of alchemical free energy calculations, but they are not typically applied in relative binding calculations, which compute the affinity difference been two ligands. Here, we describe a new "separated topologies" method, which computes relative
Jan-Patrick Melchior et al.
Physical chemistry chemical physics : PCCP, 19(42), 28540-28554 (2017-10-25)
The unique proton conduction mechanism of phosphoric acid is important for the functions of complex phosphate containing biological and technological systems (e.g. phospholipid membranes and polybenzimidazole phosphoric acid membranes for high-temperature PEM fuel cells). In neat phosphoric acid structural proton
Martina Gamba et al.
Environmental science and pollution research international, 26(3), 2421-2434 (2018-11-24)
The simultaneous adsorption of both imazalil (IMZ) and thiabendazole (TBZ) fungicides in a Cu2+-exchanged Mt was studied in this work. Kinetic studies were used to determine the rate law which describes the adsorption of individual fungicides onto the adsorbent. Adsorption
Sudhakar Ganta et al.
Dalton transactions (Cambridge, England : 2003), 44(34), 15181-15188 (2015-04-01)
A rare variety of coordination rings having the M3L6 composition are prepared by the combination of Pd(NO3)2 with an imidazolyl or benzimidazolyl appended bidentate non-chelating ligand (i.e.L1 or L2). The variable concentration 1H NMR spectra of the trinuclear complexes [Pd3(L1)6](NO3)6
Dnyaneshwar B Gophane et al.
Chemical communications (Cambridge, England), 49(10), 999-1001 (2012-12-20)
Nucleosides spin-labelled with isoindoline-derived benzimidazole ((Im)U) and benzoxazole ((Ox)U) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but (Im)U was less mobile, which was attributed to an intramolecular hydrogen bond between the
Haresh Sivaram et al.
Dalton transactions (Cambridge, England : 2003), 42(34), 12421-12428 (2013-07-19)
A series of cationic gold(I) heteroleptic complexes bearing the pyrazole-derived N-heterocyclic carbene (NHC) FPyr (1,2,3,4,6,7,8,9-octahydropyridazino[1,2-a]indazolin-11-ylidene), and either a 1,3-disubstituted benzimidazole-derived NHC of the type RR'-bimy (3: R = R' = CHPh2; 4: R = CHPh2, R' = (i)Pr; 5: R
Quim Peña et al.
Journal of inorganic biochemistry, 195, 51-60 (2019-03-30)
Reactive oxygen species (ROS) formation appears as one of the most promising pathways to induce cell death. The interesting Cu(II)/Cu(I) redox pair has been reported to biologically generate ROS and induce cell damage. Simple metal complexes, such as cisplatin, sometimes
Carmen Tejada-Casado et al.
Journal of chromatography. A, 1490, 212-219 (2017-02-23)
A novel method based on capillary zone electrophoresis-tandem mass spectrometry has been proposed and validated for the identification and simultaneous quantification of twelve benzimidazoles in meat samples. Electrophoretic separation was carried out using 500mM formic acid (pH 2.2) as background
Determination of benzimidazole in biological model samples using electropolymerized-molecularly imprinted polypyrrole modified pencil graphite sensor.
Nezhadali A, et al.
Sensors and Actuators B, Chemical, 171, 1125-1131 (2012)
Hayato Konoshima et al.
Physical chemistry chemical physics : PCCP, 14(47), 16448-16457 (2012-11-08)
Crystal structures of polymorphs of 2-(2'-hydroxyphenyl)benzimidazole (HPBI), Forms α and β, are analyzed by X-ray crystallography. The fluorescence excitation (FE) and fluorescence spectra of the polymorphs are separately observed at temperatures 77-298 K. It has been found that the electronic
Alfonso Brenlla et al.
The journal of physical chemistry. B, 117(3), 884-896 (2012-12-22)
This paper deals with the interplay between solvent properties and isomerism of 2-(2'-hydroxyphenyl)imidazo[4,5-b]pyridine (1), and the proton and charge-transfer processes that the different isomers undergo in the first-excited singlet state. We demonstrate the strong influence of these processes on the
Rym Chioukh et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2041-2048 (2014-09-23)
The coadministration of methotrexate (MTX) and proton pump inhibitors (PPIs) can result in a pharmacokinetic interaction that delays MTX elimination and subsequently increases the MTX blood concentrations. Human organic anion transporters (hOATs) are responsible for the renal tubular secretion of
Sofia Montalvão et al.
Archiv der Pharmazie, 349(2), 137-149 (2015-12-29)
A series of 2-aminobenzothiazole and benzimidazole analogs based on the clathrodin scaffold was synthesized and investigated for their antimicrobial and antiproliferative activities as well as for their effects in hepatitis C virus (HCV) replicon model. Compound 7, derived from 2-aminobenzothiazole
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