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Marta Gazal et al.
Brain research bulletin, 108, 10-17 (2014-08-12)
Chronic stressful stimuli influence disease susceptibility to depression, cardiovascular, metabolic and neurodegenerative disorders. The present work investigated antidepressant and antioxidant properties of the aqueous extract from Cecropia pachystachya in a mouse model of chronic unpredictable stress (CUS). Our results indicated
Ryoko Takasawa et al.
Bioorganic & medicinal chemistry, 16(7), 3969-3975 (2008-02-09)
Glyoxalase I (GLO I) is the rate-limiting enzyme for detoxification of methylglyoxal (MG), a side product of glycolysis, which is able to induce apoptosis. Since GLO I is known to be highly expressed in the most tumor cells and little
JiEun Yun et al.
Biochimica et biophysica acta, 1848(2), 695-701 (2014-12-03)
Isoquercitrin is a flavonoid isolated from Aster yomena, which has been used as a traditional medicinal herb. In the present study, we investigated the antifungal activity and the underlying mechanism of isoquercitrin. Isoquercitrin had a potent effect in the susceptibility
Jun Zhou et al.
Journal of pharmaceutical and biomedical analysis, 107, 273-279 (2015-01-28)
A simple, inexpensive and efficient method based on the mixed cloud point extraction (MCPE) combined with high performance liquid chromatography was developed for the simultaneous separation and determination of six flavonoids (rutin, hyperoside, quercetin-3-O-sophoroside, isoquercitrin, astragalin and quercetin) in Apocynum
Sadaf Naeem et al.
Bioorganic & medicinal chemistry, 20(3), 1251-1258 (2012-01-21)
Data on phytochemical constituents of plants commonly used in traditional Indonesian medicine have been compiled as a computer database. This database (the Indonesian Herbal constituents database, IHD) currently contains details on ∼1,000 compounds found in 33 different plants. For each
Li-Wen Tian et al.
Journal of natural products, 73(2), 160-163 (2010-01-23)
Five new phloroglucinol glycosides, eucalmainosides A-E (1-5), were isolated from the fresh fruits of Eucalyptus maideni, along with 15 flavonoids (6-20), seven (+)-oleuropeic acid derivatives (15, 16, and 22-26), three hydrolyzable tannins (32-34), and six simple phenolic compounds (21, 27-31).
Ayokunle O Ademosun et al.
Journal of basic and clinical physiology and pharmacology, 26(5), 471-477 (2015-06-02)
Citrus peels are consumed in the form of infusions, candy or wine, based on their well-documented nutritional and medicinal properties. This study sought to investigate the effect of some citrus peels' [grapefruit (Citrus paradisii), orange (Citrus sinensis) and shaddock (Citrus
Radka Václavíková et al.
Bioorganic & medicinal chemistry, 16(4), 2034-2042 (2007-11-21)
This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly
Wei Zou et al.
European journal of drug metabolism and pharmacokinetics, 40(3), 363-367 (2014-06-18)
Naringin, a major flavonoid in citrus fruits, has been proved to be a promising antitussive candidate. It undertakes complicated metabolism. In this study, human intestinal microbial metabolism of naringin was studied in vitro. Six persons' fecal water, which have intestinal
Teresa Mencherini et al.
Journal of natural products, 73(2), 247-251 (2010-01-12)
Three new saponins (1-3) and a known saponin, together with four known polyphenolic compounds, have been isolated from the fermented and dried leaves of Fadogia ancylantha (Makoni tea). The structures of compounds 1-3 were established by analysis of their spectroscopic
Mahendra Thapa et al.
Bioorganic & medicinal chemistry letters, 22(1), 353-356 (2011-11-26)
Influenza viruses are important pathogens that cause respiratory infections in humans and animals. In addition to vaccination, antiviral drugs against influenza virus play a significant role in controlling viral infections by reducing disease progression and virus transmission. Plant derived polyphenols
Elisabeta Baiceanu et al.
Molecules (Basel, Switzerland), 20(6), 11063-11075 (2015-06-18)
Artemisia abrotanum L. ("southernwood") belongs to the Artemisia genus and it is used in traditional medicine for the treatment of a variety of illnesses. Scarce data is available on the chemical composition of this medicinal plant, most research being focused
Panpan Guo et al.
Journal of separation science, 38(7), 1156-1163 (2015-01-27)
A sensitive and selective high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry method has been developed and validated for the simultaneous determination of 25 active constituents, including 21 flavonoids and four phenolic acids in the total flavonoids extract
Ki Hyun Kim et al.
Bioorganic & medicinal chemistry letters, 17(24), 6739-6743 (2007-11-22)
In our continuing study of biologically active compounds from Korean medicinal plants, we investigated the hepatoprotective constituents of the aerial parts of Lactuca indica L. (Compositae), since the methanolic extract of L. indica has hepatoprotective activity against hepatitis B virus
Hisashi Matsuda et al.
Bioorganic & medicinal chemistry, 19(9), 2835-2841 (2011-04-16)
To search for a new class of antidiabetic compounds, effects of 44 flavonoids on the adipogenesis of 3T3-L1 cells were examined. Among them, 3,4',7-trimethylkaempferol, tetramethylkaempferol, and pentamethylquercetin concentration-dependently enhanced the accumulation of triglyceride, a marker of adipogenesis. With regard to
Marta Gazal et al.
Neurochemical research, 40(7), 1421-1430 (2015-05-23)
Cecropia species are widely used in traditional medicine by its anti-diabetic, anti-hypertensive and anti-inflammatory properties. In the present study, we investigated the neuroprotective and antioxidant effects of the crude aqueous extract from Cecropia pachystachya leaves in a rat model of
Anne Pick et al.
Bioorganic & medicinal chemistry, 19(6), 2090-2102 (2011-03-01)
Flavonoids are an interesting group of natural products ubiquitously present in human diet. Their consumption has been associated with various and differing beneficial health effects. However, several flavonoids have been reported to inhibit the breast cancer resistance protein (BCRP) encoded
Andrei Mocan et al.
International journal of molecular sciences, 16(9), 21109-21127 (2015-09-26)
Aerial parts of Veronica species are used in Romanian traditional medicine for the treatment of various conditions like kidney diseases, cough, and catarrh, and are known for their wound-healing properties. In the present study, the phenolic and sterolic content and
Rui juan Song et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 995-996, 8-14 (2015-05-30)
A simple, cost-effective, and efficient method was developed for the rapid simultaneous separation and determination of six flavonoids (rutin, hyperoside, quercetin-3-O-sophoroside, isoquercitrin, astragalin and quercetin) of Apocynum venetum leaf extract by reversed phase high performance liquid chromatography using a microemulsion
Wan Cao et al.
Journal of chromatography. A, 1358, 277-284 (2014-07-23)
A rapid zwitterionic microemulsion electrokinetic chromatography (ZI-MEEKC) approach coupled with light-emitting-diode-induced fluorescence (LED-IF, 480nm) detection was proposed for the analysis of flavonoids. In the optimization process, we systematically investigated the separation conditions, including the surfactants, cosurfactants, pH, buffers and fluorescence
Transformation of Rutin to Antiproliferative Quercetin-3-glucoside by Aspergillus niger
You, J., et al.
Journal of Agricultural and Food Chemistry, 58(20), 10996-10892 (2010)
Chloé Roullier-Gall et al.
PloS one, 9(5), e97615-e97615 (2014-05-27)
The chemical composition of grape berries is influenced by various environmental conditions often considered to be representative of a "terroir". If grapes from a given terroir are assumed to reflect this origin in their chemical compositions, the corresponding wine should
Motohiko Ukiya et al.
Journal of natural products, 69(12), 1692-1696 (2006-12-28)
Ten oleanane-type triterpene glycosides, 1-10, including four new compounds, calendulaglycoside A 6'-O-methyl ester (2), calendulaglycoside A 6'-O-n-butyl ester (3), calendulaglycoside B 6'-O-n-butyl ester (5), and calendulaglycoside C 6'-O-n-butyl ester (8), along with five known flavonol glycosides, 11-15, were isolated from
Zhuo Chen et al.
Bioorganic & medicinal chemistry, 16(3), 1337-1344 (2007-11-13)
Saxifraga stolonifera, an evergreen dicotyledon, has been identified as an important resource in Chinese medicine due to its anticancer activity. In the present report, chemical components of S. stolonifera (L) Meeb which is found in Guizhou province were investigated. Ten
Claudia-Crina Toma et al.
Molecules (Basel, Switzerland), 20(6), 9560-9574 (2015-05-29)
This study was performed to evaluate the phenolic profile, antioxidant and diuretic effects of black cumin and lady-in-a-mist seeds. In the phenolic profile, differences between the two species are significant. Qualitative and quantitative analyses of the phenolic compounds were performed
Wei Yang et al.
Journal of agricultural and food chemistry, 63(42), 9269-9276 (2015-10-09)
Flavonol glycosides (FG) were analyzed in the leaves of six currant cultivars (Ribes spp.) with HPLC-DAD, HPLC-MS/MS, and NMR. The average amounts of the 12 major, identified FG constituted 86-93% (9.6-14.1 mg/g DW) of the total of 27 FG found.
C Di Giorgio et al.
Journal of natural medicines, 69(3), 267-277 (2015-02-11)
DIG, a liquid herbal preparation made from a mixture of diluted mother tinctures of Berberis vulgaris, Taraxacum officinale and Arctium lappa, was assessed for its antimutagenic properties against mitomycin C. The micronucleus assay on Chinese hamster ovary (CHO)-K1 cells was
Alina O Matei et al.
Journal of chromatographic science, 53(7), 1147-1154 (2015-01-15)
In this paper, a liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry in negative mode method was developed for the identification and quantitative determination of 13 individual phenolics (chlorogenic acid, caffeic acid, coumaric acid, ferulic acid, (+)-catechin, (-)-epicatechin, rutin, quercitrin, isoquercitrin, fisetin
Carsten Gründemann et al.
BMC complementary and alternative medicine, 14, 283-283 (2014-08-05)
In Europe, extracts of Equisetum arvense (common horsetail) have a long tradition in the treatment of inflammatory disorders. To understand the molecular basis for its use, we investigated the immunomodulatory capacity of a standardized commercially available common horsetail extract on
Christian Zorzetto et al.
Fitoterapia, 100, 95-109 (2014-12-03)
In the present work we carried out a phytochemical and biological investigation on three Hypericum species, i.e. Hypericum reflexum, Hypericum canariense and Hypericum grandifolium, from the Canary Islands where they are traditionally used as diuretic, wound healing, vermifuge, sedative and
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