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Poonam Saraf et al.
Pharmaceutical research, 32(9), 3087-3101 (2015-06-13)
The objective of this work was to compare the efficacy of self-assembling cyclic and linear RGD peptide amphiphiles as carriers for delivering paclitaxel to αvβ3 integrin overexpressing tumors. Linear (C18-ADA5-RGD) and cyclic (C18-ADA5-cRGDfK) peptide amphiphiles were synthesized and characterized for
Rajan Swami et al.
International journal of pharmaceutics, 486(1-2), 287-296 (2015-04-04)
Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonspecific targeting and inefficient penetration. Targeted delivery of anti-cancer agents solely to tumor cells introduces a smart strategy because it enhances the therapeutic index compared with untargeted drugs.
Dong Chang et al.
Journal of the American College of Nutrition, 33(5), 406-411 (2014-08-01)
To evaluate and compare the levels of free fatty acids between senile cataract patients and normal controls. Fifty consecutive patients with newly diagnosed senile cataract and 50 age- and gender-matched controls were evaluated. Subjects/patients were randomized according to selection criteria.
Yunbao Liu et al.
Journal of natural products, 73(7), 1193-1195 (2010-06-23)
Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH is the basis of established in vitro cell viability assays. An antioxidant assay
Jun-Hyung Park et al.
International journal of pharmaceutics, 491(1-2), 393-401 (2015-07-08)
Photodynamic therapy (PDT) is a promising noninvasive treatment modality for cancer. Photosensitizer and specific wave length of light are the key component of PDT. DH-I-180-3, a second generation photosensitizer, was incorporated into lipid nanoparticle for simultaneous fluorescent imaging and targeting
S M Grundy
The American journal of clinical nutrition, 60(6 Suppl), 986S-990S (1994-12-01)
Stearic acid is a long-chain saturated fatty acid. However, in contrast with other saturated fatty acids, stearic acid apparently does not raise serum cholesterol concentrations. Studies carried out three decades ago provided strong suggestive evidence that this was the case.
Alfonso Pérez-Gallardo et al.
Journal of food science and technology, 52(9), 5601-5610 (2015-09-08)
There is increased interest in berry fruits due to health benefits, and maintenance of fruit quality for longer periods of time has been a priority. We previously found that starch based coatings applied on raspberries was associated to volatile compounds
K Friedauer et al.
Journal of animal physiology and animal nutrition, 99(5), 950-961 (2014-10-30)
Early lactating cows mobilize adipose tissue (AT) to provide energy for milk yield and maintenance and are susceptible to metabolic disorders and impaired immune response. Conjugated linoleic acids (CLA), mainly the trans-10, cis-12 isomer, reduce milk fat synthesis and may
S Sehati et al.
Journal of colloid and interface science, 462, 130-139 (2015-10-11)
In this paper, the degradation of Congo red (CR) as a dye was investigated by a new synthetic photocatalyst. The synthesis was done through the intercalation of CdS in the layers of titanate (K2Ti4O9) by the assistance of ultrasound. The
A Tammaro et al.
Journal of biological regulators and homeostatic agents, 26(4), 783-784 (2012-12-18)
Magnesium stearate is a substance often used as a diluent in the manufacture of medical tablets, capsules and powders. Moreover it is usually found as a food additive or pharmaceutical excipient. We report the first case of a 28 years
Talib Hussain et al.
Acta poloniae pharmaceutica, 70(4), 749-757 (2013-08-08)
Gliclazide is an oral hypoglycemic agent, indicated in non insulin dependent diabetes mellitus and in patients with diabetic retinopathy. It has good tolerability and is a short acting sulfonyl urea that requires large dose to maintain the blood glucose level.
Mateusz Szalka et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 59, 1-11 (2014-04-22)
HPLC analysis of drug products containing bisoprolol fumarate and lactose revealed the presence of N-formylbisoprolol, which is a final product of the Maillard reaction. Formulations containing secondary amines and reducing carbohydrates are prone to the condensation of amine and carbonyl
Jian You et al.
Biomaterials, 34(18), 4510-4519 (2013-03-21)
It is difficult for most of the drug delivery systems to really display a temporal and spatial release of entrapped drug once the systems are iv administrated. We hypothesized that the photothermal effect, mediated by a near-infrared (NIR) laser and
Keiko Gotoh et al.
Journal of oleo science, 62(2), 73-79 (2013-02-09)
The soil removal behavior from poly(ethylene terephthalate) (PET) films was investigated using a microscopic image analysis system. Carbon black or stearic acid as a model soil was deposited onto a PET film. The PET film was cleaned in various aqueous
M A Denke
The American journal of clinical nutrition, 60(6 Suppl), 1044S-1049S (1994-12-01)
The effects of stearic acid on metabolism must be evaluated for stearic acid as an isolated dietary constituent and for stearic acid as a component of a natural fat. Beef products are the most common source of dietary stearic acid
Clara S Baffoe et al.
The Journal of pharmacy and pharmacology, 67(2), 189-198 (2014-12-17)
To develop and manufacture both immediate and sustained release vaginal tablets containing the anticancer drug disulfiram, which has the potential to be used as a non-invasive treatment for cervical cancer. Disulfiram-loaded vaginal tablets were manufactured at pilot scale using the
J P Neoptolemos et al.
Annals of clinical biochemistry, 27 ( Pt 1), 38-43 (1990-01-01)
Erythrocyte fatty acids were measured in 32 patients with colorectal cancer (four with recurrent disease), four patients with large colorectal adenomas, and 42 hospitalised patients without cancer. No significant differences were found with respect to any of the fatty acids
Shao-Ying Hu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(20), 3052-3055 (2013-01-15)
To prepare the sustained release solid dispersion of tripterine, using HPMC-stearic acid with the intention of improving drug dissolution and controlling drug releases moderate, so that the drug performances lower toxicity. Tripterine sustained release solid dispersions was prepared by the
E A Emken
The American journal of clinical nutrition, 60(6 Suppl), 1023S-1028S (1994-12-01)
This paper reviews results obtained by stable-isotope-tracer methods for stearic acid (18:0) and palmitic acid (16:0) metabolism and the influence of dietary linoleic acid on the metabolism of these saturated fatty acids in humans subjects. The results, based on stable-isotope-tracer
A M Turpeinen et al.
Arteriosclerosis, thrombosis, and vascular biology, 18(2), 316-322 (1998-03-04)
The effects of stearic acid (C18:0) and trans-fatty acids (trans-FAs) on measures of platelet function and prostacyclin (PGI2) production are poorly understood in humans. In this controlled dietary study, platelet function and endothelial PGI2 production were studied in healthy humans
Yuko Ishida et al.
PloS one, 8(1), e51779-e51779 (2013-01-18)
Blowflies are economic pests of the wool industry and potential vectors for epidemics. The establishment of a pesticide-free, environmentally friendly blowfly control strategy is necessary. Blowflies must feed on meat in order to initiate the cascade of events that are
Deliang Zhou et al.
Journal of pharmaceutical sciences, 103(6), 1664-1672 (2014-03-22)
The purpose of this study is to identify critical physicochemical properties of hydroxypxropyl methylcellulose (HPMC) that impact the dissolution of a controlled release tablet and develop a strategy to mitigate the HPMC lot-to-lot and vendor-to-vendor variability. A screening experiment was
Kaisar Raza et al.
Journal of liposome research, 24(4), 290-296 (2014-04-29)
Capsaicin (CP), a recent FDA-approved drug for the topical treatment of neuropathic pain, is associated with several side effects like irritation, burning sensation, and erythema, resulting in poor patient compliance. The present study is an attempt to study the effect
Carla F Sousa et al.
International journal of pharmaceutics, 495(2), 761-770 (2015-09-24)
Fluoroquinolones are antibiotics which act by penetrating into bacterial cells and inhibiting enzymes related to DNA replication, and metal complexes of these drugs have recently been investigated as one approach to counteracting bacterial resistance. In this work, we apply a
Sarah E E Berry
Nutrition research reviews, 22(1), 3-17 (2009-05-16)
The position of fatty acids in the TAG molecule (sn-1, sn-2 and sn-3) determines the physical properties of the fat, which affects its absorption, metabolism and distribution into tissues, which may have implications for the risk of CHD. The TAG
Adi Dror et al.
Applied microbiology and biotechnology, 99(22), 9449-9461 (2015-06-01)
Enzymatic production of biodiesel by transesterification of triglycerides and alcohol, catalyzed by lipases, offers an environmentally friendly and efficient alternative to the chemically catalyzed process while using low-grade feedstocks. Methanol is utilized frequently as the alcohol in the reaction due
Rahul Sonawane et al.
Expert opinion on drug delivery, 11(12), 1833-1847 (2014-08-01)
The primary aim of present work was to develop effective combination drug therapy for topical treatment of psoriasis. Betamethasone dipropionate and calcipotriol loaded solid lipid nanoparticles (CT-BD-SLNs) were prepared by hot melt high shear homogenization technique, which were then incorporated
Laurent Simon et al.
International journal of pharmaceutics, 481(1-2), 64-70 (2015-02-01)
A closed-formed solution of a perforated drug-delivery model was developed. Laplace transforms were applied to the governing equation, which included diffusion through the tubular device and mass transfer across a rectangular cut. A first-order estimate for the fraction of drug
A Vervaeck et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 472-482 (2014-07-11)
This study focused on the evaluation of prilling as a technique for the manufacturing of multiparticulate dosage forms. Prills, providing controlled and immediate drug release, were processed and finally combined in capsules yielding a fixed-dose combination. Metoprolol tartrate (MPT) and
Jitka Muzíková et al.
Acta poloniae pharmaceutica, 70(1), 129-135 (2013-04-25)
The paper compared two spray-dried lactoses Flowlac 100 and SuperTab 14SD from the standpoint of tensile strength and disintegration time of tablets, the effect of an addition of the lubricant magnesium stearate and silicified microcrystalline cellulose on these properties, and
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