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Christopher Brooks Mobley et al.
Journal of the International Society of Sports Nutrition, 12, 14-14 (2015-03-21)
We examined the acute effects of different dietary protein sources (0.19 g, dissolved in 1 ml of water) on skeletal muscle, adipose tissue and hypothalamic satiety-related markers in fasted, male Wistar rats (~250 g). Oral gavage treatments included: a) whey protein concentrate (WPC
Baohua Yang et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1737-1750 (2014-07-24)
Diosbulbin B (DB), a major constituent of the furano-norditerpenes in Dioscorea bulbifera Linn, exhibits potential antineoplasmic activity and hepatotoxicity. The metabolism and reactive metabolites of DB in vitro (with human and animal liver microsomes) and in vivo in rats were
I V Golubev et al.
Acta naturae, 6(3), 76-88 (2014-10-29)
Hydrophobization of alpha-helices is one of the general approaches used for improving the thermal stability of enzymes. A total of 11 serine residues located in alpha-helices have been found based on multiple alignments of the amino acid sequences of D-amino
F Hubert et al.
British journal of pharmacology, 171(23), 5361-5375 (2014-07-23)
This study examined the role of the main vascular cAMP-hydrolysing phosphodiesterases (cAMP-PDE) in the regulation of basal vascular tone and relaxation of rat aorta mediated by β-adrenoceptors, following heart failure (HF). Twenty-two weeks after proximal aortic stenosis, to induce HF
Robert Domitrović et al.
Toxicology, 324, 98-107 (2014-07-22)
The aim of this study was to investigate the renoprotective activity of chlorogenic acid (CA) in a murine model of cisplatin (CP)-induced kidney injury. Male BALB/cN mice were gavaged daily with CA at 3, 10 and 30mg/kg for two successive
Prashant N Mohite et al.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 33(11), 1133-1138 (2014-07-22)
Lung transplantation (LTx) is a complex surgical procedure conventionally performed with clamps on the recipient pulmonary artery (PA) and left atrial (LA) cuff, with or without cardiopulmonary bypass (CPB). The clamps may be awkward to apply and maintain on these
Scott Miller et al.
The Journal of experimental biology, 217(Pt 19), 3569-3578 (2014-07-27)
The ontogeny of carbon dioxide (CO2) sensing in zebrafish (Danio rerio) has not been examined. In this study, CO2-mediated increases in heart rate were used to gauge the capacity of zebrafish larvae to sense CO2. CO2 is thought to be
Yaoyu Zhou et al.
The Analyst, 139(24), 6529-6535 (2014-10-28)
This study demonstrates a new, unlabeled immobilized DNA-based biosensor with ordered mesoporous carbon nitride material (MCN) for the detection of Ag(+) by electrochemical impedance spectroscopy (EIS) with [Fe(CN)6](4-/3-) as the redox couple. The unlabeled immobilized DNA initially formed the hairpin-like
Wan Chen et al.
Thrombosis and haemostasis, 112(4), 700-715 (2014-07-11)
Snake venoms are excellent sources of pharmacologically active proteins and peptides, and hence are potential sources of leads for drug developments. It has been previously established that krait (Bungarus genus) venoms contain mainly neurotoxins. A screening for anticoagulants showed that
Said A S Ghozlan et al.
Archiv der Pharmazie, 348(2), 113-124 (2015-02-11)
A novel series of cyclic 2-oxindole derivatives incorporating 2-amino-tetrahydroquinolin-5-one were prepared. The structures of the prepared compounds were elucidated using different spectral tools. The regio-orientation of the reaction products was elucidated through NOE difference experiments and through using substituents on
Qingquan Guo et al.
Analytica chimica acta, 852, 244-249 (2014-12-03)
A label-free and enzyme-free sensitive fluorescent detection of human immunodeficiency virus (HIV) deoxyribonucleic acid (DNA) based on isothermal hybridization chain reaction (HCR) was developed. A G-quadruplex sequence which was incorporated into one of the two hairpin probes was inactive in
Mi Ran Choi et al.
Biopharmaceutics & drug disposition, 35(5), 264-274 (2014-03-05)
Under hyperlipidemic conditions, there are likely to be alterations in the pharmacokinetics of CYP2C11 substrates following decreased expression of CYP2C11, which is homologous to human CYP2C9. The pharmacokinetics of tolbutamide (TB) and its metabolite 4-hydroxy tolbutamide (4-OHTB) were evaluated as
William Apró et al.
American journal of physiology. Endocrinology and metabolism, 308(6), E470-E481 (2015-01-22)
Combining endurance and strength training in the same session has been reported to reduce the anabolic response to the latter form of exercise. The underlying mechanism, based primarily on results from rodent muscle, is proposed to involve AMPK-dependent inhibition of
Markus Bender et al.
Blood, 125(6), 1014-1024 (2014-12-04)
Dynamins are highly conserved large GTPases (enzymes that hydrolyze guanosine triphosphate) involved in endocytosis and vesicle transport, and mutations in the ubiquitous and housekeeping dynamin 2 (DNM2) have been associated with thrombocytopenia in humans. To determine the role of DNM2
Igor Stuparevic et al.
FEBS letters, 589(8), 924-932 (2015-03-03)
The tripartite Rpd3/Sin3/Ume6 complex represses meiotic isoforms during mitosis. We asked if it also controls starvation-induced isoforms. We report that VTH1/VTH2 encode acetate-inducible isoforms with extended 5'-regions overlapping antisense long non-coding RNAs. Rpd3 and Ume6 repress the long isoform of
Sana M Salih et al.
Biology of reproduction, 92(3), 73-73 (2015-01-23)
Preservation of ovarian function following chemotherapy for nonovarian cancers is a formidable challenge. For prepubescent girls, the only option to prevent chemotherapy damage to the ovary is ovarian tissue cryopreservation, an experimental procedure requiring invasive surgeries to harvest and reimplant
Byoung Wook Choi et al.
Phytotherapy research : PTR, 29(4), 549-553 (2015-02-03)
Five polyphenols were isolated and purified from a brown alga Ecklonia cava. These compounds showed diverse biological activities such as antioxidative, antiinflammatory, and enzyme inhibitory activities. This led us to investigate the potential of these compounds as Alzheimer's disease drugs.
Farukh Arjmand et al.
European journal of medicinal chemistry, 81, 76-88 (2014-05-16)
Nalidixic acid-DACH conjugate Cu(II) molecular entity, 1 was synthesized, thoroughly characterized by spectroscopic techniques (FT-IR, EPR and ESI-MS) and single crystal X-ray diffraction technique as a potential chemotherapeutic drug candidate for cancer oncology. Complex 1 was found to be a
Han Yuan et al.
Analytical biochemistry, 474, 78-88 (2015-01-13)
Hyaluronan (HA) in human milk mediates host responses to microbial infection via TLR4- and CD44-dependent signaling. Signaling by HA is generally size specific. Because pure HA with average molecular mass (M) of 35 kDa can elicit a protective response in
Ewa M Koźma et al.
Experimental biology and medicine (Maywood, N.J.), 239(12), 1575-1588 (2014-06-11)
Tumor transformation and progression both lead to extracellular matrix remodeling, which is also reflected in an alteration in the proportion of dermatan sulphate (DS) and chondroitin sulphate (CS) and an accumulation of the latter. In addition, a significant increase in
Takaki Amamoto et al.
Chemical & pharmaceutical bulletin, 62(7), 649-653 (2014-07-06)
We have developed a general method for controlling molecular functions using a photodegradable hydrogel; gels containing molecules made from such materials are capable of release and activation by light stimulus. As the elimination of molecular leaching from the gel before
Niklas Borg et al.
Journal of chromatography. A, 1359, 170-181 (2014-08-03)
This study has implemented and calibrated a model that describes the separation of the monomer of monoclonal antibodies from the dimer and larger oligomers on preparative-scale using cation-exchange chromatography. A general rate model with temperature dependent diffusion was coupled to
Mojgan Allahyari et al.
Journal of immunological methods, 416, 157-166 (2014-12-02)
Recombinant antigens are increasingly applied to replace native antigens in serological tests. Surface antigen 1 (SAG1) is a highly immunogenic antigen and probably represents the most explored and used antigen of Toxoplasma gondii for development of serological test kits. The
Chanida Puangpila et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 112-121 (2015-03-31)
This research reports a proof-of-concept that describes an instrumental approach that is gel free and label free at both the separation and mass spectrometry ends for the capturing and identification of differentially expressed proteins (DEPs) in diseases, e.g., cancers. The
Alina Ainbinder et al.
Cell calcium, 57(1), 14-24 (2014-12-06)
As muscle contraction requires ATP and Ca(2+), skeletal muscle function is highly dependent on communication between two major intracellular organelles: mitochondria and sarcoplasmic reticulum (SR). In adult skeletal muscle, mitochondria located within the I-band of the sarcomere are connected to
A Marijne Heeren et al.
BMC developmental biology, 15, 4-4 (2015-01-22)
In society, there is a clear need to improve the success rate of techniques to restore fertility. Therefore a deeper knowledge of the dynamics of the complex molecular environment that regulates human gametogenesis and (early) folliculogenesis in vivo is necessary.
J P Dzoyem et al.
Journal of ethnopharmacology, 160, 194-201 (2014-12-06)
Oxidative stress and inflammatory conditions are among the pathological features associated with the central nervous system in Alzheimer׳s disease. Traditionally, medicinal plants have been used to alleviate inflammation, pains and also other symptoms possibly associated with Alzheimer׳s disease. Therefore, the
Victorien Decoin et al.
BMC microbiology, 15, 72-72 (2015-04-18)
Pseudomonas fluorescens strain MFE01 secretes in abundance two Hcp proteins (haemolysin co-regulated proteins) Hcp1 and Hcp2, characteristic of a functional type 6 secretion system. Phenotypic studies have shown that MFE01 has antibacterial activity against a wide range of competitor bacteria
Seiichi Sakamoto et al.
Biochimica et biophysica acta, 1848(2), 434-443 (2014-12-03)
To investigate an interfacial behavior of the aglycon of glycyrrhizin (GC), glycyrrhetinic acid (GA), with a lipid raft model consisting of equimolar ternary mixtures of N-palmitoyl sphingomyelin (PSM), dioleoylphosphatidylcholine (DOPC), and cholesterol (CHOL), Langmuir monolayer techniques were systematically conducted. Surface
Lallie C McKenzie et al.
Journal of the American Chemical Society, 136(38), 13426-13435 (2014-08-30)
Ligand exchange is frequently used to introduce new functional groups on the surface of inorganic nanoparticles or clusters while preserving the core size. For one of the smallest clusters, triphenylphosphine (TPP)-stabilized undecagold, there are conflicting reports in the literature regarding
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