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Satoru Takahashi et al.
The Journal of biological chemistry, 278(33), 30821-30827 (2003-06-12)
Endothelial nitric-oxide synthase (eNOS), which generates the endogenous vasodilator, nitric oxide (NO), is highly regulated by post-translational modifications and protein interactions. We recently used purified proteins to characterize the mechanisms by which heat shock protein 90 (HSP90) increases eNOS activity
Hye-Ran Seo et al.
Molecules and cells, 44(2), 101-115 (2021-03-05)
The INO80 chromatin remodeling complex has roles in many essential cellular processes, including DNA replication. However, the mechanisms that regulate INO80 in these processes remain largely unknown. We previously reported that the stability of Ino80, the catalytic ATPase subunit of
Bo Wei et al.
iScience, 24(11), 103311-103311 (2021-11-16)
Neurotransmitter receptors are involved in cancer progression. Among them, the heterodimeric GABAB receptor, activated by the main inhibitory neurotransmitter GABA, is composed of the transmembrane GABAB1 and GABAB2 subunits. The oncogenic role of the isoform GABAB1e (GB1e) containing only the
Irving García-Jiménez et al.
The Journal of biological chemistry, 298(1), 101440-101440 (2021-11-23)
Metastatic lung cancer is a major cause of death worldwide. Dissemination of cancer cells can be facilitated by various agonists within the tumor microenvironment, including by lysophosphatidic acid (LPA). We postulate that Rho guanine nucleotide exchange factors (RhoGEFs), which integrate
Laura Novellasdemunt et al.
The EMBO journal, 39(3), e102771-e102771 (2019-12-24)
The intestinal stem cell (ISC) marker LGR5 is a receptor for R-spondin (RSPO) that functions to potentiate Wnt signalling in the proliferating crypt. It has been recently shown that Wnt plays a priming role for ISC self-renewal by inducing RSPO
Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes
Hresko, R. C., et al
The Journal of Biological Chemistry, 278, 21615-21622 (2003)
Kosuke Watari et al.
Communications biology, 3(1), 107-107 (2020-03-08)
Many diseases, including cancer, have been associated with impaired regulation of angiogenesis, of which vascular endothelial growth factor (VEGF)-A is a key regulator. Here, we test the contribution of N-myc downstream regulated gene 1 (NDRG1) to VEGF-A-induced angiogenesis in vascular
W Ye et al.
The Journal of biological chemistry, 270(18), 10933-10939 (1995-05-05)
We separately expressed the 58-kDa C-terminal, 42-kDa middle, 16-kDa C-terminal, and 33-kDa N-terminal regions of AP-3 (also called F1-20, AP180, NP185, and pp155), and determined their clathrin binding and assembly properties. The 58-kDa C-terminal region of AP-3 is able to
Yuki Katagiri et al.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 93(4), E225-E234 (2019-02-01)
To investigate the impact of minimal stent area (MSA) evaluated by post-procedural intravascular ultrasound (IVUS) on clinical outcomes after contemporary PCI in patients with three-vessel disease (TVD). The impact of post-procedural MSA on clinical outcomes has not yet been extensively
Ilir Agalliu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(3), 839-843 (2007-02-10)
Several epidemiologic studies have reported that carriers of germline mutations in the BRCA2 gene have an increased risk of prostate cancer, with the highest risk observed in men diagnosed at earlier ages. However, studies of the contribution of BRCA2 mutations
Ding-Ping Chen et al.
Annals of clinical and laboratory science, 34(4), 437-442 (2005-01-15)
The cis-AB is a very rare phenotype in the ABO blood group system. It corresponds to a special ABO allele encoding a glycosyltransferase that is capable of synthesizing both A and B antigens. Until now, gene sequences of only 3
Scott A Robotham et al.
Journal of the American Society for Mass Spectrometry, 26(9), 1570-1579 (2015-07-01)
In an effort to better characterize the fragmentation pathways promoted by ultraviolet photoexcitation in comparison to collision induced dissociation (CID), six adrenocorticotropic hormone (ACTH) peptides in a range of charge states were subjected to 266 nm ultraviolet photodissociation (UVPD), 193
H Fujii et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(4), 2587-2590 (1981-04-01)
A phosphoglycerate kinase (PGKase: ATP:3-phosphoglycerate 1-phosphotransferase, EC; X chromosome-linked) variant, PGKase-Tokyo, is associated with enzyme deficiency, nonspherocytic hemolytic anemia, and neurological disturbances. Because a sufficient amount of the patient's erythrocytes was not available, the variant enzyme was purified to
Lourdes Loidi et al.
Clinical endocrinology, 64(3), 330-336 (2006-02-21)
To detect common as well as rare and novel CYP21A mutations in 21-hydroxylase deficiency patients. To estimate the distribution of mutations and compare them with other European studies. To construct haplotypes linked to a recurrent novel mutation. Genetic analysis by
J R Casas-Finet et al.
Biochemistry, 31(42), 10272-10280 (1992-10-27)
The 39-kDa DNA polymerase beta (beta-Pol) molecule can be readily converted into two constituent domains by mild proteolysis; these domains are represented in an 8-kDa N-terminal fragment and a 31-kDa C-terminal fragment [Kumar et al. (1990a) J. Biol. Chem. 265
Hideyuki Takeshima et al.
Carcinogenesis, 33(12), 2384-2390 (2012-09-15)
A field for cancerization (field defect), where genetic and epigenetic alterations are accumulated in normal-appearing tissues, is involved in human carcinogenesis, especially cancers associated with chronic inflammation. Although aberrant DNA methylation is involved in the field defect and induced by
Kirsten Sandvig et al.
Molecular & cellular proteomics : MCP, 11(7), M111-M111 (2012-03-30)
Cancer biomarkers are invaluable tools for cancer detection, prognosis, and treatment. Recently, microvesicles have appeared as a novel source for cancer biomarkers. We present here the results from a proteomic analysis of microvesicles released to the extracellular environment by the
Alejandro Vaquero et al.
Nature, 450(7168), 440-444 (2007-11-16)
In contrast to stably repressive, constitutive heterochromatin and stably active, euchromatin, facultative heterochromatin has the capacity to alternate between repressive and activated states of transcription. As such, it is an instructive source to understand the molecular basis for changes in
T Airenne et al.
Genomics, 32(1), 54-64 (1996-02-15)
We have determined the structure of the human laminin gamma 2 chain gene (LAMC2), which is mutated in some patients with junctional epidermolysis bullosa. Eight lambda phage clones isolated from a genomic library and three subgenomic lambda phage clones made
Bernhard Schaaf et al.
BMC pulmonary medicine, 8, 12-12 (2008-08-14)
Neutrophil products like matrix metalloproteinases (MMP), involved in bacterial defence mechanisms, possibly induce lung damage and are elevated locally during hospital- acquired pneumonia (HAP). In HAP the virulence of bacterial species is known to be different. The aim of this
Craig A Jefferies et al.
Pediatric diabetes, 5(1), 20-25 (2004-03-27)
In pregnancies with small for gestational age (SGA) fetuses, elevated amniotic fluid tumor necrosis factor-alpha (TNF-alpha) levels have been reported. TNF-alpha has been shown to induce insulin resistance in rodents and humans. We hypothesized that an adverse fetal or early
Clemens Mittmann et al.
Cardiovascular research, 55(4), 778-786 (2002-08-15)
RGS proteins (regulators of G protein signalling) negatively regulate G protein function as GTPase activating proteins. By controlling heterotrimeric G proteins they may regulate myocardial hypertrophy and contractility. We investigated the expression of RGS proteins in the human heart and
Paresh R Shah et al.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 7(1), 46-56 (2006-03-21)
The cytoplasmic dynein-dynactin complex has been implicated in the aetiology of motor neuron degeneration in both mouse models and human forms of motor neuron disease. We have previously shown that mutations in the cytoplasmic dynein 1 heavy chain 1 gene
Nora Mörbt et al.
Proteomics, 9(21), 4920-4933 (2009-10-29)
Styrene is a volatile organic compound that is widely used as an intermediate in many industrial settings. There are known adverse health effects at environmentally significant concentrations, but little is known about the molecular effect of exposure to styrene at
S-C Wei et al.
Clinical genetics, 64(3), 243-251 (2003-08-16)
Hereditary non-polyposis colorectal cancer (HNPCC), the most common type of hereditary colorectal cancer, is thought to be a simple Mendelian disease involving DNA mismatch repair genes. The majority of mutations associated with HNPCC occur in the hMSH2 and hMLH1 genes.
T Matsuura et al.
Archives of biochemistry and biophysics, 301(2), 221-227 (1993-03-01)
The activity of the hepatic enzyme lecithin: retinol acyltransferase (LRAT), thought to catalyze the esterification of retinol for storage, was previously shown to vary directly with the vitamin A (retinol) status of the rat [Randolph, R. K., and Ross, A.
Alejandro Vaquero et al.
Nature, 450(7168), 440-444 (2007-11-16)
In contrast to stably repressive, constitutive heterochromatin and stably active, euchromatin, facultative heterochromatin has the capacity to alternate between repressive and activated states of transcription. As such, it is an instructive source to understand the molecular basis for changes in
Yi Shen et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 28(7), 1212-1220 (2019-04-17)
Circulating miRNAs have been identified as diagnostic biomarkers for esophageal squamous cell carcinoma (ESCC), but their efficacy in discovering early-stage ESCC is still unsatisfying. Esophageal squamous dysplasia (ESD) is the precursor lesion of ESCC. Notably, little is known about the
Garrett W Hill et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 45(4), 376-386 (2019-09-11)
This study examined the impact of treadmill running in normobaric hypoxia on gastrointestinal barrier permeability and the systemic inflammatory response. Ten recreationally active participants completed two 1-h bouts of matched-workload treadmill exercise (65% normoxic maximal oxygen consumption) in counterbalanced order.
Marica Grskovic et al.
The Journal of molecular diagnostics : JMD, 18(6), 890-902 (2016-10-25)
The use of circulating cell-free DNA (cfDNA) as a biomarker in transplant recipients offers advantages over invasive tissue biopsy as a quantitative measure for detection of transplant rejection and immunosuppression optimization. However, the fraction of donor-derived cfDNA (dd-cfDNA) in transplant
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