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Comparison of alterations in insulin signalling pathway in adipocytes from Type II diabetic pregnant women and women with gestational diabetes mellitus
Tomazic, M., et al
Diabetologia, 45, 502-508 (2002)
Pertussis toxin-sensitive G proteins as mediators of the signal transduction pathways activated by cytomegalovirus infection of smooth muscle cells.
Shibutani, T, et al.
The Journal of Clinical Investigation, 100, 2054-2061 (1997)
Rong Wu et al.
Cell metabolism, 29(3), 653-667 (2018-12-12)
Although emerging evidence indicates an important role of the circadian clock in modulating the diurnal oscillation of mammalian target of rapamycin complex 1 (mTORC1) signaling, the underlying molecular mechanism remains elusive. Here we show that Period2 (Per2), a core clock
Yanping Ma et al.
Current protocols in microbiology, 41, 1E-1E (2016-05-08)
Kaposi's sarcoma-associated herpesvirus (KSHV), a human gamma-herpesvirus, is etiologically linked to the development of several malignancies, mainly Kaposi's sarcoma. Expressed as an early viral protein, KSHV ORF57 is essential for lytic replication and virion production. ORF57 selectively binds to a
Paola Sacchetti et al.
Nucleic acids research, 34(19), 5515-5527 (2006-10-06)
The orphan nuclear receptor nurr1 (NR4A2) is an essential transcription factor for the acquisition and maintenance of the phenotype of dopamine (DA)-synthesizing neurons in the mesencephalon. Although structurally related to ligand-regulated nuclear receptors, nurr1 is functionally atypical due to its
Mohan Babu et al.
Methods in molecular biology (Clifton, N.J.), 564, 373-400 (2009-06-23)
Biochemical purification of affinity-tagged proteins in combination with mass spectrometry methods is increasingly seen as a cornerstone of systems biology, as it allows for the systematic genome-scale characterization of macromolecular protein complexes, representing demarcated sets of stably interacting protein partners.
E Jean Finnegan
The Plant journal : for cell and molecular biology, 84(5), 875-885 (2015-10-07)
In vernalized Arabidopsis, the extent of FLC repression and promotion of flowering are correlated with the length of winter (low temperature exposure), but how plants measure the duration of winter is unknown. Repression of FLC occurs in two phases: establishment
Activation of endothelin ETA receptors induces phosphorylation of alpha1b-adrenoreceptors in Rat-1 fibroblasts
Vazquez-Prado, J., et al
The Journal of Biological Chemistry, 272, 27330-27337 (1997)
Chronic stimulation of Nod2 mediates tolerance to bacterial products.
Hedl, Matija, et al.
Proceedings of the National Academy of Sciences of the USA, 104, 19440-19445 (2007)
Pallavi Sharma et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(32), 7072-7087 (2018-06-29)
Communications across chemical synapses are primarily mediated by neurotransmitters and their postsynaptic receptors. There are diverse molecular systems to localize and regulate the receptors at the synapse. Here, we identify HPO-30, a member of the claudin superfamily of membrane proteins
Ning Duan et al.
Journal of Cancer, 12(6), 1826-1837 (2021-02-23)
Decreased expression of proapoptotic genes can lead to the chemoresistenance in cancer therapy. Carboxyl-terminal binding protein 1 (CtBP1), a transcriptional corepressor with multiple oncogenic effects, has been previously identified to suppress the expression of two proapoptotic genes [BAX (BCL2 associated
Bo Wei et al.
iScience, 24(11), 103311-103311 (2021-11-16)
Neurotransmitter receptors are involved in cancer progression. Among them, the heterodimeric GABAB receptor, activated by the main inhibitory neurotransmitter GABA, is composed of the transmembrane GABAB1 and GABAB2 subunits. The oncogenic role of the isoform GABAB1e (GB1e) containing only the
D K Fuhrer et al.
The Journal of biological chemistry, 270(42), 24826-24830 (1995-10-20)
Protein tyrosine phosphorylation and thus dephosphorylation are part of the interleukin (IL)-11 response in mouse 3T3-L1 cells. We report here for the first time the involvement and interactions of the SH2-containing protein tyrosine phosphatase Syp in the IL-11 signal transduction
Identification of regions within the four small subunits of human replication factor C required for complex formation and DNA replication
Uhlmann, F., et al
The Journal of Biological Chemistry, 272, 10065-10071 (1997)
Mirte M Streppel et al.
Human pathology, 43(10), 1755-1763 (2012-05-01)
Mucin 16 (cancer antigen 125) is a cell surface glycoprotein that plays a role in promoting cancer cell growth in ovarian cancer. The aims of this study were to examine mucin 16 expression in a large number of digestive tract
Iman Assil-Kishawi et al.
The Journal of biological chemistry, 277(36), 32558-32561 (2002-05-25)
Contact sites between the corticotropin-releasing factor receptor type 1 (CRFR1), the sauvagine (SVG) radioligands [Tyr(0),Gln(1)]SVG ((125)I-YQS) and [Tyr(0),Gln(1), Leu(17)]SVG ((125)I-YQLS) were examined. (125)I-YQLS or (125)I-YQS was cross-linked to CRFR1 using the chemical cross-linker, disuccinimidyl suberate (DSS), which cross-links the epsilon
P Sabbatini et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 17(3), 589-594 (2007-02-16)
The objective of this study was to analyze retrospective populations with recurrent ovarian cancer to assess differences in CA-125 patterns during chemotherapy. The populations included all patients treated between January 1994 and January 2004, who received liposomal doxorubicin and topotecan
E J Nouwen et al.
Cancer research, 46(2), 866-876 (1986-02-01)
Human placental alkaline phosphatase (HPLAP), carcinoembryonic antigen (CEA), and cancer antigen 125 (CA 125) were localized immunohistochemically in paraffin sections of normal lung tissue from 16 patients, using monoclonal antibodies and an indirect avidin-biotin-peroxidase staining procedure. HPLAP and CEA were
CA-125 of fetal origin can act as a ligand for dendritic cell-specific ICAM-3-grabbing non-integrin.
Ninoslav Mitić et al.
Cellular & molecular biology letters, 19(2), 249-261 (2014-04-26)
CA-125 (coelomic epithelium-related antigen) forms the extracellular portion of transmembrane mucin 16 (MUC16). It is shed after proteolytic degradation. Due to structural heterogeneity, CA-125 ligand capacity and biological roles are not yet understood. In this study, we assessed CA-125 as
National Toxicology Program technical report series, (566)(566), 1-174 (2011-12-01)
Diethylamine is used mainly as a chemical intermediate to produce the corrosion inhibitor N,N-diethylethanolamine and a lesser amount is used to produce pesticides and insect repellants and in rubber processing. Diethylamine was nominated for study by the National Institute of
Lei Chen et al.
The Journal of international medical research, 48(10), 300060520944309-300060520944309 (2020-10-15)
To determine if iodine-125 seed implantation improved the efficacy of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) (≤5 cm). We retrospectively reviewed the medical records of 83 consecutive patients with HCC (≤5 cm) who underwent TACE or TACE-iodine-125 from January
Simona Ferraro et al.
Journal of clinical pathology, 66(4), 273-281 (2013-02-22)
Human epididymis protein 4 (HE4) measurements in serum have been proposed for improving the specificity of laboratory identification of ovarian cancer (OC). To critically revise the available literature on the comparison between the diagnostic accuracy of HE4 and carbohydrate antigen
Sernaz Uzunoglu et al.
Medical oncology (Northwood, London, England), 30(1), 447-447 (2013-01-17)
The goal of this study was to evaluate the efficacy of CA-125 area under the curve (CA-125 AUC) as a prognostic factor following surgical treatment for ovarian cancer patients. A retrospective analysis was conducted on ninety-five patients with ovarian cancer
Gesine Kögler et al.
Transplantation, 74(8), 1167-1175 (2002-11-20)
In HLA-identical sibling bone marrow transplantation, certain recipient cytokine gene polymorphism genotypes and minor histocompatibility differences influence the occurrence and severity of acute graft-versus-host disease (aGvHD). The present study investigated the role of cytokine tumor necrosis factor (TNF)-alpha and interleukin
M C Cabel et al.
Poultry science, 70(2), 241-249 (1991-02-01)
Two trials were conducted to evaluate the effects of feeding various anticoccidial products to turkeys to 8 wk and then growing to market age (16 wk for hens and 20 wk for toms). Anticoccidials evaluated in the first trial included
David O Robinson et al.
American journal of medical genetics. Part A, 146A(5), 558-569 (2008-02-05)
A series of 125 patients referred primarily with aniridia classified as either sporadic (74), familial (24), or in association with WAGR syndrome (14) or other malformations (13) was analysed for mutations, initially by karyotyping and targeted FISH analysis of chromosome
SiHyun Cho et al.
Fertility and sterility, 90(6), 2073-2079 (2008-06-17)
To investigate the clinical value of differential white blood cell counts and neutrophil-to-lymphocyte ratio (NLR), by themselves or as adjunct to CA-125, in the diagnosis of endometriosis. Retrospective study. University Medical Center. Two hundred thirty-one patients with endometriosis, 145 patients
Tingting Xiao et al.
Molecular medicine reports, 15(2), 591-596 (2016-12-22)
Pulmonary arterial hypertension (PAH) is a chronic disorder of the small pulmonary arteries, and the efficacy of the therapies and the prognosis remain poor. The pathobiology of PAH is complex, and needs to be elucidated by multiple approaches. The present
Magali Vivier et al.
European journal of medicinal chemistry, 46(11), 5705-5710 (2011-09-20)
The proteasome is a promising target in cancer therapy. However, it is ubiquitous and its inhibitors cause side effects. To target melanoma cells we synthesized new peptide aldehyde and vinylsulfone inhibitors of the proteasome conjugated to the melanin-targeting ligand (MTL)
B Fischer et al.
Theriogenology, 41(4), 879-887 (1994-01-01)
Preimplantation embryos of the pig (Days 11 to 15), cow (Days 14 to 16), sheep (Day 14) and pony (Day 16) bind epidermal growth factor (EGF) specifically. Binding was not detected in embryos of the rabbit at Day 5 or
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