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Muhammad Naveed Mushtaq et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 53, 163-170 (2019-01-23)
Zanthoxylum armatum DC (Z. armatum), belonging to Rutaceae family, has been traditionally used for the treatment of various diseases such as hypertension, abdominal pain, headache, fever, high altitude sickness, diarrhea, dysentery, and as a tonic, condiment, and an anthelmintic treatment.
Evan L Pannkuk et al.
Metabolites, 9(5) (2019-05-18)
Whole body exposure to ionizing radiation damages tissues leading to physical symptoms which contribute to acute radiation syndrome. Radiation biodosimetry aims to determine characteristic early biomarkers indicative of radiation exposure and is necessary for effective triage after an unanticipated radiological
Sergio Lario et al.
Scientific reports, 7(1), 17774-17774 (2017-12-21)
Gastric carcinogenesis is a multifactorial process described as a stepwise progression from non-active gastritis (NAG), chronic active gastritis (CAG), precursor lesions of gastric cancer (PLGC) and gastric adenocarcinoma. Gastric cancer (GC) 5-year survival rate is highly dependent upon stage of
Yi Cheng et al.
Toxicology letters, 312, 214-221 (2019-05-28)
Shikonin, a natural red colorant, is widely used for food garnishment and cosmetic ingredient in the world. Shikonin also possesses a variety of pharmacological actions, including anti-inflammation and anti-cancer activities. However, little is known about its effects on the UDP-glucuronosyltransferases
A Newman-Tancredi et al.
Cellular signalling, 63, 109383-109383 (2019-08-04)
A previous study observed bell-shaped concentration-response isotherms for activation of Gαi3 G-protein subunits by high efficacy 5-HT1A receptor agonists in a Chinese hamster ovary (CHO) cell line expressing high levels of these receptors. This suggested that a signaling switch took
Robert MacLaren et al.
Neuroscience, 398, 206-217 (2018-12-18)
The central nervous system (CNS) and gastrointestinal tract (GIT) are linked through neuro-endocrine and humoral pathways. Critically ill patients suffer severe physical and emotional stress and frequently receive acid suppressants; however, stress and acid suppression may alter GIT microbiota. This
Michele R Balik-Meisner et al.
Zebrafish, 16(4), 331-347 (2019-06-13)
Sentinel gene sets have been developed with the purpose of maximizing the information from targeted transcriptomic platforms. We recently described the development of an S1500+ sentinel gene set, which was built for the human transcriptome, utilizing a data- and knowledge-driven
R Mohammed et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 68(5), 737-747 (2018-01-30)
Hydrogen sulfide (H2S) has recently emerged as a biologically active gas with multiple effects on the cardiovascular system. We aimed to investigate the vasomotor actions of sodium sulfide (Na2S), which forms H2S and HS- in solution, in human umbilical artery
Johan Spetz et al.
Nuclear medicine and biology, 60, 11-18 (2018-03-05)
Patients with neuroendocrine tumors expressing somatostatin receptors are often treated with 177Lu[Lu]-octreotate. Despite being highly effective in animal models, 177Lu[Lu]-octreotate-based therapies in the clinical setting can be optimized further. The aims of the study were to identify and elucidate possible
Kanako Terakado Kimura et al.
Nature structural & molecular biology, 26(2), 121-128 (2019-02-07)
Many drugs target the serotonin 2A receptor (5-HT2AR), including second-generation antipsychotics that also target the dopamine D2 receptor (D2R). These drugs often produce severe side effects due to non-selective binding to other aminergic receptors. Here, we report the structures of
Chun-Sing Lam et al.
PloS one, 12(6), e0177940-e0177940 (2017-06-10)
Co-morbid depression is prevalent in patients with obstructive sleep apnea. Here we report that monoamine oxidase A (MAO-A) plays pathogenic roles in the comorbidity. We found that chronic intermittent hypoxia significantly increased the MAO-A expression in the rat hippocampus and
Hsueh-Te Lee et al.
Molecular neurobiology, 56(4), 2495-2507 (2018-07-24)
Soluble epoxide hydrolase (sEH), an enzyme with COOH-terminal hydrolase and NH2-terminal lipid phosphatase activities, is expressed in regions of the brain such as the cortex, white matter, hippocampus, substantia nigra, and striatum. sEH is involved in the regulation of cerebrovascular
Jann-Inn Tzeng et al.
Pharmacological reports : PR, 69(5), 846-850 (2017-06-18)
The aim of this experiment was to investigate a long-lasting local anesthetic bupivacaine combined with serotonin at inducing cutaneous antinociception. The skin antinociception, characterized by an inhibition of the cutaneous trunci muscle reflex (CTMR) following the pinprick on the dorsal
Tran Duy Thanh et al.
Biosensors & bioelectronics, 96, 186-193 (2017-05-12)
A high quality graphene-encapsulated AuAg alloy (AuAg-GR) nanohybrid with homogeneous structure and good reproducibility over a desired area was successfully fabricated. Taking benefits of the unique architecture, such nanohybrid was employed as an efficient electrocatalyst for sensing application. The AuAg-GR
Estefanía Moreno et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(5), 1176-1186 (2016-12-23)
The neuropeptide galanin has been shown to interact with the opioid system. More specifically, galanin counteracts the behavioral effects of the systemic administration of μ-opioid receptor (MOR) agonists. Yet the mechanism responsible for this galanin-opioid interaction has remained elusive. Using
Hadi Tabani et al.
Journal of pharmaceutical and biomedical analysis, 160, 244-267 (2018-08-16)
Monitoring of target analytes (e.g., pharmaceuticals, endogenous compounds) present in biological samples usually requires a preliminary step toward analyte isolation from surrounding matrix and enrichment for trace analysis. Evident developments have been recently made to introduce novel "green" analytical approaches
Paul R Pentel et al.
BMC biotechnology, 18(1), 46-46 (2018-07-26)
The bacterial nicotine-degrading enzyme NicA2 isolated from P. putida was studied to assess its potential use in the treatment of tobacco dependence. Rats were pretreated with varying i.v. doses of NicA2, followed by i.v. administration of nicotine at 0.03 mg/kg. NicA2
T Fukuyama et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 48(1), 78-88 (2017-10-14)
It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic dermatitis; however, the specific antipruritic mechanism of action remains unclear. To confirm itch relief and reduction of lesions in a
Jeong-Eun Choi et al.
The Journal of nutritional biochemistry, 49, 101-109 (2017-09-16)
Our previous studies found that n-3 polyunsaturated fatty acids (PUFAs) and estrogen had synergistic antidepressant-like effects. The purpose of the present study was to investigate the hypothesis that three major n-3 PUFAs, α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic
Susana Paredes-Zúñiga et al.
Progress in neuro-psychopharmacology & biological psychiatry, 92, 118-126 (2018-12-30)
Triadimefon (TDF) is a triazole fungicide extensively used in agriculture that has been found as a pollutant in numerous water sources. In mammals, it inhibits monoamine uptake through binding to the dopamine transporter, with a mechanism of action similar to
Swalpa Udit et al.
Molecular metabolism, 6(10), 1081-1091 (2017-10-17)
Metabolic viscera and their vasculature are richly innervated by peripheral sensory neurons. Here, we examined the metabolic and inflammatory profiles of mice with selective ablation of all Na While mice lacking sensory neurons displayed no differences in body weight, food
Neil C Lax et al.
Synapse (New York, N.Y.), 72(11), e22059-e22059 (2018-07-12)
Marine cyanobacteria represent a unique source in the field of drug discovery due to the secondary metabolites they produce and the structural similarity these compounds have to endogenous mammalian receptor ligands. A series of cyanobacteria were subjected to extraction, fractionation
Brenna B Maddox et al.
Autism : the international journal of research and practice, 22(8), 898-906 (2017-08-29)
Many children with autism spectrum disorder display challenging behaviors. These behaviors are not limited to those with cognitive and/or language impairments. The Collaborative and Proactive Solutions framework proposes that challenging behaviors result from an incompatibility between environmental demands and a
Chan Hum Park et al.
The American journal of Chinese medicine, 47(2), 369-383 (2019-03-05)
This study examined whether serotonin and two of its derivatives, N
Bo Kyung Lee et al.
Biomolecules & therapeutics, 26(4), 368-373 (2018-06-20)
Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula angustifolia, has antioxidant, anti-inflammatory, and neuroprotective effects, along with other
Joseph H Bisesi et al.
Environmental toxicology and chemistry, 35(4), 938-945 (2015-06-17)
Antidepressants have been found in measurable concentrations in final treated wastewater effluent and receiving waters throughout the world. Studies have shown that these concentrations are typically not overtly toxic, but the psychotropic mode of action of these chemicals warrants examination
Diana Dahan et al.
Journal of vascular research, 54(4), 246-256 (2017-08-11)
Serotonin (5-HT) is considered to play a role in pulmonary arterial hypertension by regulating vascular remodeling and smooth muscle contractility. Here, arteries from mice with inducible and smooth muscle-specific deletion of Dicer were used to address mechanisms by which microRNAs
Melissa K Passarelli et al.
Nature methods, 14(12), 1175-1183 (2017-11-14)
We report the development of a 3D OrbiSIMS instrument for label-free biomedical imaging. It combines the high spatial resolution of secondary ion mass spectrometry (SIMS; under 200 nm for inorganic species and under 2 μm for biomolecules) with the high
Hiromi Abe et al.
Biochemical and biophysical research communications, 479(4), 907-912 (2016-09-30)
Neurotrophic/growth factors derived from glial cells, especially astrocytes, have been implicated in mood disorders and the pharmacological effects of antidepressant drugs. Previous studies demonstrated that the release of glial cell line-derived neurotrophic factor (GDNF) induced by the tricyclic antidepressant amitriptyline
Camila Marroni Roncon et al.
Journal of psychopharmacology (Oxford, England), 31(6), 715-721 (2017-06-07)
The dorsomedial hypothalamus (DMH) and the dorsal periaqueductal gray (DPAG) have been implicated in the genesis and regulation of panic-related defensive behaviors, such as escape. Previous results point to an interaction between serotonergic and opioidergic systems within the DPAG to
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