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Hai Lu et al.
Medicine, 98(7), e14479-e14479 (2019-02-15)
Poststroke depression is a serious and common complication of stroke, especially the ischemic poststroke depression. Antidepressants are used in poststroke depression, and acupuncture may be an alternative approach. However, the efficacy and mechanism of acupuncture for poststroke depression has not...
Kendall H Lee et al.
Scientific reports, 7, 46675-46675 (2017-04-30)
There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such...
Jhonny Azuaje et al.
Scientific reports, 7(1), 10765-10765 (2017-09-09)
Some 5-HT
William T Donnelly et al.
Experimental physiology, 102(8), 1007-1018 (2017-07-05)
What is the central question of this study? Does activation of serotonergic neurons in the caudal medullary raphe, some of which project to the nucleus of the solitary tract, shorten the laryngeal chemoreflex? What is the main finding and its...
Ali Mahdi et al.
Rejuvenation research, 22(5), 385-389 (2018-12-12)
Reduced bioavailability of nitric oxide (NO) is accompanied by endothelial dysfunction, which precedes clinical signs of atherosclerosis. The metalloenzyme arginase reciprocally inhibits the formation of NO and available data demonstrate that arginase contributes to reduced bioavailability of NO and increases...
Joel Castro et al.
JCI insight, 4(20) (2019-09-20)
Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. While pain arises from both the skin and viscera, we investigated whether pruritogenic irritant mechanisms also function within visceral pathways. We show...
Atsushi Ishihara et al.
Bioscience, biotechnology, and biochemistry, 81(6), 1090-1098 (2017-05-10)
The inducible metabolites were analyzed in barley leaves inoculated with Bipolaris sorokiniana, the causal agent of spot blotch of barley. HPLC analysis revealed that B. sorokiniana-infected leaves accumulated 4 hydrophilic compounds. They were purified by ODS column chromatography and preparative...
Claudia L Reardon
International review of psychiatry (Abingdon, England), 28(6), 606-613 (2016-06-23)
There are several critical factors to consider in prescribing psychiatric medications to athletes. In addition to the usual considerations when prescribing any psychotropic agent to any patient, the prescriber in this case should pay careful attention to: (1) potential negative...
Martin Reznitsky et al.
Neuroscience letters, 612, 172-177 (2015-12-20)
The objective of this study is to establish which subdivision of the dorsal raphe nucleus (DRN) supplies serotonergic projections to the subthalamic nucleus (STN) in the rat brain. Several studies in recent years have shown that serotonin (5-HT) might have...
Hsiao-Chi Chuang et al.
Environmental pollution (Barking, Essex : 1987), 232, 523-532 (2017-10-11)
Sleep disorders may pose a risk to workers in the workplace. We aimed to investigate the associations between metal fume fine particulate matter (PM
Eliyahu Dremencov et al.
The international journal of neuropsychopharmacology, 20(7), 585-592 (2017-04-22)
The antidepressant effect of physical exercise has been reported in several clinical and animal studies. Since serotonin, norepinephrine, and dopamine play a central role in depression, it is possible that the beneficial effects of physical exercise are mediated via monoamine...
Satoshi Ansai et al.
Zebrafish, 14(6), 495-507 (2017-09-22)
Serotonin (5-hydroxytryptamine [5-HT]) is a bioactive monoamine that acts as a neurotransmitter in the central and peripheral nervous system of animals. Teleost fish species have serotonergic neurons in the raphe nuclei of the brainstem; however, the role of 5-HT in...
Isabella Lawandy et al.
Molecular and cellular biochemistry, 461(1-2), 57-64 (2019-07-29)
Metabolic syndrome (MetS) is associated with alterations in coronary vascular smooth muscle and endothelial function. The current study examined the contractile response of the isolated coronary arterioles to serotonin in pigs with and without MetS and investigated the signaling pathways responsible...
Pilar Alvarez-Illera et al.
Oncotarget, 8(34), 55889-55900 (2017-09-17)
Progressive decline in mitochondrial function is generally considered one of the hallmarks of aging. We have expressed a Ca
Ana Caroline Costa Sa et al.
Scientific reports, 9(1), 8795-8795 (2019-06-21)
Growing evidence suggests that peripheral factors to the brain driving neuro-inflammation could affect Alzheimer's Disease (AD) and Parkinson's Disease (PD) severity. Herpes simplex virus type 1 (HSV1) infection has been associated with AD while other related viruses, including cytomegalovirus (CMV)...
James Lomas et al.
PharmacoEconomics, 34(9), 901-912 (2016-06-13)
The National Institute for Health and Care Excellence (NICE) invited the manufacturer of vortioxetine (Lundbeck) to submit clinical and cost-effectiveness evidence for vortioxetine for the treatment of major depressive episodes (MDEs), as part of the Institute's Single Technology Appraisal (STA) process....
Yongtao Bai et al.
Biomedical chromatography : BMC, 33(9), e4542-e4542 (2019-04-05)
A highly selective and efficient LC-MS/MS method was developed to determine the plasma concentration of magnolol, hesperidin, neohesperidin and geniposide following oral administration of Zhi-Zi-Hou-Po decoction in normal and depressed rats. Plasma samples were pretreated by protein precipitation with methanol....
Peter Walentek et al.
Developmental biology, 408(2), 292-304 (2015-04-08)
Proton pump inhibitors (PPIs), which target gastric H(+)/K(+)ATPase (ATP4), are among the most commonly prescribed drugs. PPIs are used to treat ulcers and as a preventative measure against gastroesophageal reflux disease in hospitalized patients. PPI treatment correlates with an increased...
Krishna C Penumatsa et al.
American journal of physiology. Lung cellular and molecular physiology, 313(5), L752-L762 (2017-08-05)
Tissue matrix remodeling and fibrosis leading to loss of pulmonary arterial and right ventricular compliance are important features of both experimental and clinical pulmonary hypertension (PH). We have previously reported that transglutaminase 2 (TG2) is involved in PH development while...
Arnold Gammaitoni et al.
Clinical therapeutics, 40(8), 1338-1346 (2018-06-27)
Fenfluramine is being developed as a low-dose adjunctive treatment for seizures in patients with Dravet syndrome and other epileptic encephalopathies, including Lennox-Gastaut syndrome. Most patients with Dravet syndrome receive multiple antiepileptic drugs, making it challenging for caregivers to track correct...
Harun N Noristani et al.
Journal of neurotrauma, 35(24), 2924-2940 (2018-06-08)
Spinal cord injuries (SCI) are disastrous neuropathologies causing permanent disabilities. The availability of different strains of mice is valuable for studying the pathophysiological mechanisms involved in SCI. However, strain differences have a profound effect on spontaneous functional recovery after SCI....
Charlotte M Detremmerie et al.
The Journal of pharmacology and experimental therapeutics, 358(3), 558-568 (2016-06-24)
Preliminary experiments on isolated rat arteries demonstrated that thymoquinone, a compound widely used for its antioxidant properties and believed to facilitate endothelium-dependent relaxations, as a matter of fact caused endothelium-dependent contractions. The present experiments were designed to determine the mechanisms...
Emi Kiyokage et al.
The Journal of comparative neurology, 525(5), 1059-1074 (2016-11-20)
Olfactory sensory axons converge in specific glomeruli where they form excitatory synapses onto dendrites of mitral/tufted (M/T) and juxtaglomerular (JG) cells, including periglomerular (PG), external tufted (ET), and superficial-short axon cells. JG cells consist of heterogeneous subpopulations with different neurochemical...
Emilia Berin et al.
Maturitas, 85, 96-103 (2016-02-10)
Hot flushes and night sweats affect 75% of all women after menopause and is a common reason for decreased quality of life in mid-aged women. Hormone therapy is effective in ameliorating symptoms but cannot be used by all women due...
Anisha Pathak et al.
Biosensors & bioelectronics, 133, 205-214 (2019-04-03)
Surface plasmon resonance (SPR) based dopamine sensor is realized using the state-of-art technique of molecular imprinting over an optical fiber substrate. Polypyrrole (PPy) is depicted as an effective polymer for the imprinting of dopamine through a green synthesis approach. Sensitivity...
Hua Rong Lu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 148(2), 503-516 (2015-09-12)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are emerging as a powerful in vitro model for cardiac safety assessment which may allow for better identification of compounds with poor arrhythmogenic liability profiles early in the drug discovery process. Here, we describe...
Kristina Javor et al.
Biosensors & bioelectronics, 87, 1-6 (2016-08-09)
It is known that electrochemical energy can be harvested from mammalian cells, more specifically from white blood cells (WBC). This study focuses on an improved biofuel cell operating on phorbol myristate acetate (PMA) activated THP-1 human monocytic cells. Electrochemical investigation...
M Saygin et al.
Bratislavske lekarske listy, 118(7), 408-416 (2017-08-03)
To examine the impact of different types of sleep deprivation on hippocampal-mediated learning and memory in rats. Forty-eight Sprague-Dawley male rats were randomly assigned to 1 of 4 equal-size groups: (1) 12 hours of sleep per day (control). (2) total...
Kris L Sorby et al.
The Journal of experimental biology, 221(Pt 14) (2018-05-31)
Organisms increasingly encounter higher frequencies of extreme weather events as a consequence of global climate change. Currently, few strategies are available to mitigate climate change effects on animals arising from acute extreme high-temperature events. We tested the capacity of physiological...
Zina Fredj et al.
Mikrochimica acta, 185(9), 412-412 (2018-08-15)
The authors describe a method for simultaneous voltammetric determination of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). A glassy carbon electrode was modified with poly(pyrrole-3-carboxylic acid) and with platinised carbon nanofibers to obtain a sensor that can quantify...
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