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Charles C Oh et al.
Biochemical and biophysical research communications, 450(1), 628-633 (2014-06-17)
The mechanisms underlying lipotoxic/diabetic cardiomyopathy remain poorly understood. Saturated fatty acid (SFA) levels, elevated in obesity and type 2 diabetes, induce apoptosis in many cell types including cardiomyocytes. Signaling pathways, including the p38α mitogen-activated kinase (MAPK)-dependent pathway, have been implicated
Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells.
Kwon B, Lee HK, and Querfurth HW
Biochimica et Biophysica Acta, 1843(7), 1402-1413 (2014)
M Miranda et al.
FEBS letters, 588(24), 4815-4824 (2014-12-03)
The post-translational palmitoylation of WNT morphogens is critical for proper signaling during embryogenesis and adult homeostasis. The addition of palmitoyl groups to WNT proteins is catalyzed by Porcupine (PORCN). However, the Wnt amino acid residues required for recognition and palmitoylation
Alexa Patoine et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 29(9), 2004-2016 (2014-04-10)
BRIL/IFITM5 is a membrane protein present almost exclusively in osteoblasts, which is believed to adopt a type III (N-out/C-out) topology. Mutations in IFITM5 cause OI type V, but the characteristics of the mutant protein and the mechanism involved are still
Jesse Q Nguyen et al.
Pathogens and disease, 72(1), 10-18 (2014-03-13)
Francisella tularensis is a Gram-negative bacterium responsible for the human disease tularemia. The Francisella pathogenicity island (FPI) encodes a secretion system related to type VI secretion systems (T6SS) which allows F. tularensis to escape the phagosome and replicate within the
Jo-Wen Liu et al.
Journal of neurochemistry, 132(1), 85-98 (2014-08-26)
Epidermal fatty acid-binding protein (E-FABP/FABP5/DA11) binds and transport long-chain fatty acids in the cytoplasm and may play a protecting role during neuronal injury. We examined whether E-FABP protects nerve growth factor-differentiated PC12 cells (NGFDPC12 cells) from lipotoxic injury observed after
Guillaume Vares et al.
PloS one, 9(8), e106277-e106277 (2014-08-30)
Both exposure to ionizing radiation and obesity have been associated with various pathologies including cancer. There is a crucial need in better understanding the interactions between ionizing radiation effects (especially at low doses) and other risk factors, such as obesity.
Jiatao Ye et al.
Methods in molecular biology (Clifton, N.J.), 371, 111-141 (2007-07-20)
Nutrigenomics is the study of gene-nutrient interactions and how they affect the health and metabolism of an organism. Combining nutrigenomics with longevity studies is a natural extension and promises to help identify mechanisms whereby nutrients affect the aging process, life
Yan Zhang et al.
Cell biology international, 38(12), 1403-1407 (2014-07-22)
Tribbles are a family of signal-regulating proteins shown to coordinate the action and the suppression of different pathways. Tribbles homolog 3 (Trib3), the best-studied member of the mammalian tribble family, has a key function in determining cell fate when responding
Pablo de la Iglesia et al.
Rapid communications in mass spectrometry : RCM, 28(23), 2605-2616 (2014-11-05)
Esterification is one of the most important metabolic routes of lipophilic marine toxins in shellfish. In this work we assessed several chemical acylation reactions aimed at obtaining acyl ester analogues via partial synthesis from the free toxins. The procedures developed
Marie Takai et al.
Bioscience, biotechnology, and biochemistry, 78(2), 238-244 (2014-07-19)
Transmembrane protein CD36 binds multiple ligands, including oxidized low-density lipoproteins (oxLDLs) and long-chain fatty acids (LCFAs). Our aim was to determine whether LCFAs compete with oxLDLs for binding to CD36. We addressed this issue by examining the inhibitory effect of
Ulrich Koenig et al.
Autophagy, 11(2), 298-313 (2014-12-09)
The epithelial derived Harderian gland consists of 2 types of secretory cells. The more numerous type A cells are responsible for the secretion of lipid droplets, while type B cells produce dark granules of multilamellar bodies. The process of autophagy
Freddy Romero et al.
American journal of respiratory cell and molecular biology, 51(6), 840-849 (2014-06-19)
Chronic alcoholism impairs pulmonary immune homeostasis and predisposes to inflammatory lung diseases, including infectious pneumonia and acute respiratory distress syndrome. Although alcoholism has been shown to alter hepatic metabolism, leading to lipid accumulation, hepatitis, and, eventually, cirrhosis, the effects of
Justin Evans et al.
Microvascular research, 98, 145-158 (2014-05-08)
Arachidonic acid (AA), a bioactive fatty acid whose levels increase during neuroinflammation, contributes to cerebral vascular damage and dysfunction. However, the mode of injury and underlying signaling mechanisms remain unknown. Challenge of primary human brain endothelial cells (HBECs) with AA
Almudena Veiga-Lopez et al.
Endocrinology, 156(3), 911-922 (2015-01-21)
Bisphenol A (BPA) is a high production volume chemical and an endocrine disruptor. Developmental exposures to BPA have been linked to adult metabolic pathologies, but the pathways through which these disruptions occur remain unknown. This is a comprehensive interspecies association
Ming Yu et al.
Cancer letters, 360(2), 187-194 (2015-02-14)
Increased fatty acids (FAs) regulate pancreatic cancer progression, however, the detailed mechanism is not clear, and different forms of FAs may play diversified roles in pancreatic cancer. To elucidate the underlying mechanism, we compared the effects of four major types
Zhen Gao et al.
Biochemical pharmacology, 91(4), 474-482 (2014-08-26)
Palmitic acid, one of the saturated free fatty acids, impairs cardiovascular function as manifested by inducing vascular inflammation, apoptosis and over-production of reactive oxygen species (ROS) although the origin for ROS remains unclear. The present study investigated the cellular mechanisms
Claudia Bernal et al.
Journal of agricultural and food chemistry, 63(14), 3716-3724 (2015-03-24)
Sugar esters are considered as surfactants due to its amphiphilic balance that can lower the surface tension in oil/water mixtures. Enzymatic syntheses of these compounds are interesting both from economic and environmental considerations. A study was carried out to evaluate
André Engesland et al.
Journal of pharmaceutical sciences, 104(3), 1119-1127 (2015-01-06)
Cost-effective and efficient methods for permeability screening are crucial during early development of drugs, drug formulations, and cosmeceuticals. Alternatives to animal experiments are impelled for both economical and ethical reasons. The aim of this study was to determine the ability
Ali Jebali et al.
Drug and chemical toxicology, 37(4), 433-439 (2014-01-21)
Nanoparticles (NPs) can adsorb different molecules, because of their high local charge density and specific surface area. The toxicity of NPs is changed after adsorption, which may be different from unbound or unbound NPs. In this study, unbound silver nanoparticles
Shiro Koizume et al.
Molecular cancer, 14, 77-77 (2015-04-17)
Elucidation of the molecular mechanisms by which cancer cells overcome hypoxia is potentially important for targeted therapy. Complexation of hypoxia-inducible factors (HIFs) with aryl hydrocarbon receptor nuclear translocators can enhance gene expression and initiate cellular responses to hypoxia. However, multiple
Woo-Jae Park et al.
Biochimica et biophysica acta, 1841(12), 1754-1766 (2014-09-23)
Ceramide synthase 2 (CerS2) null mice cannot synthesize very-long acyl chain (C22-C24) ceramides resulting in significant alterations in the acyl chain composition of sphingolipids. We now demonstrate that hepatic triacylglycerol (TG) levels are reduced in the liver but not in
Chuan Wang et al.
PloS one, 9(7), e103071-e103071 (2014-07-23)
Inflammatory stress is an independent risk factor for the development of non-alcoholic fatty liver disease (NAFLD). Although CD36 is known to facilitate long-chain fatty acid uptake and contributes to NAFLD progression, the mechanisms that link inflammatory stress to hepatic CD36
Angelica Dessì et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 27 Suppl 2, 34-38 (2014-10-07)
The objective of our study was to evaluate the capability of the metabolomics approach to identify the variations of urine metabolites over time related to the neonatal fungal septic condition. The study population included a clinical case of a preterm
Elena Fattore et al.
International journal of food sciences and nutrition, 64(5), 648-659 (2013-02-15)
We reviewed the scientific literature on the evidence of the relationship between palm oil and adverse effects on human health. Few studies have investigated the effects of palm oil per se, and the main reason why it has been associated
J Trnovská et al.
Physiological research, 64(1), 51-60 (2014-09-07)
Cold exposure of rats leads to ameliorated glucose and triglyceride utilization with females displaying better adaptation to a cold environment. In the current study, we used hairless rats as a model of increased thermogenesis and analyzed gender-related effects on parameters
Masashi Oguri et al.
Biochimica et biophysica acta, 1838(7), 1851-1861 (2014-02-26)
The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix. The main lipid classes in the lipid matrix are ceramides (CERs), cholesterol (CHOL) and free
Harshi Weerakoon et al.
PloS one, 10(4), e0121537-e0121537 (2015-04-09)
Records on gallstones and associated ailments in Sri Lankan community are scarce, despite frequent detection of gallstone disease. Identification of the chemical composition of gallstones in the local setting is important in defining aetiopathogenic factors which in turn are useful
Pil Soo Sung et al.
Journal of virology, 88(16), 9233-9244 (2014-06-06)
Diacylglycerol acyltransferase-1 (DGAT1) is involved in the assembly of hepatitis C virus (HCV) by facilitating the trafficking of the HCV core protein to the lipid droplet. Here, we abrogated DGAT1 expression in Huh-7.5 cells by using either the transcription activator-like
Veronika Mäde et al.
ChemMedChem, 9(11), 2463-2474 (2014-08-27)
Pancreatic polypeptide (PP) is a satiety-inducing gut hormone targeting predominantly the Y4 receptor within the neuropeptide Y multiligand/multireceptor family. Palmitoylated PP-based ligands have already been reported to exert prolonged satiety-inducing effects in animal models. Here, we suggest that other lipidation
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