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Kelly E Miller et al.
The Journal of cell biology, 209(2), 211-220 (2015-04-22)
Linker histone H1 is required for mitotic chromosome architecture in Xenopus laevis egg extracts and, unlike core histones, exhibits rapid turnover on chromatin. Mechanisms regulating the recruitment, deposition, and dynamics of linker histones in mitosis are largely unknown. We found
M Branca et al.
Faraday discussions, 175, 97-111 (2014-10-02)
A variety of imaging technologies are now routinely used in the medical field, their use being continuously enlarged through the development of contrast agents. Recently nanoparticles (NPs) proved efficient to improve imaging in vivo by increasing contrast and targeting capabilities.
Parthiban Ramasamy et al.
Chemistry, an Asian journal, 10(7), 1468-1473 (2015-05-02)
The first colloidal synthesis of Cu2 GeS3 (CGS) nanocrystals with a thermodynamically metastable wurtzite crystal phase is reported. As a benefit of the sulfur precursors used in the synthesis, the shape of the as-synthesized wurtzite CGS nanocrystals can be controlled
Miho Makita et al.
The Journal of reproduction and development, 61(3), 211-217 (2015-03-11)
Recent studies in mice suggest that androgens are important for normal follicle development. However, there have been few reports concerning the action of androgens in the growth of oocytes from large animals. The purpose of this study was to determine
Alessandra Bosutti et al.
The Journal of experimental biology, 218(Pt 21), 3377-3380 (2015-09-20)
It is thought that the prime determinant of global muscle capillary density is the mean oxidative capacity. However, feedback control during maturational growth or adaptive remodelling of local muscle capillarisation is likely to be more complex than simply matching O2
Colleen E Dugan et al.
Analytical and bioanalytical chemistry, 406(20), 4851-4859 (2014-06-02)
Microfluidics has enabled new cell biology experiments. Incorporating chemical monitoring of cellular secretion into chips offers the potential to increase information content and utility of such systems. In this work, an integrated, multilayer polydimethylsiloxane microfluidic chip was developed to simultaneously
Stefan Opitz et al.
Analytical and bioanalytical chemistry, 407(4), 1107-1118 (2014-11-27)
Triton X-100 has been widely used in many analytical and preparative protocols for a long time. Nevertheless, mass spectrometry, chromatographic separation, and spectrophotometric readout may be considerably hampered by this detergent due to signal suppression, complex formation, and high blank
Reginald Tran et al.
Biomicrofluidics, 8(4), 046501-046501 (2014-11-08)
Cell culture in microfluidic systems has primarily been conducted in devices comprised of polydimethylsiloxane (PDMS) or other elastomers. As polystyrene (PS) is the most characterized and commonly used substrate material for cell culture, microfluidic cell culture would ideally be conducted
Ren Wang et al.
Journal of biochemical and molecular toxicology, 29(4), 189-197 (2014-12-23)
Gap junction intercellular communication is involved in ischemia-reperfusion (IR) injury of organs. Connexins are proteins that are critical to the function of gap junctions. To clarify the role of gap junctions in IR injury in liver cells, the function of
Xin Peng et al.
PloS one, 10(4), e0118274-e0118274 (2015-04-11)
Salvianolic acid B and rosmarinic acid are two main water-soluble active ingredients from Salvia miltiorrhiza with important pharmacological activities and clinical applications. The interactions between salvianolic acid B (or rosmarinic acid) and bovine serum albumin (BSA) in the presence and
Elizabeth A Newby et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(8), 932-941 (2015-02-07)
This study was designed to determine the role of the MEK/ERK1/2 and PI3K/Akt pathways in cortisol production and endothelial nitric oxide synthase (eNOS) phosphorylation (peNOS) in the ovine fetal adrenal in response to long-term hypoxia (LTH). Pregnant ewes were maintained
Premkamol Pengpaeng et al.
Anticancer research, 35(1), 201-205 (2015-01-01)
Enhanced cell motility is a hallmark of highly metastatic cancer cells. The anti-migratory activity of Dendrofalconerol A (DF-A), a pure bis(bibenzyls) isolated from the stem of Dendrobium falconeri (Orchidaceae) is reported in the present study. Cytotoxicity effects of DF-A on
Maqsood Ahmed et al.
Biomaterials, 35(33), 9033-9040 (2014-08-12)
There is an acute clinical need for small-calibre (<6 mm) vascular grafts for surgery. The aim of this study was to evaluate the long-term performance of a small-calibre graft produced from a nanocomposite biomaterial, polyhedral oligomeric silsesquioxane poly(carbonate-urea)urethane (POSS-PCU), in a
Menemşe Gümüşderelioğlu et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 31, 120-128 (2015-05-26)
The aim of this study was to develop boron (B)-releasing polymeric scaffold to promote regeneration of bone tissue. Boric acid-doped chitosan nanoparticles with a diameter of approx. 175 nm were produced by tripolyphosphate (TPP)-initiated ionic gelation process. The nanoparticles strongly
Yuanzhong Yang et al.
Analytica chimica acta, 872, 84-94 (2015-04-22)
In this study, the advantages of carrying out the analysis of peptides and tryptic digests of proteins under gradient elution conditions at pH 6.5 by reversed-phase liquid chromatography (RP-HPLC) and in-line electrospray ionisation mass spectrometry (ESI-MS) are documented. For these
M Tonsho et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(8), 2231-2239 (2015-04-24)
While the induction of transient mixed chimerism has tolerized MHC-mismatched renal grafts in nonhuman primates and patients, this approach has not been successful for more immunogenic organs. Here, we describe a modified delayed-tolerance-induction protocol resulting in three out of four
T Toida et al.
Glycoconjugate journal, 17(6), 393-399 (2001-04-11)
Intact and fully O-sulfonated glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, hyaluronan, heparan sulfate and heparin were chemically de-O-sulfonated on their hexosamine C-6 position (6-O-desulfonation) using N,O-bis(trimethylsilyl) acetamide. 1H NMR spectroscopy and chemical compositional analysis showed that the chemical de-O-sulfonation
Rajeswari Ravichandran et al.
Tissue engineering. Part A, 21(7-8), 1288-1298 (2015-01-07)
Heart failure due to Myocardial Infarction (MI) remains the leading cause of death worldwide due to the inability of myocardial tissue to regenerate following infarction. Current therapies could only retard the progression of disease, but fails to bring functional improvement
Yoshihiro Suzuki-Karasaki et al.
Oncotarget, 6(25), 21572-21588 (2015-06-10)
Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is a promising anticancer drug due to its tumor-selective cytotoxicity. Here we report that TRAIL exhibits distinct effects on the mitochondrial networks in malignant cells and normal cells. Live-cell imaging revealed that multiple
Kara M Zabetakis et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 50(8), 794-805 (2015-06-02)
The microbiological impact of zero-valent iron used in the remediation of groundwater was investigated by exposing a trichloroethylene-degrading anaerobic microbial community to two types of iron nanoparticles. Changes in total bacterial and archaeal population numbers were analyzed using qPCR and
Sara Bagherifard et al.
Biomaterials, 73, 185-197 (2015-09-28)
Substrate grain structure and topography play major roles in mediating cell and bacteria activities. Severe plastic deformation techniques, known as efficient metal-forming and grain refining processes, provide the treated material with novel mechanical properties and can be adopted to modify
Maren Kuhne et al.
Journal of immunological methods, 413, 45-56 (2014-07-25)
A novel method that optimizes the screening for antibody-secreting hapten-specific hybridoma cells by using flow cytometry is described. Cell clones specific for five different haptens were analyzed. We selectively double stained and analyzed fixed hybridoma cells with fluorophore-labeled haptens to
Cynthia Louis et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 134-144 (2015-05-29)
M-CSF (or CSF-1) and GM-CSF can regulate the development and function of the mononuclear phagocyte system (MPS). To address some of the outstanding and sometimes conflicting issues surrounding this biology, we undertook a comparative analysis of the effects of neutralizing
Ming Pei et al.
Bone, 78, 1-10 (2015-05-06)
Repairing large bone defects presents a significant challenge, especially in those people who have a limited regenerative capacity such as in osteoporotic (OP) patients. The aim of this study was to compare adipose stem cells (ASCs) from both normal (NORM)
Diego R Perinelli et al.
Pharmaceutical research, 32(3), 1094-1104 (2014-09-23)
This work investigated the influence of a model protein, bovine serum albumin (BSA), on the properties of a thermogelling formulation intended for administration inside body compartments where there is high albumin content, as in the case of inflamed joints; it
Majambu Mbikay et al.
FEBS open bio, 4, 755-762 (2014-10-29)
Low-density lipoprotein receptor (LDLR) mediates hepatic clearance of plasma cholesterol; proprotein convertase subtilisin/kexin 9 (PCSK9) opposes this clearance by promoting LDLR degradation. The plant flavonoid quercetin-3-β-d-glucoside (Q3G) has been shown to reduce hypercholesterolemia in experimental animals. Here, we examined how
S Rondini et al.
Infection and immunity, 83(3), 996-1007 (2014-12-31)
Nontyphoidal salmonellae, particularly Salmonella enterica serovar Typhimurium, are a major cause of invasive disease in Africa, affecting mainly young children and HIV-infected individuals. Glycoconjugate vaccines provide a safe and reliable strategy against invasive polysaccharide-encapsulated pathogens, and lipopolysaccharide (LPS) is a
Joseph A Califano et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(1), 30-38 (2015-01-08)
To determine if phosphodiesterase 5 (PDE5) inhibitors can augment immune function in patients with head and neck cancer through inhibition of myeloid-derived suppressor cells (MDSC). We performed a randomized, prospective, double blinded, placebo controlled, phase II clinical trial to determine
K Hoehlig et al.
British journal of pharmacology, 172(12), 3086-3098 (2015-02-11)
Calcitonin gene-related peptide (CGRP) plays an important role in the pathology of migraine, and recent clinical trials suggest the inhibition of CGRP-mediated processes as a new therapeutic option in migraine. In this study, we describe the generation of NOX-L41, a
Rumi Khandelia et al.
Small (Weinheim an der Bergstrasse, Germany), 11(33), 4075-4081 (2015-05-06)
Gold nanoclusters in albumin nanoparticles (nanovehicles) are used for single-photon and two-photon imaging of cancer cells following the delivery of doxorubicin through the nanovehicle. NIR excitation and emission wavelengths in the biological window (650-900 nm) make the nanovehicle an ideal
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