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109681

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Yue Cai et al.
Oncology research, 27(8), 889-899 (2019-04-04)
The thorns of Gleditsia sinensis have been historically used in Chinese medicine and are considered one of the fundamental therapeutic herbs. Its anticancer effects are currently being explored. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer
Steffi Lütkecosmann et al.
Biochemical and biophysical research communications, 482(4), 1054-1059 (2016-12-04)
Leukotriene B4 as an inflammatory mediator is an important biomarker for different respiratory diseases like asthma, chronic obstructive pulmonary disease or cystic lung fibrosis. Therefore the detection of LTB4 is helpful in the diagnosis of these pulmonary diseases. However, until
Jill E Fuller et al.
Maternal and child health journal, 21(1), 29-35 (2016-07-23)
Objectives Sources of immunization data include state registries or immunization information systems (IIS), medical records, and surveys. Little is known about the quality of these data sources or the feasibility of using IIS data for research. We assessed the feasibility
Milena Kosiorek et al.
Environmental science and pollution research international, 26(16), 16762-16780 (2019-04-19)
The aim of the study was to determine the effectiveness of soil application of manure, clay, charcoal, zeolite, and calcium oxide in remediation of soil polluted with cobalt (0, 20, 40, 80, 160, 320 mg Co kg-1 of soil). The following
Ekaterina A Dolgopolova et al.
Journal of the American Chemical Society, 141(13), 5350-5358 (2019-03-07)
Electronic structure modulation of metal-organic frameworks (MOFs) through the connection of linker "wires" as a function of an external stimulus is reported for the first time. The established correlation between MOF electronic properties and photoisomerization kinetics as well as changes
Huimin Liu et al.
Food & function, 10(6), 3603-3614 (2019-06-05)
Ginsenoside Rg2 is one of the specific ginsenosides in red ginseng, and has been reported to exhibit protective effects against neurotoxicity and memory impairment, and also inhibition of hepatic glucose production. However, the effect of Rg2 on the prevention of
Miriam Thomalla et al.
The Journal of endocrinology, 240(2), 325-343 (2018-12-07)
Adipocytes express various pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and actively participate in anti-bacterial and anti-viral host defence. Obesity is associated with adipose tissue PRR expression. The potential role of Toll-like receptor 9 (TLR9) in adipocytes has
Susan T Herman et al.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 32(2), 87-95 (2015-01-30)
Critical Care Continuous EEG (CCEEG) is a common procedure to monitor brain function in patients with altered mental status in intensive care units. There is significant variability in patient populations undergoing CCEEG and in technical specifications for CCEEG performance. The
Ryan L Hanson et al.
The Journal of cell biology, 218(4), 1282-1297 (2019-02-13)
In response to DNA damage, the transcription factor p53 accumulates in a series of pulses. While p53 dynamics play a critical role in regulating stress responses, how p53 pulsing affects target protein expression is not well understood. Recently, we showed
Joanna Klubo-Gwiezdzinska et al.
Endocrine connections, 6(7), 469-478 (2017-08-10)
Amifostine is a potent scavenger of reactive oxygen species that is used for the salivary gland protection during therapy with radioactive iodine for thyroid cancer. There are no data on the potential effect of amifostine on thyroid cancer cells. We
Piotr Kaczynski et al.
Theriogenology, 142, 169-176 (2019-10-11)
Blood vessel formation is a critical process for successful pregnancy establishment and placenta formation. Angiogenic factors such as vascular endothelial growth factor (VEGF), angiopoietins (ANGPTs) or fibroblast growth factor 2 (FGF2) are known to be involved in angiogenesis. However, the
Prasanna Kumar Athyala et al.
Biochemical and biophysical research communications, 469(2), 257-262 (2015-12-09)
Neocarzinostatin (NCS) a potent DNA-damaging, anti-tumor toxin extracted from Streptomyces carzinostaticus that recognizes double-stranded DNA bulge and induces DNA damage. 2 Fluoro (2F) Modified EpCAM RNA aptamer is a 23-mer that targets EpCAM protein, expressed on the surface of epithelial
C Xu et al.
Oncogene, 34(3), 281-289 (2014-01-15)
Mdm2 is a critical negative regulator of the tumor suppressor protein p53. Mdm2 is an E3 ligase whose overexpression leads to functional inactivation of p53. Mdm2 protein stability is regulated by several mechanisms including RING (Really Interesting New Gene) domain-mediated
Eun Hyoung Shim et al.
International journal of clinical and experimental pathology, 8(1), 458-465 (2015-03-11)
Jea-Ma-Chung-Sim-Youn-Ja-Tang (JCST), one of herbal formulae, is modified prescription base on Chung-Sim-Youn-Ja-Tang (CST) which treats cerebrovascular disease for the Tae-Eum-In (TE). This study was designed to determine the anti-inflammatory and anti-adipogenesis effect of CST and JCST in vitro. CST and
Masako Yaoita et al.
Human genetics, 135(2), 209-222 (2015-12-31)
RASopathies are autosomal dominant disorders caused by mutations in more than 10 known genes that regulate the RAS/MAPK pathway. Noonan syndrome (NS) is a RASopathy characterized by a distinctive facial appearance, musculoskeletal abnormalities, and congenital heart defects. We have recently
Hongkai Zhu et al.
Environmental science & technology, 53(13), 7859-7865 (2019-06-11)
Melamine received public and regulatory attention in 2008 following a scandal that involved the adulteration of milk and infant formula in China that affected tens of thousands of infants. Little is known about human exposure and the food chain transfer
Yiping Wang et al.
Molecular medicine reports, 11(6), 4518-4524 (2015-02-13)
Previous studies have suggested that ginsenoside Rg3 (GSRg3) extract from the medicinal plant Panax ginseng, may increase nitric oxide production via increases in the phosphorylation and expression of endothelial nitric oxide synthase (eNOS). The present study used an in vitro neonatal
Yasuhiro Uchimura et al.
Immunity, 49(3), 545-559 (2018-09-09)
Although the mammalian microbiota is well contained within the intestine, it profoundly shapes development and metabolism of almost every host organ. We questioned the range and depth of microbial metabolite penetration into the host, and how this is modulated by
Yukako Obata et al.
Molecular and cellular biochemistry, 445(1-2), 179-186 (2017-12-31)
Plasmin is a fibrinolytic factor and a serine protease that activates protease-activated receptors (PARs) to produce endothelium-derived relaxing factors such as nitric oxide and prostacyclin. Nitric oxide and prostacyclin production is regulated, at least in part, by the intracellular Ca2+
Christopher C Nguyen et al.
Journal of virology, 94(5) (2019-12-06)
The human cytomegalovirus (HCMV) endoplasmic reticulum (ER)-resident glycoprotein UL148 is posited to play roles in immune evasion and regulation of viral cell tropism. UL148 prevents cell surface presentation of the immune cell costimulatory ligand CD58 while promoting maturation and virion
Mireille-Maria Suttle et al.
Acta dermato-venereologica, 95(5), 536-541 (2014-11-27)
A slight epidermal damage can induce the Köbner reaction in psoriasis, and the “alarmin”, interleukin-33 (IL-33), may be involved in this process. Therefore, the uninvolved psoriatic skin was tape-stripped, and skin biopsies were collected at 0 day, 2 h and
Jane McHowat et al.
Frontiers in physiology, 11, 460-460 (2020-05-28)
Endothelial activation and dysfunction are hallmarks of inflammation. Neutrophil-vascular endothelium interactions have significant effects on vascular wall physiology and pathology. Myeloperoxidase (MPO)-derived products released from activated neutrophils can mediate the inflammatory response and contribute to endothelial dysfunction. 2-Chlorofatty aldehyde (2-ClFALD)
Gregor Omejec et al.
Muscle & nerve, 57(6), 951-957 (2017-12-22)
The aim of the study was to compare the utility of instrument-based assessment of peripheral nerve function with the neurologic examination in ulnar neuropathy at the elbow (UNE). We prospectively recruited consecutive patients with suspected UNE, performed a neurologic examination
Agnieszka Blitek et al.
Theriogenology, 127, 88-101 (2019-01-25)
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor family of ligand-dependent transcription factors. PPARs are important regulators of glucose and fatty acid metabolism, apoptosis, angiogenesis, cell proliferation and differentiation, and immune response. Their possible role in the female
Kanika Bajaj Pahuja et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(25), E3199-E3206 (2015-06-10)
Most secretory cargo proteins in eukaryotes are synthesized in the endoplasmic reticulum and actively exported in membrane-bound vesicles that are formed by the cytosolic coat protein complex II (COPII). COPII proteins are assisted by a variety of cargo-specific adaptor proteins
Alexandra Dimitrova et al.
Journal of alternative and complementary medicine (New York, N.Y.), 23(3), 164-179 (2017-01-24)
Neuropathy and its associated pain pose great therapeutic challenges. While there has been a recent surge in acupuncture use and research, little remains known about its effects on nerve function. This review aims to assess the efficacy of acupuncture in
Titanium-mediated amination of Grignard reagents using primary and secondary amines.
Timothy J Barker et al.
Angewandte Chemie (International ed. in English), 50(36), 8325-8328 (2011-07-20)
Andoni Echaniz-Laguna et al.
Neurogenetics, 21(1), 29-37 (2019-10-28)
Giant axonal neuropathy (GAN) is an autosomal recessive disease caused by mutations in the GAN gene encoding gigaxonin. Patients develop a progressive sensorimotor neuropathy affecting peripheral nervous system (PNS) and central nervous system (CNS). Methods: In this multicenter observational retrospective
Ana Juan-García et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 118, 719-725 (2018-06-18)
Mycotoxins are produced by a number of fungal genera spp as e.g. Aspergillus, Penicillium, Alternaria, Fusarium and Claviceps. 3-Acetyl-Deoxynivalenol (3-A-DON) and 15-Acetyl-Deoxynivalenol (15-ADON) which are produced by Fusarium, chemically belong to trichothecenes and occur in significant amounts as modified forms
Khairy M A Zoheir et al.
Theriogenology, 88, 124-130 (2016-10-30)
The present study aimed to evaluate the in vitro effect of alpha lipoic acid (ALA) addition to the culture medium on the development of the bovine secondary preantral follicles. Bovine secondary preantral follicles were collected and divided into two groups depending
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