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L P Zhang et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(9), R702-R711 (2013-03-01)
The present study investigated transient receptor potential vanilloid type 4 (TRPV4) ion channels in pancreatic stellate cells (PSCs) isolated from rats with high-fat and alcohol diet (HFA)-induced chronic pancreatitis. TRPV4 is a calcium-permeable nonselective ion channel responsive to osmotic changes
Cristiano Fava et al.
Prostaglandins & other lipid mediators, 98(3-4), 75-85 (2011-12-17)
Hypertension is a multifactorial disease in which the interplay of genetic and environmental factors that maintain blood pressure stable throughout life is altered. Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active
Berthold Koletzko et al.
Annals of nutrition & metabolism, 65(1), 49-80 (2014-09-18)
The Early Nutrition Academy supported a systematic review of human studies on the roles of pre- and postnatal long-chain polyunsaturated fatty acids (LC-PUFA) published from 2008 to 2013 and an expert workshop that reviewed the information and developed recommendations, considering
Jinhui Yang et al.
Neuropharmacology, 86, 353-361 (2014-09-10)
Increasing evidence demonstrates that different opioids, while acting μ opioid receptors, can activate distinct downstream responses, a phenomenon termed functional selectivity or biased agonism. The present study designed experiments to test whether the μ receptor agonist morphine and D-Ala(2), N-Me-Phe(4)
María Salomé Gachet et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 976-977, 6-18 (2014-12-02)
Free arachidonic acid is functionally interlinked with different lipid signaling networks including those involving prostanoid pathways, the endocannabinoid system, N-acylethanolamines, as well as steroids. A sensitive and specific LC-MS/MS method for the quantification of arachidonic acid, prostaglandin E2, thromboxane B2
Dong Chang et al.
Journal of the American College of Nutrition, 33(5), 406-411 (2014-08-01)
To evaluate and compare the levels of free fatty acids between senile cataract patients and normal controls. Fifty consecutive patients with newly diagnosed senile cataract and 50 age- and gender-matched controls were evaluated. Subjects/patients were randomized according to selection criteria.
Luis M Rodríguez-Alcalá et al.
Journal of agricultural and food chemistry, 63(42), 9341-9348 (2015-10-10)
The banned pesticide dichlorodiphenyltrichloroethane (DDT) and its main metabolite, p,p'-dichlorodiphenyldichloroethylene (DDE), are commonly found in the food chain and in all tissues of living organisms. DDE is associated with metabolic diseases acting as an endocrine disruptor and more recently with
Yaping Zhang et al.
Clinica chimica acta; international journal of clinical chemistry, 437, 31-37 (2014-07-13)
Changes in the levels of lipids are associated with breast cancer (BC). Disease-specific serum free fatty acids (FFAs) were quantified using chip-based direct-infusion nanoelectrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry (CBDInanoESI-FTICR MS) in the negative ion mode. Multiple point
Andrew L Frelinger et al.
Circulation, 113(25), 2888-2896 (2006-06-21)
Thrombotic events still occur in aspirin-treated patients with coronary artery disease. To better understand aspirin "resistance," serum thromboxane B2 (TXB2) and flow cytometric measures of arachidonic acid-induced platelet activation (before and after the ex vivo addition of aspirin and indomethacin)
Hemalatha Sundaramoorthi et al.
Platelets, 26(7), 613-619 (2015-04-23)
Zebrafish has become an excellent model system to study mammalian hemostasis. Despite our extensive efforts to develop technologies to measure zebrafish hemostasis and even with previously established thrombocyte qualitative and quantitative functional assays, quantifying thrombocyte function for high throughput applications
Wilma Neumann et al.
ChemMedChem, 10(1), 183-192 (2014-10-17)
Cyclooxygenase (COX) is an enzyme involved in tumorigenesis and is associated with tumor cell resistance against platinum-based antitumor drugs. Cisplatin analogues were conjugated with COX inhibitors (indomethacin, ibuprofen) to study the synergistic effects that were previously observed in combination treatments.
Tamás Decsi et al.
The American journal of clinical nutrition, 98(2), 543S-548S (2013-07-05)
We summarize data on the potential interaction of trans isomeric fatty acids [trans fatty acids (TFAs)] with the availability of long-chain polyunsaturated fatty acids (LC-PUFAs) in the perinatal period. Today, TFA intakes in pregnant and lactating women can be estimated
Gregory C Henderson et al.
The British journal of nutrition, 111(10), 1791-1800 (2014-02-15)
Duchenne muscular dystrophy (DMD) is a severe muscle disease that affects afflicted males from a young age, and the mdx mouse is an animal model of this disease. Although new drugs are in development, it is also essential to assess
Ako Fukami et al.
Atherosclerosis, 239(2), 577-582 (2015-03-04)
Epidemiological evidence suggests that the increased intake of omega-3 polyunsaturated fatty acids can prevent atherosclerosis-related cardiovascular diseases. Recently, serum eicosapentaenoic acid to arachidonic acid (EPA/AA) ratio has been reported to be a predictive marker of cardiovascular events. Accordingly, we examined
J Abdi et al.
The Journal of nutritional biochemistry, 25(12), 1254-1262 (2014-10-04)
The n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to enhance the effect of chemotherapeutic drugs in clinical studies in cancer patients and to induce apoptotic tumor cell death in vitro. Until now, EPA
Emily K K Tai et al.
Food & function, 4(12), 1767-1775 (2013-10-24)
Human milk is the ideal food providing optimal nutrition for healthy term infants. Its complex lipid composition is critical for infant growth and serves as a golden standard for baby formula development. Docosahexaenoic acid (C22:6 n- 3, DHA) and arachidonic
Minako Ishibashi et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(6), 1171-1179 (2013-04-13)
Liver X receptors (LXRs) are oxysterol-activated nuclear receptors that are highly expressed in macrophages and regulate lipid homeostasis and inflammation. Among putative LXR target genes, lysophosphatidylcholine acyltransferase 3 (LPCAT3) involved in the Lands cycle controls the fatty acid composition at
Dermot Cox et al.
Stroke, 37(8), 2153-2158 (2006-06-24)
Aspirin resistance may be relatively common and associated with adverse outcome. Meta-analysis has clearly shown that 75 mg plain aspirin is the lowest effective dose; however, it is not known whether the recent increased use of enteric-coated aspirin could account
Elke C G Jackson et al.
The Journal of pharmacology and experimental therapeutics, 347(3), 582-588 (2013-09-18)
Human platelet activation by collagen occurs in a dose-dependent manner. High concentrations of collagen bind to a pair of receptors, the α2β1 integrin and glycoprotein (GP)VI/Fc-receptor γ-chain (FcRγ), which stimulate a cascade of events including Syk, LAT, Btk, Gads, and
Eric A Newman
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 33(11), 1685-1695 (2013-08-22)
The retinal vasculature supplies cells of the inner and middle layers of the retina with oxygen and nutrients. Photic stimulation dilates retinal arterioles producing blood flow increases, a response termed functional hyperemia. Despite recent advances, the neurovascular coupling mechanisms mediating
Yoshinobu Kiso
Journal of pharmacological sciences, 115(4), 471-475 (2011-03-26)
Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are major constituents of cell membranes and play important roles in preserving physiological and psychological function. Recently, data from several studies have indicated that impairments in long-term potentiation (LTP), the process underlying plasticity
Alma M Astudillo et al.
Biochimica et biophysica acta, 1821(2), 249-256 (2011-12-14)
The development of mass spectrometry-based techniques is opening new insights into the understanding of arachidonic acid (AA) metabolism. AA incorporation, remodeling and release are collectively controlled by acyltransferases, phospholipases and transacylases that exquisitely regulate the distribution of AA between the
Mathieu Fiore et al.
The Journal of thoracic and cardiovascular surgery, 148(6), 3119-3125 (2014-09-13)
This study evaluated platelet function for an extended period of time in patients with a HeartMate II continuous-flow left ventricular assist device (Thoratec Corporation, Pleasanton, Calif) with light transmission aggregometry and investigated the potential role of this test in clinical
Melissa K Gregory et al.
Biochimica et biophysica acta, 1841(12), 1656-1660 (2014-10-15)
The synthesis of the omega-3 long-chain polyunsaturated fatty acids (LCPUFA) eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n--3) from dietary α-linolenic acid (ALA; 18:3n--3) requires three desaturation and three elongation steps in vertebrates. The elongation of EPA to docosapentaenoic
L Tuure et al.
Scandinavian journal of rheumatology, 44(1), 74-79 (2014-10-15)
Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal enzyme in the production of prostaglandin E2 (PGE2) and its expression is upregulated during inflammation. mPGES-1 is considered as a potential drug target for the treatment of arthritis to reduce adverse effects
George B Kudolo et al.
Journal of herbal pharmacotherapy, 4(4), 13-26 (2005-06-02)
Twelve non-diabetic volunteers (age = 39 +/- 13 years, BMI = 23.5 +/- 3.5) undertook a randomized double-blind placebo-controlled crossover study in which they ingested either 120 mg of EGb 761 or a placebo daily for 3 months and then
Sarita Ahlawat et al.
Scientific reports, 4, 5551-5551 (2014-07-06)
Cytochrome P450 (P450) enzymes are a superfamily of heme-containing enzymes involved in the metabolism of various endogenous compounds, including retinoids, glucocorticoids, and eicosanoids, that are postulated to participate in the maintenance and/or development of inflammatory and immune reactions in the
Y Min et al.
Diabetologia, 47(1), 75-81 (2003-11-25)
Gestational diabetes is a metabolic disorder affecting 2-5% of women and is a predictor of obesity, Type 2 diabetes mellitus and cardiovascular disease. Insulin resistance, a characteristic of gestational diabetes and obesity, is correlated with the fatty acids profile of
Roger C Carroll et al.
The Journal of laboratory and clinical medicine, 146(1), 30-35 (2005-07-19)
Optical platelet aggregation (OPA) with platelet-rich plasma (PRP) was compared with a Thrombelastograph (TEG) whole blood assay for monitoring arachidonic acid (AA)-induced platelet activation. Assays were performed on 47 interventional cardiology and 24 general surgery patients receiving aspirin therapy for
Lawrence K Lee et al.
The Journal of biological chemistry, 288(21), 15269-15279 (2013-03-14)
Human group IIA secreted phospholipase A2 (hGIIA) promotes tumor growth and inflammation and can act independently of its well described catalytic lipase activity via an alternative poorly understood signaling pathway. With six chemically diverse inhibitors we show that it is
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