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Fouad F Al-Qaim et al.
Journal of chromatography. A, 1345, 139-153 (2014-04-29)
An analytical method that facilitated the analysis of 11 pharmaceuticals residue (caffeine, prazosin, enalapril, carbamazepine, nifedipine, levonorgestrel, simvastatin, hydrochlorothiazide, gliclazide, diclofenac-Na, and mefenamic acid) with a single pre-treatment protocol was developed. The proposed method included an isolation and concentration procedure
Carolina Paola García et al.
Stem cell research, 12(2), 400-414 (2014-01-02)
Embryonic stem cells (ESCs) need to maintain their genomic integrity in response to DNA damage to safeguard the integrity of the organism. DNA double strand breaks (DSBs) are one of the most lethal forms of DNA damage and, if not
Mariana N Batista et al.
Archives of virology, 160(2), 399-407 (2014-12-11)
Hepatitis C is considered the major cause of cirrhosis and hepatocellular carcinoma. Conventional treatment is not effective against some hepatitis C virus (HCV) genotypes; therefore, new treatments are needed. Coffee and, more recently, caffeine, have been found to have a
Anne-Laure Gassner et al.
Journal of chromatography. A, 1353, 121-130 (2014-06-14)
Procedures for estimating the measurement uncertainty (MU) of the concentration of a given analyte in a sample are of major concern for analytical chemists. Unfortunately, it is still unclear how and why MU should be assessed. While several possibilities exist
Dimitrios Moustakas et al.
PloS one, 10(4), e0123310-e0123310 (2015-04-17)
The stimulant effect of energy drinks is primarily attributed to the caffeine they contain. Many energy drinks also contain other ingredients that might enhance the tonic effects of these caffeinated beverages. One of these additives is guarana. Guarana is a
Martin Kronschläger et al.
Experimental eye research, 127, 179-183 (2014-08-12)
The aim of the present study was to examine if topically applied caffeine influences pupil size in ketamine/xylazine anesthetized animals. Two experiments were carried out. In the first experiment, caffeine was topically applied to one of the eyes of 10
Regina Wierzejska
Roczniki Panstwowego Zakladu Higieny, 63(2), 141-147 (2012-08-30)
Caffeine is widely consumed by people of all ages. In the last period a market of caffeine-containing products, particularly energy drinks and food supplements increased. Caffeine for years is under discussion, whether has positive whether adverse impact on health. Children
[How much coffee is healthy?].
Franziska Etter
Praxis, 103(25), 1531-1532 (2014-12-11)
Rosario Villegas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7179-7189 (2014-05-23)
Axonal degeneration represents an early pathological event in neurodegeneration, constituting an important target for neuroprotection. Regardless of the initial injury, which could be toxic, mechanical, metabolic, or genetic, degeneration of axons shares a common mechanism involving mitochondrial dysfunction and production
Susanne Burdak-Rothkamm et al.
Cancer letters, 356(2 Pt B), 454-461 (2014-10-12)
Radiotherapy is an important treatment option for many human cancers. Current research is investigating the use of molecular targeted drugs in order to improve responses to radiotherapy in various cancers. The cellular response to irradiation is driven by both direct
Georgios Petrides et al.
The American journal of psychiatry, 172(1), 52-58 (2014-08-27)
Up to 70% of patients with treatment-resistant schizophrenia do not respond to clozapine. Pharmacological augmentation to clozapine has been studied with unimpressive results. The authors examined the use of ECT as an augmentation to clozapine for treatment-refractory schizophrenia. In a
Lianguo Wang et al.
Circulation research, 114(9), 1410-1421 (2014-02-27)
Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to normal excitation-contraction coupling but may also contribute to pathological cardiac alternans and arrhythmia. To measure intra-SR free [Ca(2+)] ([Ca(2+)]SR) changes in intact hearts during alternans and ventricular fibrillation (VF). Simultaneous optical mapping
Soma Banerjee et al.
Journal of molecular recognition : JMR, 27(8), 510-520 (2014-07-06)
Electron transfer (ET) reactions are important for their implications in both oxidative and reductive DNA damages. The current contribution investigates the efficacy of caffeine, a xanthine alkaloid in preventing UVA radiation induced ET from a carcinogen, benzo[a]pyrene (BP) to DNA
PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.
Ellen M McDonagh et al.
Pharmacogenetics and genomics, 24(8), 409-425 (2014-06-04)
Andrew M Greenhagen et al.
Chemosphere, 115, 13-19 (2014-03-07)
Trace amounts of pharmaceutical compounds have been detected in waters across the United States. Many compounds are released as the result of human ingestion and subsequent excretion of over-the-counter and prescription medications, and illicit drugs. This research utilized columns (30×30cm)
France Denoeud et al.
Science (New York, N.Y.), 345(6201), 1181-1184 (2014-09-06)
Coffee is a valuable beverage crop due to its characteristic flavor, aroma, and the stimulating effects of caffeine. We generated a high-quality draft genome of the species Coffea canephora, which displays a conserved chromosomal gene order among asterid angiosperms. Although
Seira Narishige et al.
British journal of pharmacology, 171(24), 5858-5869 (2014-08-28)
Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist of the main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadian rhythms and modifies phase changes in SCN-operated rhythms, the effects on caffeine on
Suzanne J L Einöther et al.
Psychopharmacology, 225(2), 251-274 (2012-12-18)
Despite the large number of studies on the behavioural effects of caffeine, an unequivocal conclusion had not been reached. In this review, we seek to disentangle a number of questions. Whereas there is a general consensus that caffeine can improve
Dong Wook Choi et al.
Biomolecules & therapeutics, 23(2), 128-133 (2015-03-15)
Although coffee is known to have antioxidant, anti-inflammatory, and antitumor properties, there have been few reports about the effect and mechanism of coffee compounds in colorectal cancer. Heat shock proteins (HSPs) are molecular chaperones that prevent cell death. Their expression
Yu-Chi Liu et al.
PLoS genetics, 10(3), e1004209-e1004209 (2014-03-22)
The olfactory systems of insects are fundamental to all aspects of their behaviour, and insect olfactory receptor neurons (ORNs) exhibit exquisite specificity and sensitivity to a wide range of environmental cues. In Drosophila melanogaster, ORN responses are determined by three
Xiao-Yu Bai et al.
Behavioural pharmacology, 25(7), 648-660 (2014-08-30)
To characterize the sedative and hypnotic profile of the novel adenosine derivative ((3S,4R,5R)-3,4-dihydroxy-5-(6-((4-hydroxy-3-methoxybenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-2-yl) methyl diaconate (WS0701), we performed a variety of behavioural tests and investigated the influence of WS0701 on various sleep stages. In mice, WS0701 significantly increased the number
Hazit Zayas et al.
Organic & biomolecular chemistry, 12(36), 6994-7003 (2014-06-17)
Six novel functional monomers: 4-(4-vinylphenyl)pyridine (M1), 4′-vinylbiphenyl-4-ol (M2), N,N-dimethyl-4′-vinylbiphenyl-3-amine (M3), (4′-vinylbiphenyl-4-yl)methanol (M4), 4′-vinylbiphenyl-4-carboxylic acid (M5) and 4-hydroxy-5-methyl-4′-vinylbiphenyl-3-carboxylic acid (M6), were examined for their ability to imprint theophylline (1). Using a molecular modelling-NMR titration approach, M2 and M6 were predicted to
Kirti Kumar Tiwari et al.
Biochemical and biophysical research communications, 450(4), 1345-1350 (2014-07-06)
Caffeine is used to prevent bronchopulmonary dysplasia (BPD) in premature neonates. Hyperoxia contributes to the development of BPD, inhibits cell proliferation and decreases cell survival. The mechanisms responsible for the protective effect of caffeine in pulmonary oxygen toxicity remain largely
Evangelia Terzopoulou et al.
Environmental science and pollution research international, 22(2), 1095-1112 (2014-08-12)
A multi-residue method, based on gas chromatography coupled to tandem mass spectrometry (GC-MS/MS), has been developed for the determination of 70 organic micropollutants from various chemical classes (organochlorinated, organophosphorous, triazines, carbamate and urea, polycyclic aromatic hydrocarbons, polychlorinated biphenyls, pharmaceuticals, phenols
K U Petersen
MMW Fortschritte der Medizin, 155 Suppl 4, 109-114 (2014-06-18)
Caffeine as an analgesic adiuvant has been discussed for many years. In a recent Cochrane review based on 19 studies with a total of 7238 patients, caffeine enhanced the efficacy of paracetamol, ibuprofen or aspirin with a number needed to
N Whitehead et al.
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 26(2), 111-125 (2013-01-22)
Compounds other than macronutrients have been shown to influence blood glucose concentrations and insulin sensitivity in people with diabetes, with caffeine being one such substance. The present study systematically reviewed the evidence of the effects of caffeine on blood glucose
In-Ah Lee et al.
Journal of gastroenterology, 49(8), 1206-1216 (2013-08-09)
The initial trigger of inflammatory bowel disease (IBD) can be partly attributed towards the interaction and invasion of intestinal epithelial cells (IECs) and submucosal compartments. Identifying safe and economical methods to block these interactions may help prevent the onset of
Youjin Je et al.
The British journal of nutrition, 111(7), 1162-1173 (2013-11-28)
Coffee consumption has been shown to be associated with various health outcomes, but no comprehensive review and meta-analysis of the association between coffee consumption and total mortality has been conducted. To quantitatively assess this association, we conducted a meta-analysis of
M Sandeep et al.
Indian journal of experimental biology, 52(12), 1165-1172 (2015-02-06)
Meclizine and caffeine combination is used for the treatment of morning sickness. Both compounds are teratogenic and caffeine is known to possess anti-fertility activity also. The present study was undertaken to evaluate the reproductive toxic effect of meclizine and caffeine
Samuel W Cramer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(14), 5664-5679 (2015-04-10)
The Ca(2+) channelopathies caused by mutations of the CACNA1A gene that encodes the pore-forming subunit of the human Cav2.1 (P/Q-type) voltage-gated Ca(2+) channel include episodic ataxia type 2 (EA2). Although, in EA2 the emphasis has been on cerebellar dysfunction, patients
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